Overcoming barriers for left atrial appendage thrombus: a systematic review of left atrial appendage closure

go back to reference January CT, Wann LS, Calkins H, Chen LY, Cigarroa JE, Cleveland JC, Ellinor PT, Ezekowitz MD, Field ME, Furie KL, Heidenreich PA, Murray KT, Shea JB, Tracy CM, Yancy CW. 2019 AHA/ACC/HRS focused update of the 2014 aha/acc/hrs guideline for the management of patients with atrial fibrillation: a report of the american college of cardiology/american heart association task force on clinical practice guidelines and the heart rhythm society in collaboration with the society of thoracic surgeons. Circulation. 2019;140(2):e125–51.PubMedCrossRef January CT, Wann LS, Calkins H, Chen LY, Cigarroa JE, Cleveland JC, Ellinor PT, Ezekowitz MD, Field ME, Furie KL, Heidenreich PA, Murray KT, Shea JB, Tracy CM, Yancy CW. 2019 AHA/ACC/HRS focused update of the 2014 aha/acc/hrs guideline for the management of patients with atrial fibrillation: a report of the american college of cardiology/american heart association task force on clinical practice guidelines and the heart rhythm society in collaboration with the society of thoracic surgeons. Circulation. 2019;140(2):e125–51.PubMedCrossRef

go back to reference Hindricks G, Potpara T, Dagres N, Arbelo E, Bax JJ, Blomström-Lundqvist C, Boriani G, Castella M, Dan G-A, Dilaveris PE, Fauchier L, Filippatos G, Kalman JM, La Meir M, Lane DA, Lebeau J-P, Lettino M, Lip GYH, Pinto FJ, Thomas GN, Valgimigli M, Van Gelder IC, Van Putte BP, Watkins CL. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Eur Heart J. 2021;42(5):373–498.PubMedCrossRef Hindricks G, Potpara T, Dagres N, Arbelo E, Bax JJ, Blomström-Lundqvist C, Boriani G, Castella M, Dan G-A, Dilaveris PE, Fauchier L, Filippatos G, Kalman JM, La Meir M, Lane DA, Lebeau J-P, Lettino M, Lip GYH, Pinto FJ, Thomas GN, Valgimigli M, Van Gelder IC, Van Putte BP, Watkins CL. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Eur Heart J. 2021;42(5):373–498.PubMedCrossRef

go back to reference Benjamin EJ, Muntner P, Alonso A, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Chang AR, Cheng S, Das SR, Delling FN, Djousse L, Elkind MSV, Ferguson JF, Fornage M, Jordan LC, Khan SS, Kissela BM, Knutson KL, Kwan TW, Lackland DT, Lewis TT, Lichtman JH, Longenecker CT, Loop MS, Lutsey PL, Martin SS, Matsushita K, Moran AE, Mussolino ME, O'Flaherty M, Pandey A, Perak AM, Rosamond WD, Roth GA, Sampson UKA, Satou GM, Schroeder EB, Shah SH, Spartano NL, Stokes A, Tirschwell DL, Tsao CW, Turakhia MP, VanWagner LB, Wilkins JT, Wong SS, Virani SS, American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee. Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association. Circulation. 2019;139(10):e56–528. https://doi.org/10.1161/CIR.0000000000000659. Benjamin EJ, Muntner P, Alonso A, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Chang AR, Cheng S, Das SR, Delling FN, Djousse L, Elkind MSV, Ferguson JF, Fornage M, Jordan LC, Khan SS, Kissela BM, Knutson KL, Kwan TW, Lackland DT, Lewis TT, Lichtman JH, Longenecker CT, Loop MS, Lutsey PL, Martin SS, Matsushita K, Moran AE, Mussolino ME, O'Flaherty M, Pandey A, Perak AM, Rosamond WD, Roth GA, Sampson UKA, Satou GM, Schroeder EB, Shah SH, Spartano NL, Stokes A, Tirschwell DL, Tsao CW, Turakhia MP, VanWagner LB, Wilkins JT, Wong SS, Virani SS, American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee. Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association. Circulation. 2019;139(10):e56–528. https://​doi.​org/​10.​1161/​CIR.​0000000000000659​.

go back to reference Glikson M, Wolff R, Hindricks G, Mandrola J, Camm AJ, Lip GYH, Fauchier L, Betts TR, Lewalter T, Saw J, Tzikas A, Sternik L, Nietlispach F, Berti S, Sievert H, Bertog S, Meier B. EHRA/EAPCI expert consensus statement on catheter-based left atrial appendage occlusion - an update. Europace. 2020;22(2):184.PubMedCrossRef Glikson M, Wolff R, Hindricks G, Mandrola J, Camm AJ, Lip GYH, Fauchier L, Betts TR, Lewalter T, Saw J, Tzikas A, Sternik L, Nietlispach F, Berti S, Sievert H, Bertog S, Meier B. EHRA/EAPCI expert consensus statement on catheter-based left atrial appendage occlusion - an update. Europace. 2020;22(2):184.PubMedCrossRef

go back to reference Lip GYH, Banerjee A, Boriani G, Chiang CE, Fargo R, Freedman B, Lane DA, Ruff CT, Turakhia M, Werring D, Patel S, Moores L. Antithrombotic Therapy for Atrial Fibrillation: CHEST Guideline and Expert Panel Report. Chest. 2018;154(5):1121–201.PubMedCrossRef Lip GYH, Banerjee A, Boriani G, Chiang CE, Fargo R, Freedman B, Lane DA, Ruff CT, Turakhia M, Werring D, Patel S, Moores L. Antithrombotic Therapy for Atrial Fibrillation: CHEST Guideline and Expert Panel Report. Chest. 2018;154(5):1121–201.PubMedCrossRef

