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Open Access 01-02-2009 | Year in Review 2008

Year in review in Intensive Care Medicine, 2008: II. Experimental, acute respiratory failure and ARDS, mechanical ventilation and endotracheal intubation

Authors: Massimo Antonelli, Elie Azoulay, Marc Bonten, Jean Chastre, Giuseppe Citerio, Giorgio Conti, Daniel De Backer, François Lemaire, Herwig Gerlach, Johan Groeneveld, Goran Hedenstierna, Duncan Macrae, Jordi Mancebo, Salvatore M. Maggiore, Alexandre Mebazaa, Philipp Metnitz, Jerôme Pugin, Jan Wernerman, Haibo Zhang

Published in: Intensive Care Medicine | Issue 2/2009

Excerpt

Also this year ICM published a number of interesting experimental articles, in large part focussed on mechanical ventilation, ARDS and sepsis. …

Nin N, Lorente JA, De Paula M, Fernandez-Segoviano P, Penuelas O, Sanchez-Ferrer A, Martinez-Caro L, Esteban A (2008) Aging increases the susceptibility to injurious mechanical ventilation. Intensive Care Med 34:923–931PubMedCrossRef

Badia JR, Ferguson ND (2008) Ventilator-induced lung injury: another sign of aging? Intensive Care Med 34:796–799PubMedCrossRef

Nin N, Lorente JA, de Paula M, El Assar M, Vallejo S, Penuelas O, Fernandez-Segoviano P, Ferruelo A, Sanchez-Ferrer A, Esteban A (2008) Rats surviving injurious mechanical ventilation show reversible pulmonary, vascular and inflammatory changes. Intensive Care Med 34:948–956PubMedCrossRef

Allardet-Servent J, Bregeon F, Delpierre S, Steinberg JG, Payan MJ, Ravailhe S, Papazian L (2008) High-frequency percussive ventilation attenuates lung injury in a rabbit model of gastric juice aspiration. Intensive Care Med 34:91–100PubMedCrossRef

Beck J, Brander L, Slutsky AS, Reilly MC, Dunn MS, Sinderby C (2008) Non-invasive neurally adjusted ventilatory assist in rabbits with acute lung injury. Intensive Care Med 34:316–323PubMedCrossRef

Meier T, Luepschen H, Karsten J, Leibecke T, Grossherr M, Gehring H, Leonhardt S (2008) Assessment of regional lung recruitment and derecruitment during a PEEP trial based on electrical impedance tomography. Intensive Care Med 34:543–550PubMedCrossRef

Schibler A, Calzia E (2008) Electrical impedance tomography: a future item on the “Christmas Wish List” of the intensivist? Intensive Care Med 34:400–401 author reply 583PubMedCrossRef

Astrom E, Uttman L, Niklason L, Aboab J, Brochard L, Jonson B (2008) Pattern of inspiratory gas delivery affects CO₂ elimination in health and after acute lung injury. Intensive Care Med 34:377–384PubMedCrossRef

Schwartges I, Schwarte LA, Fournell A, Scheeren TW, Picker O (2008) Hypercapnia induces a concentration-dependent increase in gastric mucosal oxygenation in dogs. Intensive Care Med 34:1898–1906PubMedCrossRef

10.

Hering R, Bolten JC, Kreyer S, Berg A, Wrigge H, Zinserling J, Putensen C (2008) Spontaneous breathing during airway pressure release ventilation in experimental lung injury: effects on hepatic blood flow. Intensive Care Med 34:523–527PubMedCrossRef

11.

Calzia E, Radermacher P, Pelosi P (2008) Preserved spontaneous breathing in acute lung injury: show me the money? Intensive Care Med 34:397–399PubMedCrossRef

12.

de Prost N, Dreyfuss D, Ricard JD, Saumon G (2008) Terbutaline lessens protein fluxes across the alveolo-capillary barrier during high-volume ventilation. Intensive Care Med 34:763–770PubMedCrossRef

13.

Kuebler WM (2008) Hitting new barriers in ventilator-induced lung injury. Intensive Care Med 34:592–594PubMedCrossRef

14.

Cheung PY, Obaid L, Emara M, Brierley Y, Johnson ST, Chan GS, Jewell L, Korbutt G, Bigam DL (2008) Cardio-renal recovery of hypoxic newborn pigs after 18%, 21% and 100% reoxygenation. Intensive Care Med 34:1114–1121PubMedCrossRef

15.

