Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
World Journal of Surgical Oncology
Published in: World Journal of Surgical Oncology 1/2016

Open Access 01-12-2016 | Case report

Invasive ductal carcinoma of the breast with osteoclast-like giant cells and clear cell features: a case report of a novel finding and review of the literature

Authors: Nicole K. Zagelbaum, Michael F. Ward II, Nader Okby, Howard Karpoff

Published in: World Journal of Surgical Oncology | Issue 1/2016

Login to get access

Abstract

Background

Osteoclast-like giant cells (OLGCs) are a rare histologic finding within a tumor of the breast. Although there has been discussion as to the pathogenesis and prognosis related to this finding, our understanding of its significance remains inconclusive. Clear cells are another unique histologic finding in breast tumors and are typically associated with tumors arising in other organs such as renal cell carcinoma.

Case presentation

This is a case report of a 64-year-old female who presented with one tumor identified as invasive ductal carcinoma with a combination of OLGCs and clear cell features.

Conclusions

To our knowledge, this combination of findings has not been previously described in the literature and therefore represents another morphologic manifestation of breast carcinoma. As patients are diagnosed earlier and live longer, a growing number of these rare variants may be recognized and provide opportunities to further our understanding of the associated molecular pathways which could contribute to the possibility of therapeutic intervention.
Literature
1.
Cameron JL. Current surgical therapy. 9th ed. 2012.
2.
Seo P, Stone JH. The antineutrophil cytoplasmic antibody-associated vasculitides. Am J Med. 2004;117(1):39–50.CrossRefPubMed
3.
Howlader N, N.A., Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA. SEER Cancer Statistics Review 1975-2012. Bethesda: National Cancer Institute; 2015.
4.
DeSantis CE, et al. Cancer treatment and survivorship statistics, 2014. CA Cancer J Clin. 2014;64(4):252–71.CrossRefPubMed
5.
Carter CL, Allen C, Henson DE. Relation of tumor size, lymph node status, and survival in 24,740 breast cancer cases. Cancer. 1989;63(1):181–7.CrossRefPubMed
6.
van’t Veer LJ, et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature. 2002;415(6871):530–6.CrossRef
7.
Elston CW, Ellis IO. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology. 1991;19(5):403–10.CrossRefPubMed
8.
Society A.C. Breast cancer facts and figures 2013-2014. Atlanta: American Cancer Society Inc.; 2013.
9.
10.
Tavassoli FA, Devilee P. Pathology and genetics of tumours of the breast and female genital organs. Lyon: IAPS Press; 2003. Print.
11.
Athanasou NA, et al. The origin and nature of stromal osteoclast-like multinucleated giant cells in breast carcinoma: implications for tumour osteolysis and macrophage biology. Br J Cancer. 1989;59(4):491–8.CrossRefPubMedPubMedCentral
12.
Akatsu T, et al. Gallbladder carcinoma with osteoclast-like giant cells. J Gastroenterol. 2006;41(1):83–7.CrossRefPubMed
13.
Wada Y, et al. Adenocarcinoma of the liver with osteoclast-like giant cells. Pathol Int. 2013;63(9):476–8.CrossRef
14.
Lee JS, et al. Fine needle aspiration cytology of anaplastic carcinoma with osteoclastlike giant cells of the thyroid. A case report. Acta Cytol. 1996;40(6):1309–12.CrossRefPubMed
15.
Agnantis NT, Rosen PP. Mammary carcinoma with osteoclast-like giant cells. A study of eight cases with follow-up data. Am J Clin Pathol. 1979;72(3):383–9.CrossRefPubMed
16.
Gjerdrum LM, Lauridsen MC, Sorensen FB. Breast carcinoma with osteoclast-like giant cells: morphological and ultrastructural studies of a case with review of the literature. Breast. 2001;10(3):231–6.CrossRefPubMed
17.
Niu Y, et al. Breast carcinoma with osteoclastic giant cells: case report and review of the literature. Int J Clin Exp Pathol. 2014;7(4):1788–91.PubMedPubMedCentral
18.
Hull MT, et al. Glycogen-rich clear cell carcinoma of the breast: a light and electron microscopic study. Cancer. 1981;48(9):2003–9.CrossRefPubMed
19.
Sullivan JJ, Magee HR, Donald KJ. Secretory (juvenile) carcinoma of the breast. Pathology. 1977;9(4):341–6.CrossRefPubMed
20.
