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01-06-2021 | Alkaloids | Original Paper

Two new bisindole alkaloids from Tabernaemontana macrocarpa Jack

Authors: Puteri Amelia, Alfarius Eko Nugroho, Yusuke Hirasawa, Toshio Kaneda, Takahiro Tougan, Toshihiro Horii, Hiroshi Morita

Published in: Journal of Natural Medicines | Issue 3/2021

Abstract

Two new bisindole alkaloids, bisnaecarpamines A (1) and B (2), possessing a vobasine-sarpagine type skeleton were isolated from the bark of Tabernaemontana macrocarpa Jack. Their structures were elucidated by extensive spectroscopic methods and chemical correlation. The absolute configurations of compounds 1 and 2 were established using TDDFT-ECD calculation of the selected isomers. Bisnaecarpamine A exhibited potent antimalarial activity against Plasmodium falciparum 3D7 strain with IC₅₀ value of 28.8 µM.

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Title: Two new bisindole alkaloids from Tabernaemontana macrocarpa Jack
Authors: Puteri Amelia
Alfarius Eko Nugroho
Yusuke Hirasawa
Toshio Kaneda
Takahiro Tougan
Toshihiro Horii
Hiroshi Morita
Publication date: 01-06-2021
Publisher: Springer Singapore
Keywords: Alkaloids
Antimalaria
Alkaloids
Published in: Journal of Natural Medicines / Issue 3/2021
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-021-01510-4

At a glance: The STEP trials

Springer Medicine

Two new bisindole alkaloids from Tabernaemontana macrocarpa Jack

Abstract

Graphic abstract

At a glance: The STEP trials

Springer Medicine

Abstract

Graphic abstract

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