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354 search results for:

Roflumilast 

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  1. 14-03-2024 | Roflumilast | OriginalPaper

    The PDE4 Inhibitors Roflumilast and Rolipram Rescue ADO2 Osteoclast Resorption Dysfunction

    Autosomal Dominant Osteopetrosis type II (ADO2) is a rare bone disease of impaired osteoclastic bone resorption caused by heterozygous missense mutations in the chloride channel 7 (CLCN7). Adenylate cyclase, which catalyzes the formation of cAMP …

  2. 01-02-2024 | Roflumilast | OriginalPaper

    Effect of Roflumilast, a Selective PDE4 Inhibitor, on Bone Phenotypes in ADO2 Mice

    Autosomal Dominant Osteopetrosis type II (ADO2) is a rare bone disease of impaired osteoclastic bone resorption that usually results from heterozygous missense mutations in the chloride channel 7 (CLCN7) gene. We previously created mouse models of …

  3. Open Access 04-08-2023 | Roflumilast | OriginalPaper

    PI3K/AKT signaling activation by roflumilast ameliorates rotenone-induced Parkinson’s disease in rats

    Parkinson’s disease (PD) is the second most common progressive age-related neurodegenerative disorder. Paramount evidence shed light on the role of PI3K/AKT signaling activation in the treatment of neurodegenerative disorders. PI3K/AKT signaling …

  4. Open Access 01-12-2024 | Roflumilast | OriginalPaper

    A proof of concept phase II study with the PDE-4 inhibitor roflumilast in patients with mild cognitive impairment or mild Alzheimer’s disease dementia (ROMEMA): study protocol of a double-blind, randomized, placebo-controlled, between-subjects trial

    Note: the numbers in curly brackets in this protocol refer to the SPIRIT checklist item numbers. The order of the items has been modified to group similar items (see …

  5. 16-03-2023 | Roflumilast | OriginalPaper

    Blood–Brain Barrier Rescue by Roflumilast After Transient Global Cerebral Ischemia in Rats

    Phosphodiesterase 4 inhibitors (PDE4-I), which selectively increase cyclic adenosine monophosphate (cAMP) levels, have shown neuroprotective effects after several neurological injuries inducing blood–brain barrier (BBB) damage including …

  6. 01-04-2022 | Roflumilast | OriginalPaper

    Roflumilast Reduces Pathological Symptoms of Sporadic Alzheimer’s Disease in Rats Produced by Intracerebroventricular Streptozotocin by Inhibiting NF-κB/BACE-1 Mediated Aβ Production in the Hippocampus and Activating the cAMP/BDNF Signalling Pathway

    Alzheimer’s disease (AD) is a neurological disease that gradually causes memory loss and cognitive impairment. The intracellular secondary messenger cyclic nucleotide cAMP helps in memory acquisition and consolidation. In several models of AD …

  7. 15-10-2022 | Subarachnoid Hemorrhage | Erratum

    Author Correction: Roflumilast Reduces Cerebral Inflammation in a Rat Model of Experimental Subarachnoid Hemorrhage

  8. Open Access 24-11-2022 | Plaque Psoriasis | OriginalPaper

    Pharmacokinetics of Roflumilast Cream in Chronic Plaque Psoriasis: Data from Phase I to Phase III Studies

    Psoriasis is a chronic, inflammatory, dermatologic condition that negatively impacts quality of life [ 1 ]. In patients with psoriasis receiving prescription medication for management of their disease, the vast majority receive topical treatment [ …

  9. Open Access 12-11-2022 | Plaque Psoriasis | OriginalPaper

    Effect of Roflumilast Cream (ARQ-151) on Itch and Itch-Related Sleep Loss in Adults with Chronic Plaque Psoriasis: Patient-Reported Itch Outcomes of a Phase 2b Trial

    Itch is an especially common and important symptom of psoriasis [ 1 – 3 ]. Between 60 to 90% of patients with psoriasis report pruritus, and many identify itch as their most troublesome symptom [ 1 , 2 , 4 – 9 ]. Although usually limited to …

  10. 01-12-2020 | Osteoarthrosis | OriginalPaper

    Roflumilast prevents lymphotoxin α (TNF-β)-induced inflammation activation and degradation of type 2 collagen in chondrocytes

    Osteoarthritis (OA), is an inflammatory disease widely diagnosed in the elderly population. In the USA, the age of OA patients is mostly over 60. Overall, 10% of males and 13% of females in America are diagnosed with OA [ 1 , 2 ]. The physiological …

  11. 01-12-2018 | News

    Roflumilast

    Headache, insomnia and tremor: 3 case reports
  12. 01-06-2017 | OriginalPaper

    Pharmacokinetics of Roflumilast and Its Active Metabolite Roflumilast N-Oxide in Healthy Chinese Subjects After Single and Multiple Oral Doses

    Chronic obstructive pulmonary disease (COPD), the fourth leading cause of death in the world, presents an important public health challenge [ 1 ]. The burden of COPD on Asian countries is estimated to be several folds higher than it is on Western …

  13. 01-12-2016 | News

    Roflumilast

    Pancreatitis: case report
  14. 01-04-2021 | Huntington's Disease

    Neuroprotective effects of roflumilast against quinolinic acid-induced rat model of Huntington’s disease through inhibition of NF-κB mediated neuroinflammatory markers and activation of cAMP/CREB/BDNF signaling pathway

    Huntington’s disease (HD) is a progressive neurodegenerative and hyperkinetic movement disorder. Decreased activity of cAMP-responsive element-binding protein (CREB) is thought to contribute to the death of striatal medium spiny neurons in HD. The …

  15. 01-09-2016 | News

    Roflumilast

    Diarrhoea and weight loss: 2 case reports
  16. 01-11-2015 | News

    Roflumilast

    Headache: case report
  17. 01-09-2015 | OriginalPaper

    Roflumilast: A Review in COPD

    Roflumilast (Daliresp®, Daxas®) is a selective phosphodiesterase 4 (PDE4) inhibitor that decreases systemic and pulmonary inflammation and improves disease symptoms in patients with severe chronic obstructive pulmonary disease (COPD). This article …

  18. 01-08-2017 | OriginalPaper

    Evaluation of In Vitro Cytochrome P450 Inhibition and In Vitro Fate of Structurally Diverse N-Oxide Metabolites: Case Studies with Clozapine, Levofloxacin, Roflumilast, Voriconazole and Zopiclone

    Clinical drug–drug interaction (DDI) studies are the corner stone of drug development to ensure potential risks of the cytochrome P450 (CYP)-mediated inhibition of metabolic pathways are adequately assessed for appropriate dosing decisions on the …

  19. 01-08-2010 | OriginalPaper

    Roflumilast

    In Chronic Obstructive Pulmonary Disease

    Roflumilast is an orally administered, selective phosphodiesterase 4 inhibitor that is a novel treatment for patients with severe chronic obstructive pulmonary disease (COPD).Across four randomized, double-blind, multinational trials in patients …

  20. 01-05-2004 | OriginalPaper

    Roflumilast

    APTA 2217, B9302-107, BY 217, BYK 20869

    Roflumilast [ APTA 2217, B9302-107, BY 217, BYK 20869 ] is a selective phosphodiesterase IV inhibitor. It is being developed by Altana Pharma (formerly Byk Gulden), a subsidiary of Altana Group, as an orally administered therapy for asthma, chronic …

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