Issue 3/2022
Therapeutic Antibodies in Neurological Diseases
Content (26 Articles)
Therapeutic Antibodies in Neurological Diseases: Witnessing the Continuation of the Impressive Success in Neuro-Immunotherapies
Marinos C. Dalakas, Heinz Wiendl
Evolution of Anti-B Cell Therapeutics in Autoimmune Neurological Diseases
Panos Stathopoulos, Marinos C. Dalakas
Anti-complement Agents for Autoimmune Neurological Disease
Jennifer A. McCombe, Sean J. Pittock
Neonatal Fc Receptor–Targeted Therapies in Neurology
Christopher Nelke, Marianna Spatola, Christina B. Schroeter, Heinz Wiendl, Jan D. Lünemann
Monoclonal Antibodies in the Treatment of Relapsing Multiple Sclerosis: an Overview with Emphasis on Pregnancy, Vaccination, and Risk Management
Nik Krajnc, Gabriel Bsteh, Thomas Berger, Jan Mares, Hans-Peter Hartung
Antibody Therapies for Progressive Multiple Sclerosis and for Promoting Repair
Joachim Havla, Reinhard Hohlfeld
What Have Failed, Interrupted, and Withdrawn Antibody Therapies in Multiple Sclerosis Taught Us?
Julia Krämer, Heinz Wiendl
Monoclonal Antibody Therapies Beyond Complement for NMOSD and MOGAD
Vyanka Redenbaugh, Eoin P. Flanagan
Antibody Therapies in Autoimmune Encephalitis
I. Smets, M. J. Titulaer
Paraneoplastic Autoimmune Neurological Syndromes and the Role of Immune Checkpoint Inhibitors
Sophie L. Duong, Harald Prüss
The Role of the Complement System in Chronic Inflammatory Demyelinating Polyneuropathy: Implications for Complement-Targeted Therapies
Luis A. Querol, Hans-Peter Hartung, Richard A. Lewis, Pieter A. van Doorn, Timothy R. Hammond, Nazem Atassi, Miguel Alonso-Alonso, Marinos C. Dalakas
Therapeutic Monoclonal Antibody Therapies in Chronic Autoimmune Demyelinating Neuropathies
Chiara Briani, Andrea Visentin
Immunoglobulin and Monoclonal Antibody Therapies in Guillain-Barré Syndrome
Yusuf A. Rajabally
Antibody Therapies in Autoimmune Neuromuscular Junction Disorders: Approach to Myasthenic Crisis and Chronic Management
Fiammetta Vanoli, Renato Mantegazza
Antibody Therapies in Autoimmune Inflammatory Myopathies: Promising Treatment Options
Rachel Zeng, Stefanie Glaubitz, Jens Schmidt
The Arrival of Anti-CGRP Monoclonal Antibodies in Migraine
Fred Cohen, Hsiangkuo Yuan, E. M. G. DePoy, Stephen D. Silberstein
CRISPR-Cas9 Gene Therapy for Duchenne Muscular Dystrophy
Cedric Happi Mbakam, Gabriel Lamothe, Guillaume Tremblay, Jacques P. Tremblay
Current Chemical, Biological, and Physiological Views in the Development of Successful Brain-Targeted Pharmaceutics
Magdalena Markowicz-Piasecka, Agata Markiewicz, Patrycja Darłak, Joanna Sikora, Santosh Kumar Adla, Sreelatha Bagina, Kristiina M. Huttunen
Two Diseases—One Preclinical Treatment Targeting Glycogen Synthesis
Matthew S. Gentry, Kia H. Markussen, Katherine J. Donohue
AAV-Mediated Artificial miRNA Reduces Pathogenic Polyglucosan Bodies and Neuroinflammation in Adult Polyglucosan Body and Lafora Disease Mouse Models
Emrah Gumusgoz, Sahba Kasiri, Dikran R. Guisso, Jun Wu, Matthew Dear, Brandy Verhalen, Berge A. Minassian
Bezafibrate Rescues Mitochondrial Encephalopathy in Mice via Induction of Daily Torpor and Hypometabolic State
Jingwei Lyu, Yuying Zhao, Na Zhang, Xuebi Xu, Rui Zheng, Wenfei Yu, Wang Xin, Chuanzhu Yan, Kunqian Ji
Nervonic Acid Attenuates Accumulation of Very Long-Chain Fatty Acids and is a Potential Therapy for Adrenoleukodystrophy
Marcia R. Terluk, Julianne Tieu, Siddhee A. Sahasrabudhe, Ann Moser, Paul A. Watkins, Gerald V. Raymond, Reena V. Kartha
A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity
Silke Nuber, Chee Yeun Chung, Daniel F. Tardiff, Pascal A. Bechade, Thomas D. McCaffery, Kazuma Shimanaka, Jeonghoon Choi, Belle Chang, Waseem Raja, Esther Neves, Christopher Burke, Xin Jiang, Ping Xu, Vikram Khurana, Ulf Dettmer, Saranna Fanning, Kenneth J. Rhodes, Dennis J. Selkoe, Robert H. Scannevin
Low-Dose Ziprasidone in Combination with Sertraline for First-Episode Drug-Naïve Patients with Schizophrenia: a Randomized Controlled Trial
Cheng Zhu, Xiaoni Guan, Yuechan Wang, Jiahong Liu, Thomas R. Kosten, Meihong Xiu, Fengchun Wu, Xiangyang Zhang