Douzinas EE, Livaditi O, Andrianakis I, Prigouris P, Paneris P, Villiotou V, Betrosian AP (2008) The effect of hypoxemic resuscitation from hemorrhagic shock on blood pressure restoration and on oxidative and inflammatory responses. Intensive Care Med 34:1133–1141PubMedCrossRef

16.

Joynt C, Bigam DL, Charrois G, Jewell LD, Korbutt G, Cheung PY (2008) Dose–response effects of milrinone on hemodynamics of newborn pigs with hypoxia–reoxygenation. Intensive Care Med 34:1321–1329PubMedCrossRef

17.

Lee TF, Jantzie LL, Todd KG, Cheung PY (2008) Postresuscitation N-acetylcysteine treatment reduces cerebral hydrogen peroxide in the hypoxic piglet brain. Intensive Care Med 34:190–197PubMedCrossRef

18.

Geeraerts T, Friggeri A, Mazoit JX, Benhamou D, Duranteau J, Vigue B (2008) Posttraumatic brain vulnerability to hypoxia–hypotension: the importance of the delay between brain trauma and secondary insult. Intensive Care Med 34:551–560PubMedCrossRef

19.

Stahel PF, Smith WR, Moore EE (2008) Hypoxia and hypotension, the “lethal duo” in traumatic brain injury: implications for prehospital care. Intensive Care Med 34:402–404PubMedCrossRef

20.

Marbacher S, Neuschmelting V, Graupner T, Jakob SM, Fandino J (2008) Prevention of delayed cerebral vasospasm by continuous intrathecal infusion of glyceroltrinitrate and nimodipine in the rabbit model in vivo. Intensive Care Med 34:932–938PubMedCrossRef

21.

Geiger R, Kleinsasser A, Meier S, Neu N, Pajk W, Fischer V, Treml B, Stein JI, Loeckinger A (2008) Intravenous tezosentan improves gas exchange and hemodynamics in acute lung injury secondary to meconium aspiration. Intensive Care Med 34:368–376PubMedCrossRef

22.

Rex S, Missant C, Segers P, Rossaint R, Wouters PF (2008) Epoprostenol treatment of acute pulmonary hypertension is associated with a paradoxical decrease in right ventricular contractility. Intensive Care Med 34:179–189PubMedCrossRef

23.

Pape A, Kertscho H, Meier J, Horn O, Laout M, Steche M, Lossen M, Theisen A, Zwissler B, Habler O (2008) Improved short-term survival with polyethylene glycol modified hemoglobin liposomes in critical normovolemic anemia. Intensive Care Med 34:1534–1543PubMedCrossRef

24.

Wan L, Yang N, Hiew CY, Schelleman A, Johnson L, May C, Bellomo R (2008) An assessment of the accuracy of renal blood flow estimation by Doppler ultrasound. Intensive Care Med 34:1503–1510PubMedCrossRef

25.

Hagiwara S, Iwasaka H, Matsumoto S, Noguchi T (2008) High dose antithrombin III inhibits HMGB1 and improves endotoxin-induced acute lung injury in rats. Intensive Care Med 34:361–367PubMedCrossRef

26.

Pugin J (2008) Dear Sirs, the concept of “alarmins” makes a lot of sense!. Intensive Care Med 34:218–221PubMedCrossRef

27.

Gibot S, Massin F, Cravoisy A, Barraud D, Nace L, Levy B, Bollaert PE (2007) High-mobility group box 1 protein plasma concentrations during septic shock. Intensive Care Med 33:1347–1353PubMedCrossRef

28.

Karlsson S, Pettila V, Tenhunen J, Laru-Sompa R, Hynninen M, Ruokonen E (2008) HMGB1 as a predictor of organ dysfunction and outcome in patients with severe sepsis. Intensive Care Med 34:1046–1053PubMedCrossRef

29.

Hagiwara S, Iwasaka H, Hasegawa A, Asai N, Noguchi T (2008) High-dose intravenous immunoglobulin G improves systemic inflammation in a rat model of CLP-induced sepsis. Intensive Care Med 34:1812–1819PubMedCrossRef

30.

Haraguchi G, Kosuge H, Maejima Y, Suzuki J, Imai T, Yoshida M, Isobe M (2008) Pioglitazone reduces systematic inflammation and improves mortality in apolipoprotein E knockout mice with sepsis. Intensive Care Med 34:1304–1312PubMedCrossRef

31.

