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Cardiovascular Diabetology
Published in: Cardiovascular Diabetology 1/2023

Open Access 01-12-2023 | Dapagliflozin | Review

Insights into SGLT2 inhibitor treatment of diabetic cardiomyopathy: focus on the mechanisms

Authors: Keming Huang, Xianling Luo, Bin Liao, Guang Li, Jian Feng

Published in: Cardiovascular Diabetology | Issue 1/2023

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Abstract

Among the complications of diabetes, cardiovascular events and cardiac insufficiency are considered two of the most important causes of death. Experimental and clinical evidence supports the effectiveness of SGLT2i for improving cardiac dysfunction. SGLT2i treatment benefits metabolism, microcirculation, mitochondrial function, fibrosis, oxidative stress, endoplasmic reticulum stress, programmed cell death, autophagy, and the intestinal flora, which are involved in diabetic cardiomyopathy. This review summarizes the current knowledge of the mechanisms of SGLT2i for the treatment of diabetic cardiomyopathy.

Graphical Abstract

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Metadata
Title
Insights into SGLT2 inhibitor treatment of diabetic cardiomyopathy: focus on the mechanisms
Authors
Keming Huang
Xianling Luo
Bin Liao
Guang Li
Jian Feng
Publication date
01-12-2023
Publisher
BioMed Central
Published in
Cardiovascular Diabetology / Issue 1/2023
Electronic ISSN: 1475-2840
DOI
https://doi.org/10.1186/s12933-023-01816-5

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