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Diabetic Cardiomyopathy 

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  1. Open Access 01-12-2024 | Diabetic Cardiomyopathy | OriginalPaper

    CAV3 alleviates diabetic cardiomyopathy via inhibiting NDUFA10-mediated mitochondrial dysfunction

    Diabetes mellitus is on the rise globally, with projections indicating that it will impact 10.9% of the world’s population by 2045 [ 1 ]. Diabetes mellitus significantly increases the risk of cardiovascular disease [ 2 , 3 ]. Diabetic

  2. Open Access 01-12-2024 | Diabetic Cardiomyopathy | OriginalPaper

    Growth differentiation factor 11 regulates high glucose-induced cardiomyocyte pyroptosis and diabetic cardiomyopathy by inhibiting inflammasome activation

    Diabetic cardiomyopathy (DCM) describes a series of cardiac structural and functional abnormalities caused by diabetes [ 1 ] that is independent of diabetic macrovascular complications and can lead to the development of heart failure [ 2 ]. DCM is …

  3. 22-04-2024 | Semaglutide | Online First

    Semaglutide attenuates pathological electrophysiological remodeling in diabetic cardiomyopathy via restoring Cx43 expression

    The prevalence of diabetes mellitus (DM) keeps increasing globally, with approximately 10% of the world’s population (537 million people) living with diabetes as estimated by the International Diabetes Federation in 2019, and it is predicted that …

  4. Open Access 01-12-2024 | Diabetic Cardiomyopathy | OriginalPaper

    Single-cell insights: pioneering an integrated atlas of chromatin accessibility and transcriptomic landscapes in diabetic cardiomyopathy

    Diabetic cardiomyopathy (DCM) stands as a critical health concern with increasing global prevalence [ 1 ]. Despite lacking overt cardiovascular issues, individuals with diabetes face a heightened risk of developing heart failure due to DCM. In …

  5. Open Access 01-12-2024 | Diabetic Cardiomyopathy | OriginalPaper

    Irisin attenuates type 1 diabetic cardiomyopathy by anti-ferroptosis via SIRT1-mediated deacetylation of p53

    Diabetes is a non-communicable chronic metabolic disease that threatens global health, with type 1 diabetesmellitus (T1DM) accounting for approximately 2% of all diabetes cases [ 1 , 2 ]. Diabetic cardiomyopathy (DCM) is a serious complication of …

  6. Open Access 01-12-2024 | Diabetic Cardiomyopathy | OriginalPaper

    Characterizing diabetic cardiomyopathy: baseline results from the ARISE-HF trial

    First described in postmortem studies by Rubler et al. in 1972 [ 1 ], diabetic cardiomyopathy (DbCM) is an increasingly recognized but insufficiently studied complication of diabetes leading to heart muscle disease [ 2 – 4 ]. At its early stages …

  7. 06-02-2024 | Diabetic Cardiomyopathy | ReviewPaper

    Diabetic Cardiomyopathy and Cell Death: Focus on Metal-Mediated Cell Death

    Cardiac myocyte death is an essential initiator of the pathogenesis and progression of various etiological cardiomyopathies, including diabetic cardiomyopathy (DCM), a disease that has been reported since 1972. Cardiac cell death has been detected …

  8. Open Access 01-12-2024 | Diabetic Cardiomyopathy | OriginalPaper

    Melatonin attenuates diabetic cardiomyopathy by increasing autophagy of cardiomyocytes via regulation of VEGF-B/GRP78/PERK signaling pathway

    Diabetic cardiomyopathy (DCM), characterized by abnormal myocardial structure and function, is one of the major complications of diabetes mellitus (DM) that can result in heart failure [ 1 ]. Multiple factors, such as cardiac insulin resistance …

  9. 23-12-2023 | Diabetic Cardiomyopathy | Online First

    MOTS-c Peptide Attenuated Diabetic Cardiomyopathy in STZ-Induced Type 1 Diabetic Mouse Model

    Diabetic cardiomyopathy (DCM) leads to pathological cardiac remodeling and eventual heart failure independent of other cardiac diseases [ 1 ]. With the rising prevalence of diabetes, DCM poses an increasing threat to public health. While mechanisms …

  10. 09-08-2023 | Diabetic Cardiomyopathy | ReviewPaper

    What is the impact of ferroptosis on diabetic cardiomyopathy: a systematic review

    Iron overload increases the production of harmful reactive oxygen species in the Fenton reaction, which causes oxidative stress in the body and lipid peroxidation in the cell membrane, and eventually leads to ferroptosis. Diabetes is associated …

  11. 20-12-2023 | Diabetic Cardiomyopathy | Online First

    Interplay Between TGF-β Signaling and MicroRNA in Diabetic Cardiomyopathy

    In diabetic patients, concomitant cardiovascular disease is the main factor contributing to their morbidity and mortality. Diabetic cardiomyopathy (DCM) is a form of cardiovascular disease associated with diabetes that can result in heart failure.

