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TNF-Inhibitors 

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  1. Open Access 18-04-2024 | Rheumatoid Arthritis | Online First

    A Machine Learning Approach for Prediction of CDAI Remission with TNF Inhibitors: A Concept of Precision Medicine from the FIRST Registry

    Advances in molecularly targeted anti-rheumatic therapies have revolutionized the management of rheumatoid arthritis (RA) over the past decades. The development of biologic disease-modifying anti-rheumatic drugs (bDMARDs) and targeted synthetic …

  2. 31-01-2024 | TNF-Inhibitors | Online First

    “Long-term MRI findings in Ankylosing spondylitis patients treated with TNF inhibitors for a decade”

    Ankylosing spondylitis (AS) is an inflammatory rheumatic disease that predominantly impacts the axial skeleton, including the sacroiliac joints (SIJ) and the spine [ 1 ]. The disease is more frequently found in populations with a higher prevalence …

  3. 20-11-2023 | Celecoxib | OriginalPaper

    Synthesis, molecular docking, analgesic, anti-inflammatory, and ulcerogenic evaluation of thiophene-pyrazole candidates as COX, 5-LOX, and TNFinhibitors

    The thiophene bearing pyrazole derivatives (7a-j) were synthesized and examined for their in vitro cyclooxygenase, 5-lipoxygenase, and tumour inducing factor-α inhibitory activities followed by the in vivo analgesic, anti-inflammatory, and …

  4. Open Access 31-01-2024 | Etanercept | OriginalPaper

    Forty-Eight-Month Monitoring of Disease Activity in Patients with Long-Standing Rheumatoid Arthritis Treated with TNFInhibitors: Time for Clinical Outcome Prediction and Biosimilar vs Biologic Originator Performance

    Tumor necrosis factor-α (TNF-α) is expressed as a proinflammatory and immunomodulatory transmembrane cytokine by macrophages, CD4(+) T cells, mast cells, neutrophils, and natural killer cells. The binding of TNF-α with its receptors increases the …

  5. Open Access 01-12-2023 | Shingles | OriginalPaper

    Comparative risk of infections between JAK inhibitors versus TNF inhibitors among patients with rheumatoid arthritis: a cohort study

    Rheumatoid arthritis (RA) is a systemic inflammatory disease in which synovial joints are the primary target of autoimmunity [ 1 ]. However, chronic inflammation causes not only the joint failure but also a wide spectrum of comorbidities [ 2 ].

  6. Open Access 12-12-2022 | Etanercept | ReviewPaper

    Psoriatic arthritis: review of potential biomarkers predicting response to TNF inhibitors

    Psoriatic arthritis (PsA) is a chronic and painful inflammatory immune-mediated disease. It affects up to 40% of people with psoriasis and it is associated with several comorbidities such as obesity, diabetes, metabolic syndrome, and hypertension.

  7. Open Access 30-08-2023 | Ankylosing Spondylitis | OriginalPaper

    Treatment of ankylosing spondylitis with TNFα inhibitors does not affect serum levels of tryptophan metabolites

    The imbalance between the kynurenine and serotonin pathways can have serious consequences, e.g., depression. One of the factors leading to the imbalance between the pathways of tryptophan metabolism is inflammation. The aim of our study was to …

  8. 01-02-2022 | Hepatitis B | News

    TNFinhibitors increase risk of HBV reactivation if HBsAg-positive

  9. 01-02-2022 | Shingles | News

    Tofacitinib increases risk of MACE and cancer versus TNF inhibitors

  10. 29-04-2023 | Rheumatoid Arthritis | OriginalPaper

    Association between SYVN1 and SEL1 genetic polymorphisms and remission in rheumatoid arthritis patients treated with TNFinhibitors: a machine learning approach

    Rheumatoid arthritis (RA) is a severe chronic inflammatory condition that affects joint synovium. Suppressor/enhancer of lin-12-like (SEL1L)–Synoviolin 1 (SYVN1)-mediated endoplasmic reticulum–associated degradation (ERAD) is highly associated …

