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01-04-2012 | Note

Antiplasmodial indole alkaloids from Leuconotis griffithii

Authors: Alfarius E. Nugroho, Yusuke Hirasawa, Wong Chin Piow, Toshio Kaneda, A. Hamid A. Hadi, Osamu Shirota, Wiwied Ekasari, Aty Widyawaruyanti, Hiroshi Morita

Published in: Journal of Natural Medicines | Issue 2/2012

Abstract

A new indole alkaloid, leucoridine A N-oxide (1), consisting of two units of a strychnan type of skeleton, was isolated from the leaves of Leuconotis griffithii. Its structure was elucidated by various spectroscopic means such as NMR and MS, and also by chemical means. Antiplasmodial activity against Plasmodium falciparum 3D7 of indole alkaloids isolated from L. griffithii was investigated.

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Title: Antiplasmodial indole alkaloids from Leuconotis griffithii
Authors: Alfarius E. Nugroho
Yusuke Hirasawa
Wong Chin Piow
Toshio Kaneda
A. Hamid A. Hadi
Osamu Shirota
Wiwied Ekasari
Aty Widyawaruyanti
Hiroshi Morita
Publication date: 01-04-2012
Publisher: Springer Japan
Published in: Journal of Natural Medicines / Issue 2/2012
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-011-0574-2

At a glance: The STEP trials

Springer Medicine

Antiplasmodial indole alkaloids from Leuconotis griffithii

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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