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01-06-2021 | Original Paper

Ellagitannins from Rosa roxburghii suppress poly(I:C)-induced IL-8 production in human keratinocytes

Authors: Satoru Takayama, Miho Kawanishi, Kosei Yamauchi, Daiki Tokumitsu, Hiroyuki Kojima, Teruaki Masutani, Arunasiri Iddamalgoda, Tohru Mitsunaga, Hiroyuki Tanaka

Published in: Journal of Natural Medicines | Issue 3/2021

Abstract

The anti-inflammatory effects of a 50% aqueous extract of Rosa roxburghii fruit (RRFE) and two ellagitannins (strictinin and casuarictin) isolated from the RRFE were evaluated in a cell model of skin inflammation induced by self-RNA released from epidermal cells damaged by UV ray (UVR) irradiation. The RRFE inhibited interleukin-8 (IL-8) mRNA expression in normal human epidermal keratinocytes (NHEKs) stimulated with polyinosinic:polycytidylic acid (poly(I:C)), a ligand of toll-like receptor-3 (TLR-3). The plant-derived anti-inflammatory agents, dipotassium glycyrrhizinate (GK2) and allantoin, had no influence on the IL-8 expression. The purified compounds, strictinin and casuarictin, inhibited the IL-8 mRNA expression and IL-8 release induced in NHEKs by poly(I:C). These ellagitannins were thus found to be responsible for the biological activity exhibited by the RRFE. This study demonstrates that RRFE and isolated RRFE compounds show promise as ingredients for products formulated to improve skin disorders induced by UVR irradiation.

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Title: Ellagitannins from Rosa roxburghii suppress poly(I:C)-induced IL-8 production in human keratinocytes
Authors: Satoru Takayama
Miho Kawanishi
Kosei Yamauchi
Daiki Tokumitsu
Hiroyuki Kojima
Teruaki Masutani
Arunasiri Iddamalgoda
Tohru Mitsunaga
Hiroyuki Tanaka
Publication date: 01-06-2021
Publisher: Springer Singapore
Published in: Journal of Natural Medicines / Issue 3/2021
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-021-01509-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Ellagitannins from Rosa roxburghii suppress poly(I:C)-induced IL-8 production in human keratinocytes

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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