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2679 search results for:

Paraneoplastic Syndromes 

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  1. 17-03-2024 | Lambert-Eaton Myasthenic Syndrome | Online First

    Dysautonomia in anti-Hu paraneoplastic neurological syndromes

    Autonomic nervous system dysfunction is not rare in the context of autoimmune encephalitis and paraneoplastic neurological syndromes (PNS) [ 1 ]. Patients with anti-Hu antibodies, which are among the most frequently found in PNS in adults [ 2 , 3 …

  2. 13-04-2024 | Breast Cancer | Online First

    Significant improvement in paraneoplastic neurological syndromes without identifiable anti-neural antibodies in patients with breast cancer after breast surgery

    Paraneoplastic neurological syndromes (PNS) are neurological disorders that occur in close association with tumors without direct metastasis or invasion of the tumors and in which anti-neural antibodies may be present. Cerebellar ataxia is a …

  3. 10-01-2024 | Paraneoplastic Neurologic Syndrome | ReviewPaper

    Management of Paraneoplastic Syndromes in the Era of Immune Checkpoint Inhibitors

    Our understanding of paraneoplastic neurologic syndromes (PNS) has blossomed over the past few decades. Clinicians have access to more robust diagnostic criteria and have a heightened index of suspicion for these disorders. Nonetheless, treatment …

  4. 10-07-2023 | Paraneoplastic Syndromes | ReviewPaper

    Paraneoplastic syndromes associated with classic Hodgkin lymphoma, a systematic literature review

    PNS are uncommon manifestations of cancer. The current literature about these syndromes in the setting of cHL is disintegrated. A systematic literature review of all published literature was conducted. One hundred twenty-eight patients from 115 …

  5. Open Access 01-12-2023 | Night-Blindness | ReviewPaper

    Relation between ocular paraneoplastic syndromes and Immune Checkpoint Inhibitors (ICI): review of literature

    Immune checkpoint inhibitors are considered a recent breakthrough in the treatment of advanced cancers [ 1 ]. The immune system contains several checkpoints to prevent overactivation against healthy cells. However, tumor cells use these checkpoints …

  6. Open Access 01-12-2023 | Paraneoplastic Syndromes | Erratum

    Correction to: Dual paraneoplastic syndromes in a patient with small cell lung cancer: a case report

  7. 08-03-2023 | Paraneoplastic Neurologic Syndrome | OriginalPaper

    Paraneoplastic neurological syndromes of the central nervous system: a single institution 7-year case series

    Paraneoplastic neurologic syndromes (PNSs) are a group of disorders resulting from a remote effect of a malignant neoplasm. PNSs may involve any part of the nervous system and result from an immune-mediated mechanism affecting neural tissue with a …

  8. 13-12-2022 | Lung Cancer | OriginalPaper

    SOX1 antibody-related paraneoplastic neurological syndromes: clinical correlates and assessment of laboratory diagnostic techniques

    In 2000, SOX ( Sry-like high-mobility group box ) proteins, a group of transcriptional activators involved in embryogenic processes, were identified as new targets of humoral immune response in patients with small-cell lung cancer (SCLC) [ 1 ].

  9. 01-09-2022 | Encephalitis | OriginalPaper

    Paraneoplastic neurological syndromes associated with renal or bladder cancer: case series and PRISMA-IPD systematic review

    Paraneoplastic neurological syndromes (PNS) are remote immune-mediated complications of cancer that affect 1 in 300 patients with malignancies [ 1 ]. The identification of a PNS heralds the diagnosis of an unknown cancer in up to 50–60% of cases [ …

  10. 27-04-2022 | SCLC | ReviewPaper

    Paraneoplastic Neurological Syndromes: Transitioning Between the Old and the New

    Paraneoplastic neurological syndromes (PNS) are immune-mediated neurological manifestations connected to the presence of an underlying cancer [ 1 ]. They are rare disorders that occur in variable percentages of patients with cancer (from less than …

  11. Open Access 01-04-2022 | Checkpoint Inhibitors | ReviewPaper

    Paraneoplastic Autoimmune Neurological Syndromes and the Role of Immune Checkpoint Inhibitors

    The introduction of immune checkpoint inhibitors (ICIs) in oncologic therapies has led to a paradigm shift in cancer treatment. ICIs have increased the overall survival in patients with malignant melanoma, small-cell lung cancer, and many other …

  12. Open Access 01-12-2021 | Paraneoplastic Syndromes | OriginalPaper

    Parkinsonism and dysautonomia with anti-CV2/CRMP5 associated paraneoplastic neurological syndromes mimicking multiple system atrophy: a case report

    PNS represents the remote effects of tumors on the nervous system, which is not associated with invasion or compression of the tumor but by activation of the immune system. Antibodies produced by the body against the tumor antigen may damage the …

  13. 01-07-2020 | Neurological Tests | Letter

    Anti-Hu-associated paraneoplastic syndromes triggered by immune-checkpoint inhibitor treatment

  14. 01-01-2020 | Paraneoplastic Syndromes | OriginalPaper

    Epidemiology of paraneoplastic neurological syndromes: a population-based study

    Paraneoplastic neurological syndromes (PNS) are immune-mediated complications of cancer that can affect any part of the central or peripheral nervous system [ 1 – 3 ]. Their diagnosis requires the exclusion of other conditions directly or …

  15. 01-01-2019 | SCLC | OriginalPaper

    Paraneoplastic neurological syndromes: a single institution 10-year case series

    Guichard initially proposed the concept of paraneoplastic neurologic syndromes (PNSs) in 1956 as “remote effects” of cancer on the nervous system not attributable to the site of malignant neoplasm or the direct result of nutritional or metabolic …

  16. 24-02-2022 | Electroencephalography | OriginalPaper

    Autoimmune encephalitis and paraneoplastic syndromes in Turkey: a multi-centre study

    Encephalitis amounts to an average of about 5 to 8 cases per 100,000 people yearly, and nearly half of these cases are due to unknown aetiology [ 1 , 2 ]. In the last years, there has been an increase in non-infectious, mainly autoimmune …

  17. Open Access 01-01-2020 | Metastasis | ReviewPaper

    Paraneoplastic Syndromes Associated with Laryngeal Cancer

    The symptoms and signs of various cancers are caused by the effects of the neoplasm locally, regionally, or distantly. In a few patients, these signs and symptoms are not directly produced by the primary tumor or its metastases, appearing rather …

  18. 01-12-2019 | Cutaneous Paraneoplastic Syndromes | ReviewPaper

    Paraneoplastic Syndromes for the Inpatient Dermatologist

    Paraneoplastic syndromes are diseases associated with an underlying internal malignancy. They may present as an isolated finding or as part of a constellation of other signs and symptoms. These manifestations are indirectly related to the tumor …

  19. 01-03-2022 | Lymphoma | BriefCommunication

    Paraneoplastic neurological syndromes associated with non-Hodgkin lymphoma: a case series

  20. 01-09-2018 | ReviewPaper

    Endocrine paraneoplastic syndromes in lung cancer

    Paraneoplastic syndromes are defined as a combination of clinical disorders associated with malignant diseases that are caused by the secretion of various substances by the tumor without, however, being caused by the direct growth and infiltration …

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