go back to reference Zhan Y, Joza J, AlRawahi M, Barbosa RS, Samuel M, Bernier M, Huynh T, Thanassoulis G, Essebag V. Assessment and Management of the Left Atrial Appendage Thrombus in Patients With Nonvalvular Atrial Fibrillation. Can J Cardiol. 2018;34(3):252–61.PubMedCrossRef Zhan Y, Joza J, AlRawahi M, Barbosa RS, Samuel M, Bernier M, Huynh T, Thanassoulis G, Essebag V. Assessment and Management of the Left Atrial Appendage Thrombus in Patients With Nonvalvular Atrial Fibrillation. Can J Cardiol. 2018;34(3):252–61.PubMedCrossRef

go back to reference Bajwa RJ, Kovell L, Resar JR, Arbab-Zadeh A, Mandal K, Calkins H, Berger RD. Left atrial appendage occlusion for stroke prevention in patients with atrial fibrillation. Clin Cardiol. 2017;40(10):825–31.PubMedPubMedCentralCrossRef Bajwa RJ, Kovell L, Resar JR, Arbab-Zadeh A, Mandal K, Calkins H, Berger RD. Left atrial appendage occlusion for stroke prevention in patients with atrial fibrillation. Clin Cardiol. 2017;40(10):825–31.PubMedPubMedCentralCrossRef

go back to reference Reddy VY, Sievert H, Halperin J, Doshi SK, Buchbinder M, Neuzil P, Huber K, Whisenant B, Kar S, Swarup V, Gordon N, Holmes D. Percutaneous left atrial appendage closure vs warfarin for atrial fibrillation: a randomized clinical trial. JAMA. 2014;312(19):1988–98.PubMedCrossRef Reddy VY, Sievert H, Halperin J, Doshi SK, Buchbinder M, Neuzil P, Huber K, Whisenant B, Kar S, Swarup V, Gordon N, Holmes D. Percutaneous left atrial appendage closure vs warfarin for atrial fibrillation: a randomized clinical trial. JAMA. 2014;312(19):1988–98.PubMedCrossRef

go back to reference Holmes DR, Reddy VY, Turi ZG, Doshi SK, Sievert H, Buchbinder M, Mullin CM, Sick P. Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial. Lancet. 2009;374(9689):534–42.PubMedCrossRef Holmes DR, Reddy VY, Turi ZG, Doshi SK, Sievert H, Buchbinder M, Mullin CM, Sick P. Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial. Lancet. 2009;374(9689):534–42.PubMedCrossRef

go back to reference Holmes DR, Kar S, Price MJ, Whisenant B, Sievert H, Doshi SK, Huber K, Reddy VY. Prospective randomized evaluation of the Watchman Left Atrial Appendage Closure device in patients with atrial fibrillation versus long-term warfarin therapy: the PREVAIL trial. J Am Coll Cardiol. 2014;64(1):1–12.PubMedCrossRef Holmes DR, Kar S, Price MJ, Whisenant B, Sievert H, Doshi SK, Huber K, Reddy VY. Prospective randomized evaluation of the Watchman Left Atrial Appendage Closure device in patients with atrial fibrillation versus long-term warfarin therapy: the PREVAIL trial. J Am Coll Cardiol. 2014;64(1):1–12.PubMedCrossRef

go back to reference Osmancik P, Herman D, Neuzil P, Hala P, Taborsky M, Kala P, Poloczek M, Stasek J, Haman L, Branny M, Chovancik J, Cervinka P, Holy J, Kovarnik T, Zemanek D, Havranek S, Vancura V, Opatrny J, Peichl P, Tousek P, Lekesova V, Jarkovsky J, Novackova M, Benesova K, Widimsky P, Reddy VY. Left Atrial Appendage Closure Versus Direct Oral Anticoagulants in High-Risk Patients With Atrial Fibrillation. J Am Coll Cardiol. 2020;75(25):3122–35.PubMedCrossRef Osmancik P, Herman D, Neuzil P, Hala P, Taborsky M, Kala P, Poloczek M, Stasek J, Haman L, Branny M, Chovancik J, Cervinka P, Holy J, Kovarnik T, Zemanek D, Havranek S, Vancura V, Opatrny J, Peichl P, Tousek P, Lekesova V, Jarkovsky J, Novackova M, Benesova K, Widimsky P, Reddy VY. Left Atrial Appendage Closure Versus Direct Oral Anticoagulants in High-Risk Patients With Atrial Fibrillation. J Am Coll Cardiol. 2020;75(25):3122–35.PubMedCrossRef

go back to reference Bordignon S, Bologna F, Chen S, Konstantinou A, Tsianakas N, Tohoku S, Trolese L, Chun KJ, Schmidt B. Percutaneous left atrial appendage closure in the presence of thrombus: A feasibility report. J Cardiovasc Electrophysiol. 2019;30(12):2858–63.PubMedCrossRef Bordignon S, Bologna F, Chen S, Konstantinou A, Tsianakas N, Tohoku S, Trolese L, Chun KJ, Schmidt B. Percutaneous left atrial appendage closure in the presence of thrombus: A feasibility report. J Cardiovasc Electrophysiol. 2019;30(12):2858–63.PubMedCrossRef