  12. Open Access 01-12-2023 | Diabetic Cardiomyopathy | ReviewPaper

    Potential clinical biomarkers and perspectives in diabetic cardiomyopathy

    Diabetic cardiomyopathy (DCM) is a serious cardiovascular complication and the leading cause of death in diabetic patients. Patients typically do not experience any symptoms and have normal systolic and diastolic cardiac functions in the early …

  13. Open Access 01-12-2023 | Diabetic Cardiomyopathy | OriginalPaper

    Salvianolic acid B ameliorates myocardial fibrosis in diabetic cardiomyopathy by deubiquitinating Smad7

    Since the 1950s, the incidence of diabetes mellitus (DM) has increased dramatically worldwide and has become a major public health concern. In China, there were 140.9 million diabetes patients in 2021, which means one in five people to be diabetic

  14. Open Access 01-12-2023 | Cardiomyopathy | OriginalPaper

    Acid sphingomyelinase promotes diabetic cardiomyopathy via NADPH oxidase 4 mediated apoptosis

    The patients with obesity and metabolic syndrome are more likely to exhibit signs of cardiac dysfunction. It has long been recognized that diabetic heart as clinical challenge is associated with increased incidence and risk of heart failure. The …

  15. Open Access 01-12-2023 | Diabetic Cardiomyopathy | ReviewPaper

    The interplay of inflammation, exosomes and Ca2+ dynamics in diabetic cardiomyopathy

    Diabetes mellitus is one of the prime risk factors for cardiovascular complications and is linked with high morbidity and mortality. Diabetic cardiomyopathy (DCM) often manifests as reduced cardiac contractility, myocardial fibrosis, diastolic …

  16. Open Access 01-12-2023 | Diabetic Cardiomyopathy | OriginalPaper

    Adipsin alleviates cardiac microvascular injury in diabetic cardiomyopathy through Csk-dependent signaling mechanism

    Diabetes mellitus is a non-communicable chronic disease worldwide, which is estimated that 8.8% of adult populations were afflicted in 2015. In 2040, this population is estimated to substantially hike to 10.4%, translating to 642 million diabetic

  17. Open Access 01-12-2023 | Dapagliflozin | ReviewPaper

    Insights into SGLT2 inhibitor treatment of diabetic cardiomyopathy: focus on the mechanisms

    Among the complications of diabetes, cardiovascular events and cardiac insufficiency are considered two of the most important causes of death. Experimental and clinical evidence supports the effectiveness of SGLT2i for improving cardiac …

  18. Open Access 01-12-2023 | Diabetic Cardiomyopathy | OriginalPaper

    Dual roles of myocardial mitochondrial AKT on diabetic cardiomyopathy and whole body metabolism

    While mitochondria are known to play a crucial role in myocardial function, there is still much that is not fully understood about the mechanisms involved. Cardiac muscle has high energy demands that must be met by the metabolism of fatty acids …

  19. Open Access 01-12-2023 | Diabetic Cardiomyopathy | OriginalPaper

    Dysregulation of hypoxia-inducible factor 1α in the sympathetic nervous system accelerates diabetic cardiomyopathy

    Heart function is tightly controlled by the autonomic nervous system, which is comprised of parasympathetic and sympathetic neurons. The cardiac sympathetic nervous system uses the catecholamine norepinephrine as a neurotransmitter, and modulates …

  20. Open Access 01-12-2023 | Diabetic Cardiomyopathy | OriginalPaper

    Dexmedetomidine ameliorates diabetic cardiomyopathy by inhibiting ferroptosis through the Nrf2/GPX4 pathway

    The surging prevalence of diabetes mellitus and heart failure represents a significant public health burden worldwide, and both conditions are independent risk factors for one another [ 1 ]. Diabetic cardiomyopathy (DCM) is a pathophysiological …

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