Issue 1/2018
Content (327 Articles)
Notch1 signaling in melanoma cells promoted tumor-induced immunosuppression via upregulation of TGF-β1
Zike Yang, Yanxia Qi, Nan Lai, Jiahe Zhang, Zehong Chen, Mingyu Liu, Wan Zhang, Rongcheng Luo, Shijun Kang
Relevance of 3d culture systems to study osteosarcoma environment
Angela De Luca, Lavinia Raimondi, Francesca Salamanna, Valeria Carina, Viviana Costa, Daniele Bellavia, Riccardo Alessandro, Milena Fini, Gianluca Giavaresi
EZH2 promotes hepatocellular carcinoma progression through modulating miR-22/galectin-9 axis
Shaofei Chen, Jiarui Pu, Jie Bai, Yuping Yin, Ke Wu, Jiliang Wang, Xiaoming Shuai, Jinbo Gao, Kaixiong Tao, Guobin Wang, Hang Li
Microfluidic co-culture of pancreatic tumor spheroids with stellate cells as a novel 3D model for investigation of stroma-mediated cell motility and drug resistance
Ji-Hyun Lee, Seul-Ki Kim, Iftikhar Ali Khawar, Su-Yeong Jeong, Seok Chung, Hyo-Jeong Kuh
Role of the nervous system in cancer metastasis
Nyanbol Kuol, Lily Stojanovska, Vasso Apostolopoulos, Kulmira Nurgali
Stress-inducible Protein-1 promotes metastasis of gastric cancer via Wnt/β-catenin signaling pathway
Linlin Huang, Ertao Zhai, Shirong Cai, Yi Lin, Junbin Liao, Huilin Jin, Sui Peng, Lixia Xu, Minhu Chen, Zhirong Zeng
The plant alkaloid tetrandrine inhibits metastasis via autophagy-dependent Wnt/β-catenin and metastatic tumor antigen 1 signaling in human liver cancer cells
Zhenxing Zhang, Ting Liu, Man Yu, Kangdi Li, Wenhua Li
INPP4B promotes cell survival via SGK3 activation in NPM1-mutated leukemia
Hongjun Jin, Liyuan Yang, Lu Wang, Zailin Yang, Qian Zhan, Yao Tao, Qin Zou, Yuting Tang, Jingrong Xian, Shuaishuai Zhang, Yipei Jing, Ling Zhang
Autophagy promotes metastasis and glycolysis by upregulating MCT1 expression and Wnt/β-catenin signaling pathway activation in hepatocellular carcinoma cells
Qing Fan, Liang Yang, Xiaodong Zhang, Yingbo Ma, Yan Li, Lei Dong, Zhihong Zong, Xiangdong Hua, Dongming Su, Hangyu Li, Jingang Liu
MCM6 promotes metastasis of hepatocellular carcinoma via MEK/ERK pathway and serves as a novel serum biomarker for early recurrence
Mingyu Liu, Qiaoting Hu, Mengxian Tu, Xinyi Wang, Zike Yang, Guoxiong Yang, Rongcheng Luo
Anti-tumor effects of ONC201 in combination with VEGF-inhibitors significantly impacts colorectal cancer growth and survival in vivo through complementary non-overlapping mechanisms
Jessica Wagner, C. Leah Kline, Lanlan Zhou, Vladimir Khazak, Wafik S. El-Deiry
A synthetic cell-penetrating peptide derived from nuclear localization signal of EPS8 exerts anticancer activity against acute myeloid leukemia
Yiran Chen, Xiaoling Xie, Anqin Wu, Lei Wang, Yuxing Hu, Honghao Zhang, Yuhua Li
Over-expression of oncigenic pesudogene DUXAP10 promotes cell proliferation and invasion by regulating LATS1 and β-catenin in gastric cancer
Yongcan Xu, Xiang Yu, Chenchen Wei, Fengqi Nie, Mingde Huang, Ming Sun
RETRACTED ARTICLE: miR-3928v is induced by HBx via NF-κB/EGR1 and contributes to hepatocellular carcinoma malignancy by down-regulating VDAC3
Qiaoge Zhang, Ge Song, Lili Yao, Yankun Liu, Min Liu, Shengping Li, Hua Tang
The miR-181 family promotes cell cycle by targeting CTDSPL, a phosphatase-like tumor suppressor in uveal melanoma
Leilei Zhang, Xiaoyu He, Fang Li, Hui Pan, Xiaolin Huang, Xuyang Wen, He Zhang, Bin Li, Shengfang Ge, Xiaofang Xu, Renbing Jia, Xianqun Fan
Serum DNA integrity index as a potential molecular biomarker in endometrial cancer
Enrico Vizza, Giacomo Corrado, Martina De Angeli, Mariantonia Carosi, Emanuela Mancini, Ermelinda Baiocco, Benito Chiofalo, Lodovico Patrizi, Ashanti Zampa, Giulia Piaggio, Lucia Cicchillitti
RETRACTED ARTICLE: Integrin-β5, a miR-185-targeted gene, promotes hepatocellular carcinoma tumorigenesis by regulating β-catenin stability
Zhikun Lin, Ruiping He, Haifeng Luo, Chang Lu, Zhen Ning, Yuanhang Wu, Chuanchun Han, Guang Tan, Zhongyu Wang
MicroRNA-150 enhances radiosensitivity by inhibiting the AKT pathway in NK/T cell lymphoma
Shao Jie Wu, Jun Chen, BingYi Wu, Yu Jue Wang, Kun Yuan Guo
miR-302a-5p/367-3p-HMGA2 axis regulates malignant processes during endometrial cancer development
Jian Ma, Da Li, Fan-Fei Kong, Di Yang, Hui Yang, Xiao-Xin Ma
Flavagline analog FL3 induces cell cycle arrest in urothelial carcinoma cell of the bladder by inhibiting the Akt/PHB interaction to activate the GADD45α pathway
Gangjun Yuan, Xin Chen, Zhuowei Liu, Wensu Wei, Qinghai Shu, Hussein Abou-Hamdan, Lijuan Jiang, Xiangdong Li, Rixin Chen, Laurent Désaubry, Fangjian Zhou, Dan Xie
RHBDD1 promotes colorectal cancer metastasis through the Wnt signaling pathway and its downstream target ZEB1
Mengmeng Zhang, Fei Miao, Rong Huang, Wenjie Liu, Yuechao Zhao, Tao Jiao, Yalan Lu, Fan Wu, Xiaojuan Wang, Han Wang, Hong Zhao, Hongge Ju, Shiying Miao, Linfang Wang, Wei Song
14, 15-EET induces breast cancer cell EMT and cisplatin resistance by up-regulating integrin αvβ3 and activating FAK/PI3K/AKT signaling
Jing Luo, Jian-Feng Yao, Xiao-Fei Deng, Xiao-Dan Zheng, Min Jia, Yue-Qin Wang, Yan Huang, Jian-Hua Zhu
SMURF1 facilitates estrogen receptor ɑ signaling in breast cancer cells
Huijie Yang, Na Yu, Juntao Xu, Xiaosheng Ding, Wei Deng, Guojin Wu, Xin Li, Yingxiang Hou, Zhenhua Liu, Yan Zhao, Min Xue, Sifan Yu, Beibei Wang, Xiumin Li, Gang Niu, Hui Wang, Jian Zhu, Ting Zhuang
microRNA-193a stimulates pancreatic cancer cell repopulation and metastasis through modulating TGF-β2/TGF-βRIII signalings
Chi Fang, Chen-yun Dai, Zhu Mei, Ming-jie Jiang, Dian-na Gu, Qian Huang, Ling Tian
Salinomycin, as an autophagy modulator-- a new avenue to anticancer: a review
Jiang Jiang, Hailong Li, Eskandar Qaed, Jing Zhang, Yushu Song, Rong Wu, Xinmiao Bu, Qinyan Wang, Zeyao Tang
TFAP2C promotes stemness and chemotherapeutic resistance in colorectal cancer via inactivating hippo signaling pathway
Xu Wang, Di Sun, Jiandong Tai, Si Chen, Miao Yu, Dong Ren, Lei Wang
MYL6B, a myosin light chain, promotes MDM2-mediated p53 degradation and drives HCC development
Xingwang Xie, Xueyan Wang, Weijia Liao, Ran Fei, Nan Wu, Xu Cong, Qian Chen, Lai Wei, Yu Wang, Hongsong Chen
Development and evaluation of novel tumor-targeting paclitaxel-loaded nano-carriers for ovarian cancer treatment: in vitro and in vivo
Shu Yao, Li Li, Xuan-tao Su, Kai Wang, Zai-jun Lu, Cun-zhong Yuan, Jin-bo Feng, Shi Yan, Bei-hua Kong, Kun Song
New therapeutic strategies to treat human cancers expressing mutant p53 proteins
Giovanni Blandino, Silvia Di Agostino
Dacomitinib potentiates the efficacy of conventional chemotherapeutic agents via inhibiting the drug efflux function of ABCG2 in vitro and in vivo
Xiaoran Guo, Kenneth K. W. To, Zhen Chen, Xiaokun Wang, Jianye Zhang, Min Luo, Fang Wang, Shirong Yan, Liwu Fu
FAK-ERK activation in cell/matrix adhesion induced by the loss of apolipoprotein E stimulates the malignant progression of ovarian cancer
Huiling Lai, Xuejiao Zhao, Yu Qin, Yi Ding, Ruqi Chen, Guannan Li, Marilyne Labrie, Zhiyong Ding, Jianfeng Zhou, Junbo Hu, Ding Ma, Yong Fang, Qinglei Gao
The potential role of HGF-MET signaling and autophagy in the war of Alectinib versus Crizotinib against ALK-positive NSCLC
Xing Huang
Along with its favorable prognostic role, CLCA2 inhibits growth and metastasis of nasopharyngeal carcinoma cells via inhibition of FAK/ERK signaling
Yuan-Yuan Qiang, Chang-Zhi Li, Rui Sun, Li-Sheng Zheng, Li-Xia Peng, Jun-Ping Yang, Dong-Fang Meng, Yan-Hong Lang, Yan Mei, Ping Xie, Liang Xu, Yun Cao, Wen-Wen Wei, Li Cao, Hao Hu, Qin Yang, Dong-Hua Luo, Ying-Ying Liang, Bi-Jun Huang, Chao-Nan Qian
Correction to: Serum DNA integrity index as a potential molecular biomarker in endometrial cancer
Enrico Vizza, Giacomo Corrado, Martina De Angeli, Mariantonia Carosi, Emanuela Mancini, Ermelinda Baiocco, Benito Chiofalo, Lodovico Patrizi, Ashanti Zampa, Giulia Piaggio, Lucia Cicchillitti
CDK9 inhibitors in acute myeloid leukemia
Silvia Boffo, Angela Damato, Luigi Alfano, Antonio Giordano
SOX2OT variant 7 contributes to the synergistic interaction between EGCG and Doxorubicin to kill osteosarcoma via autophagy and stemness inhibition
Wanchun Wang, Ding Chen, Kewei Zhu
The viable circulating tumor cells with cancer stem cells feature, where is the way out?
