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World Journal of Surgical Oncology

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Open Access 01-12-2016 | Research

Decreased miR-198 expression and its prognostic significance in human gastric cancer

Authors: Zhigang Cui, Xin Zheng, Di Kong

Published in: World Journal of Surgical Oncology | Issue 1/2016

Abstract

Background

MicroRNAs (miRNAs) have been proved to play important roles in the tumorigenesis and development of human gastric cancer (GC). Our study aims to investigate the expression and clinical significance of miR-198 in GC patients.

Methods

Quantitative real-time polymerase chain reaction (RT-PCR) was performed to evaluate miR-198 levels in 106 pairs of GC specimens and adjacent noncancerous tissues. Then, the associations of miR-198 expression with clinicopathological factors and patient’s survival were determined.

Results

The expression levels of miR-198 in GC tissues were significantly lower than those in corresponding noncancerous tissues (p < 0.01). Decreased miR-198 expression was significantly associated with larger tumor size, deeper invasion depth, positive lymph node metastasis, advanced tumor-node-metastasis (TNM) stage, and shorter overall survival. Moreover, multivariate regression analysis identified low miR-198 expression as an independent predictor of poor survival.

Conclusions

These findings suggested that miR-198 downregulation may be associated with progression of GC and that this miR may be an independent prognostic marker for GC patients.

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Title: Decreased miR-198 expression and its prognostic significance in human gastric cancer
Authors: Zhigang Cui
Xin Zheng
Di Kong
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2016
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/s12957-016-0784-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Decreased miR-198 expression and its prognostic significance in human gastric cancer

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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