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01-09-2008 | Basic Neurosciences, Genetics and Immunology - Short Communication

LRRK2 Gly2385Arg mutation and clinical features in a Chinese population with early-onset Parkinson’s disease compared to late-onset patients

Authors: Daniel Kam Yin Chan, Ping Wing Ng, Vincent Mok, Jonas Yeung, Zhi Ming Fang, Raymond Clarke, Edward Leung, Lawrence Wong

Published in: Journal of Neural Transmission | Issue 9/2008

Abstract

The frequency of LRRK2 Gly2385Arg mutation in Hong Kong Chinese with early-onset (age ≤45 years) Parkinson’s disease was identified and compared with late-onset patients (age >50 years) and controls. The mutation prevalence were 8.8, 8.3, and 0% for early-onset, late-onset, and controls, respectively. The mean age of onset among LRRK2 G2385R carriers was 42.7 years old for early-onset compared to 74.3 for late-onset patients. LRRK2 G2385R mutation appears to be as prevalent among early-onset as late-onset patients.

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Title: LRRK2 Gly2385Arg mutation and clinical features in a Chinese population with early-onset Parkinson’s disease compared to late-onset patients
Authors: Daniel Kam Yin Chan
Ping Wing Ng
Vincent Mok
Jonas Yeung
Zhi Ming Fang
Raymond Clarke
Edward Leung
Lawrence Wong
Publication date: 01-09-2008
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 9/2008
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-008-0065-0

At a glance: The STEP trials

Springer Medicine

LRRK2 Gly2385Arg mutation and clinical features in a Chinese population with early-onset Parkinson’s disease compared to late-onset patients

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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