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European Journal of Medical Research
Published in: European Journal of Medical Research 1/2023

Open Access 01-12-2023 | Biomarkers | Review

Current knowledge on the role of extracellular vesicles in endometrial receptivity

Authors: Cong Sui, Zhiqi Liao, Jian Bai, Dan Hu, Jing Yue, Shulin Yang

Published in: European Journal of Medical Research | Issue 1/2023

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Abstract

Endometrial receptivity has been widely understood as the capacity of the endometrium to receive implantable embryos. The establishment of endometrial receptivity involves multiple biological processes including decidualization, tissue remodeling, angiogenesis, immune regulation, and oxidative metabolism. Extracellular vesicles (EVs) are lipid-bilayer-membrane nanosized vesicles mediating cell-to-cell communication. Recently, EVs and their cargo have been proven as functional factors in the establishment of endometrial receptivity. In this review, we comprehensively summarized the alteration of endometrium/embryo-derived EVs during the receptive phase and retrospected the current findings which revealed the pivotal role and potential mechanism of EVs to promote successful implantation. Furthermore, we highlight the potentiality and limitations of EVs being translated into clinical applications such as biomarkers of endometrial receptivity or reproductive therapeutic mediators, and point out the direction for further research.
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Metadata
Title
Current knowledge on the role of extracellular vesicles in endometrial receptivity
Authors
Cong Sui
Zhiqi Liao
Jian Bai
Dan Hu
Jing Yue
Shulin Yang
Publication date
01-12-2023
Publisher
BioMed Central
Published in
European Journal of Medical Research / Issue 1/2023
Electronic ISSN: 2047-783X
DOI
https://doi.org/10.1186/s40001-023-01459-y

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