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Oropharyngeal Carcinoma 

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  1. 28-03-2024 | Human Papillomavirus | OriginalPaper

    Salvage transoral robotic surgery in recurrent oropharyngeal carcinoma: a single-center retrospective study

    The incidence of oropharyngeal squamous cell carcinoma (OPSCC) increased over the past decades due to the human papillomavirus (HPV) epidemic wave [ 1 ]. Currently, it is projected to be the head and neck squamous cell carcinoma (HNSCC) with the …

  2. Open Access 01-12-2024 | Human Papillomavirus | OriginalPaper

    Validation of the VisionArray® Chip Assay for HPV DNA Testing in Histology Specimens of Oropharyngeal Squamous Cell Carcinoma

    The detection of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) is increasingly important in the routine clinical setting. Establishing the HPV status adds valuable information for staging and prognostication of …

  3. 01-12-2024 | Sinonasal Carcinoma | OriginalPaper

    Primary Oropharyngeal SMARCA4-Deficient Carcinoma: Expanding the Diagnostic Spectrum in Head and Neck Cancer

    With the advent of molecular immunohistochemistry and next generation sequencing, Switch/sucrose non-fermentable (SWI/SNF) chromatin remodeling complex altered tumors have gained recognition recently. SWI/SNF related, matrix associated, actin …

  4. 18-10-2023 | Human Papillomavirus | OriginalPaper

    Multiparametric MRI–based radiomics model for predicting human papillomavirus status in oropharyngeal squamous cell carcinoma: optimization using oversampling and machine learning techniques

    Human papillomavirus (HPV) has emerged as an important risk factor in the oncogenesis of oropharyngeal squamous cell carcinoma (OPSCC) accounting for its rapidly increasing incidence [ 1 – 4 ]. With distinct molecular profiles, tumor …

  5. Open Access 05-03-2024 | Biomarkers | OriginalPaper

    Detection of antibody subclasses IgA, IgM and IgG against HPV L1 in HPV-positive oropharyngeal squamous cell carcinoma patients: a pilot study

    With increasing incidences in developed countries, HPV-positive OPSCCs are considered to be more sensitive to chemotherapy, radiation and combined treatment protocols compared to HPV-negative tumors. The p16 protein, routinely determined by …

  6. 19-01-2024 | Oropharyngeal Carcinoma | OriginalPaper

    A comparative evaluation of fibreoptic bronchoscopy versus C-MAC® D-BLADE-guided videolaryngoscopy for nasotracheal intubation under general anesthesia in oropharyngeal carcinoma surgery patients

    After obtaining approval from the institutional ethics committee (IECPG-243/28.06.2018, Institute Ethics Committee, AIIMS, New Delhi, India) and prospective registration in the Clinical Trial Registry of India (CTRI/2018/11/0162830; 8 November …

  7. 03-01-2024 | Human Papillomavirus | OriginalPaper

    The prognostic effect of radiological extranodal extension in HPV-positive oropharyngeal squamous cell carcinomas: a retrospective cohort analysis

    The human papillomavirus (HPV) is an important oncogenic virus causing HPV-positive (HPV +) oropharyngeal squamous cell carcinoma (OPSCC). The virus infects the basal keratinocytes of mucous membranes in the oropharynx and is oncogenic by …

  8. 05-01-2024 | Radiotherapy | OriginalPaper

    Overall survival, disease-free survival and quality of life in patients affected by HPV mediated p16+ oropharyngeal squamous cell carcinoma treated with upfront trans-oral robotic surgery vs radiotherapy or chemoradiotherapy

    The main features of patients affected by HPV-positive oropharyngeal squamous cell carcinomas (OPSCC) are the young age at diagnosis (usually less than 60 years old), white non-Hispanic ethnicity, lack of severe comorbidities, no or little tobacco …

  9. 20-01-2024 | Online First

    Deep learning–based multimodal segmentation of oropharyngeal squamous cell carcinoma on CT and MRI using self-configuring nnU-Net

    Oropharyngeal squamous cell carcinoma (OPSCC) is the most common head and neck malignancies, and its incidence has increased globally, largely driven by increased human papillomavirus (HPV) infections [ 1 , 2 ]. The multidisciplinary treatment …

  10. 01-01-2024 | Human Papillomavirus | ReviewPaper

    Global prevalence of human papillomavirus-related oral and oropharyngeal squamous cell carcinomas: a systematic review and meta-analysis

    Oral cavity and oropharyngeal cancer represent an important disease category worldwide due to its significant effects on the quality of life of patients, accounting for approximately 480,000 new cases and 230,000 deaths in 2020 [ 1 ]. Typically …

  11. Open Access 01-12-2023 | OriginalPaper

    Analysis of cells of epithelial, connective tissue and immune differentiation in HPV-positive-, HPV-negative oropharyngeal carcinoma and normal oropharyngeal tissue by immunofluorescence multiplex image cytometry: a preliminary report

    There are two subtypes of oropharyngeal squamous cell carcinomas (OPSCC): human papilloma virus (HPV) positive (+) and negative (-) [ 1 , 2 ]. Patients with HPV + OPSCC have significantly better prognoses than patients with HPV- OPSCC [ 3 – 6 ].

