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1566 search results for:

Neurological Paraneoplastic Syndromes 

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  1. 17-03-2024 | Lambert-Eaton Myasthenic Syndrome | OriginalPaper

    Dysautonomia in anti-Hu paraneoplastic neurological syndromes

    Autonomic nervous system dysfunction is not rare in the context of autoimmune encephalitis and paraneoplastic neurological syndromes (PNS) [ 1 ]. Patients with anti-Hu antibodies, which are among the most frequently found in PNS in adults [ 2 , 3 …

  2. 13-04-2024 | Breast Cancer | Online First

    Significant improvement in paraneoplastic neurological syndromes without identifiable anti-neural antibodies in patients with breast cancer after breast surgery

    Paraneoplastic neurological syndromes (PNS) are neurological disorders that occur in close association with tumors without direct metastasis or invasion of the tumors and in which anti-neural antibodies may be present. Cerebellar ataxia is a …

  3. 08-03-2023 | Paraneoplastic Neurologic Syndrome | OriginalPaper

    Paraneoplastic neurological syndromes of the central nervous system: a single institution 7-year case series

    Paraneoplastic neurologic syndromes (PNSs) are a group of disorders resulting from a remote effect of a malignant neoplasm. PNSs may involve any part of the nervous system and result from an immune-mediated mechanism affecting neural tissue with a …

  4. 13-12-2022 | Lung Cancer | OriginalPaper

    SOX1 antibody-related paraneoplastic neurological syndromes: clinical correlates and assessment of laboratory diagnostic techniques

    In 2000, SOX ( Sry-like high-mobility group box ) proteins, a group of transcriptional activators involved in embryogenic processes, were identified as new targets of humoral immune response in patients with small-cell lung cancer (SCLC) [ 1 ].

  5. 01-09-2022 | Encephalitis | OriginalPaper

    Paraneoplastic neurological syndromes associated with renal or bladder cancer: case series and PRISMA-IPD systematic review

    Paraneoplastic neurological syndromes (PNS) are remote immune-mediated complications of cancer that affect 1 in 300 patients with malignancies [ 1 ]. The identification of a PNS heralds the diagnosis of an unknown cancer in up to 50–60% of cases [ …

  6. 27-04-2022 | SCLC | ReviewPaper

    Paraneoplastic Neurological Syndromes: Transitioning Between the Old and the New

    Paraneoplastic neurological syndromes (PNS) are immune-mediated neurological manifestations connected to the presence of an underlying cancer [ 1 ]. They are rare disorders that occur in variable percentages of patients with cancer (from less than …

  7. Open Access 01-04-2022 | Checkpoint Inhibitors | ReviewPaper

    Paraneoplastic Autoimmune Neurological Syndromes and the Role of Immune Checkpoint Inhibitors

    The introduction of immune checkpoint inhibitors (ICIs) in oncologic therapies has led to a paradigm shift in cancer treatment. ICIs have increased the overall survival in patients with malignant melanoma, small-cell lung cancer, and many other …

  8. Open Access 01-12-2021 | Paraneoplastic Syndromes | OriginalPaper

    Parkinsonism and dysautonomia with anti-CV2/CRMP5 associated paraneoplastic neurological syndromes mimicking multiple system atrophy: a case report

    PNS represents the remote effects of tumors on the nervous system, which is not associated with invasion or compression of the tumor but by activation of the immune system. Antibodies produced by the body against the tumor antigen may damage the …

  9. 01-01-2020 | Paraneoplastic Syndromes | OriginalPaper

    Epidemiology of paraneoplastic neurological syndromes: a population-based study

    Paraneoplastic neurological syndromes (PNS) are immune-mediated complications of cancer that can affect any part of the central or peripheral nervous system [ 1 – 3 ]. Their diagnosis requires the exclusion of other conditions directly or …

  10. 01-01-2019 | SCLC | OriginalPaper

    Paraneoplastic neurological syndromes: a single institution 10-year case series

    Guichard initially proposed the concept of paraneoplastic neurologic syndromes (PNSs) in 1956 as “remote effects” of cancer on the nervous system not attributable to the site of malignant neoplasm or the direct result of nutritional or metabolic …

  11. 01-03-2022 | Lymphoma | BriefCommunication

    Paraneoplastic neurological syndromes associated with non-Hodgkin lymphoma: a case series

  12. Open Access 01-05-2021 | Paraneoplastic Cerebellar Degeneration | OriginalPaper

    Granzyme B in peripheral blood mononuclear cells as a measure of cell-mediated immune response in paraneoplastic neurological syndromes and malignancy

    An antitumor immune response plays a crucial role in defense against cancer. In particular, cytotoxic T lymphocytes (CTLs), and natural killer (NK) cells exert an antitumor effect by the elimination of cancer cells. Tumor-infiltrating lymphocytes …

  13. 01-10-2017 | ReviewPaper

    Diagnostics of paraneoplastic neurological syndromes

    This document presents the guidelines for onconeural antibody testing that have been developed following a consensus process built on questionnaire-based surveys, internet contacts, and discussions at workshops of the sponsoring Italian …

  14. Open Access 01-02-2019 | OriginalPaper

    The associations between serum vascular endothelial growth factor, tumor necrosis factor and interleukin 4 with the markers of blood–brain barrier breakdown in patients with paraneoplastic neurological syndromes

    The blood–brain barrier (BBB) disruption is a critical step in paraneoplastic neurological syndrome (PNS) development. Several cytokines have been implicated in BBB breakdown. However, the exact step-by-step mechanism in which PNS develops is …

  15. 01-05-2016 | OriginalPaper

    Prostate cancer, Hu antibodies and paraneoplastic neurological syndromes

    Prostate cancer is the most common cancer among American and European men. Nervous system affection caused by local tumor growth or osseous metastases are the main causes of neurological symptoms in prostate cancer patients. Prostate cancer is …

  16. 01-10-2015 | OriginalPaper

    Incidence and spectrum of paraneoplastic neurological syndromes: single center study

    Paraneoplastic neurological syndromes (PNS) are remote effects of cancer. They are much less common, but are nevertheless important because they cause severe neurological morbidity and mortality. The present cases were studied to characterize the …

  17. Open Access 01-12-2007 | ReviewPaper

    Paraneoplastic neurological syndromes

    Paraneoplastic neurological syndromes (PNS) can be defined as remote effects of cancer that are not caused by the tumor and its metastasis, or by infection, ischemia or metabolic disruptions. PNS are rare, affecting less than 1/10,000 patients …

  18. 01-03-2003 | Legacy

    Navigating the paraneoplastic neurological syndromes

  19. 01-04-2013 | ReviewPaper

    Paraneoplastic Neurological Syndromes: General Treatment Overview

    Major recent discoveries have bringing out a revised definition of paraneoplastic neurological syndromes (PNS), bringing out the concept of antibody-mediated neurological disorders, triggered or not by cancer. Classification of these diseases is …

  20. 01-09-2006 | OriginalPaper

    Intravenous immunoglobulin therapy in paraneoplastic neurological syndromes

    Combining clinical and immunological information, a neurological syndrome can now be diagnosed as a “definite” or “possible” paraneoplastic syndrome according to the newly suggested diagnostic criteria of the PNS Euronetwork. Differentiated …

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