Top

International Ophthalmology

Published in:

Open Access 27-08-2022 | Vasculitis | Original Paper

Evaluation of the retinal and choroidal microvasculature changes in cases of sarcoid and tuberculosis-associated posterior uveitis using OCT angiography

Authors: Lameece Moustafa Hassan, Ashgan Asaad, Zeinab ElSanabary, Maha M. Youssef

Published in: International Ophthalmology | Issue 2/2023

Abstract

Purpose

Using optical coherence tomography angiography (OCTA) to evaluate retinal microvascular changes in sarcoid and tuberculous (TB) posterior uveitis.

Methods

Cross-sectional observational study includes 30 eyes. FFA and OCTA images were acquired. OCTA images were analyzed for areas of capillary hypo-perfusion, disorganization of the superficial and deep capillary plexuses (SCP and DCP) and intraretinal cystoid spaces and for measuring the size of the foveal avascular zone and vessel density (VD) in the SCP and DCP.

Results

A total of 11 eyes were associated with TB and 19 with sarcoidosis. By OCTA, 100% had areas of capillary non-perfusion, 36.7% choroidal voids, 30% disorganization of the SCP and DCP and 26.6% intraretinal cystoid spaces. The VD of the DCP was significantly lower in the TB group. On comparing OCTA and FFA, parafoveal ischemia was detected more frequently on OCTA and macular edema more frequently on FFA (P = < 0.001). The BCVA was not significantly correlated with the VD of the SCP or DCP.

Conclusion

OCTA can be used in detection of early microvascular changes, segmenting retinal layers and localizing abnormalities. The presence of these changes may aid in the diagnosis of TB and sarcoid uveitis, for prognosis, follow-up and may be the only choice when FFA is contraindicated.

Mehta H, Sim DA, Keane PA et al (2015) Structural changes of the choroid in sarcoid- and tuberculosis-related granulomatous uveitis. Eye 29(8):1060–1068. https://doi.org/10.1038/eye.2015.65CrossRefPubMedPubMedCentral

Iannuzzi MC, Rybicki BA, Teirstein AS (2007) Sarcoidosis. N Engl J Med 357:2153–2165CrossRefPubMed

Babu K, Kini R, Mehta R et al (2013) Predictors for tubercular uveitis: a comparison between biopsy-proven cases of tubercular and sarcoid uveitis. Retina 32:1017–1020CrossRef

Pichi F, Sarraf D, Arepalli S et al (2017) The application of optical coherence tomography angiography in uveitis and inflammatory eye diseases. Prog Retin Eye Res 59:178–201CrossRefPubMed

Gorczynska I, Migacz J, Zawadzki R, Capps A, Werner J (2016) Comparison of amplitude-decorrelation, speckle-variance and phase-variance OCT angiography methods for imaging the human retina and choroid. Biomed Opt Express 7(3):911–942. https://doi.org/10.1364/BOE.7.000911CrossRefPubMedPubMedCentral

Leder H, Campbell J, Sepah Y (2013) Ultra-wide-field retinal imaging in the management of non-infectious retinal vasculitis. J Ophthalmic Inflamm Infect 3(1):30. https://doi.org/10.1186/1869-5760-3-30CrossRefPubMedPubMedCentral

El-Asrar A, Herbort C, Tabbara K (2010) A clinical approach to the diagnosis of retinal vasculitis. Int Ophthalmol 30:149–173CrossRefPubMed

Jabs D, Nussenblatt R, Rosenbaum J (2005) standardization of uveitis nomenclature (sun) working group standardization of uveitis nomenclature for reporting clinical data results of the first international workshop. Am J Ophthalmol 140(3):509–516CrossRefPubMed

Herbort C, Rao N, Mochizuki M, the Members of the Scientific Committee of the first International Workshop on Ocular Sarcoidosis (IWOS) (2009) International criteria for the diagnosis ocular Sarcoidosis. Ocul Immunol Inflam 17:160–169

10.

Gupta A, Sharma A, Bansal R, Sharma K (2015) Classification of intraocular tuberculosis. Ocul Immunol Inflamm 23:7–22CrossRefPubMed

11.

Coscas F, Sellam A, Glacet-Bernard A et al (2016) Normative data for vascular density in superficial and deep capillary plexuses of healthy adults assessed by optical coherence tomography angiography. Invest Ophthalmol Vis Sci 57(9):211–223. https://doi.org/10.1167/iovs.15-18793CrossRef

12.

