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Retinoblastoma 

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  1. 19-04-2024 | Retinoblastoma | Online First

    Management of Extraocular Retinoblastoma: ICMR Consensus Guidelines

    Retinoblastoma (RB) is the most common intraocular malignancy of childhood. Advanced stage presentation of RB is common in low middle-income countries (LMICs) due to lack of awareness, social taboos associated with enucleation, seeking alternative …

  2. 13-04-2024 | Retinoblastoma | Online First

    Management of Intraocular Retinoblastoma: ICMR Consensus Guidelines

    Retinoblastoma (RB) is the most common childhood intraocular malignancy. Delayed presentation due to a lack of awareness and advanced intraocular tumors are a common scenario in low-middle income countries (LMICs). Remarkable treatment advances …

  3. Open Access 01-12-2024 | Strabismus | OriginalPaper

    Strabismus management in retinoblastoma survivors

    Retinoblastoma (Rb) is the most common primary intraocular malignancy in children and this malignancy has been managed by enucleation (eye removal) for a at least 100 years [ 1 ]. Retinoblastoma management has undergone dramatic changes in the last …

  4. 20-03-2024 | Retinoblastoma | ReviewPaper

    Advanced Interventional Treatments in Retinoblastoma Management: A Comprehensive Review

    Retinoblastoma is the most common eye malignancy in children that if left untreated can invade intraocular structures, metastasize, and rarely lead to death. Traditionally treated with systemic chemotherapy, Intra-arterial chemotherapy is gaining …

  5. Open Access 01-12-2024 | Retinoblastoma | OriginalPaper

    Characteristics of patients with recurrent retinoblastoma: a survival analysis

    Retinoblastoma (RB) is the most common primary eye cancer in children and the second most common intraocular cancer worldwide. It accounts for 4% of all malignant tumors in children [ 1 ]. China reports approximately 1000 new cases of RB every year …

  6. Open Access 01-12-2024 | Retinoblastoma | Erratum

    Retraction Note: Curcumin inhibits proliferation, migration, invasion and promotes apoptosis of retinoblastoma cell lines through modulation of miR-99a and JAK/STAT pathway

  7. 16-03-2024 | Retinoblastoma | Online First

    Epidemiology, Diagnosis and Genetics of Retinoblastoma: ICMR Consensus Guidelines

    Retinoblastoma (RB) is the most common intraocular tumor in childhood. It is mainly caused by mutations in both alleles of the RB1 tumor suppressor gene that is found on chromosome 13 and regulates the cell cycle. Approximately 8000 children are …

  8. Open Access 01-12-2024 | Retinoblastoma | OriginalPaper

    Low expression of NR1D1 and NR2E3 is associated with advanced features of retinoblastoma

    Retinoblastoma (RB) is the most common pediatric intraocular malignancy, which affects one in every 16 000 to 18 000 children [ 1 ]. Nearly 95% of RB patients are diagnosed before 5 years old [ 2 ]. The majority of RB patients have a biallelic …

  9. 30-11-2023 | Retinoblastoma | OriginalPaper

    Angiographic characteristics and treatment approach in patients undergoing intra-arterial chemotherapy for retinoblastoma

    Since its development, intra-arterial chemotherapy (IAC) has become a powerful tool against retinoblastoma (RB), the most common primary intraocular malignancy in children. A methodology that requires threading a microcatheter from the insertion …

  10. Open Access 01-12-2024 | Retinoblastoma | OriginalPaper

    When the second comes first– rhabdomyosarcoma preceding heritable retinoblastoma– a case report

    Retinoblastoma (rb) is the most frequent intraocular tumor, accounting for 3% of all childhood cancers. Retinoblastoma survivors with a germline RB1 mutation are at lifetime risk to develop various types of non-ocular second primary tumors (SPTs) …

  11. Open Access 22-08-2023 | Retinoblastoma | OriginalPaper

    Inhibition of high level E2F in a RB1 proficient MYCN overexpressing chicken retinoblastoma model normalizes neoplastic behaviour

