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01-09-2008 | Biological Psychiatry - Original Article

Failure to confirm an association between Epsin 4 and schizophrenia in a Japanese population

Authors: Misty Richards, Yoshimi Iijima, Tomoko Shizuno, Yoko Kamegaya, Hiroaki Hori, Mayu Omori, Kunimasa Arima, Osamu Saitoh, Hiroshi Kunugi

Published in: Journal of Neural Transmission | Issue 9/2008

Abstract

Previous studies suggested that genetic variations in the 5′ region of Epsin 4, a gene encoding enthoprotin on chromosome 5q33, are associated with schizophrenia. However, conflicting results have also been reported. We examined the possible association in a Japanese sample of 354 patients and 365 controls. Seventeen polymorphisms of Epsin 4 [3 microsatellites and 14 single nucleotide polymorphisms (SNPs)] were selected. A microsatellite marker (D5S1403) demonstrated a significant difference in the allele frequency between patients and controls (uncorrected P = 0.04). However, there was no significant difference in the genotype or allele frequency between the two groups for the other microsatellites or SNPs. Haplotype-based analysis provided no evidence for an association. The positive result at D5S1403 no longer reached statistical significance when multiple testing was taken into consideration. Our results suggest that the examined region of Epsin 4 does not have a major influence on susceptibility to schizophrenia in Japanese.

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Title: Failure to confirm an association between Epsin 4 and schizophrenia in a Japanese population
Authors: Misty Richards
Yoshimi Iijima
Tomoko Shizuno
Yoko Kamegaya
Hiroaki Hori
Mayu Omori
Kunimasa Arima
Osamu Saitoh
Hiroshi Kunugi
Publication date: 01-09-2008
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 9/2008
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-008-0100-1

At a glance: The STEP trials

Springer Medicine

Failure to confirm an association between Epsin 4 and schizophrenia in a Japanese population

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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