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Pleural Mesothelioma 

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  1. 15-04-2024 | Pleural Mesothelioma | Online First

    Development of Patient and Caregiver Conceptual Models Investigating the Health-Related Quality of Life Impacts of Malignant Pleural Mesothelioma

    Malignant pleural mesothelioma (MPM) is a rare and usually fatal malignancy frequently linked to occupational exposure to asbestos [ 1 ], with a latency period of between 20 and 60 years. Specialised advice is often needed to confirm a diagnosis …

  2. 08-12-2023 | Pleural Mesothelioma | ReviewPaper

    Malignant Pleural Mesothelioma: Staging and Radiological Response Criteria in Patients Treated with Immune Checkpoint Inhibitors

    Malignant pleural mesothelioma (MPM) is a rare and challenging cancer associated with asbestos fiber exposure, which offers limited treatment options. Historically, platinum-based chemotherapy has been the primary approach, but recent developments …

  3. 17-11-2023 | Pleural Mesothelioma | ReviewPaper

    Updates in Management of Malignant Pleural Mesothelioma

    The therapeutic landscape of malignant pleural mesothelioma is rapidly evolving. This review provides an overview of the current treatment strategies and recent therapeutic advances.

  4. Open Access 28-11-2023 | Mesothelioma | ReviewPaper

    Genomic Landscape of Pleural Mesothelioma and Therapeutic Aftermaths

    Pleural mesothelioma is a rare malignancy that arises from the mesothelial cells lining the chest. This cancer is primarily associated with asbestos and develops 30–40 years after exposure. Once diagnosed, pleural mesothelioma progresses rapidly; …

  5. Open Access 07-09-2023 | Pleural Mesothelioma | ReviewPaper

    An overview on multimodal imaging for the diagnostic workup of pleural mesothelioma

    Pleural mesothelioma (PM) is an aggressive disease that has a strong causal relationship with asbestos exposure and represents a major challenge from both a diagnostic and therapeutic viewpoint. Despite recent improvements in patient care, PM …

  6. Open Access 01-12-2023 | Mesothelioma | OriginalPaper

    Targeting FAcilitates Chromatin Transcription complex inhibits pleural mesothelioma and enhances immunotherapy

    Diffuse pleural mesothelioma [ 1 ] (DPM) is a recalcitrant surface membrane neoplasm that, contrary to historical predictions, continues to remain prevalent worldwide with increasing incidence [ 2 ]. Conventional drug therapy in DPM has been …

  7. Open Access 01-12-2023 | Pleural Mesothelioma | OriginalPaper

    Biphasic pleural mesothelioma treated successfully with multimodal therapy: a case report

    Pleural mesothelioma (PM) is a highly aggressive tumor. The median survival of patients with the disease is about 1 year [ 1 ]. Biphasic pleural mesothelioma (BPM) is the least common histologic subtype, accounting for approximately 11% of PM cases …

  8. Open Access 22-11-2023 | Radiotherapy | Online First

    Safety and efficacy of helical tomotherapy following lung-sparing surgery in locally advanced malignant pleural mesothelioma

    Malignant pleural mesothelioma (MPM) is a rare and highly aggressive intrathoracic malignancy mainly associated with exposure to asbestos fibers. Prognosis is dismal despite multimodal treatment [ 1 , 2 ]. While MPM derives from mesothelial pleural

  9. Open Access 01-12-2023 | Checkpoint Inhibitors | OriginalPaper

    LAG3 is an independent prognostic biomarker and potential target for immune checkpoint inhibitors in malignant pleural mesothelioma: a retrospective study

    Malignant pleural mesothelioma (MPM) is a rare tumor [ 1 , 2 ] with poor prognosis. It is associated with asbestos exposure [ 3 , 4 ]; it originates from the transformation of the pleural mesothelial cells [ 5 ]. Mesothelial cells transform into to …

  10. Open Access 01-02-2023 | Pleural Mesothelioma | OriginalPaper

    BAP1, Wilms’ tumor 1, and calretinin in predicting survival and response to first-line chemotherapy in patients with pleural mesothelioma

    Pleural mesothelioma (PM) is a global health problem and increasing due to its etiopathological relations to asbestos and other carcinogenic mineral fibers. Even four decades after asbestos ban, the incidence is stable in many industrialized …