  12. Open Access 01-12-2023 | Human Papillomavirus | OriginalPaper

    Findings from a Malaysian multicentre study on oropharyngeal squamous cell carcinoma

    The recent Global Cancer Observatory (GLOBOCAN) 2020 report estimated that more than 19 million new cases of cancer were diagnosed worldwide, with cancer being the leading cause of death in approximately 57 countries [ 1 , 2 ]. Head and neck …

  13. 23-11-2023 | Human Papillomavirus | OriginalPaper

    Recurrent Oropharyngeal Squamous Cell Carcinomas Maintain Anti-tumor Immunity and Multinucleation Levels Following Completion of Radiation

    Infection with high-risk subtypes of human papillomavirus (HPV) has driven an epidemic rise in the incidence of oropharyngeal squamous cell carcinoma (OPSCC) [ 1 – 5 ], a disease formerly associated exclusively with heavy tobacco exposure [ 6 , 7 …

  14. Open Access 01-12-2023 | Human Papillomavirus | OriginalPaper

    Sex-specific aspects in patients with oropharyngeal squamous cell carcinoma: a bicentric cohort study

    Head and neck squamous cell carcinoma (HNSCC) constitute the seventh leading type of malignancy worldwide with approximately 878.000 new cases and over 444.000 deaths annually [ 1 ]. Oropharyngeal squamous cell carcinoma (OPSCC) is the only …

  15. 18-08-2023 | Oropharyngeal Cancer | OriginalPaper

    A predictive survival model for patients with stage IV oropharyngeal squamous cell carcinoma treated with chemoradiation

    The global incidence rate (cumulative risk) of oropharyngeal cancer (OPC) is 0.13 (0.21 and 0.05 for men and women respectively) [ 1 ]. Tobacco and alcohol are the most prevalent carcinogens seen worldwide [ 2 ]. In some regions such as Taiwan …

  16. Open Access 01-12-2023 | Oral Cancer | OriginalPaper

    Oral cavity and oropharyngeal carcinoma disparities in age and survival in Indigenous and non-Indigenous populations of Queensland

    Oral squamous cell carcinoma (SCC) is the 12 th most common cancer worldwide in men [ 1 ]. It has a male predilection and disproportionately affects those of lower socioeconomic status and who engage in certain habits, such as smoking, excessive …

  17. 14-10-2023 | Cytostatic Therapy | OriginalPaper

    Evaluation of neoadjuvant chemotherapy combined with PD-1 inhibitors in patients with oropharyngeal and hypopharyngeal squamous cell carcinoma: a comparative study of antitumor activity

    Head and neck squamous cell carcinoma (HNSCC) stands as the sixth most prevalent malignancy globally, contributing to an estimated half-million annual fatalities [ 1 ]. Its escalating prevalence portends an annual incidence of 1.08 million cases by …

  18. 07-10-2023 | OriginalPaper

    A predictive model for patients with local-regionally advanced oropharyngeal squamous cell carcinoma treated after cervical lymph node dissection

    Oropharyngeal squamous cell carcinoma (OPSCC) is a squamous cell carcinoma of the posterior posterior third of the tongue, tonsils, soft palate, and posterior pharyngeal wall (Lydiatt, et al. 2017 ). In 2018, there were 92,887 new cases and 51,005 …

  19. Open Access 24-04-2023 | Human Papillomavirus | ReviewPaper

    Etiology, diagnosis, treatment, and prevention of human papilloma virus-associated oropharyngeal squamous cell carcinoma

    Classical oropharyngeal squamous cell carcinoma (OPSCC) caused by alcohol consumption and smoking and HPV-associated OPSCC caused by human papillomavirus (HPV) infection have different etiologies, incidences, and prognoses. Therefore, the 8th …

  20. Open Access 19-06-2023 | Human Papillomavirus | OriginalPaper

    Liprin-α1 Expression in Tumor-Infiltrating Lymphocytes Associates with Improved Survival in Patients with HPV-Positive Oropharyngeal Squamous Cell Carcinoma

    Oropharyngeal squamous cell carcinoma (OPSCC) is a form of head and neck malignancy that has been associated with adverse prognosis (5-year survival 50–80%) [ 1 ]. Currently, the majority of newly diagnosed OPSCC patients carry human papillomavirus …

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