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River Blindness 

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  1. 01-02-2003 | OriginalPaper

    Immunopathogenesis of Onchocerca volvulus keratitis (river blindness): a novel role for endosymbiotic Wolbachia bacteria

    River blindness is thought to occur as a result of the host response to degenerating microfilariae in the eye. Utilizing a murine model of corneal inflammation (keratitis) to investigate the immune and inflammatory responses associated with river

  2. 01-06-2004 | OriginalPaper

    Control of River Blindness in West Africa: Case History of Biodiversity in a Disease Control Program

    The elimination of river blindness (onchocerciasis) in West Africa has been one of the most successful public health and economic development programs yet conducted. Control was based on aerial application of insecticides to control the aquatic …

  3. Open Access 01-12-2012 | ReviewPaper

    Empowering communities in combating river blindness and the role of NGOs: case studies from Cameroon, Mali, Nigeria, and Uganda

    The control of onchocerciasis is not only a major success story in global health, but also one of the best examples of the power of public-private partnership at the international level as well as at the national level. The onchocerciasis story is …

  4. Open Access 01-12-2023 | River Blindness | OriginalPaper

    Disease perception, impacts and coping strategies for onchocerciasis in Southeast Nigeria: a qualitative study among patients and program managers

    Onchocerciasis is a chronic and debilitating vector-borne disease caused by a filarial nematode worm, onchocerca volvulus [ 1 ]. It is also called river blindness because the vector, the black fly which transmits the parasite by biting human beings …

  5. Open Access 01-12-2024 | River Blindness | OriginalPaper

    The effects of selected neglected tropical diseases on economic performance at the macrolevel in Africa

    Neglected tropical diseases (NTDs) are a group of poverty diseases that affect over 1 billion people in the world [ 1 ]. In Africa, leprosy, lymphatic filariasis (LF), schistosomiasis and onchocerciasis are some of the common NTDs. For leprosy, if …

  6. Open Access 01-12-2024 | River Blindness | OriginalPaper

    Association of haemato-biochemical indices and blood composite ratios with microfilaridermia in Onchocerciasis patients

    Onchocerciasis, a chronic helminth infection, is one of the leading causes of morbidity and mortality worldwide [ 1 , 2 ]. The infection is caused by a filarial nematode Onchocerca volvulus and transmitted by blackfly vectors [ 3 ]. In humans …

  7. Open Access 01-12-2022 | River Blindness | OriginalPaper

    Persistence of onchocerciasis in villages in Enugu and Ogun states in Nigeria following many rounds of mass distribution of ivermectin

    Onchocerciasis (also known as river blindness) is one of the neglected tropical diseases (NTDs) targeted by the World Health Organization (WHO) for elimination as a public health problem by 2030 [ 1 ]. The disease is caused by the filarial nematode …Onchocerca volvulus,

  8. Open Access 01-12-2024 | Glaucoma | OriginalPaper

    Knowledge about glaucoma among adults in Africa: a systematic review

    Glaucoma is a chronic, progressive, degenerative optic nerve disorder causing vision loss and blindness. Early detection and treatment are crucial for controlling and preventing glaucoma-induced blindness. Good knowledge of glaucoma screening is a …

  9. 18-05-2024 | Uveitis | Online First

    RBPJ Knockdown Promotes M2 Macrophage Polarization Through Mitochondrial ROS-mediated Notch1-Jagged1-Hes1 Signaling Pathway in Uveitis

    Uveitis is an autoimmune eye disease that can be involved in the entire body and is one of the leading causes of blindness. Therefore, comprehending the mechanisms underlying the development and regulation of ocular immune responses in uveitis is …

  10. Differential susceptibility of Onchocerca volvulus microfilaria to ivermectin in two areas of contrasting history of mass drug administration in Cameroon: relevance of microscopy and molecular techniques for the monitoring of skin microfilarial repopulation within six months of direct observed treatment

    Onchocerciasis (river blindness) is a disease caused by infection with the filarial nematode Onchocerca volvulus and transmitted by female blackflies of the genus Simulium . It is one of the neglected tropical diseases with an estimated 21 million …