Roth LM. Clear-cell adenocarcinoma of the female genital tract. A light and electron microscopic study. Cancer. 1974;33(4):990–1001.CrossRefPubMed
21.
Silverberg SG. Ultrastructure and histogenesis of clear cell carcinoma of the ovary. Am J Obstet Gynecol. 1973;115(3):394–400.CrossRefPubMed
22.
Herbst AL, Scully RE. Adenocarcinoma of the vagina in adolescence. A report of 7 cases including 6 clear-cell carcinomas (so-called mesonephromas). Cancer. 1970;25(4):745–57.CrossRefPubMed
23.
24.
25.
Ovanez C, Crawford J, Asarian A, Xiao P. Invasive ductal carcinoma of the breast with clear cell and pseudo-lactating changes. J Surg Case Rep. 2014;2014(7):rju063.
26.
Kim EK, et al. Clinical application of the BI-RADS final assessment to breast sonography in conjunction with mammography. AJR Am J Roentgenol. 2008;190(5):1209–15.CrossRefPubMed
27.
Holland R, van Haelst UJ. Mammary carcinoma with osteoclast-like giant cells. Additional observations on six cases. Cancer. 1984;53(9):1963–73.CrossRefPubMed
28.
Cai G, Simsir A, Cangiarella J. Invasive mammary carcinoma with osteoclast-like giant cells diagnosed by fine-needle aspiration biopsy: review of the cytologic literature and distinction from other mammary lesions containing giant cells. Diagn Cytopathol. 2004;30(6):396–400.CrossRefPubMed
29.
Shishido-Hara Y, et al. Two cases of breast carcinoma with osteoclastic giant cells: are the osteoclastic giant cells pro-tumoural differentiation of macrophages? Diagn Pathol. 2010;5:55.CrossRefPubMedPubMedCentral
30.
31.
Toikkanen S, Joensuu H. Glycogen-rich clear-cell carcinoma of the breast: a clinicopathologic and flow cytometric study. Hum Pathol. 1991;22(1):81–3.CrossRefPubMed
32.
Howlader N, Noone AM, Krapcho M, Miller D, Bishop K, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2013, National Cancer Institute. Bethesda, MD, http://​seer.​cancer.​gov/​csr/​1975_​2013/​, based on November 2015 SEER data submission, posted to the SEER web site, April 2016.
33.
Hayes MM, Seidman JD, Ashton MA. Glycogen-rich clear cell carcinoma of the breast. A clinicopathologic study of 21 cases. Am J Surg Pathol. 1995;19(8):904–11.CrossRefPubMed
34.
Sorensen FB, Paulsen SM. Glycogen-rich clear cell carcinoma of the breast: a solid variant with mucus. A light microscopic, immunohistochemical and ultrastructural study of a case. Histopathology. 1987;11(8):857–69.CrossRef
35.
Shirley SE, et al. Clear cell carcinoma of the breast with immunohistochemical evidence of divergent differentiation. Ann Diagn Pathol. 2002;6(4):250–6.CrossRefPubMed
36.
Kuroda H, et al. Clinical and pathological features of glycogen-rich clear cell carcinoma of the breast. Breast Cancer. 2005;12(3):189–95.CrossRefPubMed
37.
Vahedi MH, A.-Y.R., Zabar KK. Primary signet ring cell carcinoma of the breast: a rare pathologic entity. Bahrain Med Bull. 2011;33(1):1–5.
38.
Shi P, et al. Lipid-rich carcinoma of the breast. A clinicopathological study of 49 cases. Tumori. 2008;94(3):342–6.PubMed
39.
Aboumrad MH, Horn Jr RC, Fine G. Lipid-secreting mammary carcinoma. Report of a case associated with Paget’s disease of the nipple. Cancer. 1963;16:521–5.CrossRefPubMed
Metadata
Title
Invasive ductal carcinoma of the breast with osteoclast-like giant cells and clear cell features: a case report of a novel finding and review of the literature
Authors
Nicole K. Zagelbaum
Michael F. Ward II
Nader Okby
Howard Karpoff
Publication date
01-12-2016
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2016
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/s12957-016-0982-6

Other articles of this Issue 1/2016

World Journal of Surgical Oncology 1/2016 Go to the issue

Research

Knockdown of ribosomal protein S15A induces human glioblastoma cell apoptosis

Research

The combination therapy of high-intensity focused ultrasound with radiotherapy in locally advanced pancreatic carcinoma

Research

Prognostic significance of K-ras mutations in pancreatic cancer: a meta-analysis

Research

The expression of microRNA 574-3p as a predictor of postoperative outcome in patients with esophageal squamous cell carcinoma

Case report

Surgically treated solitary giant gluteal and retroperitoneal neurofibroma: a case report

Research

Hepatic resection provided long-term survival for patients with intermediate and advanced-stage resectable hepatocellular carcinoma