Issue 5/2019
Content (29 Articles)
A novel humanized anti-PD-1 monoclonal antibody potentiates therapy in oral squamous cell carcinoma
Y. Cai, Fei Wang, Q. Liu, Z. Li, D. Li, Z. Sun
The bispecific anti-CD3 × anti-CD155 antibody mediates T cell immunotherapy for human prostate cancer
Huijun Zhao, Juan Ma, Ting Lei, Wanru Ma, Man Zhang
Lurbinectedin (PM01183), a selective inhibitor of active transcription, effectively eliminates both cancer cells and cancer stem cells in preclinical models of uterine cervical cancer
Eriko Yokoi, Seiji Mabuchi, Kotaro Shimura, Naoko Komura, Katsumi Kozasa, Hiromasa Kuroda, Ryoko Takahashi, Tomoyuki Sasano, Mahiru Kawano, Yuri Matsumoto, Michiko Kodama, Kae Hashimoto, Kenjiro Sawada, Tadashi Kimura
The novel PI3K inhibitor S1 synergizes with sorafenib in non-small cell lung cancer cells involving the Akt-S6 signaling
Juan Wang, Shumei Ma, Xiuhua Chen, Sanqi Zhang, Zhiyong Wang, Qibing Mei
Caffeic acid phenethyl ester exerts apoptotic and oxidative stress on human multiple myeloma cells
Elizabeth Hernandez Marin, Hana Paek, Mei Li, Yesung Ban, Marie Katie Karaga, Rangaiah Shashidharamurthy, Xinyu Wang
The role of oxidative stress in 63 T-induced cytotoxicity against human lung cancer and normal lung fibroblast cell lines
Malgorzata Kucinska, Helena Mieszczak, Hanna Piotrowska-Kempisty, Mariusz Kaczmarek, Walter Granig, Marek Murias, Thomas Erker
A mediator of phosphorylated Smad2/3, evodiamine, in the reversion of TAF-induced EMT in normal colonic epithelial cells
Wanbin Yang, Xiuli Gong, Xiulian Wang, Chao Huang
A novel tetravalent bispecific antibody targeting programmed death 1 and tyrosine-protein kinase Met for treatment of gastric cancer
Weihua Hou, Qingyun Yuan, Xingxing Yuan, Yuxiong Wang, Wei Mo, Huijie Wang, Min Yu
The availability of drug by liposomal drug delivery
Evelien A. W. Smits, José A. Soetekouw, Ebel H. E. Pieters, Coen J. P. Smits, Nicolette de Wijs-Rot, Herman Vromans
Modulator of the PI3K/Akt oncogenic pathway affects mTOR complex 2 in human adenocarcinoma cells
Blair P. Curless, Nne E. Uko, Diane F. Matesic
MICONIDINE acetate, a new selective and cytotoxic compound with synergic potential, induces cell cycle arrest and apoptosis in leukemia cells
Mariana Franzoni Maioral, Natália Marceli Stefanes, Álisson Bigolin, Gabriele Andressa Zatelli, Ana Cláudia Philippus, Miriam de Barcellos Falkenberg, Maria Cláudia Santos-Silva
MiR-181a, a new regulator of TGF-β signaling, can promote cell migration and proliferation in gastric cancer
Shaohua Ge, Haiyang Zhang, Ting Deng, Wu Sun, Tao Ning, Qian Fan, Yi Wang, Xinyi Wang, Qiumo Zhang, Zhengyang Zhou, Haiou Yang, Guoguang Ying, Yi Ba
Screening, identification of prostate cancer urinary biomarkers and verification of important spots
Huijun Zhao, Xuhong Zhao, Ting Lei, Man Zhang
Sensitization of colorectal cancer to irinotecan therapy by PARP inhibitor rucaparib
Titto Augustine, Radhashree Maitra, Jinghang Zhang, Jay Nayak, Sanjay Goel
Biodistribution, pharmacokinetics and radioimmunotherapy of 188Re-cetuximab in NCI-H292 human lung tumor-bearing nude mice
Ya-Jen Chang, Chung-Li Ho, Kai-Hung Cheng, Wan-I Kuo, Wan-Chi Lee, Keng-Li Lan, Chih-Hsien Chang
