The role of bone tissue as a versatile endocrine organ has clearly emerged recently. Osteocalcin (OCN), an osteoblast-derived polypeptide [ 1 , 2 ], regulates multiple endocrine and physiological functions, including glucose and electrolyte …
Authors:
F. Carlomagno, V. Hasenmajer, M. Spaziani, M. Tenuta, F. Sesti, C. Tarantino, C. Pozza, A. M. Isidori, D. Gianfrilli
Over the past few years, the adoption of continuous glucose monitoring (CGM) has grown rapidly as a result of improvements in sensor accuracy, greater convenience and ease of use. Accumulating evidence suggest that the use of CGM has the potential …
Authors:
Y. Wang, S. Li, J. Lu, K. Feng, X. Huang, F. Hu, M. Sun, Y. Zou, Y. Li, W. Huang, J. Zhou
Open Access
16-05-2024 | Thyroid Cancer | Original Article
Differentiated thyroid cancer (DTC) is the prevailing endocrine malignancy [ 1 ] and is predominantly treated with surgery and radioiodine [ 2 ]. Despite its generally promising clinical trajectory, patients presenting with distant metastases …
Authors:
M. Borowczyk, M. Kaczmarek-Ryś, S. Hryhorowicz, M. Sypniewski, D. Filipowicz, P. Dobosz, M. Oszywa, M. Ruchała, K. Ziemnicka
Thyroid cancer, the most prevalent type of human endocrine cancer, has shown a steeply increasing incidence during the past decades around the world. This cancer occurs much more frequently in women than in men [ 1 ]. Thyroid cancer can be …
Authors:
C. Zeng, Y. Zhang, C. Lin, W. Liang, J. Chen, Y. Chen, H. Xiao, Y. Li, H. Guan
Thyroid carcinoma is the most common malignant tumor of the head and neck. It accounts for approximately 95% of all endocrine tumors, and poses a serious threat to human health [ 1 ]. Papillary thyroid carcinoma (PTC) is one of the most common …
Osteogenesis imperfecta (OI) is a rare monogenic hereditary osteopathy with an incidence of 1 in 15,000 to 20,000 live births, characterized by bone fragility and multiple bone fractures [ 1 ]. OI is caused by alteration in synthesis and …
Authors:
Y. Wang, J. Hu, L. Sun, B. Zhou, X. Lin, Q. Zhang, O. Wang, Y. Jiang, W. Xia, X. Xing, M. Li
Transgender and gender diverse (TGD) people represent a broad spectrum of individuals whose gender identities differ from the recorded sex at birth [ 1 ]. The size of this population ranges, according to the most recent population-based studies …
Authors:
M. Marconi, M. T. Pagano, J. Ristori, S. Bonadonna, R. Pivonello, M. C. Meriggiola, G. Motta, F. Lombardo, M. Mosconi, A. Oppo, C. Cocchetti, A. Romani, S. Federici, L. Bruno, N. Verde, A. Lami, C. M. Crespi, L. Marinelli, L. Giordani, P. Matarrese, A. Ruocco, C. Santangelo, B. Contoli, M. Masocco, V. Minardi, F. Chiarotti, A. D. Fisher, M. Pierdominici
Chronic kidney disease (CKD) has been estimated to affect approximately 697.5 million individuals worldwide and to substantially increase their risk of end-stage kidney disease (ESKD) [ 1 ] Although the management of CKD has significantly improved …
Authors:
Y. Lin, C. Xie, Y. Zhang, F. Luo, Q. Gao, Y. Li, L. Su, R. Xu, X. Zhang, R. Chen, S. Zhou, P. Li, J. Liu, M. Liang, S. Nie, for the CRDS study Investigators
Open Access
10-05-2024 | Progesterone | Original Article
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisystem disease that primarily manifests as the inability to perform or participate in routine activities that were possible before the onset of the disease [ 1 ].