Tuon L, Comim CM, Petronilho F, Barichello T, Izquierdo I, Quevedo J, Dal-Pizzol F (2008) Time-dependent behavioral recovery after sepsis in rats. Intensive Care Med 34:1724–1731PubMedCrossRef

32.

Tuon L, Comim CM, Antunes MM, Constantino LS, Machado RA, Izquierdo I, Quevedo J, Dal-Pizzol F (2007) Imipramine reverses the depressive symptoms in sepsis survivor rats. Intensive Care Med 33:2165–2167PubMedCrossRef

33.

Carvalho D, Petronilho F, Vuolo F, Machado RA, Constantino L, Guerrini R, Calo G, Gavioli EC, Streck EL, Dal-Pizzol F (2008) The nociceptin/orphanin FQ-NOP receptor antagonist effects on an animal model of sepsis. Intensive Care Med 34:2284–2290PubMedCrossRef

34.

Frick CG, Fink H, Gordan ML, Eckel B, Martyn JA, Blobner M (2008) Chronic Escherichia coli infection induces muscle wasting without changing acetylcholine receptor numbers. Intensive Care Med 34:561–567PubMedCrossRef

35.

Li Y, Cui X, Li X, Solomon SB, Danner RL, Banks SM, Fitz Y, Annane D, Natanson C, Eichacker PQ (2008) Risk of death does not alter the efficacy of hydrocortisone therapy in a mouse E. coli pneumonia model: risk and corticosteroids in sepsis. Intensive Care Med 34:568–577PubMedCrossRef

36.

Ellger B, Langouche L, Richir M, Debaveye Y, Vanhorebeek I, Van Leeuwen PA, Van den Berghe G (2008) Modulation of regional nitric oxide metabolism: blood glucose control or insulin? Intensive Care Med 34:1525–1533PubMedCrossRef

37.

Ader F, Le Berre R, Fackeure R, Raze D, Menozzi FD, Viget N, Faure K, Kipnis E, Guery B, Jarraud S, Etienne J, Chidiac C (2008) In vivo effect of adhesion inhibitor heparin on Legionella nemophila pathogenesis in a murine pneumonia model. Intensive Care Med 34:1511–1519PubMedCrossRef

38.

Rossi P, Persson B, Boels PJ, Arner A, Weitzberg E, Oldner A (2008) Endotoxemic pulmonary hypertension is largely mediated by endothelin-induced venous constriction. Intensive Care Med 34:873–880PubMedCrossRef

39.

Lin HC, Wan FJ (2008) Hyperbaric oxygenation reduces overexpression of c-Fos and oxidative stress in the brain stem of experimental endotoxemic rats. Intensive Care Med 34:1122–1132PubMedCrossRef

40.

Kopel T, Losser MR, Faivre V, Payen D (2008) Systemic and hepatosplanchnic macro- and microcirculatory dose response to arginine vasopressin in endotoxic rabbits. Intensive Care Med 34:1313–1320PubMedCrossRef

41.

Ferrari F, Liu ZH, Lu Q, Becquemin MH, Louchahi K, Aymard G, Marquette CH, Rouby JJ (2008) Comparison of lung tissue concentrations of nebulized ceftazidime in ventilated piglets: ultrasonic versus vibrating plate nebulizers. Intensive Care Med 34:1718–1723PubMedCrossRef

42.

van den Akker EL, Baan CC, van den Berg B, Russcher H, Joosten K, Hokken-Koelega AC, Lamberts SW, Koper JW (2008) Ficoll-separated mononuclear cells from sepsis patients are contaminated with granulocytes. Intensive Care Med 34:912–916PubMedCrossRef

43.

Noda A, Kinoshita K, Sakurai A, Matsumoto T, Mugishima H, Tanjoh K (2008) Hyperglycemia and lipopolysaccharide decrease depression effect of interleukin 8 production by hypothermia: an experimental study with endothelial cells. Intensive Care Med 34:109–115PubMedCrossRef

44.

Dos Santos CC (2008) Advances in mechanisms of repair and remodelling in acute lung injury. Intensive Care Med 34:619–630PubMedCrossRef

45.

Negrini D, Passi A, Moriondo A (2008) The role of proteoglycans in pulmonary edema development. Intensive Care Med 34:610–618PubMedCrossRef

46.

