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Primary Biliary Cholangitis 

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  1. 30-03-2024 | Primary Biliary Cholangitis | Online First

    Osteoporosis and Primary Biliary Cholangitis: A Trans-ethnic Mendelian Randomization Analysis

    Osteoporosis is a major clinical problem in many autoimmune diseases, including primary biliary cholangitis (PBC), the most common autoimmune liver disease. Osteoporosis is a major cause of fracture and related mortality. However, it remains …

  2. 27-03-2024 | Primary Biliary Cholangitis | Online First

    Primary Biliary Cholangitis: Updates in Management and Goals of Treatment

    Primary Biliary Cholangitis (PBC) is a liver disease characterized by a chronic autoimmune T-cell medicated destruction of intrahepatic bile ducts. PBC has a hallmark autoantibody, anti-mitochondrial antibody (AMA), which is positive in 95% of …

  3. Open Access 01-12-2024 | Primary Biliary Cholangitis | OriginalPaper

    Multi-omics approaches for drug-response characterization in primary biliary cholangitis and autoimmune hepatitis variant syndrome

    Autoimmune hepatitis (AIH) is a severe and chronic progressive inflammatory liver ailment characterized by an enduring autoimmune response directed against liver autoantigens [ 1 , 2 ]. Primary cholestatic hepatitis (PBC) manifests as a chronic …

  4. Open Access 01-12-2024 | Primary Biliary Cholangitis | OriginalPaper

    The effects of low-dose IL-2 on Th17/Treg cell imbalance in primary biliary cholangitis mouse models

    Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease characterized by progressive nonsuppurative cholangitis [ 1 ]. Without pharmacological interventions, patients can progress to liver cirrhosis and hepatocellular carcinoma.

  5. 15-09-2023 | Primary Biliary Cholangitis | OriginalPaper

    ChIP-seq analysis found IL21R, a target gene of GTF2I–the susceptibility gene for primary biliary cholangitis in Chinese Han

    Primary biliary cholangitis (PBC) was a chronic autoimmune liver disease characterized by T lymphocyte-mediated intrahepatic bile duct injury, causing intrahepatic bile duct epithelial cells that may lead to cholestasis and eventually to cirrhosis …

  6. Open Access 01-12-2024 | Primary Biliary Cholangitis | OriginalPaper

    Pharmacotherapy for primary biliary cholangitis: an assessment of medication candidacy and rates of treatment

    Primary Biliary Cholangitis (PBC) is a chronic cholestatic liver disease involving the autoimmune-mediated destruction of biliary epithelial cells. PBC is a progressive disorder, and may ultimately result in hepatic fibrosis, cirrhosis, and …

  7. 12-12-2023 | Primary Biliary Cholangitis | OriginalPaper

    New Therapies on the Horizon for Primary Biliary Cholangitis

    Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease that can progress to cirrhosis and hepatic failure if left untreated. Ursodeoxycholic acid (UDCA) was introduced as a first-line drug for PBC around 1990; it remarkably …

  8. Open Access 01-12-2024 | Primary Biliary Cholangitis | OriginalPaper

    Optimal drug regimens for improving ALP biochemical levels in patients with primary biliary cholangitis refractory to UDCA: a systematic review and Bayesian network meta-analysis

    Primary biliary cholangitis (PBC) is a chronic inflammatory autoimmune-mediated liver disease that is characterized by primary progressive destruction of the small intrahepatic bile ducts, impaired biliary secretion, and hepatocellular retention …

  9. Open Access 01-12-2023 | Magnetic Resonance Cholangio Pancreatography | OriginalPaper

    Overlap syndrome of primary biliary cholangitis and primary sclerosing cholangitis: two case reports

    Overlap syndrome is a condition characterized by the coexistence of features belonging to different disorders within the spectrum of autoimmune liver diseases: autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing …

  10. Open Access 22-08-2023 | Primary Biliary Cholangitis | OriginalPaper

    A new method to estimate the histological stage of primary biliary cholangitis

    Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by inflammation of the interlobular bile ducts and interstitial bile duct cells. The natural course of disease tends to be progressive. In the absence of proper …

  11. Open Access 01-12-2023 | Primary Biliary Cholangitis | OriginalPaper

    Ultrasound imaging findings in primary biliary cholangitis

    Primary biliary cholangitis (PBC) is a chronic idiopathic disorder, characterized by bile accumulation and progressive necrosis of the intrahepatic bile ducts. Unlike primary sclerosing cholangitis (PSC), which is characterized by fibrotic changes …

