Published in:
01-09-2010 | Commentary
Tribbles homologue 3 (TRIB3) and the insulin-resistance genes in type 2 diabetes
Published in: Diabetologia | Issue 9/2010
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Tissue resistance to insulin action results from abnormalities affecting the insulin signalling cascade. This intricate molecular pathway, controlled by positive and negative regulators, affects most major areas of metabolism (Fig. 1). Our growing comprehension of the complexity of these biochemical mechanisms makes it difficult to ascertain exactly what is happening in the insulin-resistant patient.
Fig. 1
The growing complexity of the insulin-signalling network. The drawing identifies the central role of AKT/PKB in relaying the insulin signal towards a number of different pathways controlling most areas of cell metabolism. Several different regulatory inputs also converge on AKT/PKB. Dotted lines indicate translocation, solid lines indicate functional interactions. Explanations of the abbreviations are shown in the Electronic supplementary material (ESM)
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