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01-09-2008 | Basic Neurosciences, Genetics and Immunology - Original Article

An association analysis of synapse-associated protein 97 (SAP97) gene in schizophrenia

Authors: Junko Sato, Dai Shimazu, Naoki Yamamoto, Toru Nishikawa

Published in: Journal of Neural Transmission | Issue 9/2008

Abstract

SAP97 gene encodes the synaptic scaffolding PDZ proteins that interact with the l-alpha-amino-3-hydroxyl-5-methylisoxazole-4-propionate (AMPA), kainate and N-methyl-d-aspartate (NMDA) type glutamate receptors. Because the disturbed glutamate neurotransmission has been implicated in the pathophysiology of schizophrenia, we investigated association between the SAP97 gene and schizophrenia. We genotyped 23 SNPs capturing the known common haplotype variations of the gene in a sample comprising 229 schizophrenic patients and 214 matched controls. In a single marker analysis, ten SNPs displayed nominally significant (P < 0.05) association with schizophrenia, although the P values of these SNPs were non-significant after the Bonferroni correction. We also compared haplotype estimates based on case—control genotypes and observed significant association of eight-two- and three- SNP haplotypes with schizophrenia following permutation-based correction. Further examination of the above series of SNPs or haplotypes in each gender revealed significant associations between some of these SNPs or haplotypes and the disorder only in males. The present findings suggest that the SAP97 gene may be a susceptibility factor in male schizophrenics and that the modification of the glutamate receptors-SAP97 signaling pathway could be involved in the disease pathophysiology.

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Title: An association analysis of synapse-associated protein 97 (SAP97) gene in schizophrenia
Authors: Junko Sato
Dai Shimazu
Naoki Yamamoto
Toru Nishikawa
Publication date: 01-09-2008
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 9/2008
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-008-0085-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

An association analysis of synapse-associated protein 97 (SAP97) gene in schizophrenia

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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