Top

BMC Cardiovascular Disorders

Published in:

Open Access 01-12-2024 | Hypertension | Research

Relationship between methylenetetrahydrofolate reductase C677T gene polymorphism and neutrophil gelatinase-associated lipocalin in early renal injury in H-type hypertension

Authors: Chi Zhang, Qiu-Ping Xin, Yun-BO Xie, Xiang-Yu Guo, En-Hong Xing, Zhi-Jie Dou, Cui Zhao

Published in: BMC Cardiovascular Disorders | Issue 1/2024

Abstract

Objective

To analyse the relationship between the polymorphisms of the H-type hypertensive methylenetetrahydrofolate reductase (MTHFR) C677T gene and neutrophil gelatinase-associated lipocalin (NGAL) in early kidney injury.

Method

A total of 279 hospitalised patients with hypertension were selected and grouped according to their homocysteine (Hcy) level. If their blood Hcy level was ≥ 10 µmol/L they were assigned to the H-type hypertensive group, and if it was < 10 µmol/L they were assigned to the non-H-type hypertensive group. Blood lipid indexes, renal function indexes and blood glucose indexes were collected, and the differences between the two groups were compared. Furthermore, MTHFR C677T genotype distribution and allele frequency and Hcy level of MTHFR C677T genotype were compared, and logistic multiple regression analysis was conducted for the correlation of different genotypes of MTHFR C677T and the early kidney injury marker NGAL.

Results

In the non-H-type hypertensive group, the levels of Hcy and NGAL, cystatin, blood urea nitrogen, serum creatinine, uric acid, serum β2-microglobulin and urinary microalbumin-to-creatinine ratio increased significantly, and the glomerular filtration rate level decreased significantly, when compared with the H-type hypertensive group, with statistical differences (p < 0.05). The H-type hypertensive group and the non-H-type hypertensive group had significant differences in the CC, CT and TT genotypes and allele frequencies at the MTHFR C677T locus. The MTHFR C677T gene mutation rate of the H-type hypertensive group was significantly higher than that of the non-H-type hypertensive group. The H-type hypertensive group had higher levels of the TT genotype and CT genotype Hcy. There was a statistical difference (p < 0.05).

Conclusion

Methylenetetrahydrofolate reductase C677T polymorphism is correlated with the Hcy level, and its gene polymorphism will affect the Hcy level. Methylenetetrahydrofolate reductase C677T polymorphism has an interactive effect with NGAL. Screening NGAL and reducing Hcy levels are valuable methods for the prevention and treatment of early renal injury in patients with H-type hypertension and help improve the prognosis of patients and their quality of life.

Chen Dj, Li C, Cai HR, Zhuang JQ, Huang YL, Peng XH, et al. Effect of Banxia Baizhu Tianma Tang for H-type hypertension: a protocol for a systematic review. Med (Baltim). 2020;99(9):e19309. https://doi.org/10.1097/MD.0000000000019309.CrossRef

Chen YN, Wei P, Yu J. Higher concentration of serum C-terminal cross-linking telopeptide of type I collagen is positively related with inflammatory factors in postmenopausal women with H-type hypertension and osteoporosis. Orthop Surg. 2019;11(6):1135–41. https://doi.org/10.1111/os.12567.CrossRefPubMedPubMedCentral

Shi Y, Wang X, Yu C, Zhou W, Wang T, Zhu L, et al. Association of a Novel Nutritional Index with Stroke in Chinese Population with Hypertension: insight from the China H-Type Hypertension Registry Study. Front Nutr. 2023;10:997180. https://doi.org/10.3389/fnut.2023.997180.CrossRefPubMedPubMedCentral

Antonaros F, Lanfranchi S, Locatelli C, Martelli A, Olivucci G, Cicchini E, et al. One-carbon pathway and cognitive skills in children with Down syndrome. Sci Rep. 2021;11(1):4225. https://doi.org/10.1038/s41598-021-83379-7.CrossRefPubMedPubMedCentral

Wang Y, Fan X, Fan B, Jiang KR, Zhang HX, Kang F, et al. Scutellarin reduce the Homocysteine Level and Alleviate Liver Injury in type 2 diabetes model. Front Pharmacol. 2020;11:538407. https://doi.org/10.3389/fphar.2020.538407.CrossRefPubMedPubMedCentral