  12. Open Access 19-09-2023 | Primary Biliary Cholangitis | OriginalPaper

    Prognostic significance of liver stiffness in patients with primary biliary cholangitis: validation of Baveno VII criteria

    Primary biliary cholangitis (PBC) is a slowly progressive disease with a natural course of 10–15 years, but high-risk patients can progress rapidly to decompensated cirrhosis and even death [ 1 ]. Early identification of such patients and timely …

  13. Open Access 15-08-2023 | Primary Biliary Cholangitis | OriginalPaper

    Noninvasive prediction of insufficient biochemical response after ursodeoxycholic acid treatment in patients with primary biliary cholangitis based on pretreatment nonenhanced MRI

    Primary biliary cholangitis (PBC) is an autoimmune-mediated intrahepatic cholestatic disease characterised by progressive, nonsuppurative, destructive intrahepatic cholangitis, leading to hepatic fibrosis and eventually cirrhosis and a range of …

  14. 16-10-2023 | Primary Biliary Cholangitis | OriginalPaper

    MGAT5/TMEM163 variant is associated with prognosis in ursodeoxycholic acid-treated patients with primary biliary cholangitis

    Primary biliary cholangitis (PBC) is a chronic immune-mediated liver disease, which is histo-pathologically characterised by destruction of intrahepatic bile ducts resulting in cholestasis and progressive fibrosis [ 1 ]. Amongst PBC patients …

  15. Open Access 01-12-2023 | Septicemia | OriginalPaper

    Vibrio vulnificus sepsis after shrimp shelling in a patient with preexisting primary biliary cholangitis: a case report

    The clinical and epidemiological characteristics of Vibrio vulnificus infection were first reported in 1979 by Blake et al . V. vulnificus is a slightly halophilic Gram-negative bacillus with an optimal salt concentration of 2–3% that lives in …

  16. Open Access 01-12-2023 | Primary Biliary Cholangitis | OriginalPaper

    Soluble immune checkpoints are elevated in patients with primary biliary cholangitis

    Primary biliary cholangitis (PBC) is a chronically progressive, cholestatic liver disease characterised by non-suppurative inflammation mediated by an autoimmune response [ 1 ]. It mostly occurs in middle-aged women [ 2 ]. The onset of PBC is …

  17. Open Access 01-12-2023 | Hepatocellular Carcinoma | OriginalPaper

    Overlap syndrome of autoimmune hepatitis and primary biliary cholangitis complicated with atypical hepatocellular carcinoma: a case report

    Primary Biliary Cholangitis (PBC) is an uncommon cholestatic, chronic, autoimmune disease. The global incidence rate is between 0.33 and 0.58 per 100,000 inhabitants/year and the prevalence varies from 1.91 to 40.2 per 100,000 individuals [ 1 ]. In …

  18. Open Access 01-12-2023 | Primary Biliary Cholangitis | ReviewPaper

    CT and MR imaging of primary biliary cholangitis: a pictorial review

    Primary biliary cholangitis (PBC) is a rare chronic autoimmune-mediated cholestatic liver disease involving medium and small bile ducts that can lead to liver fibrosis and cirrhosis. To date, the pathogenesis of PBC remains elusive, and there is …

  19. Open Access 01-12-2023 | Primary Biliary Cholangitis | OriginalPaper

    High neutrophil-lymphocyte ratio indicates a worse response to ursodeoxycholic acid in primary biliary cholangitis: a retrospective cohort study

    Primary biliary cholangitis (PBC, formerly known as primary biliary cirrhosis) is a chronic and cholestatic autoimmune liver disease characterized by the destruction of intrahepatic small bile ducts, leading to inflammation, fibrosis, hepatic …

  20. Open Access 01-12-2023 | Primary Biliary Cholangitis | OriginalPaper

    Integrative bioinformatics analysis and experimental validation of key biomarkers for risk stratification in primary biliary cholangitis

    Primary biliary cholangitis (PBC) is an autoimmune liver disease, characterized by female predominance, non-suppurative destruction of small bile ducts, and specific anti-mitochondrial antibodies (AMAs) [ 1 , 2 ]. The etiology and pathogenesis of …

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