Y. T. Luo, J. Cheng, X. Feng, S. J. He, Y. W. Wang, Q. Huang
Upregulation of lactate-inducible snail protein suppresses oncogene-mediated senescence through p16INK4a inactivation
Xiangrui Li, Zhijian Zhang, Yao Zhang, Yuxiang Cao, Huijun Wei, Zhihao Wu
Wilms’ tumor 1-associating protein promotes renal cell carcinoma proliferation by regulating CDK2 mRNA stability
Jingyuan Tang, Feng Wang, Gong Cheng, Shuhui Si, Xi Sun, Jie Han, Hao Yu, Wei Zhang, Qiang Lv, Ji-Fu Wei, Haiwei Yang
Osteoglycin (OGN) reverses epithelial to mesenchymal transition and invasiveness in colorectal cancer via EGFR/Akt pathway
Xiang Hu, Ya-Qi Li, Qing-Guo Li, Yan-Lei Ma, Jun-Jie Peng, San-Jun Cai
Efficient targeted tumor imaging and secreted endostatin gene delivery by anti-CD105 immunoliposomes
Huiqin Zhuo, Baoshi Zheng, Jianming Liu, Yong Huang, Huiling Wang, Duo Zheng, Naiquan Mao, Jinyu Meng, Sufang Zhou, Liping Zhong, Yongxiang Zhao
TNFα induces Ca2+ influx to accelerate extrinsic apoptosis in hepatocellular carcinoma cells
Jianjun Zhu, Mingpeng Jin, Jiaojiao Wang, Hui Zhang, Yousheng Wu, Deyang Li, Xiaoying Ji, Hushan Yang, Chun Yin, Tingting Ren, Jinliang Xing
Blockade of TIM3 relieves immunosuppression through reducing regulatory T cells in head and neck cancer
Jian-Feng Liu, Lei Wu, Lei-Lei Yang, Wei-Wei Deng, Liang Mao, Hao Wu, Wen-Feng Zhang, Zhi-Jun Sun
Downregulation of castor zinc finger 1 predicts poor prognosis and facilitates hepatocellular carcinoma progression via MAPK/ERK signaling
Ji-Long Wang, Meng-yuan Yang, Shuai Xiao, Bo Sun, Yi-Ming Li, Lian-Yue Yang
CADM2, as a new target of miR-10b, promotes tumor metastasis through FAK/AKT pathway in hepatocellular carcinoma
Dongliang Li, Yongjian Zhang, He Zhang, Chao Zhan, Xin Li, Tu Ba, Zini Qiu, Fang E, Guixiang Lv, Chendan Zou, Chuxuan Wang, Lining Si, Chaoxia Zou, Qiang Li, Xu Gao
Tearing down the walls: FDA approves next generation sequencing (NGS) assays for actionable cancer genomic aberrations
Matteo Allegretti, Alessandra Fabi, Simonetta Buglioni, Aline Martayan, Laura Conti, Edoardo Pescarmona, Gennaro Ciliberto, Patrizio Giacomini
Reprogramming Tumor-Immune Cell Interface in Solid and Hematological Malignancies to Enhance Response to Therapy
Maria Teresa Di Martino, Francesca Zazzeroni, Massimo Donadelli, Claudia Chiodoni, Michele Caraglia, Katia Scotlandi, Stefania Meschini, Carlo Leonetti
RETRACTED ARTICLE: MicroRNA-1468 promotes tumor progression by activating PPAR-γ-mediated AKT signaling in human hepatocellular carcinoma
Zhikui Liu, Yufeng Wang, Changwei Dou, Liankang Sun, Qing Li, Liang Wang, Qiuran Xu, Wei Yang, Qingguang Liu, Kangsheng Tu
EEF1D overexpression promotes osteosarcoma cell proliferation by facilitating Akt-mTOR and Akt-bad signaling
Dong-dong Cheng, Shi-jie Li, Bin Zhu, Shu-min Zhou, Qing-cheng Yang
C-Myc-dependent repression of two oncogenic miRNA clusters contributes to triptolide-induced cell death in hepatocellular carcinoma cells
Shu-Guang Li, Qian-Wei Shi, Ling-yan Yuan, Li-ping Qin, Yan Wang, Yu-Qing Miao, Zhe Chen, Chang-Quan Ling, Wen-xing Qin
RETRACTED ARTICLE: Exosomal microRNA-32-5p induces multidrug resistance in hepatocellular carcinoma via the PI3K/Akt pathway
Xiao Fu, Mengjie Liu, Shengyang Qu, Jiequn Ma, Yamin Zhang, Tingting Shi, Hongqing Wen, Yujuan Yang, Shuhong Wang, Jing Wang, Kejun Nan, Yu Yao, Tao Tian
Novel smac mimetic APG-1387 elicits ovarian cancer cell killing through TNF-alpha, Ripoptosome and autophagy mediated cell death pathway
Bao-Xia Li, Heng-Bang Wang, Miao-Zhen Qiu, Qiu-Yun Luo, Han-Jie Yi, Xiang-Lei Yan, Wen-Tao Pan, Lu-Ping Yuan, Yu-Xin Zhang, Jian-Hua Xu, Lin Zhang, Da-Jun Yang
Stearoyl-CoA desaturase-1 promotes colorectal cancer metastasis in response to glucose by suppressing PTEN
Hui Ran, Yemin Zhu, Ruyuan Deng, Qi Zhang, Xisheng Liu, Ming Feng, Jie Zhong, Shuhai Lin, Xuemei Tong, Qing Su
Monitoring the effect of first line treatment in RAS/RAF mutated metastatic colorectal cancer by serial analysis of tumor specific DNA in plasma
C. B. Thomsen, T. F. Hansen, R. F. Andersen, J. Lindebjerg, L. H. Jensen, A. Jakobsen
LncRNA-TUSC7/miR-224 affected chemotherapy resistance of esophageal squamous cell carcinoma by competitively regulating DESC1
Zhi-wei Chang, Yong-xu Jia, Wei-jie Zhang, Li-jie Song, Ming Gao, Ming-jun Li, Rui-hua Zhao, Jing Li, Ya-li Zhong, Qiao-zhi Sun, Yan-ru Qin
Targeting KRAS in metastatic colorectal cancer: current strategies and emerging opportunities
Manuela Porru, Luca Pompili, Carla Caruso, Annamaria Biroccio, Carlo Leonetti
Long non-coding RNA MIAT promotes gastric cancer growth and metastasis through regulation of miR-141/DDX5 pathway
Min Sha, Mei Lin, Jia Wang, Jun Ye, Jie Xu, Ning Xu, Junxing Huang
CDK5RAP3 suppresses Wnt/β-catenin signaling by inhibiting AKT phosphorylation in gastric cancer
Chao-Hui Zheng, Jia-Bin Wang, Man-Qiang Lin, Peng-Yang Zhang, Li-Chao Liu, Jian-Xian Lin, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Jian-Wei Xie, Ping Li, Chang-Ming Huang
Correction to: RHBDD1 promotes colorectal cancer metastasis through the Wnt signaling pathway and its downstream target ZEB1
Mengmeng Zhang, Fei Miao, Rong Huang, Wenjie Liu, Yuechao Zhao, Tao Jiao, Yalan Lu, Fan Wu, Xiaojuan Wang, Han Wang, Hong Zhao, Hongge Ju, Shiying Miao, Linfang Wang, Wei Song
The interplay of reactive oxygen species and the epidermal growth factor receptor in tumor progression and drug resistance
Meng-Shih Weng, Jer-Hwa Chang, Wen-Yueh Hung, Yi-Chieh Yang, Ming-Hsien Chien
Induction of apoptosis in imatinib sensitive and resistant chronic myeloid leukemia cells by efficient disruption of bcr-abl oncogene with zinc finger nucleases
Ningshu Huang, Zhenglan Huang, Miao Gao, Zhenhong Luo, Fangzhu Zhou, Lin Liu, Qing Xiao, Xin Wang, Wenli Feng
Metformin induces autophagy and G0/G1 phase cell cycle arrest in myeloma by targeting the AMPK/mTORC1 and mTORC2 pathways
Yan Wang, Wenbin Xu, Zixun Yan, Weili Zhao, Jianqing Mi, Junmin Li, Hua Yan
BRD7 expression and c-Myc activation forms a double-negative feedback loop that controls the cell proliferation and tumor growth of nasopharyngeal carcinoma by targeting oncogenic miR-141
Yukun Liu, Ran Zhao, Yanmei Wei, Mengna Li, Heran Wang, Weihong Niu, Yao Zhou, Yuanzheng Qiu, Songqing Fan, Yihao Zhan, Wei Xiong, Yanhong Zhou, Xiaoling Li, Zheng Li, Guiyuan Li, Ming Zhou
PHD-finger domain protein 5A functions as a novel oncoprotein in lung adenocarcinoma
Yan Yang, Jian Zhu, Tiantian Zhang, Jing Liu, Yumei Li, Yue Zhu, Lingjie Xu, Rui Wang, Fang Su, Yurong Ou, Qiong Wu
Growth differentiation factor 15 contributes to marrow adipocyte remodeling in response to the growth of leukemic cells
Wei Lu, Yun Wan, Zhiqiang Li, Bin Zhu, Chunrong Yin, Haiyan Liu, Shaoxin Yang, Yuanmei Zhai, Yehua Yu, Yanyu Wei, Jun Shi
Treatment of B-cell precursor acute lymphoblastic leukemia with the Galectin-1 inhibitor PTX008
Helicia Paz, Eun Ji Joo, Chih-Hsing Chou, Fei Fei, Kevin H. Mayo, Hisham Abdel-Azim, Haike Ghazarian, John Groffen, Nora Heisterkamp
5′/ 3′ imbalance strategy to detect ALK fusion genes in circulating tumor RNA from patients with non-small cell lung cancer
Yongqing Tong, Zhijun Zhao, Bei Liu, Anyu Bao, Hongyun Zheng, Jian Gu, Mary McGrath, Ying Xia, Bihua Tan, Chunhua Song, Yan Li
Inhibiting YAP expression suppresses pancreatic cancer progression by disrupting tumor-stromal interactions
Zhengdong Jiang, Cancan Zhou, Liang Cheng, Bin Yan, Ke Chen, Xin Chen, Liang Zong, Jianjun Lei, Wanxing Duan, Qinhong Xu, Xuqi Li, Zheng Wang, Qingyong Ma, Jiguang Ma
Inflammatory interferon activates HIF-1α-mediated epithelial-to-mesenchymal transition via PI3K/AKT/mTOR pathway
Yen-Hsiu Yeh, Ho-Fu Hsiao, Yen-Cheng Yeh, Tien-Wen Chen, Tsai-Kun Li
miR-148b-3p inhibits gastric cancer metastasis by inhibiting the Dock6/Rac1/Cdc42 axis
Xiaowei Li, Mingzuo Jiang, Di Chen, Bing Xu, Rui Wang, Yi Chu, Weijie Wang, Lin Zhou, Zhijie Lei, Yongzhan Nie, Daiming Fan, Yulong Shang, Kaichun Wu, Jie Liang
The anti-tumor efficacy of CDK4/6 inhibition is enhanced by the combination with PI3K/AKT/mTOR inhibitors through impairment of glucose metabolism in TNBC cells
Daniele Cretella, Andrea Ravelli, Claudia Fumarola, Silvia La Monica, Graziana Digiacomo, Andrea Cavazzoni, Roberta Alfieri, Alessandra Biondi, Daniele Generali, Mara Bonelli, Pier Giorgio Petronini
SGK1 inhibition-induced autophagy impairs prostate cancer metastasis by reversing EMT
Weiwei Liu, Xuchu Wang, Yiyun Wang, Yibei Dai, Yiyi Xie, Ying Ping, Binbin Yin, Pan Yu, Zhenping Liu, Xiuzhi Duan, Zhaoping Liao, Yuhua Chen, Chunhua Liu, Xiang Li, Zhihua Tao
Mature and progenitor endothelial cells perform angiogenesis also under protease inhibition: the amoeboid angiogenesis
Anastasia Chillà, Francesca Margheri, Alessio Biagioni, Mario Del Rosso, Gabriella Fibbi, Anna Laurenzana
Lipid accumulation in human breast cancer cells injured by iron depletors
Maida De Bortoli, Elena Taverna, Elisa Maffioli, Patrizia Casalini, Francesco Crisafi, Vikas Kumar, Claudio Caccia, Dario Polli, Gabriella Tedeschi, Italia Bongarzone
MiR-10a-5p targets TFAP2C to promote gemcitabine resistance in pancreatic ductal adenocarcinoma
Guangbing Xiong, Hua Huang, Mengyu Feng, Gang Yang, Suli Zheng, Lei You, Lianfang Zheng, Ya Hu, Taiping Zhang, Yupei Zhao
Radiotherapy-induced cell death activates paracrine HMGB1-TLR2 signaling and accelerates pancreatic carcinoma metastasis
Xuelian Chen, Lirong Zhang, Yujie Jiang, Lian Song, Yanfang Liu, Fang Cheng, Xin Fan, Xiongfeng Cao, Aihua Gong, Dongqing Wang, Haitao Zhu
Alternative splicing of human telomerase reverse transcriptase in gliomas and its modulation mediated by CX-5461
Guihong Li, Jing Shen, Junguo Cao, Guangtong Zhou, Ting Lei, Yuxue Sun, Haijun Gao, Yaonan Ding, Weidong Xu, Zhixin Zhan, Yong Chen, Haiyan Huang
