Issue 6/2021
Content (13 Articles)
Single- and multiple-dose pharmacokinetics, potential for CYP3A inhibition, and food effect in patients with cancer and healthy subjects receiving ipatasertib
Vikram Malhi, Nageshwar Budha, Rucha Sane, Jian Huang, Bianca Liederer, Raymond Meng, Premal Patel, Yuzhong Deng, Andres Cervantes, Josep Tabernero, Luna Musib
The use of vitamin E in preventing taxane-induced peripheral neuropathy
Muhammad Ali Heiba, Soheir Sayed Ismail, Mohamed Sabry, Walid Abd Elmoniem Bayoumy, Khaled Abdel-Aziz Kamal
Impact of fedratinib on the pharmacokinetics of transporter probe substrates using a cocktail approach
Ken Ogasawara, Rebecca N. Wood-Horrall, Mark Thomas, Michael Thomas, Liangang Liu, Mary Liu, Yongjun Xue, Sekhar Surapaneni, Leonidas N. Carayannopoulos, Simon Zhou, Maria Palmisano, Gopal Krishna
Zileuton inhibits arachidonate-5-lipoxygenase to exert antitumor effects in preclinical cervical cancer models
Liling Li, Yifang Xiao, Zhengzheng Xu, Shaoshuai Wang
Human placental extract ameliorates methotrexate-induced hepatotoxicity in rats via regulating antioxidative and anti-inflammatory responses
Mamdooh Ghoneum, Mohamed S. A. El-Gerbed
Ruxolitinib exposure in patients with acute and chronic graft versus host disease in routine clinical practice—a prospective single-center trial
Nora Isberner, Sabrina Kraus, Götz Ulrich Grigoleit, Fatemeh Aghai, Max Kurlbaum, Sebastian Zimmermann, Hartwig Klinker, Oliver Scherf-Clavel
Megestrol acetate is a specific inducer of CYP3A4 mediated by human pregnane X receptor
Yakun Chen, Yong Tang, Jeffrey Z. Nie, Yuanqin Zhang, Daotai Nie
Population pharmacokinetic analysis of entrectinib in pediatric and adult patients with advanced/metastatic solid tumors: support of new drug application submission
Mario González-Sales, Nassim Djebli, Georgina Meneses-Lorente, Vincent Buchheit, Guillaume Bonnefois, Pierre-Olivier Tremblay, Nicolas Frey, François Mercier
Population pharmacokinetic analysis of crizotinib in children with progressive/recurrent high-grade and diffuse intrinsic pontine gliomas
Elizabeth G. Gibson, Olivia Campagne, Nicholas S. Selvo, Amar Gajjar, Clinton F. Stewart
EVs delivery of miR-1915-3p improves the chemotherapeutic efficacy of oxaliplatin in colorectal cancer
Zhenhuan Xiao, Yun Liu, Qun Li, Qinyuan Liu, Yong Liu, Yan Luo, Songzhi Wei
Phase I/II study to assess the clinical pharmacology and safety of single ascending and multiple subcutaneous doses of PF-06881894 in women with non-distantly metastatic breast cancer
Hsuan-Ming Yao, Sarah Ruta Jones, Serafin Morales, Shahrzad Moosavi, Jeffrey Zhang, Amy Freyman, Faith D. Ottery
Pretherapeutic screening for Dihydropyrimidine deshydrogenase deficiency in measuring uracilemia in dialysis patients leads to a high rate of falsely positive results
Clotilde Gaible, Céline Narjoz, Marie-Anne Loriot, Stéphane Roueff, Nicolas Pallet
Correction to: Aurora B kinase as a therapeutic target in acute lymphoblastic leukemia
Hiroaki Goto, Yuki Yoshino, Mieko Ito, Junichi Nagai, Tadashi Kumamoto, Takesi Inukai, Yukari Sakurai, Naoyuki Miyagawa, Dai Keino, Tomoko Yokosuka, Fuminori Iwasaki, Satoshi Hamanoue, Masae Shiomi, Shoko Goto