Dixon B, Campbell DJ, Santamaria JD (2008) Elevated pulmonary dead space and coagulation abnormalities suggest lung microvascular thrombosis in patients undergoing cardiac surgery. Intensive Care Med 34:1216–1223PubMedCrossRef

47.

Ranucci M (2008) Aprotinin and microvascular thrombosis in cardiac surgery. Intensive Care Med 34:1175–1176PubMedCrossRef

48.

Arcaroli J, Sankoff J, Liu N, Allison DB, Maloney J, Abraham E (2008) Association between urokinase haplotypes and outcome from infection-associated acute lung injury. Intensive Care Med 34:300–307PubMedCrossRef

49.

Cavallazzi R, Nair A, Vasu T, Marik PE (2008) Natriuretic peptides in acute pulmonary embolism: a systematic review. Intensive Care Med 34:2147–2156PubMedCrossRef

50.

Lefebvre A, Kural-Menasche S, Darmon M, Thiery G, Feugeas JP, Schlemmer B, Azoulay E (2008) Use of N-terminal pro-brain natriuretic peptide to detect cardiac origin in critically ill cancer patients with acute respiratory failure. Intensive Care Med 34:833–839PubMedCrossRef

51.

Wagner PD (2008) The multiple inert gas elimination technique (MIGET). Intensive Care Med 34:994–1001PubMedCrossRef

52.

Maniscalco M, Zedda A, Faraone S, Carratu P, Sofia M (2008) Evaluation of a transcutaneous carbon dioxide monitor in severe obesity. Intensive Care Med 34:1340–1344PubMedCrossRef

53.

Meduri GU, Marik PE, Chrousos GP, Pastores SM, Arlt W, Beishuizen A, Bokhari F, Zaloga G, Annane D (2008) Steroid treatment in ARDS: a critical appraisal of the ARDS network trial and the recent literature. Intensive Care Med 34:61–69PubMedCrossRef

54.

Fernandez R, Trenchs X, Klamburg J, Castedo J, Serrano JM, Besso G, Tirapu JP, Santos A, Mas A, Parraga M, Jubert P, Frutos F, Anon JM, Garcia M, Rodriguez F, Yebenes JC, Lopez MJ (2008) Prone positioning in acute respiratory distress syndrome: a multicenter randomized clinical trial. Intensive Care Med 34:1487–1491PubMedCrossRef

55.

Abroug F, Ouanes-Besbes L, Elatrous S, Brochard L (2008) The effect of prone positioning in acute respiratory distress syndrome or acute lung injury: a meta-analysis. Areas of uncertainty and recommendations for research. Intensive Care Med 34:1002–1011PubMedCrossRef

56.

Standley TD, Smith HL, Brennan LJ, Wilkins IA, Bradley PG, Barrera Groba C, Davey AJ, Menon DK, Wheeler DW (2008) Room air dilution of heliox given by facemask. Intensive Care Med 34:1469–1476PubMedCrossRef

57.

Gosselink R, Bott J, Johnson M, Dean E, Nava S, Norrenberg M, Schonhofer B, Stiller K, van de Leur H, Vincent JL (2008) Physiotherapy for adult patients with critical illness: recommendations of the European Respiratory Society and European Society of Intensive Care Medicine Task Force on Physiotherapy for critically ill patients. Intensive Care Med 34:1188–1199PubMedCrossRef

58.

Vassilakopoulos T (2008) Ventilator-induced diaphragm dysfunction: the clinical relevance of animal models. Intensive Care Med 34:7–16PubMedCrossRef

59.

Pelosi P, Rocco PR (2008) Effects of mechanical ventilation on the extracellular matrix. Intensive Care Med 34:631–639PubMedCrossRef

60.

Burns KE, Lellouche F, Lessard MR (2008) Automating the weaning process with advanced closed-loop systems. Intensive Care Med 34:1757–1765PubMedCrossRef

61.

Arnal JM, Wysocki M, Nafati C, Donati S, Granier I, Corno G, Durand-Gasselin J (2008) Automatic selection of breathing pattern using adaptive support ventilation. Intensive Care Med 34:75–81PubMedCrossRef

62.

Rose L, Presneill JJ, Johnston L, Cade JF (2008) A randomised, controlled trial of conventional versus automated weaning from mechanical ventilation using SmartCare trade mark/PS. Intensive Care Med 34:1788–1795PubMedCrossRef

63.

Laghi F (2008) Weaning: can the computer help? Intensive Care Med 34:1746–1748PubMedCrossRef

64.