Iron-dependent cell death as executioner of cancer stem cells
Bin Zhao, Xin Li, Ye Wang, Peng Shang
GDF15 promotes the proliferation of cervical cancer cells by phosphorylating AKT1 and Erk1/2 through the receptor ErbB2
Shan Li, Yan-Min Ma, Peng-Sheng Zheng, Ping Zhang
SP1-induced upregulation of lncRNA SPRY4-IT1 exerts oncogenic properties by scaffolding EZH2/LSD1/DNMT1 and sponging miR-101-3p in cholangiocarcinoma
Yi Xu, Yue Yao, Xingming Jiang, Xiangyu Zhong, Zhidong Wang, Chunlong Li, Pengcheng Kang, Kaiming Leng, Daolin Ji, Zhenglong Li, Lining Huang, Wei Qin, Yunfu Cui
The phospholipase DDHD1 as a new target in colorectal cancer therapy
Stefania Raimondo, Marta Cristaldi, Simona Fontana, Laura Saieva, Francesca Monteleone, Giovanna Calabrese, Gianluca Giavaresi, Rosalba Parenti, Riccardo Alessandro
MiR-760 suppresses human colorectal cancer growth by targeting BATF3/AP-1/cyclinD1 signaling
Ling Cao, Yulin Liu, Dan Wang, Lan Huang, Feng Li, Jinbo Liu, Chaoqi Zhang, Zhibo Shen, Qun Gao, Weitang Yuan, Yi Zhang
Next-generation sequencing analysis of receptor-type tyrosine kinase genes in surgically resected colon cancer: identification of gain-of-function mutations in the RET proto-oncogene
Duarte Mendes Oliveira, Katia Grillone, Chiara Mignogna, Valentina De Falco, Carmelo Laudanna, Flavia Biamonte, Rosa Locane, Francesco Corcione, Massimiliano Fabozzi, Rosario Sacco, Giuseppe Viglietto, Donatella Malanga, Antonia Rizzuto
The CXCL5/CXCR2 axis contributes to the epithelial-mesenchymal transition of nasopharyngeal carcinoma cells by activating ERK/GSK-3β/snail signalling
Wen-Ze Qiu, Hai-Bo Zhang, Wei-Xiong Xia, Liang-Ru Ke, Jing Yang, Ya-Hui Yu, Hu Liang, Xin-Jun Huang, Guo-Ying Liu, Wang-Zhong Li, Yan-Qun Xiang, Tie-Bang Kang, Xiang Guo, Xing Lv
The perfect personalized cancer therapy: cancer vaccines against neoantigens
Luigi Aurisicchio, Matteo Pallocca, Gennaro Ciliberto, Fabio Palombo
Role of metabolism in cancer cell radioresistance and radiosensitization methods
Le Tang, Fang Wei, Yingfen Wu, Yi He, Lei Shi, Fang Xiong, Zhaojian Gong, Can Guo, Xiayu Li, Hao Deng, Ke Cao, Ming Zhou, Bo Xiang, Xiaoling Li, Yong Li, Guiyuan Li, Wei Xiong, Zhaoyang Zeng
Targeting chemotherapy-resistant leukemia by combining DNT cellular therapy with conventional chemotherapy
Branson Chen, Jong Bok Lee, Hyeonjeong Kang, Mark D. Minden, Li Zhang
Attenuation of TGFBR2 expression and tumour progression in prostate cancer involve diverse hypoxia-regulated pathways
Hui Zhou, Guanqing Wu, Xueyou Ma, Jun Xiao, Gan Yu, Chunguang Yang, Nan Xu, Bao Zhang, Jun Zhou, Zhangqun Ye, Zhihua Wang
Androgen receptor and heat shock protein 27 co-regulate the malignant potential of molecular apocrine breast cancer
Xiaozhen Liu, Changyun Feng, Junjun Liu, Lu Cao, Guomin Xiang, Fang Liu, Shuling Wang, Jiao Jiao, Yun Niu
Bortezomib enhances radiosensitivity in oral cancer through inducing autophagy-mediated TRAF6 oncoprotein degradation
Yuan-Hua Wu, Wun-Syuan Wu, Li-Ching Lin, Chiang-Shin Liu, Sheng-Yow Ho, Bour-Jr Wang, Bu-Miin Huang, Ya-Ling Yeh, Hui-Wen Chiu, Wei-Lei Yang, Ying-Jan Wang
Integrins as therapeutic targets in the organ-specific metastasis of human malignant melanoma
Ruixia Huang, Einar K. Rofstad
The dual blockade of MET and VEGFR2 signaling demonstrates pronounced inhibition on tumor growth and metastasis of hepatocellular carcinoma
Yu Zhang, Xiaomei Gao, Ying Zhu, Dhruba Kadel, Haoran Sun, Jing Chen, Qin Luo, Haoting Sun, Luyu Yang, Jing Yang, Yuanyuan Sheng, Yan Zheng, Kejin Zhu, Qiongzhu Dong, Lunxiu Qin
miR-221 stimulates breast cancer cells and cancer-associated fibroblasts (CAFs) through selective interference with the A20/c-Rel/CTGF signaling
Maria Francesca Santolla, Rosamaria Lappano, Francesca Cirillo, Damiano Cosimo Rigiracciolo, Anna Sebastiani, Sergio Abonante, Pierfrancesco Tassone, Pierosandro Tagliaferri, Maria Teresa Di Martino, Marcello Maggiolini, Adele Vivacqua
Serum miR-22 as potential non-invasive predictor of poor clinical outcome in newly diagnosed, uniformly treated patients with diffuse large B-cell lymphoma: an explorative pilot study
Francesco Marchesi, Giulia Regazzo, Francesca Palombi, Irene Terrenato, Andrea Sacconi, Manuela Spagnuolo, Sara Donzelli, Mirella Marino, Cristiana Ercolani, Anna Di Benedetto, Giovanni Blandino, Gennaro Ciliberto, Andrea Mengarelli, Maria Giulia Rizzo
NHERF1 and tumor microenvironment: a new scene in invasive breast carcinoma
Concetta Saponaro, Alessandro Vagheggini, Emanuela Scarpi, Matteo Centonze, Ivana Catacchio, Ondina Popescu, Maria Irene Pastena, Francesco Giotta, Nicola Silvestris, Anita Mangia
A novel small molecule inhibitor of MDM2-p53 (APG-115) enhances radiosensitivity of gastric adenocarcinoma
Hanjie Yi, Xianglei Yan, Qiuyun Luo, Luping Yuan, Baoxia Li, Wentao Pan, Lin Zhang, Haibo Chen, Jing Wang, Yubin Zhang, Yifan Zhai, Miao-Zhen Qiu, Da-Jun Yang
Cyclizing-berberine A35 induces G2/M arrest and apoptosis by activating YAP phosphorylation (Ser127)
Wuli Zhao, Hong Liu, Junxia Wang, Mengyan Wang, Rongguang Shao
Matrix stiffness-upregulated LOXL2 promotes fibronectin production, MMP9 and CXCL12 expression and BMDCs recruitment to assist pre-metastatic niche formation
Sifan Wu, Qiongdan Zheng, Xiaoxia Xing, Yinying Dong, Yaohui Wang, Yang You, Rongxin Chen, Chao Hu, Jie Chen, Dongmei Gao, Yan Zhao, Zhiming Wang, Tongchun Xue, Zhenggang Ren, Jiefeng Cui
SPIN1, negatively regulated by miR-148/152, enhances Adriamycin resistance via upregulating drug metabolizing enzymes and transporter in breast cancer
Xu Chen, Ya-Wen Wang, Peng Gao
The dysregulation of tRNAs and tRNA derivatives in cancer
Shi-qiong Huang, Bao Sun, Zong-ping Xiong, Yan Shu, Hong-hao Zhou, Wei Zhang, Jing Xiong, Qing Li
Inactivation of the tight junction gene CLDN11 by aberrant hypermethylation modulates tubulins polymerization and promotes cell migration in nasopharyngeal carcinoma
Hsin-Pai Li, Chen-Ching Peng, Chih-Ching Wu, Chien-Hsun Chen, Meng-Jhe Shih, Mei-Yuan Huang, Yi-Ru Lai, Yung-Li Chen, Ting-Wen Chen, Petrus Tang, Yu-Sun Chang, Kai-Ping Chang, Cheng-Lung Hsu
Physical interaction of STAT1 isoforms with TGF-β receptors leads to functional crosstalk between two signaling pathways in epithelial ovarian cancer
Xiaoling Tian, Wencai Guan, Lingyun Zhang, Wenwen Sun, Daibing Zhou, Qunbo Lin, Weimin Ren, Lubna Nadeem, Guoxiong Xu
Chibby suppresses aerobic glycolysis and proliferation of nasopharyngeal carcinoma via the Wnt/β-catenin-Lin28/let7-PDK1 cascade
Cheng-fu Cai, Guo-dong Ye, Dong-yan Shen, Wei Zhang, Mao-li Chen, Xin-xin Chen, Da-xiong Han, Yan-jun Mi, Qi-cong Luo, Wang-yu Cai, Shu-yu Yang
RETRACTED ARTICLE: LncMAPK6 drives MAPK6 expression and liver TIC self-renewal
Guanqun Huang, Hui Jiang, Yueming He, Ye Lin, Wuzheng Xia, Yuanwei Luo, Min Liang, Boyun Shi, Xinke Zhou, Zhixiang Jian
RETRACTED ARTICLE: LncRNA TUG1 promoted KIAA1199 expression via miR-600 to accelerate cell metastasis and epithelial-mesenchymal transition in colorectal cancer
Junfeng Sun, Jiyi Hu, Guojun Wang, Zhen Yang, Chunlin Zhao, Xiefu Zhang, Jiaxiang Wang
The PARP inhibitor olaparib potentiates the effect of the DNA damaging agent doxorubicin in osteosarcoma
Hye Jeong Park, Jun Sang Bae, Kyoung Min Kim, Young Jae Moon, See-Hyoung Park, Sang Hoon Ha, Usama Khamis Hussein, Zhongkai Zhang, Ho Sung Park, Byung-Hyun Park, Woo Sung Moon, Jung Ryul Kim, Kyu Yun Jang
Correction to: Novel smac mimetic APG-1387 elicits ovarian cancer cell killing through TNF-alpha, Ripoptosome and autophagy mediated cell death pathway
Bao-Xia Li, Heng-Bang Wang, Miao-Zhen Qiu, Qiu-Yun Luo, Han-Jie Yi, Xiang-Lei Yan, Wen-Tao Pan, Lu-Ping Yuan, Yu-Xin Zhang, Jian-Hua Xu, Lin Zhang, Da-Jun Yang
Patient-derived multicellular tumor spheroids towards optimized treatment for patients with hepatocellular carcinoma
Yeonhwa Song, Jin-Sun Kim, Se-Hyuk Kim, Yoon Kyung Park, Eunsil Yu, Ki-Hun Kim, Eul-Ju Seo, Heung-Bum Oh, Han Chu Lee, Kang Mo Kim, Haeng Ran Seo
Immune checkpoint therapy in liver cancer
Feng Xu, Tianqiang Jin, Yuwen Zhu, Chaoliu Dai
SOX30 is a key regulator of desmosomal gene suppressing tumor growth and metastasis in lung adenocarcinoma
Xianglin Hao, Fei Han, Bangjin Ma, Ning Zhang, Hongqiang Chen, Xiao Jiang, Li Yin, Wenbin Liu, Lin Ao, Jia Cao, Jinyi Liu
Correction to: Next-generation sequencing analysis of receptor-type tyrosine kinase genes in surgically resected colon cancer: identification of gain-of-function mutations in the RET proto-oncogene
Duarte Mendes Oliveira, Katia Grillone, Chiara Mignogna, Valentina De Falco, Carmelo Laudanna, Flavia Biamonte, Rosa Locane, Francesco Corcione, Massimiliano Fabozzi, Rosario Sacco, Giuseppe Viglietto, Donatella Malanga, Antonia Rizzuto
Long non-coding RNA UBE2CP3 enhances HCC cell secretion of VEGFA and promotes angiogenesis by activating ERK1/2/HIF-1α/VEGFA signalling in hepatocellular carcinoma
Jinduan Lin, Shunwang Cao, Yu Wang, Yanwei Hu, Hongwei Liu, Jiehua Li, Jing Chen, Pan Li, Jumei Liu, Qian Wang, Lei Zheng
Combination therapy with protein kinase inhibitor H89 and Tetrandrine elicits enhanced synergistic antitumor efficacy
Man Yu, Ting Liu, Yicheng Chen, Yafang Li, Wenhua Li
Gastrin inhibits gastric cancer progression through activating the ERK-P65-miR23a/27a/24 axis
Li-Dong Zu, Xing-Chun Peng, Zhi Zeng, Jing-Long Wang, Li-Li Meng, Wei-Wei Shen, Chun-Ting Hu, Ye Yang, Guo-Hui Fu
TRIM52 up-regulation in hepatocellular carcinoma cells promotes proliferation, migration and invasion through the ubiquitination of PPM1A
Yi Zhang, Ran Tao, Shan-Shan Wu, Cui-Cui Xu, Jie-Ling Wang, Jie Chen, Yong-Sheng Yu, Zheng-Hao Tang, Xiao-Hua Chen, Guo-Qing Zang