go back to reference Jin L-S, Ke J-Y, Lin Y-N, Li L, Fu J-Y, Chen Y-L, Qiu Y-X, Li X-W, Pan Y-Q, Li Y-C. Percutaneous left atrial appendage closure using the LAmbre device in patients with atrial fibrillation and left atrial appendage thrombus. Front Cardiovasc Med. 2022;9:1071119.PubMedPubMedCentralCrossRef Jin L-S, Ke J-Y, Lin Y-N, Li L, Fu J-Y, Chen Y-L, Qiu Y-X, Li X-W, Pan Y-Q, Li Y-C. Percutaneous left atrial appendage closure using the LAmbre device in patients with atrial fibrillation and left atrial appendage thrombus. Front Cardiovasc Med. 2022;9:1071119.PubMedPubMedCentralCrossRef

go back to reference Sharma SP, Cheng J, Turagam MK, Gopinathannair R, Horton R, Lam YY, Tarantini G, DAmico G, Freixa Rofastes X, Lange M, Natale A, Lakkireddy DR. Feasibility of left atrial appendage occlusion in left atrial appendage thrombus a systematic review. JACC Clin Electrophysiol. 2020;6(4):414–24.PubMedCrossRef Sharma SP, Cheng J, Turagam MK, Gopinathannair R, Horton R, Lam YY, Tarantini G, DAmico G, Freixa Rofastes X, Lange M, Natale A, Lakkireddy DR. Feasibility of left atrial appendage occlusion in left atrial appendage thrombus a systematic review. JACC Clin Electrophysiol. 2020;6(4):414–24.PubMedCrossRef

go back to reference Meier B, Blaauw Y, Khattab AA, Lewalter T, Sievert H, Tondo C, Glikson M. EHRA/EAPCI expert consensus statement on catheter-based left atrial appendage occlusion. Europace. 2014;16(10):1397–416.PubMedCrossRef Meier B, Blaauw Y, Khattab AA, Lewalter T, Sievert H, Tondo C, Glikson M. EHRA/EAPCI expert consensus statement on catheter-based left atrial appendage occlusion. Europace. 2014;16(10):1397–416.PubMedCrossRef

go back to reference Wintgens LIS, Maarse M, Swaans MJ, Rensing BJWM, Van Dijk VF, Boersma LVA. The WATCHMAN left atrial appendage closure device for patients with atrial fibrillation: current status and future perspectives. Expert Rev Med Devices. 2020;17(7):615–26.PubMedCrossRef Wintgens LIS, Maarse M, Swaans MJ, Rensing BJWM, Van Dijk VF, Boersma LVA. The WATCHMAN left atrial appendage closure device for patients with atrial fibrillation: current status and future perspectives. Expert Rev Med Devices. 2020;17(7):615–26.PubMedCrossRef

go back to reference Messas N, Ibrahim R. The Amplatzer Amulet Device: Technical Considerations and Procedural Approach. Interv Cardiol Clin. 2018;7(2):213–8.PubMed Messas N, Ibrahim R. The Amplatzer Amulet Device: Technical Considerations and Procedural Approach. Interv Cardiol Clin. 2018;7(2):213–8.PubMed

go back to reference Schnupp S, Ajmi I, Brachmann J, Mahnkopf C. Lifetech LAmbre: a new promising and novel device in the interventional stroke prevention. Future Cardiol. 2019;15(6):405–10.PubMedCrossRef Schnupp S, Ajmi I, Brachmann J, Mahnkopf C. Lifetech LAmbre: a new promising and novel device in the interventional stroke prevention. Future Cardiol. 2019;15(6):405–10.PubMedCrossRef

go back to reference Marroquin L, Tirado-Conte G, Pracoń R, Streb W, Gutierrez H, Boccuzzi G, Arzamendi-Aizpurua D, Cruz-González I, Ruiz-Nodar JM, Kim JS, Freixa X, Lopez-Minguez JR, De Backer O, Ruiz-Salmeron R, Dominguez A, McInerney A, Peral V, Estevez-Loureiro R, Fernandez-Nofrerias E, Freitas-Ferraz AB, Saia F, Huczek Z, Gheorghe L, Salinas P, Demkow M, Delgado-Arana JR. Heart. 2022;108(14):1098–106.PubMedCrossRef Marroquin L, Tirado-Conte G, Pracoń R, Streb W, Gutierrez H, Boccuzzi G, Arzamendi-Aizpurua D, Cruz-González I, Ruiz-Nodar JM, Kim JS, Freixa X, Lopez-Minguez JR, De Backer O, Ruiz-Salmeron R, Dominguez A, McInerney A, Peral V, Estevez-Loureiro R, Fernandez-Nofrerias E, Freitas-Ferraz AB, Saia F, Huczek Z, Gheorghe L, Salinas P, Demkow M, Delgado-Arana JR. Heart. 2022;108(14):1098–106.PubMedCrossRef

go back to reference Beneduce A, Ancona F, Marzi A, Radinovic A, D’Angelo G, Agricola E, Della Bella P, Mazzone P. Percutaneous treatment of persistent left atrial appendage thrombus using watchman FLX no-touch implantation technique and cerebral protection system. JACC Clin Electrophysiol. 2019;5(10):1231–2.PubMedCrossRef Beneduce A, Ancona F, Marzi A, Radinovic A, D’Angelo G, Agricola E, Della Bella P, Mazzone P. Percutaneous treatment of persistent left atrial appendage thrombus using watchman FLX no-touch implantation technique and cerebral protection system. JACC Clin Electrophysiol. 2019;5(10):1231–2.PubMedCrossRef

go back to reference Lange M, Bültel H, Weglage H, Löffeld P, Wichter T. Closure of Left Atrial Appendage With Persistent Distal Thrombus using an Amplatzer Amulet Occluder. J Invasive Cardiol. 2016;28(9):E75–6.PubMed Lange M, Bültel H, Weglage H, Löffeld P, Wichter T. Closure of Left Atrial Appendage With Persistent Distal Thrombus using an Amplatzer Amulet Occluder. J Invasive Cardiol. 2016;28(9):E75–6.PubMed

