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The journal of nutrition, health & aging

Published in:

01-12-2019

Impact of Number of Drug Types on Clinical Outcome in Patients with Acute Hip Fracture

Authors: Hiroki Maki, H. Wakabayashi, M. Nakamichi, R. Momosaki

Published in: The journal of nutrition, health & aging | Issue 10/2019

Abstract

Objectives

This study aims to investigate the impact of the number of drug types on clinical outcomes for patients with acute hip fracture.

Designs

This is a retrospective cross-sectional study.

Setting

A hospital-based database constructed by the Japan Medical Data Center.

Participants

Consecutive patients exhibiting acute hip fractures on admission between April 2014 and November 2017 were included.

Measurements

Relationships among the numbers of varying drug types of ≥6 and ≤5 as well as clinical outcomes were analyzed in 11,073 patients aged ≥65 years. The primary outcome was defined as the Barthel Index efficiency, with the secondary outcome being the length of hospital stay.

Results

Median Barthel Index scores at admission and discharge were 5 (interquartile range: 5–20) and 50 (interquartile range: 20–85). The Barthel Index efficiency was significantly higher in the group having received 5 or fewer drug variations taken (1.45 ± 1.77) than in the group receiving 6 or more drug types taken (0.94 ± 1.18) during hospital stays (p < 0.001). The length of hospital stay was significantly shorter in the group receiving 5 or fewer drug types taken (29.9 ± 23.8) than in the group having 6 or more drug types taken (44.3 ± 30.3) during hospital stays (p < 0.001), with the latter number being independently associated with the Barthel Index efficiency and length of hospital stay.

Conclusions

Number of drug types of 6 or more were associated with lower Barthel Index efficiency and longer lengths of hospital stays.

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Title: Impact of Number of Drug Types on Clinical Outcome in Patients with Acute Hip Fracture
Authors: Hiroki Maki
H. Wakabayashi
M. Nakamichi
R. Momosaki
Publication date: 01-12-2019
Publisher: Springer Paris
Published in: The journal of nutrition, health & aging / Issue 10/2019
Print ISSN: 1279-7707
Electronic ISSN: 1760-4788
DOI: https://doi.org/10.1007/s12603-019-1250-6

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Impact of Number of Drug Types on Clinical Outcome in Patients with Acute Hip Fracture

Abstract

Objectives

Designs

Setting

Participants

Measurements

Results

Conclusions

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Abstract

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Results

Conclusions

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