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01-06-2021 | Original Paper

Anti-Vpr activities of sesqui- and diterpenoids from the roots and rhizomes of Kaempferia candida

Authors: Prema, Takeshi Kodama, Hnin Htet Wai Nyunt, Hla Ngwe, Ikuro Abe, Hiroyuki Morita

Published in: Journal of Natural Medicines | Issue 3/2021

Abstract

New copaene-type and nerolidol-type sesquiterpenoids, 7-hydroxymustakone (1) and 15-hydroxynerolidol (2), and a 15-norlabdane diterpenoid, kaempcandiol (3), together with four known compounds (4–7) were isolated from the chloroform extract of Kaempferia candida roots and rhizomes. The structures of the new compounds 1–3 were elucidated based on 1D and 2D NMR and HRESIMS spectroscopic analyses. The extract of the K. candida roots and rhizomes and all isolated compounds 1–7 possessed HIV-1 viral protein R (Vpr) inhibitory activities on the TREx-HeLa-Vpr cell line at a 5 μM concentration, without detectable cytotoxicity.

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Title: Anti-Vpr activities of sesqui- and diterpenoids from the roots and rhizomes of Kaempferia candida
Authors: Prema
Takeshi Kodama
Hnin Htet Wai Nyunt
Hla Ngwe
Ikuro Abe
Hiroyuki Morita
Publication date: 01-06-2021
Publisher: Springer Singapore
Published in: Journal of Natural Medicines / Issue 3/2021
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-020-01480-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Anti-Vpr activities of sesqui- and diterpenoids from the roots and rhizomes of Kaempferia candida

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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