Extracellular gamma-synuclein promotes tumor cell motility by activating β1 integrin-focal adhesion kinase signaling pathway and increasing matrix metalloproteinase-24, -2 protein secretion
Caiyun Liu, Like Qu, Chuanke Zhao, Chengchao Shou
Emerging role of lipid metabolism alterations in Cancer stem cells
Mei Yi, Junjun Li, Shengnan Chen, Jing Cai, Yuanyuan Ban, Qian Peng, Ying Zhou, Zhaoyang Zeng, Shuping Peng, Xiaoling Li, Wei Xiong, Guiyuan Li, Bo Xiang
The oncogenic neurotrophin receptor tropomyosin-related kinase variant, TrkAIII
Antonietta Rosella Farina, Lucia Cappabianca, Pierdomenico Ruggeri, Luciana Gneo, Cristina Pellegrini, Maria-Concetta Fargnoli, Andrew Reay Mackay
RETRACTED ARTICLE: LncGPR107 drives the self-renewal of liver tumor initiating cells and liver tumorigenesis through GPR107-dependent manner
Guanqun Huang, Hui Jiang, Ye Lin, Wuzheng Xia, Yuanwei Luo, Yanpeng Wu, Weilong Cai, Xinke Zhou, Xianhan Jiang
Prolonged inhibition of class I PI3K promotes liver cancer stem cell expansion by augmenting SGK3/GSK-3β/β-catenin signalling
Fengchao Liu, Xiaoling Wu, Xin Jiang, Yanzhi Qian, Jian Gao
ER-α36 mediates cisplatin resistance in breast cancer cells through EGFR/HER-2/ERK signaling pathway
Linlin Zhu, Jiao Zou, Yuanyin Zhao, Xiaomei Jiang, Yang Wang, Xiangwei Wang, Bin Chen
Liquid biopsy in mice bearing colorectal carcinoma xenografts: gateways regulating the levels of circulating tumor DNA (ctDNA) and miRNA (ctmiRNA)
Jessica Gasparello, Matteo Allegretti, Elisa Tremante, Enrica Fabbri, Carla Azzurra Amoreo, Paolo Romania, Elisa Melucci, Katia Messana, Monica Borgatti, Patrizio Giacomini, Roberto Gambari, Alessia Finotti
Reactive oxygen species in haematopoiesis: leukaemic cells take a walk on the wild side
Rodrigo Prieto-Bermejo, Marta Romo-González, Alejandro Pérez-Fernández, Carla Ijurko, Ángel Hernández-Hernández
Reprogramming the murine colon cancer microenvironment using lentivectors encoding shRNA against IL-10 as a component of a potent DC-based chemoimmunotherapy
Joanna Rossowska, Natalia Anger, Agnieszka Szczygieł, Jagoda Mierzejewska, Elżbieta Pajtasz-Piasecka
Metabolic reprogramming-based characterization of circulating tumor cells in prostate cancer
Jing Chen, Shunwang Cao, Bo Situ, Juan Zhong, Yanwei Hu, Shufen Li, Jinlan Huang, Jiasen Xu, Shiyang Wu, Jinduan Lin, Qianwen Zhao, Zhen Cai, Lei Zheng, Qian Wang
Supervillin promotes epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma in hypoxia via activation of the RhoA/ROCK-ERK/p38 pathway
Xueran Chen, Shangrong Zhang, Zhen Wang, Fengsong Wang, Xinwang Cao, Quan Wu, Chenggang Zhao, Huihui Ma, Fang Ye, Hongzhi Wang, Zhiyou Fang
Augmented antitumor activity by olaparib plus AZD1775 in gastric cancer through disrupting DNA damage repair pathways and DNA damage checkpoint
Xiaoting Lin, Dongshao Chen, Cheng Zhang, Xiaotian Zhang, Zhongwu Li, Bin Dong, Jing Gao, Lin Shen
Downregulated miR-98-5p promotes PDAC proliferation and metastasis by reversely regulating MAP4K4
Yue Fu, Xinchun Liu, Qiuyang Chen, Tongtai Liu, Cheng Lu, Jun Yu, Yi Miao, Jishu Wei
CPNE1 is a target of miR-335-5p and plays an important role in the pathogenesis of non-small cell lung cancer
Haicheng Tang, Jianjie Zhu, Wenwen Du, Shunlin Liu, Yuanyuan Zeng, Zongli Ding, Yang Zhang, Xueting Wang, Zeyi Liu, Jianan Huang
3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase
Wan Li, Jinyi Liu, Weiqi Fu, Xiangjin Zheng, Liwen Ren, Shiwei Liu, Jinhua Wang, Tengfei Ji, Guanhua Du
17β-estradiol upregulates IL6 expression through the ERβ pathway to promote lung adenocarcinoma progression
Quanfu Huang, Zheng Zhang, Yongde Liao, Changyu Liu, Sheng Fan, Xiao Wei, Bo Ai, Jing Xiong
Long non-coding RNA UFC1 promotes gastric cancer progression by regulating miR-498/Lin28b
Xu Zhang, Wei Liang, Jibin Liu, Xueyan Zang, Jianmei Gu, Lei Pan, Hui Shi, Min Fu, Zhenhua Huang, Yu Zhang, Hui Qian, Pengcheng Jiang, Wenrong Xu
Novel oncogene COPS3 interacts with Beclin1 and Raf-1 to regulate metastasis of osteosarcoma through autophagy
Fan Zhang, Taiqiang Yan, Wei Guo, Kunkun Sun, Shidong Wang, Xing Bao, Kuisheng Liu, Bingxin Zheng, Hongliang Zhang, Tingting Ren
Up-regulation of FGF15/19 signaling promotes hepatocellular carcinoma in the background of fatty liver
Guozhen Cui, Robert C. Martin, Hang Jin, Xingkai Liu, Harshul Pandit, Hengjun Zhao, Lu Cai, Ping Zhang, Wei Li, Yan Li
Activities of stromal and immune cells in HPV-related cancers
Marconi Rego Barros Jr, Cristiane Moutinho Lagos de Melo, Maria Luiza Carneiro Moura Gonçalves Rego Barros, Rita de Cássia Pereira de Lima, Antonio Carlos de Freitas, Aldo Venuti
(Arg)9-SH2 superbinder: a novel promising anticancer therapy to melanoma by blocking phosphotyrosine signaling
An-dong Liu, Hui Xu, Ya-nan Gao, Dan-ni Luo, Zhao-feng Li, Courtney Voss, Shawn S. C. Li, Xuan Cao
Endometrial cancer prognosis correlates with the expression of L1CAM and miR34a biomarkers
Giacomo Corrado, Valentina Laquintana, Rossella Loria, Mariantonia Carosi, Laura de Salvo, Isabella Sperduti, Ashanti Zampa, Lucia Cicchillitti, Giulia Piaggio, Giuseppe Cutillo, Rita Falcioni, Enrico Vizza
Therapeutic potential of combined BRAF/MEK blockade in BRAF-wild type preclinical tumor models
Anais Del Curatolo, Fabiana Conciatori, Ursula Cesta Incani, Chiara Bazzichetto, Italia Falcone, Vincenzo Corbo, Sabrina D’Agosto, Adriana Eramo, Giovanni Sette, Isabella Sperduti, Teresa De Luca, Mirko Marabese, Senji Shirasawa, Ruggero De Maria, Aldo Scarpa, Massimo Broggini, Donatella Del Bufalo, Francesco Cognetti, Michele Milella, Ludovica Ciuffreda
miR-182 suppresses invadopodia formation and metastasis in non-small cell lung cancer by targeting cortactin gene
Yongwen Li, Hongbing Zhang, Hao Gong, Yin Yuan, Ying Li, Cong Wang, Weiting Li, Zihe Zhang, Minghui Liu, Hongyu Liu, Jun Chen
Protein phosphatase 2A activation mechanism contributes to JS-K induced caspase-dependent apoptosis in human hepatocellular carcinoma cells
Ling Liu, Zile Huang, Jingjing Chen, Jiangang Wang, Shuying Wang
M1-like tumor-associated macrophages activated by exosome-transferred THBS1 promote malignant migration in oral squamous cell carcinoma
Meng Xiao, Jianjun Zhang, Wanjun Chen, Wantao Chen
STK25-induced inhibition of aerobic glycolysis via GOLPH3-mTOR pathway suppresses cell proliferation in colorectal cancer
Fan Wu, Pin Gao, Wei Wu, Zaozao Wang, Jie Yang, Jiabo Di, Beihai Jiang, Xiangqian Su
SPOP promotes ATF2 ubiquitination and degradation to suppress prostate cancer progression
Jian Ma, Kun Chang, Jingtao Peng, Qing Shi, Hualei Gan, Kun Gao, Kai Feng, Fujiang Xu, Hailiang Zhang, Bo Dai, Yao Zhu, Guohai Shi, Yijun Shen, Yiping Zhu, Xiaojian Qin, Yao Li, Pingzhao Zhang, Dingwei Ye, Chenji Wang
Simultaneous E-cadherin and PLEKHA7 expression negatively affects E-cadherin/EGFR mediated ovarian cancer cell growth
Katia Rea, Francesca Roggiani, Loris De Cecco, Francesco Raspagliesi, Maria Luisa Carcangiu, Joyce Nair-Menon, Marina Bagnoli, Ileana Bortolomai, Delia Mezzanzanica, Silvana Canevari, Antonis Kourtidis, Panos Z. Anastasiadis, Antonella Tomassetti
Exosomal miR-9 inhibits angiogenesis by targeting MDK and regulating PDK/AKT pathway in nasopharyngeal carcinoma
Juan Lu, Qi-Hui Liu, Fan Wang, Jia-Jie Tan, Yue-Qin Deng, Xiao-Hong Peng, Xiong Liu, Bao Zhang, Xia Xu, Xiang-Ping Li
SIRT7 suppresses the epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis by promoting SMAD4 deacetylation
Wenlu Li, Dandan Zhu, Shuaihua Qin
LINC01287/miR-298/STAT3 feedback loop regulates growth and the epithelial-to-mesenchymal transition phenotype in hepatocellular carcinoma cells
Yichao Mo, Longguang He, Zeru Lai, Zhiheng Wan, Qinshou Chen, Sibo Pan, Liangfu Li, Dasheng Li, Junwei Huang, Fan Xue, Siyao Che
Paramount therapy for young and fit patients with mantle cell lymphoma: strategies for front-line therapy
Haige Ye, Aakash Desai, Shengjian Huang, Dayoung Jung, Richard Champlin, Dongfeng Zeng, Fangfang Yan, Krystle Nomie, Jorge Romaguera, Makhdum Ahmed, Michael L. Wang
Regorafenib suppresses colon tumorigenesis and the generation of drug resistant cancer stem-like cells via modulation of miR-34a associated signaling
Mao-Hua Cai, Xiao-Gang Xu, Shi-Li Yan, Ze Sun, Yin Ying, Bai-Kui Wang, Yue-Xing Tu
miR-589 promotes gastric cancer aggressiveness by a LIFR-PI3K/AKT-c-Jun regulatory feedback loop
Feifei Zhang, Kaitao Li, Mingxin Pan, Weidong Li, Juan Wu, Mingyi Li, Liang Zhao, Hui Wang
PARP inhibitor veliparib and HDAC inhibitor SAHA synergistically co-target the UHRF1/BRCA1 DNA damage repair complex in prostate cancer cells
Linglong Yin, Youhong Liu, Yuchong Peng, Yongbo Peng, Xiaohui Yu, Yingxue Gao, Bowen Yuan, Qianling Zhu, Tuoyu Cao, Leye He, Zhicheng Gong, Lunquan Sun, Xuegong Fan, Xiong Li
Motor neuron and pancreas homeobox 1/HLXB9 promotes sustained proliferation in bladder cancer by upregulating CCNE1/2
Mingkun Chen, Rongpei Wu, Gang Li, Cundong Liu, Lei Tan, Kanghua Xiao, Yunlin Ye, Zike Qin
Correction to: Emerging role of lipid metabolism alterations in Cancer stem cells
Mei Yi, Junjun Li, Shengnan Chen, Jing Cai, Yuanyuan Ban, Qian Peng, Ying Zhou, Zhaoyang Zeng, Shuping Peng, Xiaoling Li, Wei Xiong, Guiyuan Li, Bo Xiang
BMP4 promotes hepatocellular carcinoma proliferation by autophagy activation through JNK1-mediated Bcl-2 phosphorylation
Ganlu Deng, Shan Zeng, Yanling Qu, Qingqing Luo, Cao Guo, Ling Yin, Ying Han, Yiyi Li, Changjing Cai, Yaojie Fu, Hong Shen
Lycorine inhibits glioblastoma multiforme growth through EGFR suppression
Jia Shen, Tao Zhang, Zheng Cheng, Ni Zhu, Hua Wang, Li Lin, Zexia Wang, Haotian Yi, Meichun Hu
PBX3/MEK/ERK1/2/LIN28/let-7b positive feedback loop enhances mesenchymal phenotype to promote glioblastoma migration and invasion
Xiupeng Xu, Zhongyuan Bao, Yinlong Liu, Kuan Jiang, Tongle Zhi, Dong Wang, Liang Fan, Ning Liu, Jing Ji