  11. 08-07-2023 | Pleural Mesothelioma | OriginalPaper

    An anoikis-based gene signature for predicting prognosis in malignant pleural mesothelioma and revealing immune infiltration

    An aggressive tumor of serosal surfaces, including pleura and peritoneum, called malignant mesothelioma. The prevalence of malignant pleural mesothelioma (MPM), which is an aggressive, treatment-resistant malignancy likely brought on by widespread …

  12. Open Access 01-12-2022 | Pleural Mesothelioma | OriginalPaper

    Lymphocyte predominance in blood, pleural fluid, and tumour stroma; a prognostic marker in pleural mesothelioma

    Malignant pleural mesothelioma (MPM) is an aggressive cancer of the pleura with a median survival of 9–14 months from diagnosis. Until relatively recently the mainstay of treatment was palliative chemotherapy (Cisplatin/Pemetrexed) which infers …

  13. 07-04-2023 | Pleural Mesothelioma | OriginalPaper

    Genetic analysis of familial predisposition in the pathogenesis of malignant pleural mesothelioma

    Malignant mesothelioma (MM) is a malignant tumor that develops from the serous surfaces of the pleura, peritoneum, and pericardium, and rarely from the tunica vaginalis in the testis, 90% of which are of pleural origin. Malignant pleural

  14. Open Access 12-08-2023 | Bevacizumab | OriginalPaper

    Cost Effectiveness and Budget Impact of Nivolumab Plus Ipilimumab Versus Platinum Plus Pemetrexed (with and Without Bevacizumab) in Patients with Unresectable Malignant Pleural Mesothelioma in Switzerland

    Malignant pleural mesothelioma (MPM) is a rare and highly aggressive cancer which affects the mesothelial cells of the pleura. Other types of mesothelioma occurring in the abdomen (peritoneum), heart (pericardium), or testicles (tunica vaginalis) …

  15. Open Access 01-12-2022 | Pleural Mesothelioma | OriginalPaper

    Systemic treatment in patients with malignant pleural mesothelioma – real life experience

    Malignant pleural mesothelioma (MPM) is a rare, aggressive malignancy of the pleural cavity linked to asbestos exposure. Despite recent treatment advances, prognosis remains poor with a median survival of approximately 1-year, and 5-year survival …

  16. Open Access 01-12-2022 | Pleural Mesothelioma | OriginalPaper

    Malignant pleural mesothelioma: treatment patterns and humanistic burden of disease in Europe

    Malignant pleural mesothelioma (MPM) is an aggressive and rare tumour, originating from mesothelial cells lining the pleura [ 1 , 2 ]. MPM is the most common form of mesothelioma, accounting for over 90,000 deaths per year globally [ 1 ], with …

  17. 30-08-2022 | Pleural Mesothelioma | OriginalPaper

    Malignant Sarcomatoid Pleural Mesothelioma Presenting as a Chest Wall Tumor

    Malignant mesothelioma is a rare and aggressive neoplasm with a median survival of less than 12 months and a 5-year survival rate of less than 5%. Malignant pleural mesothelioma is usually a diffuse disease with male predominance and occurs in the …

  18. 31-08-2022 | Metastasis | OriginalPaper

    Synchronous Pleural and Peritoneal Mesothelioma: a Case Report and Narrative Review

    Malignant mesotheliomas most often affect the pleura and tend to spread locally within the originating cavity. Mesotheliomas are already rare diseases, and cases with synchronous pleural and peritoneal involvement are scarce in the literature.

  19. 03-06-2022 | Pleural Mesothelioma | ReviewPaper

    The Evolving Therapeutic Landscape for Malignant Pleural Mesothelioma

    Mesothelioma is an aggressive malignancy arising from cells of the mesothelium, a serous membrane that forms the outer linings of the thoracic and abdominal cavities (hence, pleural and peritoneal mesothelioma), but also the heart and testes …

  20. Open Access 01-12-2022 | Pleural Mesothelioma | OriginalPaper

    Dynamic contrast-enhanced MRI in malignant pleural mesothelioma: prediction of outcome based on DCE-MRI measurements in patients undergoing cytotoxic chemotherapy

    Malignant pleural mesothelioma (MPM) is a rare thoracic malignancy that affects the pleura and is often associated with exposure to asbestos. Of newly diagnosed patients, the majority of patients present with an advanced disease are not suitable …

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