go back to reference Saccà S, Ferro J, Umemoto T, Turri R, Penzo C, Pacchioni A. A New Strategy for Transcatheter Left Atrial Appendage Closure With Cerebral Embolic Protection in Patient With Left Auricular Thrombosis and Total Contraindication to Long-Term Anticoagulation. J Invasive Cardiol. 2017;29(3):E37–8.PubMed Saccà S, Ferro J, Umemoto T, Turri R, Penzo C, Pacchioni A. A New Strategy for Transcatheter Left Atrial Appendage Closure With Cerebral Embolic Protection in Patient With Left Auricular Thrombosis and Total Contraindication to Long-Term Anticoagulation. J Invasive Cardiol. 2017;29(3):E37–8.PubMed

go back to reference Jalal Z, Iriart X, Dinet M-L, Selly J-B, Tafer N, Renou P, Sibon I, Thambo J-B. Extending percutaneous left atrial appendage closure indications using the AMPLATZER™ Cardiac Plug device in patients with persistent left atrial appendage thrombus: The thrombus trapping technique. Arch Cardiovasc Dis. 2016;109(12):659–66.PubMedCrossRef Jalal Z, Iriart X, Dinet M-L, Selly J-B, Tafer N, Renou P, Sibon I, Thambo J-B. Extending percutaneous left atrial appendage closure indications using the AMPLATZER™ Cardiac Plug device in patients with persistent left atrial appendage thrombus: The thrombus trapping technique. Arch Cardiovasc Dis. 2016;109(12):659–66.PubMedCrossRef

go back to reference Lee O-H, Kim J-S, Pak H-N, Hong G-R, Shim CY, Uhm J-S, Cho I-J, Joung B, Yu C-W, Lee H-J, Kang W-C, Shin E-S, Choi R-K, Lim D-S, Jang Y. Feasibility of Left Atrial Appendage Occlusion for Left Atrial Appendage Thrombus in Patients With Persistent Atrial Fibrillation. Am J Cardiol. 2018;121(12):1534–9.PubMedCrossRef Lee O-H, Kim J-S, Pak H-N, Hong G-R, Shim CY, Uhm J-S, Cho I-J, Joung B, Yu C-W, Lee H-J, Kang W-C, Shin E-S, Choi R-K, Lim D-S, Jang Y. Feasibility of Left Atrial Appendage Occlusion for Left Atrial Appendage Thrombus in Patients With Persistent Atrial Fibrillation. Am J Cardiol. 2018;121(12):1534–9.PubMedCrossRef

go back to reference Popescu SȘ, Heeger C-H, Keelani A, Tilz RR. Percutaneous Left Atrial Appendage Closure with the LAmbre Device Protected by a Cerebral Protection System in a 76-Year-Old Man with Persistent Left Atrial Appendage Thrombus. Am J Case Rep. 2022;23:e937063.PubMedPubMedCentralCrossRef Popescu SȘ, Heeger C-H, Keelani A, Tilz RR. Percutaneous Left Atrial Appendage Closure with the LAmbre Device Protected by a Cerebral Protection System in a 76-Year-Old Man with Persistent Left Atrial Appendage Thrombus. Am J Case Rep. 2022;23:e937063.PubMedPubMedCentralCrossRef

go back to reference Tan BEX, Depta JP. Transcatheter cerebral embolic protection during WATCHMAN procedure in two patients with persistent left atrial appendage thrombus: Case report with review of the literature. Catheter Cardiovasc Interv. 2021;97(2):365–8.PubMedCrossRef Tan BEX, Depta JP. Transcatheter cerebral embolic protection during WATCHMAN procedure in two patients with persistent left atrial appendage thrombus: Case report with review of the literature. Catheter Cardiovasc Interv. 2021;97(2):365–8.PubMedCrossRef

go back to reference Tsai C-F, Huang P-S, Chiu F-C, Chen J-J, Chang S-N, Hsu J-C, Chua S-K, Cheng H-L, Wang Y-C, Hwang J-J, Tsai C-T. Bailout left atrial appendage occluder for pulmonary vein isolation and electrical cardioversion in patients with atrial fibrillation and left atrial appendage thrombus: a pilot study. Clin Res Cardiol. 2023;112(6):772–83.PubMedCrossRef Tsai C-F, Huang P-S, Chiu F-C, Chen J-J, Chang S-N, Hsu J-C, Chua S-K, Cheng H-L, Wang Y-C, Hwang J-J, Tsai C-T. Bailout left atrial appendage occluder for pulmonary vein isolation and electrical cardioversion in patients with atrial fibrillation and left atrial appendage thrombus: a pilot study. Clin Res Cardiol. 2023;112(6):772–83.PubMedCrossRef

go back to reference Bellmann B, Rillig A, Leistner DM, Kasner M, Skurk C, Landmesser U, Park J-W. Left atrial appendage closure in a patient with left atrial appendage thrombus using a novel fish ball technique. Int J Cardiol. 2017;234:146–9.PubMedCrossRef Bellmann B, Rillig A, Leistner DM, Kasner M, Skurk C, Landmesser U, Park J-W. Left atrial appendage closure in a patient with left atrial appendage thrombus using a novel fish ball technique. Int J Cardiol. 2017;234:146–9.PubMedCrossRef

