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Annals of Nuclear Medicine
Published in: Annals of Nuclear Medicine 7/2021

01-07-2021 | Computed Tomography | Original Article

Effect of morphological findings in computed tomography on the quantitative values in single-photon emission computed tomography for patients with antiresorptive agent-related osteonecrosis of the jaw: a cross-sectional study

Authors: Yoshikazu Kobayashi, Taro Okui, Masakazu Tsujimoto, Hirotaka Ikeda, Koji Satoh, Daisuke Kanamori, Naoko Fujii, Hiroshi Toyama, Koichiro Matsuo

Published in: Annals of Nuclear Medicine | Issue 7/2021

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Abstract

Objective

Quantitative analyses of gamma-ray accumulation in single-photon emission computed tomography (SPECT), and the evaluation of antiresorptive agent-related osteonecrosis of the jaw (ARONJ) have been reported recently. However, the relationship between the quantitative parameters calculated from SPECT and the detailed morphological changes observed in computed tomography (CT) remains unclear. This study aimed to investigate patients’ characteristics and morphological changes observed on CT, and their effects on the quantitative values in SPECT.

Methods

From April 2017 to March 2019, patients diagnosed with ARONJ at our hospital were enrolled. The data obtained before September 2017 were reviewed retrospectively, and other data were collected prospectively. CT scans were evaluated for internal texture, sequestrum formation, periosteal reaction, cortical perforation, bone expansion, and pathological fracture. For quantitative assessment, the ratio of the maximum standardized uptake value (SUV) to the mean SUV in the temporal bone (rSUVmax) was calculated from SPECT images. The factors affecting rSUVmax were investigated by multiple regression analysis. The statistical significance level was set at α = 0.05.

Results

Overall, 55 lesions of 42 patients (median age and interquartile range, 75 [67–80 years], 27 female) were evaluated. Male sex (p = 0.007) and bilateral location (p < 0.0001) were selected as variables in the multivariate analysis. Adjusted coefficient of determination R2 was 0.59 (p < 0.0001).