Paired box 8 suppresses tumor angiogenesis and metastasis in gastric cancer through repression of FOXM1 via induction of microRNA-612
Liyan Wang, Xiaotong Bo, Qinghua Zheng, Wenhong Ge, Yanhua Liu, Bin Li
Downregulation of miR-133a-3p promotes prostate cancer bone metastasis via activating PI3K/AKT signaling
Yubo Tang, Jincheng Pan, Shuai Huang, Xinsheng Peng, Xuenong Zou, Yongxiang Luo, Dong Ren, Xin Zhang, Ronggang Li, Peiheng He, Qingde Wa
Regulation of tNOX expression through the ROS-p53-POU3F2 axis contributes to cellular responses against oxaliplatin in human colon cancer cells
Huei-Yu Chen, Atikul Islam, Tien-Ming Yuan, Shi-Wen Chen, Pei-Fen Liu, Pin Ju Chueh
Exosomal TRIM3 is a novel marker and therapy target for gastric cancer
Hailong Fu, Huan Yang, Xu Zhang, Bo Wang, Jiahui Mao, Xia Li, Mei Wang, Bin Zhang, Zixuan Sun, Hui Qian, Wenrong Xu
The expansion of targetable biomarkers for CAR T cell therapy
Michelle H. Townsend, Gajendra Shrestha, Richard A. Robison, Kim L. O’Neill
miR-22/KAT6B axis is a chemotherapeutic determiner via regulation of PI3k-Akt-NF-kB pathway in tongue squamous cell carcinoma
Yixue Gu, Hao Liu, Fangren Kong, Jiahui Ye, Xiaoting Jia, Zhijie Zhang, Nan Li, Jiang Yin, Guopei Zheng, Zhimin He
Ajuba inhibits hepatocellular carcinoma cell growth via targeting of β-catenin and YAP signaling and is regulated by E3 ligase Hakai through neddylation
Min Liu, Ke Jiang, Guibin Lin, Peng Liu, Yumei Yan, Tian Ye, Gang Yao, Martin P. Barr, Dapeng Liang, Yang Wang, Peng Gong, Songshu Meng, Haozhe Piao
Transgelin-2 is a novel target of KRAS-ERK signaling involved in the development of pancreatic cancer
Yan Sun, Wenfang Peng, Weiwei He, Man Luo, Guilin Chang, Jiping Shen, Xiaoping Zhao, Yu Hu
WIPF1 antagonizes the tumor suppressive effect of miR-141/200c and is associated with poor survival in patients with PDAC
Yu Pan, Fengchun Lu, Ping Xiong, Maoen Pan, Zheyang Zhang, Xianchao Lin, Minggui Pan, Heguang Huang
Phytosomal curcumin causes natural killer cell-dependent repolarization of glioblastoma (GBM) tumor-associated microglia/macrophages and elimination of GBM and GBM stem cells
Sumit Mukherjee, Angela Fried, Rahman Hussaini, Richard White, Juliet Baidoo, Sri Yalamanchi, Probal Banerjee
RETRACTED ARTICLE: Long non-coding RNA TPT1-AS1 promotes cell growth and metastasis in cervical cancer via acting AS a sponge for miR-324-5p
Hui Jiang, Guanqun Huang, Nianzhang Zhao, Ting Zhang, Mengni Jiang, Yueming He, Xinke Zhou, Xianhan Jiang
SWATH-MS based quantitative proteomics analysis reveals that curcumin alters the metabolic enzyme profile of CML cells by affecting the activity of miR-22/IPO7/HIF-1α axis
Francesca Monteleone, Simona Taverna, Riccardo Alessandro, Simona Fontana
RETRACTED ARTICLE: Exosome-mediated transfer of lncRNA PART1 induces gefitinib resistance in esophageal squamous cell carcinoma via functioning as a competing endogenous RNA
Min Kang, Meiping Ren, Yan Li, Yuqiong Fu, Minmin Deng, Changping Li
circFBLIM1 act as a ceRNA to promote hepatocellular cancer progression by sponging miR-346
Ning Bai, Eming Peng, Xingsheng Qiu, Ning Lyu, Zhejia Zhang, Yiming Tao, Xinying Li, Zhiming Wang
Emerging roles of Myc in stem cell biology and novel tumor therapies
Go J. Yoshida
HZ08 suppresses RelB-activated MnSOD expression and enhances Radiosensitivity of prostate Cancer cells
Yanyan Zhang, Zhi Xu, Jiaji Ding, Chunli Tan, Weizi Hu, Yunman Li, Wenlong Huang, Yong Xu
Hippo component YAP promotes focal adhesion and tumour aggressiveness via transcriptionally activating THBS1/FAK signalling in breast cancer
Jie Shen, Beibei Cao, Yatao Wang, Chenshen Ma, Zhuo Zeng, Liang Liu, Xiaolan Li, Deding Tao, Jianping Gong, Daxing Xie
Regulation of the adaptation to ER stress by KLF4 facilitates melanoma cell metastasis via upregulating NUCB2 expression
Dongmei Zhang, Jingrong Lin, Yulin Chao, Lu Zhang, Lei Jin, Na Li, Ruiping He, Binbin Ma, Wenzhi Zhao, Chuanchun Han
Circular RNA IARS (circ-IARS) secreted by pancreatic cancer cells and located within exosomes regulates endothelial monolayer permeability to promote tumor metastasis
Jie Li, Zhonghu Li, Peng Jiang, Minjie Peng, Xi Zhang, Kai Chen, Hui Liu, Huaqiang Bi, Xiangde Liu, Xiaowu Li
High expression of Ras-related protein 1A promotes an aggressive phenotype in colorectal cancer via PTEN/FOXO3/CCND1 pathway
Liguo Liu, Xuebing Yan, Dapeng Wu, Yi Yang, Mengcheng Li, Yang Su, Wenchao Yang, Zezhi Shan, Yuping Gao, Zhiming Jin
Osteopontin alters DNA methylation through up-regulating DNMT1 and sensitizes CD133+/CD44+ cancer stem cells to 5 azacytidine in hepatocellular carcinoma
Xiaomei Gao, Yuanyuan Sheng, Jing Yang, Chaoqun Wang, Rui Zhang, Ying Zhu, Ze Zhang, Kaili Zhang, Shican Yan, Haoting Sun, Jinwang Wei, Xuan Wang, Xinxin Yu, Yu Zhang, Qin Luo, Yan Zheng, Peng Qiao, Yue Zhao, Qiongzhu Dong, Lunxiu Qin
Overexpression of the Kininogen-1 inhibits proliferation and induces apoptosis of glioma cells
Jinfang Xu, Jun Fang, Zhonghao Cheng, Longlong Fan, Weiwei Hu, Feng Zhou, Hong Shen
RETRACTED ARTICLE: Reprogramming glioblastoma multiforme cells into neurons by protein kinase inhibitors
Jie Yuan, Fan Zhang, Dennis Hallahan, Zhen Zhang, Liming He, Ling-Gang Wu, Meng You, Qin Yang
RIF1 promotes human epithelial ovarian cancer growth and progression via activating human telomerase reverse transcriptase expression
Yong-Bin Liu, Ying Mei, Jing Long, Yu Zhang, Dong-Li Hu, Hong-Hao Zhou
ANXA2 promotes esophageal cancer progression by activating MYC-HIF1A-VEGF axis
Sai Ma, Chen-Chen Lu, Li-Yan Yang, Juan-Juan Wang, Bo-Shi Wang, Hong-Qing Cai, Jia-Jie Hao, Xin Xu, Yan Cai, Yu Zhang, Ming-Rong Wang
Isoliquiritigenin suppresses human melanoma growth by targeting miR-301b/LRIG1 signaling
Shijian Xiang, Huoji Chen, Xiaojun Luo, Baichao An, Wenfeng Wu, Siwei Cao, Shifa Ruan, Zhuxian Wang, Lidong Weng, Hongxia Zhu, Qiang Liu
Protease-activated receptor-1 (PAR1) promotes epithelial-endothelial transition through Twist1 in hepatocellular carcinoma
Ting Xiao, Qiang Zhang, Shumin Zong, Wei-long Zhong, Yuan Qin, Zhun Bi, Shuang Chen, Hui-juan Liu, Jun-jie Wei, Bi-jiao Zhou, Lu-meng Wang, Hong-gang Zhou, Yan-rong Liu, Tao Sun, Cheng Yang
Long noncoding RNA HEGBC promotes tumorigenesis and metastasis of gallbladder cancer via forming a positive feedback loop with IL-11/STAT3 signaling pathway
Liang Yang, Qingxiang Gao, Xiaoxiong Wu, Feiling Feng, Kaiyun Xu
PCBP1 depletion promotes tumorigenesis through attenuation of p27Kip1 mRNA stability and translation
Hongshun Shi, Hui Li, Ronghua Yuan, Wen Guan, Xiaomei Zhang, Shaoyang Zhang, Wenliang Zhang, Fang Tong, Li Li, Zhihong Song, Changwei Wang, Shulan Yang, Haihe Wang
TSSC3 promotes autophagy via inactivating the Src-mediated PI3K/Akt/mTOR pathway to suppress tumorigenesis and metastasis in osteosarcoma, and predicts a favorable prognosis
Guo-sheng Zhao, Zi-ran Gao, Qiao Zhang, Xue-feng Tang, Yang-fan Lv, Zhao-si Zhang, Yuan Zhang, Qiu-lin Tan, Dong-bin Peng, Dian-ming Jiang, Qiao-Nan Guo
MKRN2 inhibits migration and invasion of non-small-cell lung cancer by negatively regulating the PI3K/Akt pathway
Jun Jiang, Yitong Xu, Hongjiu Ren, Muli Wudu, Qiongzi Wang, Xin Song, Hongbo Su, Xizi Jiang, Lihong Jiang, Xueshan Qiu
Dual effect of DLBCL-derived EXOs in lymphoma to improve DC vaccine efficacy in vitro while favor tumorgenesis in vivo
Zhenzhen Chen, Liangshun You, Lei Wang, Xianbo Huang, Hui Liu, Ju ying Wei, Li Zhu, Wenbin Qian
Anti-inflammatory signaling by mammary tumor cells mediates prometastatic macrophage polarization in an innovative intraductal mouse model for triple-negative breast cancer
Jonas Steenbrugge, Koen Breyne, Kristel Demeyere, Olivier De Wever, Niek N. Sanders, Wim Van Den Broeck, Cecile Colpaert, Peter Vermeulen, Steven Van Laere, Evelyne Meyer
Triptolide inhibits Epstein-Barr nuclear antigen 1 expression by increasing sensitivity of mitochondria apoptosis of nasopharyngeal carcinoma cells
Heng Zhou, Yu Liu, Chao Wang, Limei Liu, Huan Wang, Yaqian Zhang, Cong Long, Xiaoping Sun
HJURP promotes hepatocellular carcinoma proliferation by destabilizing p21 via the MAPK/ERK1/2 and AKT/GSK3β signaling pathways
Tianchi Chen, Hechen Huang, Yuan Zhou, Lei Geng, Tian Shen, Shengyong Yin, Lin Zhou, Shusen Zheng
KPNA2 promotes metabolic reprogramming in glioblastomas by regulation of c-myc
Jie Li, Qian Liu, Zihao Liu, Qian Xia, Zihao Zhang, Rui Zhang, Taihong Gao, Guangyan Gu, Yanan Wang, Dan Wang, Xiuyang Chen, Yihang Yang, Dong He, Tao Xin
MAP17 predicts sensitivity to platinum-based therapy, EGFR inhibitors and the proteasome inhibitor bortezomib in lung adenocarcinoma
Irene Ferrer, Álvaro Quintanal-Villalonga, Sonia Molina-Pinelo, Jose Manuel Garcia-Heredia, Marco Perez, Rocío Suárez, Santiago Ponce-Aix, Luis Paz-Ares, Amancio Carnero
IL-33 facilitates proliferation of colorectal cancer dependent on COX2/PGE2
Yongkui Li, Jie Shi, Shanshan Qi, Jian Zhang, Dong Peng, Zhenzhen Chen, Guobin Wang, Zheng Wang, Lin Wang
Inhibitory effects of low intensity pulsed ultrasound on osteoclastogenesis induced in vitro by breast cancer cells
Valeria Carina, Viviana Costa, Stefania Pagani, Angela De Luca, Lavinia Raimondi, Daniele Bellavia, Stefania Setti, Milena Fini, Gianluca Giavaresi
PTEN lipid phosphatase inactivation links the hippo and PI3K/Akt pathways to induce gastric tumorigenesis
Wenting Xu, Zhen Yang, Chuan Xie, Yin Zhu, Xu Shu, Zhe Zhang, Nianshuang Li, Na Chai, Song Zhang, Kaichun Wu, Yongzhan Nie, Nonghua Lu
Downregulating CD26/DPPIV by apigenin modulates the interplay between Akt and Snail/Slug signaling to restrain metastasis of lung cancer with multiple EGFR statuses
Jer-Hwa Chang, Chao-Wen Cheng, Yi-Chieh Yang, Wan-Shen Chen, Wen-Yueh Hung, Jyh-Ming Chow, Pai-Sheng Chen, Michael Hsiao, Wei-Jiunn Lee, Ming-Hsien Chien