go back to reference Aytemir K, Aminian A, Asil S, Canpolat U, Kaya EB, Şahiner L, Evranos B, Yorgun H, Özer N. First case of percutaneous left atrial appendage closure by amulet™ device in a patient with left atrial appendage thrombus. Int J Cardiol. 2016;223:28–30.PubMedCrossRef Aytemir K, Aminian A, Asil S, Canpolat U, Kaya EB, Şahiner L, Evranos B, Yorgun H, Özer N. First case of percutaneous left atrial appendage closure by amulet™ device in a patient with left atrial appendage thrombus. Int J Cardiol. 2016;223:28–30.PubMedCrossRef

go back to reference Dugo D, Bordignon S, Konstantinou A, Perrotta L, Fürnkranz A, Chun JKR, Schmidt B. Locked Away: Percutaneous Closure of a Malignant Left Atrial Appendage to Constrain an Unresolvable Thrombus. Circ Arrhythm Electrophysiol. 2016;9(8):e004127.PubMedCrossRef Dugo D, Bordignon S, Konstantinou A, Perrotta L, Fürnkranz A, Chun JKR, Schmidt B. Locked Away: Percutaneous Closure of a Malignant Left Atrial Appendage to Constrain an Unresolvable Thrombus. Circ Arrhythm Electrophysiol. 2016;9(8):e004127.PubMedCrossRef

go back to reference Lee O-H, Uhm J-S, Kim J-S, Cho I-J, Hong G-R, Pak H-N, Jang Y. Percutaneous isolation of left atrial appendage thrombus. J Cardiol Cases. 2017;16(3):67–9.PubMedPubMedCentralCrossRef Lee O-H, Uhm J-S, Kim J-S, Cho I-J, Hong G-R, Pak H-N, Jang Y. Percutaneous isolation of left atrial appendage thrombus. J Cardiol Cases. 2017;16(3):67–9.PubMedPubMedCentralCrossRef

go back to reference De Roeck F, Scott B, Verheye S, Vermeersch P. Percutaneous left atrial appendage occlusion in a lamin A/C gene mutation related cardiomyopathy patient with persistent left atrial appendage thrombus: a case report. Acta Cardiol. 2019;74(2):182–3.PubMedCrossRef De Roeck F, Scott B, Verheye S, Vermeersch P. Percutaneous left atrial appendage occlusion in a lamin A/C gene mutation related cardiomyopathy patient with persistent left atrial appendage thrombus: a case report. Acta Cardiol. 2019;74(2):182–3.PubMedCrossRef

go back to reference Chang D, Kapur S, Romero J, Koplan BA, Tadros TM. CE-454611–3 High risk left atrial appendage closure in patients with a persistent left atrial appendage thrombus. Heart Rhythm. 2023;20(5):S9–10.CrossRef Chang D, Kapur S, Romero J, Koplan BA, Tadros TM. CE-454611–3 High risk left atrial appendage closure in patients with a persistent left atrial appendage thrombus. Heart Rhythm. 2023;20(5):S9–10.CrossRef

go back to reference Mohandes M, Pernigotti A, Morr CI, Bardají A. Percutaneous Left Atrial Appendage Closure in the Presence of Thrombus Using LAmbre Device and Cerebral Protection System. Korean Circ J. 2020;50(3):281–3.PubMedPubMedCentralCrossRef Mohandes M, Pernigotti A, Morr CI, Bardají A. Percutaneous Left Atrial Appendage Closure in the Presence of Thrombus Using LAmbre Device and Cerebral Protection System. Korean Circ J. 2020;50(3):281–3.PubMedPubMedCentralCrossRef

go back to reference Kaczmarek K, Cygankiewicz I, Streb W, Plaksej R, Jakubowski P, Kalarus Z, Ptaszynski P, Wranicz JK, Babicz-Sadowska A, Markiewicz A, Grygier M. Percutaneous Occlusion of the Left Atrial Appendage with Thrombus Irresponsive to Antithrombotic Therapy. J Clin Med. 2021;10(4):726. https://doi.org/10.3390/jcm10040726.CrossRefPubMedPubMedCentral Kaczmarek K, Cygankiewicz I, Streb W, Plaksej R, Jakubowski P, Kalarus Z, Ptaszynski P, Wranicz JK, Babicz-Sadowska A, Markiewicz A, Grygier M. Percutaneous Occlusion of the Left Atrial Appendage with Thrombus Irresponsive to Antithrombotic Therapy. J Clin Med. 2021;10(4):726. https://​doi.​org/​10.​3390/​jcm10040726.CrossRefPubMedPubMedCentral

go back to reference Marcon L, Sicuso R, Galli S, Majocchi B, Carbucicchio C, Tondo C, Fassini GM. TriGuard Embolic Protection Device in percutaneous cardiac interventions with intracavitary cardiac thrombosis: A case series. Pacing Clin Electrophysiol. 2024;47(1):106–12. https://doi.org/10.1111/pace.14712.CrossRefPubMed Marcon L, Sicuso R, Galli S, Majocchi B, Carbucicchio C, Tondo C, Fassini GM. TriGuard Embolic Protection Device in percutaneous cardiac interventions with intracavitary cardiac thrombosis: A case series. Pacing Clin Electrophysiol. 2024;47(1):106–12. https://​doi.​org/​10.​1111/​pace.​14712.CrossRefPubMed

go back to reference CruzGonzalez I, Fuertes M, Barahona, MorenoSamos JC, Barreiro-Perez M, Rodríguez-Collado J, Gonzalez-Calle D, Sanchez PL. Left Atrial appendage occlusion in the presence of Thrombus With a LAmbre device. JACC Cardiovasc Interv. 2017;10(21):2224–6.PubMedCrossRef CruzGonzalez I, Fuertes M, Barahona, MorenoSamos JC, Barreiro-Perez M, Rodríguez-Collado J, Gonzalez-Calle D, Sanchez PL. Left Atrial appendage occlusion in the presence of Thrombus With a LAmbre device. JACC Cardiovasc Interv. 2017;10(21):2224–6.PubMedCrossRef

