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01-06-2019 | Antiviral Agents | Letter

Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Reply to Skog O, Klingel K, Roivainen M et al [letter]

Authors: Jessica L. Dunne, Sarah J. Richardson, Mark A. Atkinson, Maria E. Craig, Knut Dahl-Jørgensen, Malin Flodström-Tullberg, Heikki Hyöty, Richard E. Lloyd, Noel G. Morgan, Alberto Pugliese

Published in: Diabetologia | Issue 6/2019

Excerpt

To the Editor: We are pleased that Skog et al [1] have accepted the challenge to respond to our recent ‘For Debate’ article [2]. In this, we proposed that both vaccination and trials with antiviral therapies are warranted, based on decades of studies implicating an association between enterovirus infections and type 1 diabetes. It is pleasing to observe these conclusions were similarly supported by Skog et al [1]. …

Skog O, Klingel K, Roivainen M, Korsgren O (2019) Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Diabetologia. https://doi.org/10.1007/s00125-019-4841-1

Dunne JL, Richardson SJ, Atkinson MA et al (2019) Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes. Diabetologia 62(5):744–753. https://doi.org/10.1007/s00125-019-4811-7 CrossRefPubMedPubMedCentral

Campbell-Thompson M, Fu A, Kaddis JS et al (2016) Insulitis and beta-cell mass in the natural history of type 1 diabetes. Diabetes 65(3):719–731. https://doi.org/10.2337/db15-0779 CrossRefPubMed

Wasserfall C, Nick HS, Campbell-Thompson M et al (2017) Persistence of pancreatic insulin mRNA expression and proinsulin protein in type 1 diabetes pancreata. Cell Metab 26(3):568–575. https://doi.org/10.1016/j.cmet.2017.08.013 CrossRefPubMedPubMedCentral

Oram RA, Jones AG, Besser RE et al (2014) The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells. Diabetologia 57(1):187–191. https://doi.org/10.1007/s00125-013-3067-x CrossRefPubMed

Sun J, Cui J, He Q, Chen Z, Arvan P, Liu M (2015) Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes. Mol Asp Med 42:105–118. https://doi.org/10.1016/j.mam.2015.01.001 CrossRef

Brozzi F, Eizirik DL (2016) ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes. Ups J Med Sci 121(2):133–139. https://doi.org/10.3109/03009734.2015.1135217 CrossRefPubMedPubMedCentral

Gallagher GR, Brehm MA, Finberg RW et al (2015) Viral infection of engrafted human islets leads to diabetes. Diabetes 64(4):1358–1369. https://doi.org/10.2337/db14-1020 CrossRefPubMed

Petzold A, Solimena M, Knoch KP (2015) Mechanisms of beta cell dysfunction associated with viral infection. Curr Diab Rep 15(10):73. https://doi.org/10.1007/s11892-015-0654-x CrossRefPubMedPubMedCentral

10.

Richardson SJ, Leete P, Bone AJ, Foulis AK, Morgan NG (2013) Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1. Diabetologia 56(1):185–193. https://doi.org/10.1007/s00125-012-2745-4 CrossRefPubMed

11.

Allen DW, Kim KW, Rawlinson WD, Craig ME (2018) Maternal virus infections in pregnancy and type 1 diabetes in their offspring: Systematic review and meta-analysis of observational studies. Rev Med Virol 28(3):e1974. https://doi.org/10.1002/rmv.1974 CrossRefPubMed

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Yeung WC, Rawlinson WD, Craig ME (2011) Enterovirus infection and type 1 diabetes mellitus: systematic review and meta-analysis of observational molecular studies. BMJ 342:d35. https://doi.org/10.1136/bmj.d35 CrossRefPubMedPubMedCentral

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Dotta F, Censini S, van Halteren AG et al (2007) Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients. ProcNatlAcadSciUSA 104(12):5115–5120. https://doi.org/10.1073/pnas.0700442104 CrossRef

14.

Morgan NG, Richardson SJ (2014) Enteroviruses as causative agents in type 1 diabetes: loose ends or lost cause? Trends Endocrinol Metab 25(12):611–619. https://doi.org/10.1016/j.tem.2014.08.002 CrossRefPubMed

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Richardson SJ, Leete P, Dhayal S et al (2014) Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas. Diabetologia 57(2):392–401. https://doi.org/10.1007/s00125-013-3094-7 CrossRefPubMed

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Laiho JE, Oikarinen M, Richardson SJ et al (2016) Relative sensitivity of immunohistochemistry, multiple reaction monitoring mass spectrometry, in situ hybridization and PCR to detect Coxsackievirus B1 in A549 cells. J Clin Virol 77:21–28. https://doi.org/10.1016/j.jcv.2016.01.015 CrossRefPubMedPubMedCentral

17.

Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG (2009) The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes. Diabetologia 52(6):1143–1151. https://doi.org/10.1007/s00125-009-1276-0 CrossRefPubMed

18.

Jonsson A, Yngve E, Karlsson M, Ingvast S, Skog O, Korsgren O (2019) Protein kinase R is constitutively expressed in the human pancreas. J Histochem Cytochem 67(2):99–105. https://doi.org/10.1369/0022155418802838 CrossRefPubMed

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Proventionbio (2017) Provention Bio, Inc. Announces clinical program focus on intercepting and preventing the onset of type 1 diabetes. Available from http://investors.proventionbio.com/2017-07-18-Provention-Bio-Inc-Announces-Clinical-Program-Focused-on-Intercepting-and-Preventing-the-Onset-of-Type-1-Diabetes. Accessed 26 March 2019

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Perrett KP, Jachno K, Nolan TM, Harrison LC (2019) Association of rotavirus vaccination with the incidence of type 1 diabetes in children. JAMA Pediatr 173(3):280–282. https://doi.org/10.1001/jamapediatrics.2018.4578 CrossRefPubMedPubMedCentral

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Honeyman MC, Coulson BS, Stone NL et al (2000) Association between rotavirus infection and pancreatic islet autoimmunity in children at risk of developing type 1 diabetes. Diabetes 49(8):1319–1324. https://doi.org/10.2337/diabetes.49.8.1319 CrossRefPubMed

Title: Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Reply to Skog O, Klingel K, Roivainen M et al [letter]
Authors: Jessica L. Dunne
Sarah J. Richardson
Mark A. Atkinson
Maria E. Craig
Knut Dahl-Jørgensen
Malin Flodström-Tullberg
Heikki Hyöty
Richard E. Lloyd
Noel G. Morgan
Alberto Pugliese
Publication date: 01-06-2019
Publisher: Springer Berlin Heidelberg
Keywords: Antiviral Agents
Vaccination
Type 1 Diabetes
Published in: Diabetologia / Issue 6/2019
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI: https://doi.org/10.1007/s00125-019-4873-6

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