Liu S, Liu M, Li Q, Liu XP, Wang Y, Mambiya M, et al. Association of single nucleotide polymorphisms of MTHFR, TCN2, RNF213 with susceptibility to hypertension and blood pressure. Biosci Rep. 2019;39(12):BSR20191454. https://doi.org/10.1042/BSR20191454.CrossRefPubMedPubMedCentral

Zhao X, Hui Q-C, Xu R, Gao N, Cao P. Resveratrol: a New Approach to Ameliorate Hyperhomocysteinaemia-Induced Renal Dysfunction. Exp Ther Med. 2022;24(2):510. https://doi.org/10.3892/etm.2022.11437.CrossRefPubMedPubMedCentral

Ordooei Javan A, Salamzadeh J, Shokouhi S, Sahraei Z. Evaluation of renal toxicity of Colistin Therapy with Neutrophil Gelatinase-Associated Lipocalin: a biomarker of renal tubular damage. Iran J Kidney Dis. 2017;11(6):447–55.PubMed

Calleri A, Alessandria C. Renal damage in Hepatorenal Syndrome: A still Unsolved Issue. Clin Res Hepatol Gastroenterol. 2023;47(7):102178. https://doi.org/10.1016/j.clinre.2023.102178.CrossRefPubMed

10.

Blood Pressure Alliance (China)., 2019 Chinese Guidelines for the Prevention and Treatment of Hypertension (Revised Version) [S]. Chinese Journal of Cardiovascular Diseases. 2019; 24 (1): 52–78. doi:0.3969/j.issn.1007-5410.2019.01.001.

11.

2018 Chinese Guidelines for Prevention and Treatment of Hypertension-a Report of the Revision Committee of Chinese Guidelines for Prevention and Treatment of Hypertension [S]. J Geriatr Cardiol. 2019;16(3):182–241. https://doi.org/10.11909/j.issn.1671-5411.2019.03.014.CrossRef

12.

Zhang C, Zhang DD, Feng YM, et al. Relationship between morning peak phenomenon and early renal injury NGAL in H-type hypertension. Blood Press. 2022;31(1):200–6.CrossRefPubMed

13.

Deng X, Tang C, Wu J, Han R, Fang F. Changes of nutritional status and the variations of serum indicators of patients with chronic kidney disease accompanied by hypothyroidism taking thyroid hormone replacement therapy as the therapeutic models. Saudi J Biol Sci. 2019;26(8):2091–5. https://doi.org/10.1016/j.sjbs.2019.09.023.CrossRefPubMedPubMedCentral

14.

Yang QH, Lu YW, Deng YH, Xu JY, Zhang X. Homocysteine level is positively and independently associated with serum creatinine and urea nitrogen levels in old male patients with hypertension. Sci Rep. 2020;10(1):18050. https://doi.org/10.1038/s41598-020-75073-x.CrossRefPubMedPubMedCentral

15.

Su XY, Li XB, Xing JW, Qian C, Li M, Bo G, et al. Effect of MTHFR gene polymorphism on serum homocysteine level and coronary artery lesions in H-type hypertension patients. Chin J Geriatric Cardiovasc Cerebrovasc Dis. 2019;21(8):826–9. https://doi.org/10.3969/j.issn.1009-0126.2019.08.011.CrossRef

16.

Chen XH, Ruan CC, Ge Q, Ma Y, Xu JZ, Zhang ZB, et al. Deficiency of complement C3a and C5a receptors prevents angiotensin II-induced hypertension via regulatory T cells. Circ Res. 2018;122(7):970–83. https://doi.org/10.1161/CIRCRESAHA.117.312153.CrossRefPubMed

17.

Loperena R, Van Beusecum JP, Itani HA, Engel N, Laroumanie F, Xiao L, et al. Hypertension and increased endothelial mechanical stretch promote monocyte differentiation and activation: roles of STAT3, interleukin 6 and hydrogen peroxide. Cardiovasc Res. 2018;114(11):1547–63. https://doi.org/10.1093/cvr/cvy112.CrossRefPubMedPubMedCentral

18.