go back to reference Cammalleri V, Ussia GP, Muscoli S, De Vico P, Romeo F. Transcatheter occlusion of left atrial appendage with persistent thrombus using a trans-radial embolic protection device. J Cardiovasc Med (Hagerstown). 2016;17(Suppl 2):e224.PubMedCrossRef Cammalleri V, Ussia GP, Muscoli S, De Vico P, Romeo F. Transcatheter occlusion of left atrial appendage with persistent thrombus using a trans-radial embolic protection device. J Cardiovasc Med (Hagerstown). 2016;17(Suppl 2):e224.PubMedCrossRef

go back to reference Pak H-N, Shim C-Y, Kim JS, Park J-W, Jang Y. Self-expandable device for percutaneous closing of left atrial appendage with organized thrombus in a patient with permanent atrial fibrillation. Can J Cardiol. 2013;29(10):1329.e1-1329.e3.PubMedCrossRef Pak H-N, Shim C-Y, Kim JS, Park J-W, Jang Y. Self-expandable device for percutaneous closing of left atrial appendage with organized thrombus in a patient with permanent atrial fibrillation. Can J Cardiol. 2013;29(10):1329.e1-1329.e3.PubMedCrossRef

go back to reference Yadav PK, Wang DD, Eng MH, O’Neill WW. Watchman in ascending aorta for systemic protection (WAASP): Novel use of Watchman in ascending aorta for embolic protection-first in man. Catheter Cardiovasc Interv. 2018;92(2):433–6.PubMedCrossRef Yadav PK, Wang DD, Eng MH, O’Neill WW. Watchman in ascending aorta for systemic protection (WAASP): Novel use of Watchman in ascending aorta for embolic protection-first in man. Catheter Cardiovasc Interv. 2018;92(2):433–6.PubMedCrossRef

go back to reference Martins JL, Paiva L, Costa M, Gonçalves L. Thrombus in left atrial appendage - Overcoming percutaneous closure limitations. Rev Port Cardiol (Engl Ed). 2018;37(3):269–70.PubMedCrossRef Martins JL, Paiva L, Costa M, Gonçalves L. Thrombus in left atrial appendage - Overcoming percutaneous closure limitations. Rev Port Cardiol (Engl Ed). 2018;37(3):269–70.PubMedCrossRef

go back to reference Del Furia F, Ancona MB, Giannini F, Jabbour RJ, Regazzoli D, Mangieri A, Latib A, Colombo A, Montorfano M. First-in-man Percutaneous LAA Closure With an Amplatzer Amulet and TriGuard Embolic Protection Device in a Patient With LAA Thrombus. J Invasive Cardiol. 2017;29(4):E51–2.PubMed Del Furia F, Ancona MB, Giannini F, Jabbour RJ, Regazzoli D, Mangieri A, Latib A, Colombo A, Montorfano M. First-in-man Percutaneous LAA Closure With an Amplatzer Amulet and TriGuard Embolic Protection Device in a Patient With LAA Thrombus. J Invasive Cardiol. 2017;29(4):E51–2.PubMed

go back to reference Warden BA, Diep C, Ran R, Thomas M, Cigarroa JE. The effect of heparin infusion intensity on outcomes for bridging hospitalized patients with atrial fibrillation. Clin Cardiol. 2019;42(10):995–1002.PubMedPubMedCentralCrossRef Warden BA, Diep C, Ran R, Thomas M, Cigarroa JE. The effect of heparin infusion intensity on outcomes for bridging hospitalized patients with atrial fibrillation. Clin Cardiol. 2019;42(10):995–1002.PubMedPubMedCentralCrossRef

go back to reference Tsao CW, Aday AW, Almarzooq ZI, Anderson CAM, Arora P, Avery CL, Baker-Smith CM, Beaton AZ, Boehme AK, Buxton AE, Commodore-Mensah Y, Elkind MSV, Evenson KR, Eze-Nliam C, Fugar S, Generoso G, Heard DG, Hiremath S, Ho JE, Kalani R, Kazi DS, Ko D, Levine DA, Liu J, Ma J, Magnani JW, Michos ED, Mussolino ME, Navaneethan SD, Parikh NI, Poudel R, Rezk-Hanna M, Roth GA, Shah NS, St-Onge M-P, Thacker EL, Virani SS, Voeks JH, Wang N-Y, Wong ND, Wong SS, Yaffe K, Martin SS. Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association. Circulation. 2023;147(8):e93–621.PubMedCrossRef Tsao CW, Aday AW, Almarzooq ZI, Anderson CAM, Arora P, Avery CL, Baker-Smith CM, Beaton AZ, Boehme AK, Buxton AE, Commodore-Mensah Y, Elkind MSV, Evenson KR, Eze-Nliam C, Fugar S, Generoso G, Heard DG, Hiremath S, Ho JE, Kalani R, Kazi DS, Ko D, Levine DA, Liu J, Ma J, Magnani JW, Michos ED, Mussolino ME, Navaneethan SD, Parikh NI, Poudel R, Rezk-Hanna M, Roth GA, Shah NS, St-Onge M-P, Thacker EL, Virani SS, Voeks JH, Wang N-Y, Wong ND, Wong SS, Yaffe K, Martin SS. Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association. Circulation. 2023;147(8):e93–621.PubMedCrossRef