    Retinoblastoma is the most common intraocular childhood cancer and originates in the neural retina [ 1 ]. The majority of retinoblastomas are caused by bi-allelic RB1 inactivation [ 2 ]. However, in a subset of cases (< 5%) RB1 is proficient and …

  12. 14-11-2023 | Retinoblastoma | OriginalPaper

    Branchioma: immunohistochemical and molecular genetic study of 23 cases highlighting frequent loss of retinoblastoma 1 immunoexpression

    Branchioma is an uncommon benign neoplasm with an adult male predominance, typically occurring in the lower neck region. Different names have been used for this entity in the past (ectopic hamartomatous thymoma, branchial anlage mixed tumor …

  13. Open Access 01-01-2024 | Retinoblastoma | OriginalPaper

    Targeted therapies in retinoblastoma: GD2-directed immunotherapy following autologous stem cell transplantation and evaluation of alternative target B7-H3

    Retinoblastoma (RB) is the most common malignant eye-tumor in children [ 1 ]. Stage-adjusted therapy strategies ranging from local therapies, systemic chemotherapy, radiation to high-dose chemotherapy with autologous stem cell transplantation …

  14. Open Access 24-08-2023 | Retinoblastoma | OriginalPaper

    Correlation of gene expression with magnetic resonance imaging features of retinoblastoma: a multi-center radiogenomics validation study

    Retinoblastoma is the most common primary intraocular cancer in children, occurring in one in every 15,000–20,000 live births [ 1 ]. It is also one of the few malignancies that is routinely treated without prior histopathologic or genetic analysis.

  15. Open Access 01-12-2023 | Retinoblastoma | OriginalPaper

    Presentation pattern and survival rate of retinoblastoma following chemotherapy: a prospective study

    Retinoblastoma (RB) is a prevalent form of pediatric cancer that originates from the embryonal cells of the retina. It is the most commonly occurring primary intraocular cancer in children and has a high likelihood of being successfully treated …

  16. 13-12-2023 | Retinoblastoma | Online First

    Optic nerve thickening on high-spatial-resolution MRI predicts early-stage postlaminar optic nerve invasion in retinoblastoma

    Retinoblastoma is a cancer of the retina that affects young children. The survival rate for retinoblastoma is high, with over 95% of patients surviving if the cancer is diagnosed early and treated appropriately [ 1 ]. However, if retinoblastoma

  17. Open Access 01-12-2023 | Implant Prosthodontics | OriginalPaper

    Rehabilitation of severe dentofacial deformity after early radiotherapy of retinoblastoma: a case report

    Retinoblastoma is the most common intraocular neoplasm in the very young and accounts for 3% of all childhood malignancies [ 1 ]. Chemotherapy and radiation therapy (RT) as well as enucleation have been used for treating this eye cancer. However …

  18. Open Access 01-12-2023 | Retinoblastoma | OriginalPaper

    Clinical characteristics, treatment and prognosis of infants with retinoblastoma: a multicenter, 10-year retrospective analysis

    Retinoblastoma (RB) is the most common malignant tumor in children, and its incidence ranks the third in all age groups of ocular malignancies [ 1 ]. The incidence rate of RB was at 1 in 15,000–20,000 live birth across population, corresponding to …

  19. Open Access 01-12-2023 | Retinoblastoma | OriginalPaper

    Polyester 5–0 suture for porous implant placement after retinoblastoma enucleation: analysis of 120 sockets

    Despite progress in globe-saving treatment modalities for retinoblastoma, enucleation and insertion of a primary orbital implant, is still the preferred treatment of choice for advanced cases to provide acceptable cosmesis [ 1 , 2 ]. Overall …

  20. Open Access 25-07-2023 | Cancer in Pregnancy | OriginalPaper

    Surgical resection of retinoblastoma-associated bladder leiomyosarcoma during pregnancy: a case report

    Successful management of leiomyosarcoma of the bladder diagnosed during pregnancy in a woman with a medical history of retinoblastoma.

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