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01-06-2021 | Alkaloids | Note

Five matrine-type alkaloids from Sophora tonkinensis

Authors: Qing Tang, Ding Luo, Ding-Chai Lin, Wen-Zhi Wang, Can-Jie Li, Xue-Fang Zhuo, Zhong-Nan Wu, Yu-Bo Zhang, Guo-Cai Wang, Yao-Lan Li

Published in: Journal of Natural Medicines | Issue 3/2021

Abstract

Five matrine-type alkaloids (1‒5) including two new compounds (1 and 3) and a new natural product (2) were isolated from the roots of Sophora tonkinesis. Their structures were identified by extensive spectroscopic analysis (UV, IR, HRESIMS and NMR). The absolute configurations of 2 and 3 were determined by X-ray diffraction. Compounds 1‒5 were evaluated their activity against inflammatory cytokines TNF-α and IL-6 levels on LPS-induced RAW 264.7 macrophages, and compound 1 showed the most significant activity, potent than that of matrine, the representative ingredient from Sophora plants.

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Title: Five matrine-type alkaloids from Sophora tonkinensis
Authors: Qing Tang
Ding Luo
Ding-Chai Lin
Wen-Zhi Wang
Can-Jie Li
Xue-Fang Zhuo
Zhong-Nan Wu
Yu-Bo Zhang
Guo-Cai Wang
Yao-Lan Li
Publication date: 01-06-2021
Publisher: Springer Singapore
Keywords: Alkaloids
Alkaloids
Published in: Journal of Natural Medicines / Issue 3/2021
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-021-01498-x

At a glance: The STEP trials

Springer Medicine

Five matrine-type alkaloids from Sophora tonkinensis

Abstract

Graphic abstract

At a glance: The STEP trials

Springer Medicine

Abstract

Graphic abstract

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