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The journal of nutrition, health & aging
Published in: The journal of nutrition, health & aging 10/2019

01-12-2019 | Dementia | Editorial

Incident Dementia in Trials of Antihypertensive Treatments

Authors: Timo E. Strandberg, A. Benetos, M. Petrovic

Published in: The journal of nutrition, health & aging | Issue 10/2019

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Excerpt

The Systolic Blood Pressure Intervention Trial (SPRINT) Memory and Cognition in Decreased Hypertension (MIND) study (1), failed to show a significant effect on the primary endpoint (probable dementia, hazard ratio [HR] 0.83; 95% CI, 0.67–1.04). Because this may be due to limited power, the results of SPRINT MIND were put in the context of major randomised and controlled hypertension trials (RCT) in which incident dementia had been adjudicated. …
Literature
1.
2.
Rouch L, Cestac P, Hanon O, et al. Antihypertensive drugs, prevention of cognitive decline and dementia: a systematic review of observational studies, randomized controlled trials and meta-analyses, with discussion of potential mechanisms. CNS Drugs. 2015;29:113–30CrossRef
3.
Moll van Charante EP, Richard E, Eurelings LS, et al. Effectiveness of a 6-year multidomain vascular care intervention to prevent dementia (preDIVA): a cluster-randomised controlled trial. Lancet. 2016;388:797–805CrossRef
4.
Metadata
Title
Incident Dementia in Trials of Antihypertensive Treatments
Authors
Timo E. Strandberg
A. Benetos
M. Petrovic
Publication date
01-12-2019
Publisher
Springer Paris
Published in
The journal of nutrition, health & aging / Issue 10/2019
Print ISSN: 1279-7707
Electronic ISSN: 1760-4788
DOI
https://doi.org/10.1007/s12603-019-1262-2

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