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2246 search results for:

Primary Myelofibrosis 

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  1. 06-11-2023 | Ruxolitinib | Letter

    Safe utilization of ruxolitinib in simultaneous primary myelofibrosis and warm autoimmune hemolytic anemia

  2. Open Access 01-12-2023 | Primary Myelofibrosis | OriginalPaper

    Trends in overall mortality among US veterans with primary myelofibrosis

    Myelofibrosis (MF) is a myeloproliferative neoplasm characterized by bone marrow fibrosis, extramedullary hematopoiesis, and burdensome constitutional symptoms [ 1 , 2 ]. MF can be either primary (PMF), arising de novo, or secondary to …

  3. 17-04-2023 | Primary Myelofibrosis | ContinuingEducation

    Primary myelofibrosis-related glomerulopathy with renal extramedullary hematopoiesis

    A 62-year-old male was referred to the nephrology department with lower extremity edema, foamy urine, and abdominal discomfort. Two years earlier, he had been diagnosed with primary myelofibrosis. Molecular analysis identified CALR exon 9 mutation …

  4. 22-06-2022 | Nephroblastoma | OriginalPaper

    Clinical features and next-generation sequencing landscape of essential thrombocythemia, prefibrotic primary myelofibrosis, and overt fibrotic primary myelofibrosis: a Chinese monocentric retrospective study

    Myeloproliferative neoplasms (MPNs) are clonal haematopoietic stem cell diseases characterized by the abnormal proliferation of one or more myeloid lineages, including BCR-ABL-positive chronic myeloid leukaemia, BCR-ABL-negative polycythemia vera …

  5. 13-03-2023 | Fluorescence in Situ Hybridization | Letter

    Successful Hematopoietic Cell Transplantation for Infantile Primary Myelofibrosis/VPS45 Deficiency: Case Report and Review of Literature

    VPS45 deficiency (PMF) is a very rare primary immune deficiency that carries a poor prognosis as most patients reported died between 3 months and 3 years of age. Twenty patients described in the literature including the one in this report [ 1 – 5 …

  6. 01-02-2022 | Primary Myelofibrosis

    Circulating CD34+ cells of primary myelofibrosis patients contribute to myeloid-dominant hematopoiesis and bone marrow fibrosis in immunodeficient mice

    Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) which has been believed to originate from hematopoietic stem cells (HSCs). PMF is characterized by de novo bone marrow (BM) fibrosis with deposition of reticulin and collagen …

  7. Open Access 01-12-2020 | Primary Myelofibrosis | OriginalPaper

    A distinct molecular mutational profile and its clinical impact in essential thrombocythemia and primary myelofibrosis patients

    Primary Myelofibrosis and Essential thrombocythemia are classical Philadelphia-negative myeloproliferative neoplasms (MPNs), characterized by stem cell-derived clonal proliferation of one or more of myeloid lineage cells. The incidence of the …

  8. Open Access 01-02-2021 | Primary Myelofibrosis | OriginalPaper

    Prognostic value of ASXL1 mutations in patients with primary myelofibrosis and its relationship with clinical features: a meta-analysis

    Additional sex combs like 1 (ASXL1) mutations are one of the most common molecular biological abnormalities in patients with primary myelofibrosis (PMF), and the effect of these mutations on prognosis remains controversial. Hence, we conducted a …

  9. 01-01-2021 | Primary Myelofibrosis | OriginalPaper

    Loss of Normal Polyploid Spectrum as Marker of Clonality in Acute Megakaryoblastic Leukemia Evolving from Pre-Existing Primary Myelofibrosis

  10. 01-04-2022 | Primary Myelofibrosis | Letter

    Different number of circulating CD34 + cells in essential thrombocythemia, prefibrotic/early primary myelofibrosis, and overt primary myelofibrosis

  11. Extramedullary hematopoiesis in an inguinal lymph node: an unusual presentation of primary myelofibrosis

    Extramedullary hematopoiesis (EMH), a pathophysiologic response, is more often associated with either a benign reactive hematological disease or a hematological malignancy. EMH is a proliferation of hematopoietic tissue outside of the bone marrow …

  12. 01-05-2020 | Erythropoietin | OriginalPaper

    JAK2 exon 12 mutations in cases with JAK2V617F-negative polycythemia vera and primary myelofibrosis

    Molecular detection of JAK2 mutation (V617F or exon 12) is included as a major diagnostic criterion for polycythemia vera (PV) by the WHO 2016 guidelines. JAK2 exon 12 mutations are seen in about 2–5% of JAK2V617F-negative cases of PV. Mutations …

  13. 01-10-2019 | Myelodysplastic Syndrome | OriginalPaper

    Genomic characterization in triple-negative primary myelofibrosis and other myeloid neoplasms with bone marrow fibrosis

    Triple-negative primary myelofibrosis (TN-PMF) and other myeloid neoplasms with associated bone marrow fibrosis such as the myelodysplastic syndromes (MDS-F) or the myelodysplastic/myeloproliferative neoplasms (MDS/MPN-F) are rare entities, often …

  14. 01-10-2021 | Splenectomy | OriginalPaper

    Novel findings of splenic extramedullary hematopoiesis during primary myelofibrosis, post-essential thrombocythemia, and post-polycythemia vera myelofibrosis

    BCR–ABL-fusion-negative myeloproliferative neoplasms (MPNs) with myelofibrosis (MF) include primary MF, post-polycythemia vera MF and post-essential thrombocythemia MF. Clonal extramedullary hematopoiesis (EMH) can occur during MPN pathogenesis.

  15. 01-06-2022 | Primary Myelofibrosis | Letter

    Higher red blood cell distribution width predicts thrombosis risk in primary and secondary myelofibrosis

  16. 16-04-2022 | Chronic Myeloproliferative Neoplasms | OriginalPaper

    Secondary chronic myeloid leukemia in a patient with CALR and ASXL1-mutated primary myelofibrosis

    Development of secondary CML has only been casually described, with few reports attempting to analyze and explain the mechanisms behind this phenomenon. Reported cases vary with regard to presumed pathogenesis and clinical characteristics, but …

  17. Open Access 01-12-2019 | Primary Myelofibrosis | OriginalPaper

    Systematization of analytical studies of polycythemia vera, essential thrombocythemia and primary myelofibrosis, and a meta-analysis of the frequency of JAK2, CALR and MPL mutations: 2000–2018

    Myeloproliferative neoplasms (MPN) is a group of eight clinical entities that include those of the BCR-ABL1 -negative phenotype, named Philadelphia-negative MPN. These diseases are generated by a clonal disorder in hematopoietic stem cells that …

  18. 01-07-2021 | Computed Tomography

    Volumetric splenomegaly in patients with essential thrombocythemia and prefibrotic/early primary myelofibrosis

    Non-palpable, volumetric splenomegaly at diagnosis was evaluated using computed tomography in patients with essential thrombocythemia (ET) and prefibrotic/early primary myelofibrosis (pre-PMF) based on 2016 World Health Organization guidelines.

  19. 01-04-2021 | Primary Myelofibrosis | OriginalPaper

    Clinical impacts of the mutational spectrum in Japanese patients with primary myelofibrosis

    Patients with primary myelofibrosis (PMF) have a poorer prognosis than those with other subtypes of myeloproliferative neoplasms (MPNs). To investigate the relationship between gene mutations and the prognosis of Japanese PMF patients, we analyzed …

  20. 01-01-2021 | Lymphoma

    The Journey of Primary Myelofibrosis to Splenic Marginal Zone Lymphoma on the Wheels of Ruxolitinib

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