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Virology Journal
Published in: Virology Journal 1/2023

Open Access 01-12-2023 | Zika Virus | Review

CRISPR–Cas system to discover host-virus interactions in Flaviviridae

Authors: Zahra Ramezannia, Ali Shamekh, Hossein Bannazadeh Baghi

Published in: Virology Journal | Issue 1/2023

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Abstract

The Flaviviridae virus family members cause severe human diseases and are responsible for considerable mortality and morbidity worldwide. Therefore, researchers have conducted genetic screens to enhance insight into viral dependency and develop potential anti-viral strategies to treat and prevent these infections. The host factors identified by the clustered regularly interspaced short palindromic repeats (CRISPR) system can be potential targets for drug development. Meanwhile, CRISPR technology can be efficiently used to treat viral diseases as it targets both DNA and RNA. This paper discusses the host factors related to the life cycle of viruses of this family that were recently discovered using the CRISPR system. It also explores the role of immune factors and recent advances in gene editing in treating flavivirus-related diseases. The ever-increasing advancements of this technology may promise new therapeutic approaches with unique capabilities, surpassing the traditional methods of drug production and treatment.
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Metadata
Title
CRISPR–Cas system to discover host-virus interactions in Flaviviridae
Authors
Zahra Ramezannia
Ali Shamekh
Hossein Bannazadeh Baghi
Publication date
01-12-2023
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2023
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/s12985-023-02216-7

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