go back to reference Ghaffarpasand E, Tehrani MD, Marszalek J, Chi G. Non-vitamin K antagonist oral anticoagulants for the treatment of intracardiac thrombosis. J Thromb Thrombolysis. 2018;46(3):332–8.PubMedCrossRef Ghaffarpasand E, Tehrani MD, Marszalek J, Chi G. Non-vitamin K antagonist oral anticoagulants for the treatment of intracardiac thrombosis. J Thromb Thrombolysis. 2018;46(3):332–8.PubMedCrossRef

go back to reference Nelles D, Lambers M, Schafigh M, Morais P, Schueler R, Vij V, Tiyerili V, Weber M, Schrickel JW, Nickenig G, Hammerstingl C, Sedaghat A. Clinical outcomes and thrombus resolution in patients with solid left atrial appendage thrombi: results of a single-center real-world registry. Clin Res Cardiol. 2021;110(1):72–83.PubMedCrossRef Nelles D, Lambers M, Schafigh M, Morais P, Schueler R, Vij V, Tiyerili V, Weber M, Schrickel JW, Nickenig G, Hammerstingl C, Sedaghat A. Clinical outcomes and thrombus resolution in patients with solid left atrial appendage thrombi: results of a single-center real-world registry. Clin Res Cardiol. 2021;110(1):72–83.PubMedCrossRef

go back to reference Haussig S, Mangner N, Dwyer MG, Lehmkuhl L, Lücke C, Woitek F, Holzhey DM, Mohr FW, Gutberlet M, Zivadinov R, Schuler G, Linke A. Effect of a Cerebral Protection Device on Brain Lesions Following Transcatheter Aortic Valve Implantation in Patients With Severe Aortic Stenosis: The CLEAN-TAVI Randomized Clinical Trial. JAMA. 2016;316(6):592–601.PubMedCrossRef Haussig S, Mangner N, Dwyer MG, Lehmkuhl L, Lücke C, Woitek F, Holzhey DM, Mohr FW, Gutberlet M, Zivadinov R, Schuler G, Linke A. Effect of a Cerebral Protection Device on Brain Lesions Following Transcatheter Aortic Valve Implantation in Patients With Severe Aortic Stenosis: The CLEAN-TAVI Randomized Clinical Trial. JAMA. 2016;316(6):592–601.PubMedCrossRef

go back to reference Kapadia SR, Makkar R, Leon M, Abdel-Wahab M, Waggoner T, Massberg S, Rottbauer W, Horr S, Sondergaard L, Karha J, Gooley R, Satler L, Stoler RC, Messé SR, Baron SJ, Seeger J, Kodali S, Krishnaswamy A, Thourani VH, Harrington K, Pocock S, Modolo R, Allocco DJ, Meredith IT, Linke A. Cerebral Embolic Protection during Transcatheter Aortic-Valve Replacement. N Engl J Med. 2022;387(14):1253–63.PubMedCrossRef Kapadia SR, Makkar R, Leon M, Abdel-Wahab M, Waggoner T, Massberg S, Rottbauer W, Horr S, Sondergaard L, Karha J, Gooley R, Satler L, Stoler RC, Messé SR, Baron SJ, Seeger J, Kodali S, Krishnaswamy A, Thourani VH, Harrington K, Pocock S, Modolo R, Allocco DJ, Meredith IT, Linke A. Cerebral Embolic Protection during Transcatheter Aortic-Valve Replacement. N Engl J Med. 2022;387(14):1253–63.PubMedCrossRef

go back to reference Limite LR, Radinovic A, Cianfanelli L, Altizio S, Peretto G, Frontera A, D’Angelo G, Baratto F, Marzi A, Ancona F, Ingallina G, Capogrosso C, Stella S, Melillo F, Agricola E, Della Bella P, Mazzone P. Outcome of left atrial appendage closure using cerebral protection system for thrombosis: no patient left behind. Pacing Clin Electrophysiol. 2022;45(1):23–34.PubMedCrossRef Limite LR, Radinovic A, Cianfanelli L, Altizio S, Peretto G, Frontera A, D’Angelo G, Baratto F, Marzi A, Ancona F, Ingallina G, Capogrosso C, Stella S, Melillo F, Agricola E, Della Bella P, Mazzone P. Outcome of left atrial appendage closure using cerebral protection system for thrombosis: no patient left behind. Pacing Clin Electrophysiol. 2022;45(1):23–34.PubMedCrossRef

go back to reference Boccuzzi GG, Montabone A, D’Ascenzo F, Colombo F, Ugo F, Muraglia S, De Backer O, Nombela-Franco L, Meincke F, Mazzone P. Cerebral protection in left atrial appendage closure in the presence of appendage thrombosis. Catheter Cardiovasc Interv. 2021;97(3):511–5.PubMedCrossRef Boccuzzi GG, Montabone A, D’Ascenzo F, Colombo F, Ugo F, Muraglia S, De Backer O, Nombela-Franco L, Meincke F, Mazzone P. Cerebral protection in left atrial appendage closure in the presence of appendage thrombosis. Catheter Cardiovasc Interv. 2021;97(3):511–5.PubMedCrossRef

go back to reference Fuster V, Rydén LE, Cannom DS, Crijns HJ, Curtis AB, Ellenbogen KA, Halperin JL, Kay GN, Le Huezey J-Y, Lowe JE, Olsson SB, Prystowsky EN, Tamargo JL, Wann LS. 2011 ACCF/AHA/HRS focused updates incorporated into the ACC/AHA/ESC 2006 Guidelines for the management of patients with atrial fibrillation: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines developed in partnership with the European Society of Cardiology and in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. J Am Coll Cardiol. 2011;57(11):e101–98.PubMedCrossRef Fuster V, Rydén LE, Cannom DS, Crijns HJ, Curtis AB, Ellenbogen KA, Halperin JL, Kay GN, Le Huezey J-Y, Lowe JE, Olsson SB, Prystowsky EN, Tamargo JL, Wann LS. 2011 ACCF/AHA/HRS focused updates incorporated into the ACC/AHA/ESC 2006 Guidelines for the management of patients with atrial fibrillation: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines developed in partnership with the European Society of Cardiology and in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. J Am Coll Cardiol. 2011;57(11):e101–98.PubMedCrossRef