Prinianakis G, Plataki M, Kondili E, Klimathianaki M, Vaporidi K, Georgopoulos D (2008) Effects of relaxation of inspiratory muscles on ventilator pressure during pressure support. Intensive Care Med 34:70–74PubMedCrossRef

65.

Younes M (2008) Why does airway pressure rise sometimes near the end of inflation during pressure support? Intensive Care Med 34:1–3PubMedCrossRef

66.

Demory D, Arnal JM, Wysocki M, Donati S, Granier I, Corno G, Durand-Gasselin J (2008) Recruitability of the lung estimated by the pressure volume curve hysteresis in ARDS patients. Intensive Care Med 34:2019–2025PubMedCrossRef

67.

Patroniti N, Saini M, Zanella A, Weismann D, Isgro S, Bellani G, Foti G, Pesenti A (2008) Measurement of end-expiratory lung volume by oxygen washin-washout in controlled and assisted mechanically ventilated patients. Intensive Care Med 34:2235–2240PubMedCrossRef

68.

Reske AW, Busse H, Amato MB, Jaekel M, Kahn T, Schwarzkopf P, Schreiter D, Gottschaldt U, Seiwerts M (2008) Image reconstruction affects computer tomographic assessment of lung hyperinflation. Intensive Care Med 34:2044–2053PubMedCrossRef

69.

Rodrigues RS, Miller PR, Bozza FA, Marchiori E, Zimmerman GA, Hoffman JM, Morton KA (2008) FDG-PET in patients at risk for acute respiratory distress syndrome: a preliminary report. Intensive Care Med 34:2273–2278PubMedCrossRef

70.

Clec’h C, Simon P, Hamdi A, Hamza L, Karoubi P, Fosse JP, Gonzalez F, Vincent F, Cohen Y (2008) Are daily routine chest radiographs useful in critically ill, mechanically ventilated patients? A randomized study. Intensive Care Med 34:264–270PubMedCrossRef

71.

El-Khatib MF, Zeineldine SM, Jamaleddine GW (2008) Effect of pressure support ventilation and positive end expiratory pressure on the rapid shallow breathing index in intensive care unit patients. Intensive Care Med 34:505–510PubMedCrossRef

72.

Rusterholtz T, Bollaert PE, Feissel M, Romano-Girard F, Harlay ML, Zaehringer M, Dusang B, Sauder P (2008) Continuous positive airway pressure vs. proportional assist ventilation for noninvasive ventilation in acute cardiogenic pulmonary edema. Intensive Care Med 34:840–846PubMedCrossRef

73.

Ferreira JC, Chipman DW, Kacmarek RM (2008) Trigger performance of mid-level ICU mechanical ventilators during assisted ventilation: a bench study. Intensive Care Med 34:1669–1675PubMedCrossRef

74.

Thille AW, Cabello B, Galia F, Lyazidi A, Brochard L (2008) Reduction of patient–ventilator asynchrony by reducing tidal volume during pressure-support ventilation. Intensive Care Med 34:1477–1486PubMedCrossRef

75.

Rose L, Hawkins M (2008) Airway pressure release ventilation and biphasic positive airway pressure: a systematic review of definitional criteria. Intensive Care Med 34:1766–1773PubMedCrossRef

76.

Mojoli F, Iotti GA, Gerletti M, Lucarini C, Braschi A (2008) Carbon dioxide rebreathing during non-invasive ventilation delivered by helmet: a bench study. Intensive Care Med 34:1454–1460PubMedCrossRef

77.

Racca F, Appendini L, Gregoretti C, Varese I, Berta G, Vittone F, Ferreyra G, Stra E, Ranieri VM (2008) Helmet ventilation and carbon dioxide rebreathing: effects of adding a leak at the helmet ports. Intensive Care Med 34:1461–1468PubMedCrossRef

78.

Moerer O, Beck J, Brander L, Costa R, Quintel M, Slutsky AS, Brunet F, Sinderby C (2008) Subject–ventilator synchrony during neural versus pneumatically triggered non-invasive helmet ventilation. Intensive Care Med 34:1615–1623PubMedCrossRef

79.

Xirouchaki N, Kondili E, Vaporidi K, Xirouchakis G, Klimathianaki M, Gavriilidis G, Alexandopoulou E, Plataki M, Alexopoulou C, Georgopoulos D (2008) Proportional assist ventilation with load-adjustable gain factors in critically ill patients: comparison with pressure support. Intensive Care Med 34:2026–2034PubMedCrossRef

80.

