Skip to main content
Top
Published in: Antimicrobial Resistance & Infection Control 1/2020

01-12-2020 | Enterotoxigenic Escherichia Coli | Short report

Flies from a tertiary hospital in Rwanda carry multidrug-resistant Gram-negative pathogens including extended-spectrum beta-lactamase-producing E. coli sequence type 131

Authors: Stefan E. Heiden, Mathis S. E. Kurz, Jürgen Bohnert, Claude Bayingana, Jules M. Ndoli, Augustin Sendegeya, Jean Bosco Gahutu, Elias Eger, Frank P. Mockenhaupt, Katharina Schaufler

Published in: Antimicrobial Resistance & Infection Control | Issue 1/2020

Login to get access

Abstract

Multidrug-resistant gram-negative (MRGN) bacteria are a serious threat to global health. We used genomics to study MRGN obtained from houseflies in a tertiary Rwandan hospital. Our analysis revealed a high abundance of different MRGN including E. coli pathogenic lineage ST131 suggesting the important role of flies in disseminating highly virulent pathogens in clinical settings and beyond.
Appendix
Available only for authorised users
Literature
1.
go back to reference Brogan DM, Mossialos E. A critical analysis of the review on antimicrobial resistance report and the infectious disease financing facility. Glob Health. 2016;12:8.CrossRef Brogan DM, Mossialos E. A critical analysis of the review on antimicrobial resistance report and the infectious disease financing facility. Glob Health. 2016;12:8.CrossRef
2.
go back to reference Khamesipour F, Lankarani KB, Honarvar B, Kwenti TE. A systematic review of human pathogens carried by the housefly (Musca domestica L.). BMC Public Health. 2018;18(1):1049.CrossRef Khamesipour F, Lankarani KB, Honarvar B, Kwenti TE. A systematic review of human pathogens carried by the housefly (Musca domestica L.). BMC Public Health. 2018;18(1):1049.CrossRef
3.
go back to reference Alves TD, Lara GHB, ParizMaluta R, Ribeiro MG, Leite DD. Carrier flies of multidrug-resistant Escherichia coli as potential dissemination agent in dairy farm environment. Sci Total Environ. 2018;633:1345–51.CrossRef Alves TD, Lara GHB, ParizMaluta R, Ribeiro MG, Leite DD. Carrier flies of multidrug-resistant Escherichia coli as potential dissemination agent in dairy farm environment. Sci Total Environ. 2018;633:1345–51.CrossRef
4.
go back to reference Boiocchi F, Davies DP, Hilton AC. An Examination of Flying Insects in Seven Hospitals in the United Kingdom and Carriage of Bacteria by True Flies (Diptera: Calliphoridae, Dolichopodidae, Fanniidae, Muscidae, Phoridae, Psychodidae, Sphaeroceridae). J Med Entomol. 2019;56(6):1684–97. Boiocchi F, Davies DP, Hilton AC. An Examination of Flying Insects in Seven Hospitals in the United Kingdom and Carriage of Bacteria by True Flies (Diptera: Calliphoridae, Dolichopodidae, Fanniidae, Muscidae, Phoridae, Psychodidae, Sphaeroceridae). J Med Entomol. 2019;56(6):1684–97.
5.
go back to reference Kurz MSE, Bayingana C, Ndoli JM, Sendegeya A, Durst A, Pfuller R, et al. Intense pre-admission carriage and further acquisition of ESBL-producing Enterobacteriaceae among patients and their caregivers in a tertiary hospital in Rwanda. Tropical Med Int Health. 2017;22(2):210–20.CrossRef Kurz MSE, Bayingana C, Ndoli JM, Sendegeya A, Durst A, Pfuller R, et al. Intense pre-admission carriage and further acquisition of ESBL-producing Enterobacteriaceae among patients and their caregivers in a tertiary hospital in Rwanda. Tropical Med Int Health. 2017;22(2):210–20.CrossRef
6.
