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208 search results for:

Niclosamide 

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  1. Open Access 07-06-2023 | Niclosamide | ReviewPaper

    Repurposing Niclosamide as a plausible neurotherapeutic in autism spectrum disorders, targeting mitochondrial dysfunction: a strong hypothesis

    Autism Spectrum Disorders (ASD) are a complex set of neurodevelopmental manifestations which present in the form of social and communication deficits. Affecting a growing proportion of children worldwide, the exact pathogenesis of this disorder is …

  2. Open Access 01-12-2023 | Niclosamide | OriginalPaper

    Presumed veterinary niclosamide-induced retinal toxicity in a human: a case report

    Niclosamide has been commonly prescribed for the treatment of intestinal parasite infections for several decades. This drug kills tapeworms by inhibiting oxidative phosphorylation in the mitochondria and anaerobic adenosine triphosphate (ATP) …

  3. 01-05-2023 | Niclosamide | News

    Niclosamide overdose

    Bull's eye maculopathy and drug toxicity following accidental exposure: case report
  4. Open Access 01-12-2021 | Amyotrophic Lateral Sclerosis | OriginalPaper

    Targeting S100A4 with niclosamide attenuates inflammatory and profibrotic pathways in models of amyotrophic lateral sclerosis

    Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative disease characterized by progressive loss of motor neurons in the brain and spinal cord. It is the most common form of motor neuron disease [ 6 ], with an onset occurring at …

  5. Open Access 01-12-2023 | Ramipril | OriginalPaper

    Niclosamide from an anthelmintic drug to a promising adjuvant therapy for diabetic kidney disease: randomized clinical trial

    Diabetic kidney disease (DKD) develops in approximately 40% of patients with type 2 diabetes and is associated with significant mortality [ 1 ]. Diabetic kidney disease is defined clinically by persistent elevated urinary albumin creatinine ratio …

  6. Open Access 01-11-2020 | Glioblastoma | OriginalPaper

    Combined effects of niclosamide and temozolomide against human glioblastoma tumorspheres

    Patients with glioblastoma (GBM), the most common type of primary brain tumor, have a poor prognosis, with a median overall survival of about 17.5 months in Korea (Kim et al. 2017a ). Standard treatments in patients with GBM include chemotherapy …

  7. 01-03-2022 | Niclosamide | OriginalPaper

    Niclosamide downregulates LOX-1 expression in mouse vascular smooth muscle cells and changes the composition of atherosclerotic plaques in ApoE−/− mice

    Genetic lineage tracing studies have shown that phenotypic switching of vascular smooth muscle cells (VSMCs) results in less-differentiated cells, including macrophage-like cells that lack traditional VSMC markers. This switching contributes to …

  8. 01-07-2021 | Niclosamide | OriginalPaper

    Improved Endothelium-Dependent Relaxation of Thoracic Aorta in Niclosamide-Treated Diabetic Rats

    Diabetes‐induced endothelial dysfunction is critical for the development of diabetic cardiovascular complications. The aim of this study was to investigate the effect of niclosamide (Nic) on vascular endothelial dysfunction in streptozotocin …

  9. Niclosamide suppresses the expansion of follicular helper T cells and alleviates disease severity in two murine models of lupus via STAT3

    Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease, with manifestations in multiple organ systems [ 1 ]. Damage to tissues in SLE results from the production of autoantibodies and immune complexes, mediated by the interplay …

  10. Open Access 01-08-2020 | Lung Cancer | OriginalPaper

    Effects of salinomycin and niclosamide on small cell lung cancer and small cell lung cancer circulating tumor cell lines

    Tumor dissemination and recurrence is attributed to highly resistant cancer stem cells (CSCs) which may constitute a fraction of circulating tumor cells (CTCs). Small cell lung cancer (SCLC) constitutes a suitable model to investigate the relation …

  11. 01-12-2018 | ReviewPaper

    Current status of androgen receptor-splice variant 7 inhibitor niclosamide in castrate-resistant prostate-cancer

    Castrate-Resistant Prostate-Cancer (CRPC) is one of the most common malignancies occurring in men. Unfortunately, even if several recently approved agents clinically improved the outcome of CRPC patients, none of these is curative especially for a …

  12. 01-10-2018 | OriginalPaper

    Niclosamide as an adjuvant to etanercept in treatment patients with active rheumatoid arthritis: an 8-week randomized controlled pilot study

    This study designed to identify the therapeutic efficacy of niclosamide (NCL) in Iraqi patients suffering from active rheumatoid arthritis (RA) who were using etanercept (ETN) for more than 3 months and still had high or moderate active RA. One …

  13. Open Access 01-12-2018 | OriginalPaper

    Phase II trial to investigate the safety and efficacy of orally applied niclosamide in patients with metachronous or sychronous metastases of a colorectal cancer progressing after therapy: the NIKOLO trial

    Colorectal cancer (CRC) is the second most common cause of all cancer deaths in Europe and the Western world with a lifetime risk of approximately 5% [ 1 ]. Despite the implementation of early detection programs about 20–25% of all patients have …

  14. Open Access 01-12-2016 | OriginalPaper

    Niclosamide induced cell apoptosis via upregulation of ATF3 and activation of PERK in Hepatocellular carcinoma cells

    Hepatocellular carcinoma (HCC) is one of the most common and aggressive human malignancies in the world [ 1 ]. It is a major public health issue worldwide according to epidemiological data, and the incidence is high in East Asia.

  15. 01-07-2016 | OriginalPaper

    Combined niclosamide with cisplatin inhibits epithelial-mesenchymal transition and tumor growth in cisplatin-resistant triple-negative breast cancer

    Women with triple-negative breast cancer have worse prognosis compared to other breast cancer subtypes. Acquired drug resistance remains to be an important reason influencing triple-negative breast cancer treatment efficacy. A prevailing theory …

  16. 01-12-2015 | OriginalPaper

    Niclosamide inhibits the inflammatory and angiogenic activation of human umbilical vein endothelial cells

    Vascular endothelial cells play an important role in the regulation of vascular tone, vascular permeability, angiogenesis and vascular inflammatory response [ 1 , 2 ].

  17. 01-04-2015 | OriginalPaper

    Inhibitory effects of niclosamide on inflammation and migration of fibroblast-like synoviocytes from patients with rheumatoid arthritis

    Rheumatoid arthritis (RA) is a common chronic inflammatory disease that may cause synovial inflammation, hyperplasia of the synovial tissues, and joint damage [ 1 ]. Fibroblast-like synoviocytes (FLS) are key players in the pathophysiological …

  18. 01-05-2024 | Cancer Immunotherapy | ReviewPaper

    Comprehensive review of the repositioning of non-oncologic drugs for cancer immunotherapy

    Drug repositioning or repurposing has gained worldwide attention as a plausible way to search for novel molecules for the treatment of particular diseases or disorders. Drug repurposing essentially refers to uncovering approved or failed compounds …

  19. 22-03-2024 | ReviewPaper

    Dynamic interplay of nuclear receptors in tumor cell plasticity and drug resistance: Shifting gears in malignant transformations and applications in cancer therapeutics

    Recent advances have brought forth the complex interplay between tumor cell plasticity and its consequential impact on drug resistance and tumor recurrence, both of which are critical determinants of neoplastic progression and therapeutic …

  20. 20-03-2024 | Events

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