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Breast Cancer Research and Treatment

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28-04-2022 | Breast Cancer | Epidemiology

Hypertensive diseases of pregnancy and risk of breast cancer in the Black Women’s Health Study

Authors: Zahna Bigham, Yvonne Robles, Karen M. Freund, Julie R. Palmer, Kimberly A. Bertrand

Published in: Breast Cancer Research and Treatment | Issue 1/2022

Abstract

Purpose

Compared to white women, Black women have increased risk of developing hypertensive diseases of pregnancy (HDOP) and have a higher incidence of aggressive breast cancer subtypes. Few studies of HDOP and breast cancer risk have included large numbers of Black women. This study examined the relation of HDOP to incidence of breast cancer overall and by estrogen receptor (ER) status in Black women.

Methods

We followed 42,982 parous women in the Black Women’s Health Study, a nationwide prospective study of Black women. Multivariable Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) to assess associations of self-reported HDOP, including preeclampsia and gestational hypertension, with breast cancer incidence overall and by ER subtype, adjusted for age and established breast cancer risk factors.

Results

Over 20 years of follow-up, we identified 2376 incident breast cancer cases. History of HDOP (11.7%) was not associated with breast cancer risk overall (HR 0.98; 95% CI 0.87, 1.11). HRs for invasive ER+ and ER– breast cancer were 1.11 (95% CI 0.93, 1.34) and 0.81 (95% CI 0.61, 1.07), respectively.

Conclusions

HDOP was not associated with risk of overall breast cancer in Black women. A suggestive inverse association with ER– breast cancer may reflect an anti-tumorigenic hormone profile in HDOP, but those results require confirmation in other studies.

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Title: Hypertensive diseases of pregnancy and risk of breast cancer in the Black Women’s Health Study
Authors: Zahna Bigham
Yvonne Robles
Karen M. Freund
Julie R. Palmer
Kimberly A. Bertrand
Publication date: 28-04-2022
Publisher: Springer US
Keywords: Breast Cancer
Breast Cancer
Hypertension
Pre-Eclampsia
Hypertension
Published in: Breast Cancer Research and Treatment / Issue 1/2022
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-022-06606-3

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