Colombo D, Cammarota G, Bergamaschi V, De Lucia M, Corte FD, Navalesi P (2008) Physiologic response to varying levels of pressure support and neurally adjusted ventilatory assist in patients with acute respiratory failure. Intensive Care Med 34:2010–2018PubMedCrossRef

81.

Carvalho AR, Spieth PM, Pelosi P, Vidal Melo MF, Koch T, Jandre FC, Giannella-Neto A, de Abreu MG (2008) Ability of dynamic airway pressure curve profile and elastance for positive end-expiratory pressure titration. Intensive Care Med 34:2291–2299PubMedCrossRef

82.

Dellamonica J, Louis B, Lyazidi A, Vargas F, Brochard L (2008) Intrapulmonary percussive ventilation superimposed on conventional ventilation: bench study of humidity and ventilator behaviour. Intensive Care Med 34:2035–2043PubMedCrossRef

83.

Andrieu MC, Quentin C, Orlikowski D, Desmarais G, Isabey D, Louis B, Lofaso F (2008) Inductive plethysmography to control volume-targeted ventilation for leak compensation. Intensive Care Med 34:1150–1155PubMedCrossRef

84.

Lovat R, Watremez C, Van Dyck M, Van Caenegem O, Verschuren F, Hantson P, Jacquet LM (2008) Smart bag vs. standard bag in the temporary substitution of the mechanical ventilation. Intensive Care Med 34:355–360PubMedCrossRef

85.

Beecroft JM, Ward M, Younes M, Crombach S, Smith O, Hanly PJ (2008) Sleep monitoring in the intensive care unit: comparison of nurse assessment, actigraphy and polysomnography. Intensive Care Med 34:2076–2083PubMedCrossRef

86.

Griesdale DE, Bosma TL, Kurth T, Isac G, Chittock DR (2008) Complications of endotracheal intubation in the critically ill. Intensive Care Med 34:1835–1842PubMedCrossRef

87.

Zanella A, Cressoni M, Epp M, Stylianou M, Kolobow T (2008) A double-layer tracheal tube cuff designed to prevent leakage: a bench-top study. Intensive Care Med 34:1145–1149PubMedCrossRef

88.

Fernandez R, Bacelar N, Hernandez G, Tubau I, Baigorri F, Gili G, Artigas A (2008) Ward mortality in patients discharged from the ICU with tracheostomy may depend on patient’s vulnerability. Intensive Care Med 34:1878–1882PubMedCrossRef

89.

Blot F, Similowski T, Trouillet JL, Chardon P, Korach JM, Costa MA, Journois D, Thiery G, Fartoukh M, Pipien I, Bruder N, Orlikowski D, Tankere F, Durand-Zaleski I, Auboyer C, Nitenberg G, Holzapfel L, Tenaillon A, Chastre J, Laplanche A (2008) Early tracheotomy versus prolonged endotracheal intubation in unselected severely ill ICU patients. Intensive Care Med 34:1779–1787PubMedCrossRef

90.

Scales DC, Kahn JM (2008) Tracheostomy timing, enrollment and power in ICU clinical trials. Intensive Care Med 34:1743–1745PubMedCrossRef

Title: Year in review in Intensive Care Medicine, 2008: II. Experimental, acute respiratory failure and ARDS, mechanical ventilation and endotracheal intubation
Authors: Massimo Antonelli
Elie Azoulay
Marc Bonten
Jean Chastre
Giuseppe Citerio
Giorgio Conti
Daniel De Backer
François Lemaire
Herwig Gerlach
Johan Groeneveld
Goran Hedenstierna
Duncan Macrae
Jordi Mancebo
Salvatore M. Maggiore
Alexandre Mebazaa
Philipp Metnitz
Jerôme Pugin
Jan Wernerman
Haibo Zhang
Publication date: 01-02-2009
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 2/2009
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-008-1380-5

At a glance: The STEP trials

Springer Medicine

Year in review in Intensive Care Medicine, 2008: II. Experimental, acute respiratory failure and ARDS, mechanical ventilation and endotracheal intubation

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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Regional cooling of the extracorporeal blood circuit: a novel anticoagulation approach for renal replacement therapy?

Adverse drug reactions and deliberate self-poisoning as cause of admission to the intensive care unit: a 1-year prospective observational cohort study

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