The rhenium(I)-diselenoether anticancer drug targets ROS, TGF-β1, VEGF-A, and IGF-1 in an in vitro experimental model of triple-negative breast cancers
Philippe Collery, Vijay Veena, Adhikesavan Harikrishnan, Didier Desmaele
The cellular effects of novel triazine nitrogen mustards in glioblastoma LBC3, LN-18 and LN-229 cell lines
Rafał Krętowski, Danuta Drozdowska, Beata Kolesińska, Zbigniew Kamiński, Justyna Frączyk, Marzanna Cechowska-Pasko
In vitro and in vivo cytotoxic activity and human serum albumin interaction for a methoxy-styryl-thiosemicarbazone
Otávio Augusto Chaves, Isabela S. de Castro, Carla Marins Goulart, Myrtes S. S. Bellieny, José Carlos Netto-Ferreira, Juliana Echevarria-Lima, Aurea Echevarria
Nifuroxazide induces apoptosis, inhibits cell migration and invasion in osteosarcoma
Yi Luo, Anqi Zeng, Aiping Fang, Linjiang Song, Chen Fan, Chenjuan Zeng, Tinghong Ye, Hao Chen, Chongqi Tu, Yongmei Xie
Lopinavir-NO, a nitric oxide-releasing HIV protease inhibitor, suppresses the growth of melanoma cells in vitro and in vivo
Svetlana Paskas, Emanuela Mazzon, Maria Sofia Basile, Eugenio Cavalli, Yousef Al-Abed, Mingzhu He, Sara Rakocevic, Ferdinando Nicoletti, Sanja Mijatovic, Danijela Maksimovic-Ivanic
Modified ingenol semi-synthetic derivatives from Euphorbia tirucalli induce cytotoxicity on a large panel of human cancer cell lines
Viviane A. O Silva, Marcela N. Rosa, Olga Martinho, Amilcar Tanuri, João Paulo Lima, Luiz F. Pianowski, Rui M. Reis
Bispecific anti-CD3 x anti-B7-H3 antibody mediates T cell cytotoxic ability to human melanoma in vitro and in vivo
Juan Ma, Tengfei Shang, Pan Ma, Xin Sun, Jin Zhao, Ximing Sun, Man Zhang
The antitumor efficacy of monomeric disintegrin obtustatin in S-180 sarcoma mouse model
Narine Ghazaryan, Naira Movsisyan, Joana Catarina Macedo, Sara Vaz, Naira Ayvazyan, Luis Pardo, Elsa Logarinho
A phase I study of the antibody drug conjugate ASG-5ME, an SLC44A4-targeting antibody carrying auristatin E, in metastatic castration-resistant prostate cancer
Deaglan McHugh, Mario Eisenberger, Elisabeth I. Heath, Justine Bruce, Daniel C. Danila, Dana E. Rathkopf, Jarett Feldman, Susan F. Slovin, Banmeet Anand, Rong Chu, Jacqueline Lackey, Leonard Reyno, Emmanuel S. Antonarakis, Michael J. Morris
A phase I study of ontuxizumab, a humanized monoclonal antibody targeting endosialin, in Japanese patients with solid tumors
Toshihiko Doi, Takeshi Aramaki, Hirofumi Yasui, Kei Muro, Masafumi Ikeda, Takuji Okusaka, Yoshitaka Inaba, Kenya Nakai, Hiroki Ikezawa, Ryo Nakajima
Chemotherapy in pregnancy: exploratory study of the effects of paclitaxel on the expression of placental drug transporters
Paul Berveiller, Olivier Mir, Séverine A. Degrelle, Vassilis Tsatsaris, Lise Selleret, Jean Guibourdenche, Danièle Evain-Brion, Thierry Fournier, Sophie Gil
The drug lag and associated factors for orphan anticancer drugs in Japan compared to the United States
Hiroki Nakayama, Naoki Matsumaru, Katsura Tsukamoto
Human antigen R and drug resistance in tumors
Fenghai Zhou, Fa Zhang, Chuan Zhou, Mengtian Liang, Zhonglin Cai, Haidi Lv, Wenjuan Li, Xupan Wei