IL-6-mediated cross-talk between human preadipocytes and ductal carcinoma in situ in breast cancer progression
Hoe Suk Kim, Minji Jung, Sul Ki Choi, Jisu Woo, Yin Ji Piao, Eun Hye Hwang, Hyelim Kim, Seung Ja Kim, Woo Kyung Moon
HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma
Xin Xiao, Wei Wang, Yuqian Li, Di Yang, Xiaokang Li, Chao Shen, Yan Liu, Xianzhu Ke, Shuo Guo, Zheng Guo
RETRACTED ARTICLE: SP1-induced lncRNA AGAP2-AS1 expression promotes chemoresistance of breast cancer by epigenetic regulation of MyD88
Huaying Dong, Wei Wang, Shaowei Mo, Ru Chen, Kejian Zou, Jing Han, Fan Zhang, Jianguo Hu
Relationship between epithelial-to-mesenchymal transition and the inflammatory microenvironment of hepatocellular carcinoma
Long Yan, Feng Xu, Chao-liu Dai
Chemotherapy-induced niche perturbs hematopoietic reconstitution in B-cell acute lymphoblastic leukemia
Chao Tang, Ming-Hao Li, Ya-Li Chen, Hui-Ying Sun, Sheng-Li Liu, Wei-Wei Zheng, Meng-Yi Zhang, Hui Li, Wei Fu, Wen-Jun Zhang, Ai-Bin Liang, Zhong-Hua Tang, Deng-Li Hong, Bin-Bing S. Zhou, Cai-Wen Duan
HMGB1 knockdown increases MM cell vulnerability by regulating autophagy and DNA damage repair
Xing Guo, Donghua He, Enfan Zhang, Jing Chen, Qingxiao Chen, Yi Li, Li Yang, Yang Yang, Yi Zhao, Gang Wang, Jingsong He, Zhen Cai
Astragaloside IV inhibits lung cancer progression and metastasis by modulating macrophage polarization through AMPK signaling
Fei Xu, Wen-Qiang Cui, Ying Wei, Jie Cui, Jian Qiu, Ling-Li Hu, Wei-Yi Gong, Jing-Cheng Dong, Bao-Jun Liu
Chitinase 3-like 1-CD44 interaction promotes metastasis and epithelial-to-mesenchymal transition through β-catenin/Erk/Akt signaling in gastric cancer
Biao Geng, Jinshun Pan, Ting Zhao, Jie Ji, Chen Zhang, Ying Che, Jing Yang, Hui Shi, Juan Li, Hong Zhou, Xianmin Mu, Che Xu, Chao Wang, Yue Xu, Zheng Liu, Hao Wen, Qiang You
BMP9, but not BMP10, acts as a quiescence factor on tumor growth, vessel normalization and metastasis in a mouse model of breast cancer
Marie Ouarné, Claire Bouvard, Gabriela Boneva, Christine Mallet, Johnny Ribeiro, Agnès Desroches-Castan, Emmanuelle Soleilhac, Emmanuelle Tillet, Olivier Peyruchaud, Sabine Bailly
Corosolic acid, a natural triterpenoid, induces ER stress-dependent apoptosis in human castration resistant prostate cancer cells via activation of IRE-1/JNK, PERK/CHOP and TRIB3
Bo Ma, Hang Zhang, Yu Wang, Ang Zhao, Zhiming Zhu, Xiaowen Bao, Yang Sun, Lin Li, Qi Zhang
Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours
Zeribe C. Nwosu, Nadia Battello, Melanie Rothley, Weronika Piorońska, Barbara Sitek, Matthias P. Ebert, Ute Hofmann, Jonathan Sleeman, Stefan Wölfl, Christoph Meyer, Dominik A. Megger, Steven Dooley
RBM38 plays a tumor-suppressor role via stabilizing the p53-mdm2 loop function in hepatocellular carcinoma
Jiazhou Ye, Rong Liang, Tao Bai, Yan Lin, Rongyun Mai, Meng Wei, Xinqin Ye, Lequn Li, Feixiang Wu
Clinical applications of liquid biopsy as prognostic and predictive biomarkers in hepatocellular carcinoma: circulating tumor cells and circulating tumor DNA
Jie Li, Xu Han, Xiaona Yu, Zongzhen Xu, Guangsheng Yang, Bingqi Liu, Peng Xiu
Long noncoding RNA MIR31HG inhibits hepatocellular carcinoma proliferation and metastasis by sponging microRNA-575 to modulate ST7L expression
Shaoying Yan, Zhenrong Tang, Ke Chen, Yuyang Liu, Gangfeng Yu, Qiuxu Chen, Hao Dang, Fengjiao Chen, Jiaji Ling, Liying Zhu, Ailong Huang, Hua Tang
PHF8 upregulation contributes to autophagic degradation of E-cadherin, epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma
Wuhua Zhou, Li Gong, Qinchuan Wu, Chunyang Xing, Bajin Wei, Tianchi Chen, Yuan Zhou, Shengyong Yin, Bin Jiang, Haiyang Xie, Lin Zhou, Shusen Zheng
Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress
Xiaodong Zhang, Yan Li, Yingbo Ma, Liang Yang, Tao Wang, Xin Meng, Zhihong Zong, Xun Sun, Xiangdong Hua, Hangyu Li
Renal cancer: new models and approach for personalizing therapy
Simona di Martino, Gabriele De Luca, Ludovica Grassi, Giulia Federici, Romina Alfonsi, Michele Signore, Antonio Addario, Laura De Salvo, Federica Francescangeli, Massimo Sanchez, Valentina Tirelli, Giovanni Muto, Isabella Sperduti, Steno Sentinelli, Manuela Costantini, Luca Pasquini, Michele Milella, Mustapha Haoui, Giuseppe Simone, Michele Gallucci, Ruggero De Maria, Désirée Bonci
ERRα suppression enhances the cytotoxicity of the MEK inhibitor trametinib against colon cancer cells
Sheng Zhou, Hongwei Xia, Huanji Xu, Qiulin Tang, Yongzhan Nie, Qi yong Gong, Feng Bi
The putative tumour suppressor miR-1-3p modulates prostate cancer cell aggressiveness by repressing E2F5 and PFTK1
Sen-Mao Li, Huan-Lei Wu, Xiao Yu, Kun Tang, Shao-Gang Wang, Zhang-Qun Ye, Jia Hu
FOXC1 induces cancer stem cell-like properties through upregulation of beta-catenin in NSCLC
Sisi Cao, Zhuo Wang, Xiujuan Gao, Wenjuan He, Yue Cai, Hui Chen, Rong Xu
Endothelial cells promote metastasis of prostate cancer by enhancing autophagy
Ruizhe Zhao, Xiaoyu Bei, Boyu Yang, Xiaohai Wang, Chenyi Jiang, Fei Shi, Xingjie Wang, Yiping Zhu, Yifeng Jing, Bangmin Han, Shujie Xia, Qi Jiang
LncRNA SLCO4A1-AS1 facilitates growth and metastasis of colorectal cancer through β-catenin-dependent Wnt pathway
Jiangtao Yu, Zhiyang Han, Ziquan Sun, Yue Wang, Ming Zheng, Chunfang Song
Regulation of PTEN expression by noncoding RNAs
Wang Li, Ting Zhang, Lianying Guo, Lin Huang
FBP1 loss contributes to BET inhibitors resistance by undermining c-Myc expression in pancreatic ductal adenocarcinoma
Bo Wang, Ping Fan, Jingyuan Zhao, Heyu Wu, Xin Jin, Heshui Wu
LGR5, a novel functional glioma stem cell marker, promotes EMT by activating the Wnt/β-catenin pathway and predicts poor survival of glioma patients
Jin Zhang, Hongqing Cai, Lixin Sun, Panpan Zhan, Meng Chen, Feng Zhang, Yuliang Ran, Jinghai Wan
The roles of tumor-derived exosomes in non-small cell lung cancer and their clinical implications
Hongmei Zheng, Yuting Zhan, Sile Liu, Junmi Lu, Jiadi Luo, Juan Feng, Songqing Fan
TIPE3 hypermethylation correlates with worse prognosis and promotes tumor progression in nasopharyngeal carcinoma
Xian-Yue Ren, Xin Wen, Ying-Qing Li, Jian Zhang, Qing-Mei He, Xiao-Jing Yang, Xin-Ran Tang, Ya-Qin Wang, Pan-Pan Zhang, Xiao-Zhong Chen, Bin Cheng, Jun Ma, Na Liu
LMO3 promotes hepatocellular carcinoma invasion, metastasis and anoikis inhibition by directly interacting with LATS1 and suppressing Hippo signaling
Yang Cheng, Tianlu Hou, Jian Ping, Tianyang Chen, Baobing Yin
SPAG5 promotes hepatocellular carcinoma progression by downregulating SCARA5 through modifying β-catenin degradation
Hongliang Liu, Junwen Hu, Ran Wei, Longfei Zhou, Hua Pan, Hongchao Zhu, Mingwen Huang, Jun Luo, Wei Xu
miR-4317 suppresses non-small cell lung cancer (NSCLC) by targeting fibroblast growth factor 9 (FGF9) and cyclin D2 (CCND2)
Xi He, Si-yuan Chen, Zhao Yang, Jie Zhang, Wei Wang, Mei-yue Liu, Yi Niu, Xiao-mei Wei, Hong-min Li, Wan-ning Hu, Guo-gui Sun
HSCs-derived COMP drives hepatocellular carcinoma progression by activating MEK/ERK and PI3K/AKT signaling pathways
Qing Li, Cong Wang, Yufeng Wang, Liankang Sun, Zhikui Liu, Liang Wang, Tao Song, Yingmin Yao, Qingguang Liu, Kangsheng Tu
The effects of ultrasound exposure on P-glycoprotein-mediated multidrug resistance in vitro and in vivo
Chixiong Huang, Senlin Huang, Hairui Li, Xinzhong Li, Bing Li, Lintao Zhong, Junfeng Wang, Meishen Zou, Xiang He, Hao Zheng, Xiaoyun Si, Wangjun Liao, Yulin Liao, Li Yang, Jianping Bin
Integrated genomic analyses in PDX model reveal a cyclin-dependent kinase inhibitor Palbociclib as a novel candidate drug for nasopharyngeal carcinoma
Cheng-Lung Hsu, Kar-Wai Lui, Lang-Ming Chi, Yung-Chia Kuo, Yin-Kai Chao, Chun-Nan Yeh, Li-Yu Lee, Yenlin Huang, Tung-Liang Lin, Mei-Yuan Huang, Yi-Ru Lai, Yuan-Ming Yeh, Hsien-Chi Fan, An-Chi Lin, Yen-Jung Lu, Chia-Hsun Hsieh, Kai-Ping Chang, Ngan-Ming Tsang, Hung-Ming Wang, Alex Y. Chang, Yu-Sun Chang, Hsin-Pai Li
The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model
Pascal Häfliger, Julien Graff, Matthias Rubin, Amandine Stooss, Matthias S. Dettmer, Karl-Heinz Altmann, Jürg Gertsch, Roch-Philippe Charles
miR-203 inhibits ovarian tumor metastasis by targeting BIRC5 and attenuating the TGFβ pathway
Baojin Wang, Xia Li, Guannan Zhao, Huan Yan, Peixin Dong, Hidemichi Watari, Michelle Sims, Wei Li, Lawrence M Pfeffer, Yuqi Guo, Junming Yue
Effects of repurposed drug candidates nitroxoline and nelfinavir as single agents or in combination with erlotinib in pancreatic cancer cells
Serena Veschi, Laura De Lellis, Rosalba Florio, Paola Lanuti, Alberto Massucci, Nicola Tinari, Michele De Tursi, Pierluigi di Sebastiano, Marco Marchisio, Clara Natoli, Alessandro Cama
RETRACTED ARTICLE: Long noncoding RNA MLK7-AS1 promotes ovarian cancer cells progression by modulating miR-375/YAP1 axis
Huan Yan, Hong Li, Pengyun Li, Xia Li, Jianjian Lin, Linlin Zhu, Maria A. Silva, Xiaofang Wang, Ping Wang, Zhan Zhang
MiR-452 promotes an aggressive colorectal cancer phenotype by regulating a Wnt/β-catenin positive feedback loop
Tingting Li, Xiangyu Jian, Han He, Qiuhua Lai, Xianzheng Li, Danling Deng, Tengfei Liu, Jiehong Zhu, Hongli Jiao, Yaping Ye, Shuyang Wang, Minhui Yang, Lin Zheng, Weijie Zhou, Yanqing Ding
Recent advances in searching c-Myc transcriptional cofactors during tumorigenesis
Matteo Caforio, Cristina Sorino, Stefano Iacovelli, Maurizio Fanciulli, Franco Locatelli, Valentina Folgiero
An ABCG2 non-substrate anticancer agent FL118 targets drug-resistant cancer stem-like cells and overcomes treatment resistance of human pancreatic cancer
Xiang Ling, Wenjie Wu, Chuandong Fan, Chao Xu, Jianqun Liao, Laurie J. Rich, Ruea-Yea Huang, Elizabeth A. Repasky, Xinjiang Wang, Fengzhi Li