go back to reference Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Disk and Dilution Susceptibility Tests for Bacteria Isolated from Animals—Third Edition: Approved Standard M31-A3. 2008, CLSI, Wayne,PA, USA. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Disk and Dilution Susceptibility Tests for Bacteria Isolated from Animals—Third Edition: Approved Standard M31-A3. 2008, CLSI, Wayne,PA, USA.
7.
go back to reference Stoesser N, Sheppard AE, Pankhurst L, De Maio N, Moore CE, Sebra R, et al. Evolutionary history of the global emergence of the Escherichia coli epidemic clone ST131. MBio. 2016;7(2):e02162.CrossRef Stoesser N, Sheppard AE, Pankhurst L, De Maio N, Moore CE, Sebra R, et al. Evolutionary history of the global emergence of the Escherichia coli epidemic clone ST131. MBio. 2016;7(2):e02162.CrossRef
8.
go back to reference Schaufler K, Semmler T, Wieler LH, Wohrmann M, Baddam R, Ahmed N, et al. Clonal spread and interspecies transmission of clinically relevant ESBL-producing Escherichia coli of ST410--another successful pandemic clone? FEMS Microbiol Ecol. 2016;92(1):fiv155.CrossRef Schaufler K, Semmler T, Wieler LH, Wohrmann M, Baddam R, Ahmed N, et al. Clonal spread and interspecies transmission of clinically relevant ESBL-producing Escherichia coli of ST410--another successful pandemic clone? FEMS Microbiol Ecol. 2016;92(1):fiv155.CrossRef
9.
go back to reference Wullt B, Bergsten G, Samuelsson M, Svanborg C. The role of P fimbriae for Escherichia coli establishment and mucosal inflammation in the human urinary tract. Int J Antimicrob Agents. 2002;19(6):522–38.CrossRef Wullt B, Bergsten G, Samuelsson M, Svanborg C. The role of P fimbriae for Escherichia coli establishment and mucosal inflammation in the human urinary tract. Int J Antimicrob Agents. 2002;19(6):522–38.CrossRef
10.
go back to reference Begum YA, Rydberg HA, Thorell K, Kwak YK, Sun L, Joffre E, et al. In Situ Analyses Directly in Diarrheal Stool Reveal Large Variations in Bacterial Load and Active Toxin Expression of Enterotoxigenic Escherichia coli and Vibrio cholerae. mSphere. 2018;3(1):e00517.CrossRef Begum YA, Rydberg HA, Thorell K, Kwak YK, Sun L, Joffre E, et al. In Situ Analyses Directly in Diarrheal Stool Reveal Large Variations in Bacterial Load and Active Toxin Expression of Enterotoxigenic Escherichia coli and Vibrio cholerae. mSphere. 2018;3(1):e00517.CrossRef
11.
go back to reference Evers EG, Blaak H, Hamidjaja RA, de Jonge R, Schets FM. A QMRA for the transmission of ESBL-producing Escherichia coli and Campylobacter from poultry farms to humans through flies. Risk Anal. 2016;36(2):215–27.CrossRef Evers EG, Blaak H, Hamidjaja RA, de Jonge R, Schets FM. A QMRA for the transmission of ESBL-producing Escherichia coli and Campylobacter from poultry farms to humans through flies. Risk Anal. 2016;36(2):215–27.CrossRef
Metadata
Title
Flies from a tertiary hospital in Rwanda carry multidrug-resistant Gram-negative pathogens including extended-spectrum beta-lactamase-producing E. coli sequence type 131
Authors
Stefan E. Heiden
Mathis S. E. Kurz
Jürgen Bohnert
Claude Bayingana
Jules M. Ndoli
Augustin Sendegeya
Jean Bosco Gahutu
Elias Eger
Frank P. Mockenhaupt
Katharina Schaufler
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Antimicrobial Resistance & Infection Control / Issue 1/2020
Electronic ISSN: 2047-2994
DOI
https://doi.org/10.1186/s13756-020-0696-y

Other articles of this Issue 1/2020

Antimicrobial Resistance & Infection Control 1/2020 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.