  11. 01-07-2023 | Etanercept | News

    Switching TNFinhibitors causes AEs and symptoms related to underlying disease

  12. 01-04-2022 | Netherton Syndrome | OriginalPaper

    Cocktails of KLK5 Protease Inhibitors and Anti-TNFα Therapeutics: an Effective Treatment for Netherton Syndrome

    Netherton syndrome (NS) is a rare, severe type of ichthyosis, often lethal in neonates, for which there is no therapy. Spink5−/− mice recapitulate major NS hallmarks and die homogeneously within 5 h from birth due to severe epidermal barrier …

  13. 01-12-2021 | Etanercept

    Differential impacts of TNFα inhibitors on the transcriptome of Th cells

    TNFα inhibitors (TNFis) have emerged as one of the most effective classes of drugs for inflammatory arthritis, including rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. Thus far, there are five commonly used TNFis [ 1 ] …

  14. 01-12-2021 | Methotrexate

    Switching from TNFα inhibitor to tacrolimus as maintenance therapy in rheumatoid arthritis after achieving low disease activity with TNFα inhibitors and methotrexate: 24-week result from a non-randomized, prospective, active-controlled trial

    Rheumatoid arthritis (RA) is an autoimmune disease with progressive joint damage and deformities, eventually resulting in functional disability [ 1 ]. Due to early diagnosis, treat-to-target strategies, and effective disease-modifying …

  15. 10-03-2022 | Etanercept | OriginalPaper

    Differential efficacy of TNF inhibitors with or without the immunoglobulin fragment crystallizable (Fc) portion in rheumatoid arthritis: the ANSWER cohort study

    Rheumatoid factor (RF) binds to the fragment crystallizable (Fc) portion of immunoglobulin. It could bind to the Fc portion of anti-TNF inhibitors (TNFi) and attenuate the clinical efficacy. We tried to determine whether the therapeutic efficacy …

  16. Open Access 01-12-2021 | Etanercept | OriginalPaper

    Biologic TNFinhibitors reduce microgliosis, neuronal loss, and tau phosphorylation in a transgenic mouse model of tauopathy

    Alzheimer’s disease (AD) is a progressive neurodegenerative disease that was first discovered in 1906 by the German clinical psychiatrist and neuroanatomist, Aloïs Alzheimer [ 1 ]. The neuropathological alterations reported by Alzheimer in 1906 …

  17. Open Access 09-06-2023 | TNF-Inhibitors | OriginalPaper

    Hematologic Malignancy Risk in Inflammatory Arthritis Patients Treated with TNF Inhibitors: The Real-Life Data from the HUR-BIO Registry

    Tumor necrosis factor (TNF, cachectin, TNF-α) is a proinflammatory master cytokine with a large variety of biological activities: it modulates the production of inflammatory mediators, cell proliferation, cytotoxicity, and immune regulation [ 1 ].

  18. 01-04-2021 | Lymphoma | News

    TNF-alpha inhibitors: potential risk of mycosis fungoides

  19. Open Access 01-12-2023 | Etanercept | OriginalPaper

    Efficacy and safety of TNF inhibitors in the treatment of juvenile idiopathic arthritis: a systematic literature review

    Juvenile idiopathic arthritis (JIA), the most common rheumatic disease observed in children, has been defined as “arthritis of unknown etiology that begins before the 16th birthday and persists for at least 6 weeks” by the International League of …

  20. 06-07-2021 | Isoniazid | OriginalPaper

    Screening for latent tuberculosis before starting TNF-alpha inhibitors in a population with high BCG vaccination rates

    It is assumed that in candidates for TNF-alpha inhibitor (TNFi) treatment, tuberculin skin test (TST) may be unreliable, since BCG vaccination causes false positive and drugs cause false negative results, favoring the use of Quantiferon or T-spot …

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