Conclusion

Sex and horizontal progression of the disease may affect individually calibrated SUVs in SPECT for patients with ARONJ.
Literature
1.
Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg. 2003;61:1115–7.CrossRef
2.
Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B, et al. American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw–2014 update. J Oral Maxillofac Surg. 2014;72:1938–56.CrossRef
3.
Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O’Ryan F, et al. Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus. J Bone Miner Res. 2015;30:3–23.CrossRef
4.
Japanese Allied Committee on Oseteonecrosis of the Jaw, Yoneda T, Yoneda T, Hagino H, Sugimoto T, Ohta H, Takahashi S, et al. Antiresorptive agent-related osteonecrosis of the jaw: Position Paper 2017 of the Japanese Allied Committee on Osteonecrosis of the Jaw. J Bone Miner Metab. 2017;35:6–19.CrossRef
5.
Carlson ER. Management of antiresorptive osteonecrosis of the jaws with primary surgical resection. J Oral Maxillofac Surg. 2014;72(4):655–7.CrossRef
6.
Schwartz HC, O’Ryan FS. Re: management of antiresorptive osteonecrosis of the jaws with primary surgical resection. J Oral Maxillofac Surg. 2014;72:1641.CrossRef
7.
Reich W, Bilkenroth U, Schubert J, Wickenhauser C, Eckert AW. Surgical treatment of bisphosphonate-associated osteonecrosis: prognostic score and long-term results. J Craniomaxillofac Surg. 2015;43:1809–22.CrossRef
8.
Dore F, Filippi L, Biasotto M, Chiandussi S, Cavalli F, Di Lenarda R. Bone scintigraphy and SPECT/CT of bisphosphonate-induced osteonecrosis of the jaw. J Nucl Med. 2009;50:30–5.CrossRef
9.
Rustemeyer J, Melenberg A, Junker K, Sari-Rieger A. Osteonecrosis of the maxilla related to long-standing methamphetamine abuse: a possible new aspect in the etiology of osteonecrosis of the jaw. Oral Maxillofac Surg. 2014;18:237–41.CrossRef
10.
Assaf AT, Zrnc TA, Remus CC, Adam G, Zustin J, Heiland M, et al. Intraindividual comparison of preoperative (99m)Tc-MDP SPECT/CT and intraoperative and histopathological findings in patients with bisphosphonate- or denosumab-related osteonecrosis of the jaw. J Craniomaxillofac Surg. 2015;43:1461–9.CrossRef
11.
Miyashita H, Shiba H, Kawana H, Nakahara T. Clinical utility of three-dimensional SPECT/CT imaging as a guide for the resection of medication-related osteonecrosis of the jaw. Int J Oral Maxillofac Surg. 2015;44:1106–9.CrossRef
12.
Miyashita H, Kameyama K, Morita M, Nakagawa T, Nakahara T. Three-dimensional radiologic-pathologic correlation of medication-related osteonecrosis of the jaw using 3D bone SPECT/CT imaging. Dento Maxillo Fac Radiol. 2019;48:20190208.CrossRef
13.
Ogura I, Sasaki Y, Sue M, Oda T, Kameta A, Hayama K. Tc-99m hydroxymethylene diphosphonate SPECT/CT for the evaluation of osteonecrosis of the jaw: preliminary study on diagnostic ability of maximum standardised uptake value. Clin Radiol. 2020;75:46–50.CrossRef
14.
Ogura I, Kobayashi E, Nakahara K, Igarashi K, Haga-Tsujimura M, Toshima H. Quantitative SPECT/CT imaging for medication-related osteonecrosis of the jaw: a preliminary study using volume-based parameters, comparison with chronic osteomyelitis. Ann Nucl Med. 2019;33:776–82.CrossRef
15.
Okui T, Kobayashi Y, Tsujimoto M, Satoh K, Toyama H, Matsuo K. Quantitative evaluation of anti-resorptive agent-related osteonecrosis of the jaw using bone single photon emission computed tomography in clinical settings: relationship between clinical stage and imaging. Ann Nucl Med. 2020;34:620–8.CrossRef
16.
Yamamoto Y, Mitsunaga S, Horikawa A, Hino A, Kurihara H. Quantitative bone scan imaging using BSI and BUV: an approach to evaluate ARONJ early. Ann Nucl Med. 2020;34:74–9.CrossRef
17.
Guggenberger R, Fischer DR, Metzler P, Andreisek G, Nanz D, Jacobsen C, et al. Bisphosphonate-induced osteonecrosis of the jaw: comparison of disease extent on contrast-enhanced MR imaging, [18F] fluoride PET/CT, and conebeam CT imaging. AJNR Am J Neuroradiol. 2013;34:1242–7.CrossRef
18.
Huber FA, Schumann P, von Spiczak J, Wurnig MC, Klarhöfer M, Finkenstaedt T, et al. Medication-related osteonecrosis of the jaw-Comparison of bone imaging using ultrashort echo-time magnetic resonance imaging and cone-beam computed tomography. Invest Radiol. 2020;55:160–7.CrossRef
19.
Taniguchi T, Ariji Y, Nozawa M, Naitoh M, Kuroiwa Y, Kurita K, et al. Computed tomographic assessment of early changes of the mandible in bisphosphonate-treated patients. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122:362–72.CrossRef
20.
Baba A, Goto TK, Ojiri H, Takagiwa M, Hiraga C, Okamura M, et al. CT imaging features of antiresorptive agent-related osteonecrosis of the jaw/medication-related osteonecrosis of the jaw. Dento Maxillo Fac Radiol. 2018;47:20170323.CrossRef
21.
Kakinuma R, Moriyama N, Muramatsu Y, Gomi S, Suzuki M, Nagasawa H, et al. Ultra-high-resolution computed tomography of the lung: image quality of a prototype scanner. PLoS ONE. 2015;10:0137165.
22.
Yoshioka K, Tanaka R, Takagi H, Ueyama Y, Kikuchi K, Chiba T, et al. Ultra-high-resolution CT angiography of the artery of Adamkiewicz: a feasibility study. Neuroradiology. 2018;60:109–15.CrossRef
23.
Murayama K, Suzuki S, Nagata H, Oda J, Nakahara I, Katada K, et al. Visualization of lenticulostriate arteries on CT angiography using ultra-high-resolution CT compared with conventional-detector CT. AJNR Am J Neuroradiol. 2020;41:219–23.CrossRef
24.
Inai R, Nakahara R, Morimitsu Y, Akagi N, Marukawa Y, Matsushita T, et al. Bone microarchitectural analysis using ultra-high-resolution CT in tiger vertebra and human tibia. Eur Radiol Exp. 2020;4:4.CrossRef
25.
Umeda T, Koizumi M, Fukai S, Miyaji N, Motegi K, Nakazawa S, et al. Evaluation of bone metastatic burden by bone SPECT/CT in metastatic prostate cancer patients: defining threshold value for total bone uptake and assessment in radium-223 treated patients. Ann Nucl Med. 2018;32:105–13.CrossRef
26.
Tsujimoto M, Shirakawa S, Teramoto A, Ishiguro M, Nakane K, Ida Y, et al. Fluctuation of quantitative values on acquisition time and the reconstruction conditions in 99mTc-SPECT. Nucl Med Commun. 2018;39:601–9.CrossRef
27.
Fabbricini R, Catalano L, Pace L, et al. Bone scintigraphy and SPECT/CT in bisphosphonate-induced osteonecrosis of the jaw. J Nucl Med. 2009;50:1385 (Author reply:1385).CrossRef
28.
Watanabe S, Nakajima K, Mizokami A, Yaegashi H, Noguchi N, Kawashiri S, et al. Bone scan index of the jaw: a new approach for evaluating early-stage anti-resorptive agents-related osteonecrosis. Ann Nucl Med. 2017;31:201–10.CrossRef
Metadata
Title
Effect of morphological findings in computed tomography on the quantitative values in single-photon emission computed tomography for patients with antiresorptive agent-related osteonecrosis of the jaw: a cross-sectional study
Authors
Yoshikazu Kobayashi
Taro Okui
Masakazu Tsujimoto
Hirotaka Ikeda
Koji Satoh
Daisuke Kanamori
Naoko Fujii
Hiroshi Toyama
Koichiro Matsuo
Publication date
01-07-2021
Publisher
Springer Singapore
Published in
Annals of Nuclear Medicine / Issue 7/2021
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-021-01624-5

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