  11. 01-12-2020 | River Blindness

    Status of parasitological indicators and morbidity burden of onchocerciasis after years of successive implementation of mass distribution of ivermectin in selected communities of Yeki and Asosa districts, Ethiopia

    Human onchocerciasis (river blindness), caused by the filarial nematode Onchocerca volvulus , is a vector-borne parasitic disease of public health and socio-economic concern in the sub-Sahara Africa. It is transmitted by the bite of infected …

  12. Open Access 01-12-2023 | River Blindness | OriginalPaper

    Successful management of poisoning with ivermectin (Mectizan) in the Obala health district (Centre Region, Cameroon): a case report

    Ivermectin is a macrocyclic lactone produced by the actinomycete Streptomyces avermitilis [ 1 ]. This drug was first used in veterinary medicine until clinical trials revealed a very potent microfilaricidal action in human onchocerciasis [ 2 ].

  13. Open Access 01-12-2023 | Ivermectin | OriginalPaper

    Non-adherence to ivermectin in onchocerciasis-endemic communities with persistent infection in the Bono Region of Ghana: a mixed-methods study

    Onchocerciasis is a debilitating neglected tropical disease (NTD) caused by Onchocerca volvulus , a filarial nematode transmitted by blackflies of the genus Simulium [ 1 ]. In 2017, it was estimated that at least 220 million people required …

  14. Open Access 01-12-2023 | River Blindness | OriginalPaper

    Coverage of preventive measures and surveillance for neglected tropical diseases in hard-to-reach communities in Ghana

    Neglected tropical diseases (NTDs) are a major public health issue affecting poor populations living in tropical environment, and hard-to-reach areas [ 1 , 2 ]. According to a World Bank study, more than half of sub-Saharan Africa’s population …

  15. Open Access 01-12-2023 | Leishmania | OriginalPaper

    Burden of neglected tropical diseases and access to medicine and diagnostics in Ethiopia: a scoping review

    Neglected tropical diseases (NTDs) are a group of more than twenty preventable and treatable infectious diseases in the tropics [ 1 ], which affect around 1.7 billion people in 149 countries worldwide [ 2 – 4 ]. Of these, 40% live in Africa with …

  16. Open Access 01-12-2022 | River Blindness | OriginalPaper

    The prevalence of onchocerciasis in Africa and Yemen, 2000–2018: a geospatial analysis

    Onchocerciasis is a disease caused by infection with the filarial nematode Onchocerca volvulus , which is transmitted to humans by the bite of the infected black fly ( Simulium spp.). Over time, infection can cause permanent blindness or severe …

  17. Open Access 01-12-2024 | OriginalPaper

    Severe morbidity and hospital-based mortality from Rift Valley fever disease between November 2017 and March 2020 among humans in Uganda

    Rift Valley fever (RVF) is caused by the Rift Valley fever virus (RVFV) which is an enveloped phlebovirus that infects animals and humans [ 1 ] causing a spectrum of disease manifestations. Before 2000, outbreaks were infrequent and cases were …

  18. Open Access 01-12-2023 | River Blindness | OriginalPaper

    Perceptions of the roles, impact, challenges and needs of community drug distributors in the control and elimination of neglected tropical diseases in difficult-to-access communities in Ghana

    Neglected Tropical Diseases (NTDs) are a diverse group of infections and conditions that thrive in tropical and subtropical countries, and cause significant morbidity, social stigma, and death [ 1 – 8 ]. It is estimated that more than one billion …

  19. Open Access 01-12-2024 | Glioma | OriginalPaper

    Tumor associated microglia/macrophages utilize GPNMB to promote tumor growth and alter immune cell infiltration in glioma

    Tumor-associated microglia and blood-derived macrophages (TAMs) play a central role in modulating the immune suppressive microenvironment in glioma. Here, we show that GPNMB is predominantly expressed by TAMs in human glioblastoma multiforme and …

  20. Open Access 01-12-2024 | OriginalPaper

    Ethnobotanical study of traditional medicinal plants used by the local people in Habru District, North Wollo Zone, Ethiopia

    Medicinal plants are vital resources for primary health care of people around the world [ 1 ]. Approximately 80% of the global population is estimated to utilize medicinal plants for disease treatment, and in African nations, this percentage is …

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