Authors:
Cornelia Pipper, Linda Bliem, Luis E. León, Daniela Mennickent, Claudia Bodner, Enrique Guzmán‑Gutiérrez, Michael Stingl, Eva Untersmayr, Bernhard Wagner, Romina Bertinat, Nuno Sepúlveda, Francisco Westermeier
Open Access
06-05-2024 | Acromegaly | Original Article
Acromegaly is a disease characterized by excessive secretion of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) [ 1 ]. While increased GH in acromegaly causes a decrease in total body fat by increasing lipolysis and lipid oxidation, it …
Authors:
M. Coskun, H. N. Sendur, A. Babayeva, M. N. Cerit, E. T. Cerit, M. M. Yalcin, A. E. Altinova, M. Akturk, M. A. Karakoc, F. B. Toruner
Thyroid nodules are a common finding among the general population [ 1 , 2 ]. Their prevalence has been estimated at around 4% if assessed via palpation, which is the least sensitive diagnostic method, and autopsy data from patients with no history …
Authors:
V. Oteri, S. Piane, E. Cocci
Open Access
02-05-2024 | Hypertension | Original Article
Cushing’s disease, the most common form of endogenous Cushing’s syndrome, is a rare and debilitating condition caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary tumour, resulting in excessive secretion of cortisol from the …
Authors:
R. Pivonello, M. Fleseriu, J. Newell-Price, A. Shimatsu, R. A. Feelders, P. Kadioglu, A. Tabarin, T. C. Brue, E. B. Geer, A. Piacentini, A. M. Pedroncelli, B. M. K. Biller
Open Access
02-05-2024 | Erythropoietin | Original Article
Obesity is considered to be a persistent worldwide health epidemic. Despite advances in its management, the incidence of this disorder and its complications is still rising, suggesting that more attention should be focused on developing new …
Authors:
A. Fernandez-Pombo, P. M. Lorenzo, M. C. Carreira, D. Gomez-Arbelaez, A. I. Castro, D. Primo, J. Rodriguez, I. Sajoux, J. Baltar, D. de Luis, D. Bellido, A. B. Crujeiras, F. F. Casanueva
Hyperlipidemia is a metabolic syndromes X disease caused by abnormal fat metabolism or transport, which has been a significant public health issue in recent years due to its increasing incidence and prevalence worldwide [ 1 ]. Hyperlipidemia …
The flip-flop phenomenon relates to the alternating manner of 131 I and fluorodeoxyglucose (FDG) uptake occurred in well-differentiated or poorly differentiated thyroid cancers [ 35 ]. Anaplastic thyroid cancer (ATC), as a dedifferentiated tumor …
Authors:
S. Heydarzadeh, A. A. Moshtaghie, M. Daneshpour, M. Hedayati
Craniopharyngioma is a histologically benign (grade 1 according to the World Health Organization classification) tumor, which accounts for 2–5% of all primary intracranial neoplasms [ 1 ]. Despite the benign histology, craniopharyngioma often …
Authors:
M. Losa, E. Mazza, E. Pedone, G. Nocera, N. Liscia, M. Reni, P. Mortini
Open Access
29-04-2024 | Hypothyroidism | Original Article
Immune checkpoint inhibitors (ICPIs) have radically changed the history of a wide spectrum of different neoplasms, including both solid and hematologic tumors [ 1 – 3 ].
Authors:
M. Albertelli, G. Rossi, E. Nazzari, C. Genova, F. Biello, E. Rijavec, M. G. Dal Bello, L. Patti, M. Tagliamento, G. Barletta, P. Morabito, M. Boschetti, A. Dotto, D. Campana, D. Ferone, F. Grossi
Open Access
29-04-2024 | Semaglutide | Original Article
Glucagon-like peptide-1 receptor agonists (GLP1-RAs) are an effective class of drugs for the treatment of type 2 diabetes mellitus (T2D), with well-defined safety and tolerability profiles. Their use is associated with better glycemic control and …
Authors:
C. Formichi, W. Baronti, G. de Gennaro, M. Cerrai Ceroni, L. Nigi, L. Rizzo, F. Dotta
Graves’ disease (GD) is the most common type of autoimmune thyroid diseases [ 1 ]. Graves’ orbitopathy (GO) is the most common extrathyroidal GD manifestation, and 25–50% of GD patients develop GO, manifested as proptosis due to expansion of …
Authors:
R. Wu, N. Li, X. Wang, S. Wang, J. Tan, R. Wang, W. Zheng