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Open Access 01-09-2008 | Alzheimer's Disease and Related Disorders - Original Article

Increased EEG gamma band activity in Alzheimer’s disease and mild cognitive impairment

Authors: J. A. van Deursen, E. F. P. M. Vuurman, F. R. J. Verhey, V. H. J. M. van Kranen-Mastenbroek, W. J. Riedel

Published in: Journal of Neural Transmission | Issue 9/2008

Abstract

High frequency (30–70 Hz) gamma band oscillations in the human electro-encephalogram (EEG) are thought to reflect perceptual and cognitive processes. It is therefore interesting to study these measures in cognitive impairment and dementia. To evaluate gamma band oscillations as a diagnostic biomarker in Alzheimer’s disease (AD) and mild cognitive impairment (MCI), 15 psychoactive drug naïve AD patients, 20 MCI patients and 20 healthy controls participated in this study. Gamma band power (GBP) was measured in four conditions viz. resting state, music listening, story listening and visual stimulation. To evaluate test–retest reliability (TRR), subjects underwent a similar assessment one week after the first. The overall TRR was high. Elevated GBP was observed in AD when compared to MCI and control subjects in all conditions. The results suggest that elevated GBP is a reproducible and sensitive measure for cognitive dysfunction in AD in comparison with MCI and controls.

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Title: Increased EEG gamma band activity in Alzheimer’s disease and mild cognitive impairment
Authors: J. A. van Deursen
E. F. P. M. Vuurman
F. R. J. Verhey
V. H. J. M. van Kranen-Mastenbroek
W. J. Riedel
Publication date: 01-09-2008
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 9/2008
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-008-0083-y

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Increased EEG gamma band activity in Alzheimer’s disease and mild cognitive impairment

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