Enhanced efficacy of histone deacetylase inhibitor combined with bromodomain inhibitor in glioblastoma
Wei Meng, Baocheng Wang, Weiwei Mao, Jiajia Wang, Yang Zhao, Qifeng Li, Chenran Zhang, Yujie Tang, Jie Ma
Melanoma cell-secreted exosomal miR-155-5p induce proangiogenic switch of cancer-associated fibroblasts via SOCS1/JAK2/STAT3 signaling pathway
Xiaocheng Zhou, Tinglin Yan, Chunming Huang, Zhi Xu, Lin Wang, Erhui Jiang, Hui Wang, Yang Chen, Ke Liu, Zhe Shao, Zhengjun Shang
Suppression of lung cancer progression by isoliquiritigenin through its metabolite 2, 4, 2’, 4’-Tetrahydroxychalcone
Changliang Chen, Anitha K. Shenoy, Ravi Padia, Dongdong Fang, Qing Jing, Ping Yang, Shi-Bing Su, Shuang Huang
Inhibition of STAT3 blocks protein synthesis and tumor metastasis in osteosarcoma cells
Dongqing Zuo, Kristen L Shogren, Jie Zang, Donna E Jewison, Brian E Waletzki, Alan L Miller II, Scott H Okuno, Zhengdong Cai, Michael J Yaszemski, Avudaiappan Maran
Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules
Zaira Boussadia, Jessica Lamberti, Fabrizio Mattei, Elisabetta Pizzi, Rossella Puglisi, Cristiana Zanetti, Luca Pasquini, Federica Fratini, Luca Fantozzi, Federica Felicetti, Katia Fecchi, Carla Raggi, Massimo Sanchez, Stefania D’Atri, Alessandra Carè, Massimo Sargiacomo, Isabella Parolini
Mechanism of piR-DQ590027/MIR17HG regulating the permeability of glioma conditioned normal BBB
Xue Leng, Jun Ma, Yunhui Liu, Shuyuan Shen, Hai Yu, Jian Zheng, Xiaobai Liu, Libo Liu, Jiajia Chen, Lini Zhao, Xuelei Ruan, Yixue Xue
GLI2 promotes cell proliferation and migration through transcriptional activation of ARHGEF16 in human glioma cells
Dengliang Huang, Yiting Wang, Linlin Xu, Limin Chen, Minzhang Cheng, Wei Shi, Huanting Xiong, Detina Zalli, Shiwen Luo
Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway
Yulin Peng, Yan Wang, Ning Tang, Dongdong Sun, Yulong Lan, Zhenlong Yu, Xinyu Zhao, Lei Feng, Baojing Zhang, Lingling Jin, Fabiao Yu, Xiaochi Ma, Chuanzhu Lv
Correction to: Anti-tumor effects of Atractylenolide I on bladder cancer cells
Rui Yu, Bi-xia Yu, Jun-feng Chen, Xiu-yi Lv, Ze-jun Yan, Yue Cheng, Qi Ma
Temozolomide-Perillyl alcohol conjugate impairs Mitophagy flux by inducing lysosomal dysfunction in non-small cell lung Cancer cells and sensitizes them to irradiation
Minghui Chang, Xingguo Song, Xinran Geng, Xingwu Wang, Weijun Wang, Thomas C. Chen, Li Xie, Xianrang Song
Synergistic inhibitory effects of capsaicin combined with cisplatin on human osteosarcoma in culture and in xenografts
Yang Wang, Xu Deng, Chang Yu, Guosheng Zhao, Jing Zhou, Ge Zhang, Ming Li, Dianming Jiang, Zhengxue Quan, Yuan Zhang
MicroRNA-302a/d inhibits the self-renewal capability and cell cycle entry of liver cancer stem cells by targeting the E2F7/AKT axis
Yu-Shui Ma, Zhong-Wei Lv, Fei Yu, Zheng-Yan Chang, Xian-Ling Cong, Xiao-Ming Zhong, Gai-Xia Lu, Jian Zhu, Da Fu
Long noncoding RNA AFAP1-AS1 acts as a competing endogenous RNA of miR-423-5p to facilitate nasopharyngeal carcinoma metastasis through regulating the Rho/Rac pathway
Yu Lian, Fang Xiong, Liting Yang, Hao Bo, Zhaojian Gong, Yumin Wang, Fang Wei, Yanyan Tang, Xiayu Li, Qianjin Liao, Hui Wang, Ming Zhou, Bo Xiang, Xu Wu, Yong Li, Xiaoling Li, Xiang Chen, Guiyuan Li, Can Guo, Zhaoyang Zeng, Wei Xiong
AFF3 upregulation mediates tamoxifen resistance in breast cancers
Yawei Shi, Yang Zhao, Yunjian Zhang, NiJiati AiErken, Nan Shao, Runyi Ye, Ying Lin, Shenming Wang
Elevated Na/H exchanger 1 (SLC9A1) emerges as a marker for tumorigenesis and prognosis in gliomas
Xiudong Guan, Lanxin Luo, Gulnaz Begum, Gary Kohanbash, Qingkun Song, Aparna Rao, Nduka Amankulor, Baoshan Sun, Dandan Sun, Wang Jia
HIF-2α promotes conversion to a stem cell phenotype and induces chemoresistance in breast cancer cells by activating Wnt and Notch pathways
Yuanyuan Yan, Fangxiao Liu, Li Han, Lin Zhao, Jianjun Chen, Olufunmilayo I Olopade, Miao He, Minjie Wei
Aberrant miRNAs expressed in HER-2 negative breast cancers patient
Cornelia Braicu, Lajos Raduly, Gabriela Morar-Bolba, Roxana Cojocneanu, Ancuta Jurj, Laura-Ancuta Pop, Valentina Pileczki, Cristina Ciocan, Alin Moldovan, Alexandru Irimie, Alexandru Eniu, Patriciu Achimas-Cadariu, Angelo Paradiso, Ioana Berindan-Neagoe
The deubiquitinating enzyme UCHL1 is a favorable prognostic marker in neuroblastoma as it promotes neuronal differentiation
Yuting Gu, Fan Lv, Mingxing Xue, Kai Chen, Cheng Cheng, Xinyuan Ding, Min Jin, Guofeng Xu, Yanyun Zhang, Zhixiang Wu, Leizhen Zheng, Yeming Wu
Hydroxychloroquine induced lung cancer suppression by enhancing chemo-sensitization and promoting the transition of M2-TAMs to M1-like macrophages
Yong Li, Fengjun Cao, Mingxing Li, Pindong Li, Yuandong Yu, Longchao Xiang, Tao Xu, Jinhua Lei, Yun Yan Tai, Jianyong Zhu, Bingbing Yang, Yingpin Jiang, Xiufang Zhang, Long Duo, Ping Chen, Xiongjie Yu
Lentinan inhibits tumor angiogenesis via interferon γ and in a T cell independent manner
Shengming Deng, Guoxi Zhang, Jiajie Kuai, Peng Fan, Xuexiang Wang, Pei Zhou, Dan Yang, Xichen Zheng, Xiaomei Liu, Qunli Wu, Yuhui Huang
Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects
Lu Xu, Yang Zhang, Kang Tian, Xi Chen, Rongxin Zhang, Xindi Mu, Yueguang Wu, Duchuang Wang, Shanshan Wang, Fang Liu, Taishu Wang, Jinrui Zhang, Shuyan Liu, Yingqiu Zhang, Caixia Tu, Han Liu
Nobel committee honors tumor immunologists
Anand Rotte, Gabriella D’Orazi, Madhuri Bhandaru
ATF3 inhibits the tumorigenesis and progression of hepatocellular carcinoma cells via upregulation of CYR61 expression
Cong Chen, Chao Ge, Zheng Liu, Liangyu Li, Fangyu Zhao, Hua Tian, Taoyang Chen, Hong Li, Ming Yao, Jinjun Li
Carbonyl reductase 1 is a new target to improve the effect of radiotherapy on head and neck squamous cell carcinoma
Miyong Yun, Ae Jin Choi, Young Chan Lee, Munkyoo Kong, Ji-Youn Sung, Sung Soo Kim, Young-Gyu Eun
Over-expressed lncRNA HOTAIRM1 promotes tumor growth and invasion through up-regulating HOXA1 and sequestering G9a/EZH2/Dnmts away from the HOXA1 gene in glioblastoma multiforme
Qi Li, Chengya Dong, Jiayue Cui, Yubo Wang, Xinyu Hong
The role of cellular reactive oxygen species in cancer chemotherapy
Haotian Yang, Rehan M Villani, Haolu Wang, Matthew J Simpson, Michael S Roberts, Min Tang, Xiaowen Liang
Correction to: Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours
Zeribe C. Nwosu, Nadia Battello, Melanie Rothley, Weronika Piorońska, Barbara Sitek, Matthias P. Ebert, Ute Hofmann, Jonathan Sleeman, Stefan Wölfl, Christoph Meyer, Dominik A. Megger, Steven Dooley
RETRACTED ARTICLE: MicroRNA-31-5p regulates chemosensitivity by preventing the nuclear location of PARP1 in hepatocellular carcinoma
Ke-ting Que, Yun Zhou, Yu You, Zhen Zhang, Xiao-ping Zhao, Jian-ping Gong, Zuo-jin Liu
Vitexin compound 1, a novel extraction from a Chinese herb, suppresses melanoma cell growth through DNA damage by increasing ROS levels
Nian Liu, Kuan Song Wang, Min Qi, Ying Jun Zhou, Guang Yao Zeng, Juan Tao, Jian Da Zhou, Jiang Lin Zhang, Xiang Chen, Cong Peng
Correction to: PHF8 upregulation contributes to autophagic degradation of E-cadherin, epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma
Wuhua Zhou, Li Gong, Qinchuan Wu, Chunyang Xing, Bajin Wei, Tianchi Chen, Yuan Zhou, Shengyong Yin, Bin Jiang, Haiyang Xie, Lin Zhou, Shusen Zheng
GABA, glutamine, glutamate oxidation and succinic semialdehyde dehydrogenase expression in human gliomas
Zoltán Hujber, Gergő Horváth, Gábor Petővári, Ildikó Krencz, Titanilla Dankó, Katalin Mészáros, Hajnalka Rajnai, Norbert Szoboszlai, William P. J. Leenders, András Jeney, László Tretter, Anna Sebestyén
Tunicamycin specifically aggravates ER stress and overcomes chemoresistance in multidrug-resistant gastric cancer cells by inhibiting N-glycosylation
Jian Wu, Sheng Chen, Hao Liu, Zhe Zhang, Zhen Ni, Jie Chen, Zhiping Yang, Yongzhan Nie, Daiming Fan
Long non-coding RNA DANCR promotes malignant phenotypes of bladder cancer cells by modulating the miR-149/MSI2 axis as a ceRNA
Yonghao Zhan, Zhicong Chen, Yifan Li, Anbang He, Shiming He, Yanqing Gong, Xuesong Li, Liqun Zhou
LAT2 regulates glutamine-dependent mTOR activation to promote glycolysis and chemoresistance in pancreatic cancer
Mengyu Feng, Guangbing Xiong, Zhe Cao, Gang Yang, Suli Zheng, Jiangdong Qiu, Lei You, Lianfang Zheng, Taiping Zhang, Yupei Zhao
CircRNA circRNA_102171 promotes papillary thyroid cancer progression through modulating CTNNBIP1-dependent activation of β-catenin pathway
Wen Bi, Jiayu Huang, Chunlei Nie, Bo Liu, Guoqing He, Jihua Han, Rui Pang, Zhaoming Ding, Jin Xu, Jiewu Zhang
Downregulation of CLDN7 due to promoter hypermethylation is associated with human clear cell renal cell carcinoma progression and poor prognosis
Yifan Li, Yanqing Gong, Xianghui Ning, Ding Peng, Libo Liu, Shiming He, Kan Gong, Cuijian Zhang, Xuesong Li, Liqun Zhou
Compound kushen injection suppresses human acute myeloid leukaemia by regulating the Prdxs/ROS/Trx1 signalling pathway
Yanxia Jin, Qian Yang, Li Liang, Lu Ding, Yuxing Liang, Dongdong Zhang, Balu Wu, Tian Yang, Hailing Liu, Tingting Huang, Hui Shen, Honglei Tu, Yunbao Pan, Yongchang Wei, Yi Yang, Fuling Zhou
Semaphorin 5A drives melanoma progression: role of Bcl-2, miR-204 and c-Myb
Simona D’Aguanno, Elisabetta Valentini, Maria Grazia Tupone, Marianna Desideri, Marta Di Martile, Manuela Spagnuolo, Simonetta Buglioni, Cristiana Ercolani, Italia Falcone, Marco De Dominici, Michele Milella, Maria Giulia Rizzo, Bruno Calabretta, Carlo Cota, Andrea Anichini, Daniela Trisciuoglio, Donatella Del Bufalo
LncRNA XIST/miR-34a axis modulates the cell proliferation and tumor growth of thyroid cancer through MET-PI3K-AKT signaling
Hua Liu, Haoyu Deng, Yajie Zhao, Can Li, Yu Liang