Mo RH, Li M, Mai JJ, Liu CB. Effectiveness of urinary NGAL combined with serum CysC in predicting the severity of clinical illness in patients with renal injury and acute heart failure. Chin Med Sci. 2021;11(13):203–5. https://doi.org/10.3969/j.issn.2095-0616.2021.13.053.CrossRef

19.

De Bhailis ÁM, Kalra PA. Hypertension and the kidneys. Br J Hosp Med (Lond). 2022;83(5):1–11. https://doi.org/10.12968/hmed.2021.0440.CrossRefPubMed

20.

Li M, Zhan A, Huang X, Hu L, Zhou W, Wang T, et al. Positive association between triglyceride glucose index and arterial stiffness in hypertensive patients: the China H-type hypertension Registry Study. Cardiovasc Diabetol. 2020;19(1):139. https://doi.org/10.1186/s12933-020-01124-2.CrossRefPubMedPubMedCentral

21.

Wu Y, Wang T, Chen LP, Li R, Huang D, Ke S. Relation between blood pressure variability and renal injury in patients with H-type hypertension. China Med. 2019;14(2):166–9. https://doi.org/10.3760/j.issn.1673-4777.2019.02.002.CrossRef

22.

Jiang HM, Huang LG, Tian JH, Yang JL, Huang S, Shang JJ, et al. Correlation between red blood cell distribution width and early renal injury in elderly patients with H-type hypertension. China Med. 2019;14(10):1479–83. https://doi.org/10.3760/j.issn.1673-4777.2019.10.010.CrossRef

23.

Mtiraoui N, Ezzidi I, Chaieb M, Marmouche H, Aouni Z, Chaieb A, et al. MTHFR C677T and A1298C gene polymorphisms and hyperhomocysteinemia as risk factors of diabetic nephropathy in type 2 diabetes patients. Diabetes Res Clin Pract. 2007;75(1):99–106. https://doi.org/10.1016/j.diabres.2006.05.018.CrossRefPubMed

24.

Trovato FM, Catalano D, Ragusa A, Martines GF, Pirri C, Buccheri MA, Di Nora C, Trovato GM. Relationship of MTHFR gene polymorphisms with renal and cardiac disease. World J Nephrol. 2015;4(1):127–37. https://doi.org/10.5527/wjn.v4.i1.127.CrossRefPubMedPubMedCentral

25.

Munshi R, Panchal F, Kulkarni V, Chaurasia A. Methylenetetrahydrofolate reductase polymorphism in healthy volunteers and its correlation with homocysteine levels in patients with thrombosis. Indian J Pharmacol. 2019;51(4):248–54. https://doi.org/10.4103/ijp.IJP_215_19.CrossRefPubMedPubMedCentral

Title: Relationship between methylenetetrahydrofolate reductase C677T gene polymorphism and neutrophil gelatinase-associated lipocalin in early renal injury in H-type hypertension
Authors: Chi Zhang
Qiu-Ping Xin
Yun-BO Xie
Xiang-Yu Guo
En-Hong Xing
Zhi-Jie Dou
Cui Zhao
Publication date: 01-12-2024
Publisher: BioMed Central
Keywords: Hypertension
Hypertension
Kidney Injury
Published in: BMC Cardiovascular Disorders / Issue 1/2024
Electronic ISSN: 1471-2261
DOI: https://doi.org/10.1186/s12872-024-03704-6

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Relationship between methylenetetrahydrofolate reductase C677T gene polymorphism and neutrophil gelatinase-associated lipocalin in early renal injury in H-type hypertension

Abstract

Objective

Method

Results

Conclusion

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Method

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 1/2024

Association between baseline glycated hemoglobin level and atrial fibrillation recurrence following cryoballoon ablation among patients with and without diabetes

Adult-type anomalous origin of the left coronary artery from the pulmonary artery and right coronary-right atrial fistula: a case report

Potential impact of blood cholesterol guidelines on statin treatment in the U.S. population using interrupted time series analysis

Elucidating the mechanisms of formononetin in modulating atherosclerotic plaque formation in ApoE-/- mice

Whole-exome sequencing revealed a likely pathogenic variant in NF1 causing neurofibromatosis type I and Arrhythmogenic Cardiomyopathy

Ceramides and pro-inflammatory cytokines for the prediction of acute coronary syndrome: a multi-marker approach

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page