Kim A, Rodger D, Shahidzadeh A et al (2016) Quantifying retinal microvascular changes in uveitis using spectral domain optical coherence tomography angiography (SD-OCTA). Am J Ophthalmol 171:101–112CrossRefPubMedPubMedCentral

13.

Cerquaglia A, Iaccheri B, Fiore T, Fruttini D et al (2019) New insights on ocular sarcoidosis: an optical coherence tomography angiography study. Ocul Immunol Inflamm 27(7):1057–1066. https://doi.org/10.1080/09273948.2018.1497665CrossRefPubMed

14.

Agarwal A, Aggarwal K, Deokar A et al (2016) OCTA study group, optical coherence tomography angiography features of paradoxical worsening in tubercular multifocal serpiginoid choroiditis. Ocul Immunol Inflamm 24(6):621–630. https://doi.org/10.1080/09273948.2016.1207785CrossRefPubMed

15.

Mahendradas P, Maruyama K, Mizuuchi K et al (2020) Multimodal imaging in ocular sarcoidosis. Ocul Immunol Inflamm 28(8):1205–1211. https://doi.org/10.1080/09273948.2020.1751210CrossRefPubMed

16.

Emre S, Guven-Yılmaz S, Ulusoy M, Ates H (2019) Optical coherence tomography angiography findings in Behcet patients. Int Ophthalmol 39(10):2391–2399. https://doi.org/10.1007/s10792-019-01080-1CrossRefPubMed

17.

Dupas B, Minvielle W, Bonnin S et al (2018) Association between vessel density and visual acuity in patients with diabetic retinopathy and poorly controlled type 1 diabetes. JAMA Ophthalmol 136:721–728. https://doi.org/10.1001/jamaophthalmol.2018.1319CrossRefPubMedPubMedCentral

18.

Salmon JF (2020) Uveitis. In: Kanski clinical ophthalmology—a systemic approach, 9th edn, pp 428–484

19.

Klufas M, Phasukkijwatana N, Iafe N et al (2017) Optical coherence tomography angiography reveals choriocapillaris flow reduction in placoid chorioretinitis. Ophthalmol Retina 1(1):77–91. https://doi.org/10.1016/j.oret.2016.08.008CrossRefPubMed

20.

Khairallah M, Abroug N, Khochtali S et al (2017) Optical coherence tomography angiography in patients with behcet uveitis. Retina 37(9):1678–1691CrossRefPubMed

21.

Abucham-Neto J, TorricelliLuiA A et al (2018) Comparison between optical coherence tomography angiography and fluorescein angiography findings in retinal vasculitis. Int J Retina Vitr 4:15. https://doi.org/10.1186/s40942-018-0117-zCrossRef

22.

Bloch-Michel E, Nussenblatt R (1987) International uveitis study group recommendations for the evaluation of intraocular inflammatory disease. Am J Ophthalmol 103(2):234–235CrossRefPubMed

Title: Evaluation of the retinal and choroidal microvasculature changes in cases of sarcoid and tuberculosis-associated posterior uveitis using OCT angiography
Authors: Lameece Moustafa Hassan
Ashgan Asaad
Zeinab ElSanabary
Maha M. Youssef
Publication date: 27-08-2022
Publisher: Springer Netherlands
Keywords: Vasculitis
Tuberculosis
Sarcoidosis
Vasculitis
Uveitis
Angiography
Tuberculosis
Edema
Sarcoidosis
Published in: International Ophthalmology / Issue 2/2023
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-022-02464-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Evaluation of the retinal and choroidal microvasculature changes in cases of sarcoid and tuberculosis-associated posterior uveitis using OCT angiography

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 2/2023

Efficacy of binocular vision training and Fresnel press-on prism on children with esotropia and amblyopia

Clinical features, etiological reasons, and treatment results in patients who developed acute acquired nonaccomodative esotropia

Assessment of risk factors on eye dryness in young adults using visual display device in both contact lens wearers and non-wearers

Disinsertion-distal myectomy and tucking of inferior oblique combined with superior oblique full tendon advancement in superior oblique palsy

Angle Kappa agreement between Scheimpflug tomography, combined placido Scheimpflug and combined slit scanning placido systems

Grading for suction loss in small incision lenticule extraction