Helicobacter pylori CagA promotes epithelial mesenchymal transition in gastric carcinogenesis via triggering oncogenic YAP pathway
Nianshuang Li, Yan Feng, Yi Hu, Cong He, Chuan Xie, Yaobin Ouyang, Stephen C. Artim, Deqiang Huang, Yin Zhu, Zhijun Luo, Zhongming Ge, Nonghua Lu
Distinct expression profiles and functions of Kindlins in breast cancer
Paula Azorin, Florian Bonin, Ahmad Moukachar, Aurélie Ponceau, Sophie Vacher, Ivan Bièche, Elisabetta Marangoni, Laetitia Fuhrmann, Anne Vincent-Salomon, Rosette Lidereau, Keltouma Driouch
Artemisinin derivatives inactivate cancer-associated fibroblasts through suppressing TGF-β signaling in breast cancer
Yuyuan Yao, Qinglong Guo, Yue Cao, Yangmin Qiu, Renxiang Tan, Zhou Yu, Yuxin Zhou, Na Lu
EBV-miR-BART8-3p induces epithelial-mesenchymal transition and promotes metastasis of nasopharyngeal carcinoma cells through activating NF-κB and Erk1/2 pathways
Cheng Lin, Jingfeng Zong, Wansong Lin, Minghui Wang, Yuanji Xu, Rui Zhou, Shaojun Lin, Qiaojuan Guo, Honglin Chen, Yunbin Ye, Bin Zhang, Jianji Pan
RETRACTED ARTICLE: MNAT1 is overexpressed in colorectal cancer and mediates p53 ubiquitin-degradation to promote colorectal cancer malignance
Shan Zhou, Jinping Lu, Yuejin Li, Chan Chen, Yongqiang Cai, Gongjun Tan, Zhengke Peng, Zhenlin Zhang, Zigang Dong, Tiebang Kang, Faqing Tang
Correction to: Emerging roles of Myc in stem cell biology and novel tumor therapies
Go J. Yoshida
Increasing intratumor C/EBP-β LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer
Iris C. Salaroglio, Elena Gazzano, Ahmad Abdullrahman, Eleonora Mungo, Barbara Castella, Gamal Eldein Fathy Abd-ellatef Abd-elrahman, Massimo Massaia, Massimo Donadelli, Menachem Rubinstein, Chiara Riganti, Joanna Kopecka
Abnormally elevated USP37 expression in breast cancer stem cells regulates stemness, epithelial-mesenchymal transition and cisplatin sensitivity
Tao Qin, Bai Li, Xiaoyue Feng, Shujun Fan, Lei Liu, Dandan Liu, Jun Mao, Ying Lu, Jinfeng Yang, Xiaotang Yu, Qingqing Zhang, Jun Zhang, Bo Song, Man Li, Lianhong Li
Inhibition of TPL2 by interferon-α suppresses bladder cancer through activation of PDE4D
Zhe Qiang, Zong-yuan Zhou, Ting Peng, Pu-zi Jiang, Nan Shi, Emmanuel Mfotie Njoya, Bahtigul Azimova, Wan-li Liu, Wei-hua Chen, Guo-lin Zhang, Fei Wang
Long noncoding RNA LINC00511 contributes to breast cancer tumourigenesis and stemness by inducing the miR-185-3p/E2F1/Nanog axis
Guanming Lu, Yueyong Li, Yanfei Ma, Jinlan Lu, Yongcheng Chen, Qiulan Jiang, Qiang Qin, Lifeng Zhao, Qianfang Huang, Zhizhai Luo, Shiqing Huang, Zhongheng Wei
Gain of UBE2D1 facilitates hepatocellular carcinoma progression and is associated with DNA damage caused by continuous IL-6
Chuanchuan Zhou, Fengrui Bi, Jihang Yuan, Fu Yang, Shuhan Sun
Hypoxia potentiates gemcitabine-induced stemness in pancreatic cancer cells through AKT/Notch1 signaling
Zhengle Zhang, Han Han, Yuping Rong, Kongfan Zhu, Zhongchao Zhu, Zhigang Tang, Chenglong Xiong, Jing Tao
Dysregulation of miR-6868-5p/FOXM1 circuit contributes to colorectal cancer angiogenesis
Ye Wang, Meijuan Wu, Zengjie Lei, Mengxi Huang, Zhiping Li, Liya Wang, Qijun Cao, Dong Han, Yue Chang, Yanyan Chen, Xiaobei Liu, Lijun Xue, Xiaobei Mao, Jian Geng, Yanan Chen, Tingting Dai, Lili Ren, Qian Wang, Hongju Yu, Cheng Chen, Xiaoyuan Chu
Inhibition of skin carcinogenesis by suppression of NF-κB dependent ITGAV and TIMP-1 expression in IL-32γ overexpressed condition
Yong Sun Lee, Chung Hee Lee, Jun Tae Bae, Kyung Tak Nam, Dae Bong Moon, Ok Kyung Hwang, Jeong Soon Choi, Tae Hoon Kim, Hyoung Ok Jun, Young Suk Jung, Dae Yeon Hwang, Sang-Bae Han, Do Young Yoon, Jin Tae Hong
miR-296-5p suppresses EMT of hepatocellular carcinoma via attenuating NRG1/ERBB2/ERBB3 signaling
Dong-Min Shi, Li-Xin Li, Xin-Yu Bian, Xue-Jiang Shi, Li-Li Lu, Hong-Xin Zhou, Ting-Jia Pan, Jian Zhou, Jia Fan, Wei-Zhong Wu
GPR119 agonist enhances gefitinib responsiveness through lactate-mediated inhibition of autophagy
Ji Hye Im, Keon Wook Kang, Sun Young Kim, Yoon Gyoon Kim, Yong Jin An, Sunghyouk Park, Byung Hwa Jeong, Song-Yi Choi, Jin-Sun Lee, Keon Wook Kang
HDAC2 depletion promotes osteosarcoma’s stemness both in vitro and in vivo: a study on a putative new target for CSCs directed therapy
Marcella La Noce, Francesca Paino, Luigi Mele, Gianpaolo Papaccio, Tarik Regad, Angela Lombardi, Federica Papaccio, Vincenzo Desiderio, Virginia Tirino
Mutated Von Hippel-Lindau-renal cell carcinoma (RCC) promotes patients specific natural killer (NK) cytotoxicity
Anna Maria Trotta, Sara Santagata, Serena Zanotta, Crescenzo D’Alterio, Maria Napolitano, Giuseppina Rea, Rosa Camerlingo, Fabio Esposito, Elvira Lamantia, Annamaria Anniciello, Giovanni Botti, Nicola Longo, Gerardo Botti, Sandro Pignata, Sisto Perdonà, Stefania Scala
RBMS2 inhibits the proliferation by stabilizing P21 mRNA in breast cancer
Xi Sun, Yue Hu, Jing Wu, Liang Shi, Lei Zhu, Pei-Wen Xi, Ji-Fu Wei, Qiang Ding
Hypermethylation of DMTN promotes the metastasis of colorectal cancer cells by regulating the actin cytoskeleton through Rac1 signaling activation
Ya-Ping Ye, Hong-Li Jiao, Shu-Yang Wang, Zhi-Yuan Xiao, Dan Zhang, Jun-Feng Qiu, Ling-Jie Zhang, Ya-Li Zhao, Ting-Ting Li, Li-Liang, Wen-Ting Liao, Yan-Qing Ding
Tetraspanin 1 promotes epithelial-to-mesenchymal transition and metastasis of cholangiocarcinoma via PI3K/AKT signaling
Yan Wang, Yingjian Liang, Guangchao Yang, Yaliang Lan, Jihua Han, Jiabei Wang, Dalong Yin, Ruipeng Song, Tongsen Zheng, Shugeng Zhang, Shangha Pan, Xirui Liu, Mingxi Zhu, Yao Liu, Yifeng Cui, Fanzheng Meng, Bo Zhang, Shuhang Liang, Hongrui Guo, Yufeng Liu, Md Khaled Hassan, Lianxin Liu
Promoter hypomethylation mediated upregulation of MicroRNA-10b-3p targets FOXO3 to promote the progression of esophageal squamous cell carcinoma (ESCC)
Yi-fang Lu, Jia-rui Yu, Zhao Yang, Guan-xia Zhu, Peng Gao, Huan Wang, Si-yuan Chen, Jie Zhang, Mei-yue Liu, Yi Niu, Xiao-mei Wei, Wei Wang, Feng-jin Ye, Li-xin Zhang, Yue Zhao, Guo-gui Sun
Co-occurring KRAS mutation/LKB1 loss in non-small cell lung cancer cells results in enhanced metabolic activity susceptible to caloric restriction: an in vitro integrated multilevel approach
Elisa Caiola, Francesca Falcetta, Silvia Giordano, Mirko Marabese, Marina C. Garassino, Massimo Broggini, Roberta Pastorelli, Laura Brunelli
The natural polyphenol curcumin induces apoptosis by suppressing STAT3 signaling in esophageal squamous cell carcinoma
Ying Liu, Xinhua Wang, Shuang Zeng, Xiane Zhang, Jimin Zhao, Xiaoyan Zhang, Xinhuan Chen, Wanjing Yang, Yili Yang, Ziming Dong, Jingyu Zhu, Xin Xu, Fang Tian
IMPDH2 promotes colorectal cancer progression through activation of the PI3K/AKT/mTOR and PI3K/AKT/FOXO1 signaling pathways
Shiyu Duan, Wenqing Huang, Xiaoting Liu, Xuming Liu, Nana Chen, Qiong Xu, Yukun Hu, Wen Song, Jun Zhou
STON2 negatively modulates stem-like properties in ovarian cancer cells via DNMT1/MUC1 pathway
Shanshan Xu, Yongfang Yue, Songfa Zhang, Caiyun Zhou, Xiaodong Cheng, Xing Xie, Xinyu Wang, Weiguo Lu
Targeted radiotherapy of pigmented melanoma with 131I-5-IPN
Xiaodong Xu, Lujie Yuan, Yongkang Gai, Qingyao Liu, Lianglan Yin, Yaqun Jiang, Yichun Wang, Yongxue Zhang, Xiaoli Lan
The epithelial-to-mesenchymal transition induced by tumor-associated macrophages confers chemoresistance in peritoneally disseminated pancreatic cancer
Kazuya Kuwada, Shunsuke Kagawa, Ryuichi Yoshida, Shuichi Sakamoto, Atene Ito, Megumi Watanabe, Takeshi Ieda, Shinji Kuroda, Satoru Kikuchi, Hiroshi Tazawa, Toshiyoshi Fujiwara
Transmembrane protein GRINA modulates aerobic glycolysis and promotes tumor progression in gastric cancer
Dan-Hua Xu, Qing Li, Hao Hu, Bo Ni, Xu Liu, Chen Huang, Zi-Zhen Zhang, Gang Zhao
Isoalantolactone induces apoptosis through ROS-mediated ER stress and inhibition of STAT3 in prostate cancer cells
Wei Chen, Ping Li, Yi Liu, Yu Yang, Xueting Ye, Fangyi Zhang, Hang Huang
Bypassing drug resistance by triggering necroptosis: recent advances in mechanisms and its therapeutic exploitation in leukemia
Xianbo Huang, Feng Xiao, Yuan Li, Wenbin Qian, Wei Ding, Xiujin Ye
Stemness marker ALDH1A1 promotes tumor angiogenesis via retinoic acid/HIF-1α/VEGF signalling in MCF-7 breast cancer cells
Valerio Ciccone, Erika Terzuoli, Sandra Donnini, Antonio Giachetti, Lucia Morbidelli, Marina Ziche
Tspan8 and Tspan8/CD151 knockout mice unravel the contribution of tumor and host exosomes to tumor progression
Kun Zhao, Zhe Wang, Thilo Hackert, Claudia Pitzer, Margot Zöller
The epigenetically downregulated factor CYGB suppresses breast cancer through inhibition of glucose metabolism
Yixiao Feng, Mingjun Wu, Shuman Li, Xiaoqian He, Jun Tang, Weiyan Peng, Beilei Zeng, Chuxia Deng, Guosheng Ren, Tingxiu Xiang
Epigenetic reprogramming of epithelial mesenchymal transition in triple negative breast cancer cells with DNA methyltransferase and histone deacetylase inhibitors
Yanrong Su, Nathan R. Hopfinger, Theresa D. Nguyen, Thomas J. Pogash, Julia Santucci-Pereira, Jose Russo
X-ray irradiation induced Disabled-2 gene promoter de-methylation enhances radiosensitivity of non-small-cell lung carcinoma cells
Shuang Ma, Wan-Lin Zhang, Bruce D. Leckey Jr, Hong-Tao Xu, Lian-He Yang, Endi Wang
LINC01296/miR-26a/GALNT3 axis contributes to colorectal cancer progression by regulating O-glycosylated MUC1 via PI3K/AKT pathway
Bing Liu, Shimeng Pan, Yang Xiao, Qianqian Liu, Jingchao Xu, Li Jia
Cyclin G2 suppresses Wnt/β-catenin signaling and inhibits gastric cancer cell growth and migration through Dapper1
Jinlan Gao, Chenyang Zhao, Qi Liu, Xiaoyu Hou, Sen Li, Xuesha Xing, Chunhua Yang, Yang Luo
Inhibition of Stearoyl-CoA desaturase 1 reverts BRAF and MEK inhibition-induced selection of cancer stem cells in BRAF-mutated melanoma
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