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Open Access 01-09-2008 | Biological Psychiatry - Original Article

The functional anatomy of semantic retrieval is influenced by gender, menstrual cycle, and sex hormones

Authors: C. Konrad, A. Engelien, S. Schöning, P. Zwitserlood, A. Jansen, E. Pletziger, P. Beizai, A. Kersting, P. Ohrmann, E. Luders, R. R. Greb, W. Heindel, V. Arolt, H. Kugel

Published in: Journal of Neural Transmission | Issue 9/2008

Abstract

This study examines the neurobiology of semantic retrieval and describes the influence of gender, menstrual cycle, and sex hormones on semantic networks. Healthy right-handed subjects (12 men, 12 women) were investigated with 3T-fMRI during synonym generation. Behavioral performance and sex hormone levels were assessed. Women were examined during the early follicular and midluteal cycle phase. The activation pattern in all groups involved left frontal and temporal as well as bilateral medial frontal, cingulate, occipital, basal ganglia, and cerebellar regions. Men showed greater left frontal activation than women in both menstrual cycle phases. Women yielded high correlations of left prefrontal activation with estradiol in the midluteal phase and with progesterone in both phases. Testosterone levels correlated highly with left prefrontal activation in all three groups. In all, we describe a cerebral network involved in semantic processing and demonstrate that it is significantly affected by gender and sex steroid hormones.

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Title: The functional anatomy of semantic retrieval is influenced by gender, menstrual cycle, and sex hormones
Authors: C. Konrad
A. Engelien
S. Schöning
P. Zwitserlood
A. Jansen
E. Pletziger
P. Beizai
A. Kersting
P. Ohrmann
E. Luders
R. R. Greb
W. Heindel
V. Arolt
H. Kugel
Publication date: 01-09-2008
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 9/2008
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-008-0073-0

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The functional anatomy of semantic retrieval is influenced by gender, menstrual cycle, and sex hormones

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