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Gynecology and Obstetrics

Editor's Choice

Infrequent zoledronate fights postmenopausal vertebral fracture risk

Women with a healthy bone mineral density may benefit from occasional infusions of zoledronate between age 50 and 60 years.

Sequential oral agents do not equal insulin in gestational diabetes

Sequential oral metformin and glyburide is not equivalent to insulin for gestational diabetes with respect to the proportion of infants born large for gestational age.

Current and future immunotherapy for breast cancer

Explore the recent major clinical trials of immunotherapy in breast cancer and find out more about promising emerging options, such as vaccines, bispecific antibodies, and cellular therapies.

Myocarditis in a complex postpartum adolescent

An 18-year-old postpartum patient is admitted with concomitant acute myocarditis and congenital long QT syndrome with electrical storm and incessant Torsade de Pointes. What would your management strategy be?

Empty sella syndrome: an update

Empty sella is generally an incidental radiological finding, but when endocrine, neurological, ophthalmological, or psychiatric symptoms occur empty sella syndrome must be promptly diagnosed.

Novel SERD shows promise in advanced breast cancer

Imlunestrant, either alone or alongside abemaciclib, could be an option after progression on endocrine therapy for patients with ER-positive advanced breast cancer.

Manging AF in breast cancer patients

Breast cancer patients have an increased risk of developing atrial fibrillation, due to both the cancer and its treatment, but the underlying mechanisms are still not well understood. What considerations should you make when treating these patients?

The many faces of PCOS

Examine the clinical and genetic data on familial clustering of PCOS features in both women and men, and discover the evidence supporting the existence of a male equivalent of PCOS.

Emerging therapies for brain metastases

Therapies designed to penetrate the blood-brain barrier and target key drivers like EGFR, ALK, HER2, and BRAF have revolutionized treatment of brain metastases from non-small-cell lung cancer, breast cancer, and melanoma.

Fractures in adulthood linked to later fracture risk

Any fracture in adulthood may be associated with an increased risk for future fracture, regardless of the age at which the first fracture occurs.

Risk of cardiovascular events with menopausal hormone therapies

Cardiovascular risks vary in women using MHT, particularly for oral combined estrogen–progestin therapy and tibolone.

Type 1 diabetes and glucose control during labor and delivery

An update on diabetes management during labor and delivery in women with type 1 diabetes, focusing on insulin administration, carbohydrate supply, and the use of diabetes technology.

When less is more: radiotherapy for early breast cancer

Recent advances have significantly altered the radiotherapy landscape of early-stage breast cancer. Delve into the trial data, reported since 2019, that have changed radiation treatment paradigms for this patient population.

Clinical utility of anti-Müllerian hormone in female children and adolescents

AMH is considered a valuable tool for the evaluation of conditions such as polycystic ovary syndrome, precocious puberty, differences in sex development, and primary ovarian insufficiency.

Quitting smoking early after cancer diagnosis improves survival

A prospective cohort study has shown that quitting smoking after a cancer diagnosis is associated with improved survival, with the greatest benefit for those quitting within 6 months.

Romosozumab for the treatment of osteoporosis

The monoclonal antibody romosozumab has a transient but robust bone anabolic effect. Find out what is currently known about its clinical efficacy and safety for the treatment of primary and secondary osteoporosis.

Reducing the lymphedema risk in breast cancer

Evidence-based recommendations from an expert panel on risk reduction practices for people at risk for or with breast cancer-related lymphedema. Covering topics ranging from screening and patient education to considerations for exercise and air travel.

Updates in breast cancer screening and diagnosis

Explore the current recommendations for breast cancer screening and the available imaging modalities as well as considerations for special populations, such as transgender patients.

Role of thyroid and leptin hormones in male fertility

Leptin and thyroid hormones have a crucial role in male reproductive function. What is known about the crosstalk between these hormones and their impact on fertility in men who have hypothyroidism with obesity?

Pulmonary embolism in a patient with hemophilia

A woman with factor V and VIII deficiency developed a pulmonary embolism during pregnancy. Although thromboembolic events may not be the first consideration in the setting of hemophilia, this case shows they can occur.