go back to reference Hwang JJ, Chen JJ, Lin SC, Tseng YZ, Kuan P, Lien WP, Lin FY, Chu SH, Hung CR, How SW. Diagnostic accuracy of transesophageal echocardiography for detecting left atrial thrombi in patients with rheumatic heart disease having undergone mitral valve operations. Am J Cardiol. 1993;72(9):677–81.PubMedCrossRef Hwang JJ, Chen JJ, Lin SC, Tseng YZ, Kuan P, Lien WP, Lin FY, Chu SH, Hung CR, How SW. Diagnostic accuracy of transesophageal echocardiography for detecting left atrial thrombi in patients with rheumatic heart disease having undergone mitral valve operations. Am J Cardiol. 1993;72(9):677–81.PubMedCrossRef

go back to reference Li J, Li Q, Alqahtany FS, Algahtani FH, Kim HJ, Li Y, Ock Kim Y. Evaluating the novel parameters for assessing the LAA function and thrombus formation with nonvalvular atrial fibrillation. Saudi J Biol Sci. 2021;28(1):560–5.PubMedCrossRef Li J, Li Q, Alqahtany FS, Algahtani FH, Kim HJ, Li Y, Ock Kim Y. Evaluating the novel parameters for assessing the LAA function and thrombus formation with nonvalvular atrial fibrillation. Saudi J Biol Sci. 2021;28(1):560–5.PubMedCrossRef

go back to reference Romero J, Cao JJ, Garcia MJ, Taub CC. Cardiac imaging for assessment of left atrial appendage stasis and thrombosis. Nat Rev Cardiol. 2014;11(8):470–80.PubMedCrossRef Romero J, Cao JJ, Garcia MJ, Taub CC. Cardiac imaging for assessment of left atrial appendage stasis and thrombosis. Nat Rev Cardiol. 2014;11(8):470–80.PubMedCrossRef

go back to reference Baran J, Stec S, Pilichowska-Paszkiet E, Zaborska B, Sikora-Frąc M, Kryński T, Michałowska I, Łopatka R, Kułakowski P. Intracardiac echocardiography for detection of thrombus in the left atrial appendage: comparison with transesophageal echocardiography in patients undergoing ablation for atrial fibrillation: the Action-Ice I Study. Circ Arrhythm Electrophysiol. 2013;6(6):1074–81.PubMedCrossRef Baran J, Stec S, Pilichowska-Paszkiet E, Zaborska B, Sikora-Frąc M, Kryński T, Michałowska I, Łopatka R, Kułakowski P. Intracardiac echocardiography for detection of thrombus in the left atrial appendage: comparison with transesophageal echocardiography in patients undergoing ablation for atrial fibrillation: the Action-Ice I Study. Circ Arrhythm Electrophysiol. 2013;6(6):1074–81.PubMedCrossRef

go back to reference Nielsen-Kudsk JE, Berti S, Caprioglio F, Ronco F, Arzamendi D, Betts T, Tondo C, Christen T, Allocco DJ. Intracardiac Echocardiography to Guide Watchman FLX Implantation: The ICE LAA Study. JACC Cardiovasc Interv. 2023;16(6):643–51.PubMedCrossRef Nielsen-Kudsk JE, Berti S, Caprioglio F, Ronco F, Arzamendi D, Betts T, Tondo C, Christen T, Allocco DJ. Intracardiac Echocardiography to Guide Watchman FLX Implantation: The ICE LAA Study. JACC Cardiovasc Interv. 2023;16(6):643–51.PubMedCrossRef

go back to reference Hutchinson MD, Jacobson JT, Michele JJ, Silvestry FE, Callans DJ. A comparison of intracardiac and transesophageal echocardiography to detect left atrial appendage thrombus in a swine model. J Interv Card Electrophysiol. 2010;27(1):3–7.PubMedCrossRef Hutchinson MD, Jacobson JT, Michele JJ, Silvestry FE, Callans DJ. A comparison of intracardiac and transesophageal echocardiography to detect left atrial appendage thrombus in a swine model. J Interv Card Electrophysiol. 2010;27(1):3–7.PubMedCrossRef

go back to reference Saksena S, Sra J, Jordaens L, Kusumoto F, Knight B, Natale A, Kocheril A, Nanda NC, Nagarakanti R, Simon AM, Viggiano MA, Lokhandwala T, Chandler ML. A prospective comparison of cardiac imaging using intracardiac echocardiography with transesophageal echocardiography in patients with atrial fibrillation: the intracardiac echocardiography guided cardioversion helps interventional procedures study. Circ Arrhythm Electrophysiol. 2010;3(6):571–7.PubMedCrossRef Saksena S, Sra J, Jordaens L, Kusumoto F, Knight B, Natale A, Kocheril A, Nanda NC, Nagarakanti R, Simon AM, Viggiano MA, Lokhandwala T, Chandler ML. A prospective comparison of cardiac imaging using intracardiac echocardiography with transesophageal echocardiography in patients with atrial fibrillation: the intracardiac echocardiography guided cardioversion helps interventional procedures study. Circ Arrhythm Electrophysiol. 2010;3(6):571–7.PubMedCrossRef