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Pruritus 

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  1. 15-02-2024 | Pruritus | ReviewPaper

    Pruritus in Pregnancy

    Pruritus is a commonly described symptom during pregnancy. Despite its high prevalence, it is often considered trivial but causes significant patient discomfort. It is important to assess and investigate the patient thoroughly as some conditions …

  2. Open Access 26-02-2024 | Pruritus | ReviewPaper

    Cholestatic Pruritus: Pathophysiology, Current Management Approach, and Emerging Therapies

    Cholestasis is defined as the reduction of bile flow through intrahepatic canaliculi due to the gradual destruction of epithelial cells or through obstruction of the large ducts of the biliary tree. One of the consequences of chronic cholestasis …

  3. Open Access 16-02-2024 | Atopic Dermatitis | OriginalPaper

    Assessing Itch Severity: Content Validity and Psychometric Properties of a Patient-Reported Pruritus Numeric Rating Scale in Atopic Dermatitis

    Atopic dermatitis (AD) is a chronic, inflammatory skin disease, in which pruritus, or itch, is a key symptom [ 1 ]. While 50% of cases first present in childhood, AD can present at any time, and 26% of adults with AD report onset after adolescence …

  4. Open Access 06-01-2024 | Atopic Dermatitis | ReviewPaper

    Cutaneous Components Leading to Pruritus, Pain, and Neurosensitivity in Atopic Dermatitis: A Narrative Review

    Atopic dermatitis (AD) is a chronic, relapsing immunoinflammatory skin condition characterized by sensations such as pruritis, pain, and neuronal hypersensitivity. The mechanisms underlying these sensations are multifactorial and involve complex …

  5. 16-11-2023 | Pruritus | ReviewPaper

    What’s New in Cutaneous T-Cell Lymphoma-Associated Pruritus

    Cutaneous T-cell lymphomas are a heterogenous group of lymphomas that cause various skin manifestations. Severe pruritus occurs frequently in cutaneous T-cell lymphoma and negatively impacts patients’ quality of life. The pathophysiology of …

  6. Open Access 09-01-2024 | Pruritus | OriginalPaper

    Impact of Difelikefalin on the Health-Related Quality of Life of Haemodialysis Patients with Moderate-To-Severe Chronic Kidney Disease-Associated Pruritus: A Single-Arm Intervention Trial

    Chronic kidney disease-associated pruritus (CKD-aP) is a distressing condition experienced by patients with advanced chronic kidney disease, particularly those receiving haemodialysis [ 1 – 3 ], and is associated with an increased risk of …

  7. Open Access 13-10-2023 | Pruritus | OriginalPaper

    Pruritus related to trastuzumab and pertuzumab in HER2 + breast cancer patients

    Human epidermal growth factor 2 (HER2) is a transmembrane receptor that plays an integral role in the control of epithelial cell growth and differentiation [ 1 ]. Amplification of this receptor has been reported in many forms of cancer and is …

  8. Open Access 14-10-2023 | Hydrotherapy | OriginalPaper

    Efficacy of Avène Hydrotherapy on Chronic Pruritus in Patients with Plaque Psoriasis

    Psoriasis is one of the most common chronic inflammatory skin diseases, and plaque psoriasis is by far the most common clinical form of psoriasis [ 1 , 2 ]. Management of psoriasis is challenging, particularly in pediatric and elderly patients …

  9. 17-07-2023 | Pruritus | Letter

    Ondansetron as a Supportive Therapeutic Agent for Severe Pruritus in Pediatric Patients with Chronic Cholestasis

  10. Open Access 09-08-2023 | Pruritus | ReviewPaper

    An update on mechanisms of pruritus and their potential treatment in primary cutaneous T-cell lymphoma

    Primary cutaneous T-cell lymphomas (CTCL), which include mycosis fungoides (MF) and Sézary syndrome (SS), are a group of lymphoproliferative disorders characterized by clonal accumulation of neoplastic T-lymphocytes in the skin. Severe pruritus

  11. 29-08-2023 | Pruritus | Report

    Use of tofacitinib in recalcitrant cases of chronic pruritus of unknown origin

  12. Open Access 01-10-2023 | Pruritus | OriginalPaper

    Neurotrophin-4 and Brain-Derived Neurotrophic Factor Serum Levels in Renal Transplant Recipients with Chronic Pruritus

    Chronic pruritus (CP) is a common symptom defined as a sensation that provokes the desire to scratch and which lasts for at least 6 weeks. It affects approximately 13.5% of the general adult population, and its prevalence increases with age [ 1 ].

  13. 12-05-2023 | Opioids | ReviewPaper

    Chronic kidney disease–associated pruritus: what is known and its application in children

    Chronic kidney disease–associated pruritus (CKD-aP) or uremic pruritus (UP) is a frequent symptom in patients with kidney failure receiving kidney replacement therapy. Severe chronic kidney disease–associated pruritus correlates with poor outcome …

  14. Open Access 12-05-2023 | Pruritus | OriginalPaper

    Uremic pruritus: prevalence, determinants, and its impact on health-related quality of life and sleep in Indian patients undergoing hemodialysis

    Pruritus is a distressing symptom that is common in patients with chronic kidney disease (CKD) and end-stage kidney disease (ESKD) on dialysis and has a negative impact on these patients' quality of life (QOL). The pruritus caused by CKD known as …

  15. Open Access 24-08-2023 | Pruritus | OriginalPaper

    Validation of the Peak Pruritus Numerical Rating Scale as a Patient-Reported Outcome Measure in Prurigo Nodularis

    Prurigo nodularis (PN) is a chronic intensely pruritic inflammatory skin disease characterized by the presence of numerous hyperkeratotic and/or fibrotic nodules, commonly located on the extremities and trunk [ 1 ]. When treating PN, the primary …

  16. 07-08-2023 | Irritable Bowel Syndrome | Letter

    Irritable bowel syndrome and interstitial cystitis/bladder pain syndrome are associated with pruritus bidirectionally in U.S. adults

    Pruritus commonly underlies both dermatologic and non-dermatologic systemic disorders and can be as debilitating as chronic pain [ 5 ]. Pruritus may be mediated in part by mast cells, which are also involved in neurogenic inflammation. Several …

  17. Open Access 01-04-2023 | Pruritus | OriginalPaper

    Cost Effectiveness of Difelikefalin Compared to Standard Care for Treating Chronic Kidney Disease Associated Pruritus (CKD-aP) in People with Kidney Failure Receiving Haemodialysis

    Chronic kidney disease-associated pruritus (CKD-aP) affects 40–70% of patients undergoing haemodialysis for kidney failure and is associated with a generalised persistent and refractory itching [ 1 , 2 ]. Patients experiencing CKD-aP are associated …

  18. 09-08-2023 | Pruritus | Online First

    Pruritus Ani—Not an Itch that Can Be Ignored

    Despite its prevalence and suspected neoplastic associations, pruritus ani is a condition that is both under-reported and under-researched. There is a lack of knowledge surrounding the condition and consequent ambiguous diagnostic pathways …

  19. 30-06-2023 | Pruritus | ReviewPaper

    Pruritus: An Approach to Diagnosis and Management for the Inpatient Dermatologist

    Pruritus is a common complaint among dermatologic patients and has a profound impact on quality of life [ 1 ]. Inpatient dermatologists play a significant role in diagnosing cutaneous pathologies. Studies show that inpatient dermatology consults …

  20. Open Access 09-08-2023 | Primary Biliary Cholangitis | Erratum

    Correction to: Impact of Pruritus on Quality of Life and Current Treatment Patterns in Patients with Primary Biliary Cholangitis

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