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9257 search results for:

Moderate Mental Retardation 

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  1. 01-06-2008 | OriginalPaper

    Psychiatric morbidity with focus on obsessive–compulsive disorder in an Israeli cohort of adolescents with mild to moderate mental retardation

    The study evaluated the prevalence of DSM-IV-TR-defined psychiatric disorders in adolescents with mental retardation, with a focus on obsessive–compulsive disorder (OCD), for which data at present are sparse. Eighty-seven adolescents with mild to …

  2. Open Access 01-12-2024 | Pulmonary Hypertension | OriginalPaper

    Clinical and genetic analysis of methylmalonic aciduria in 60 patients from Southern China: a single center retrospective study

    Methylmalonic aciduria (MMA) is a rare group of genetic metabolic disorders caused by defects in methylmalonyl coenzyme A mutase (MCM) or intracellular cobalamin (cbl) metabolism. These defects lead to the accumulation of methylmalonic acid and …

  3. Open Access 01-12-2024 | Autism Spectrum Disorder | OriginalPaper

    Phenotypic and genetic analysis of children with unexplained neurodevelopmental delay and neurodevelopmental comorbidities in a Chinese cohort using trio-based whole-exome sequencing

    Neurodevelopmental delay (NDD) is a group of common neurological diseases with high clinical heterogeneity during childhood [ 1 ] and affects approximately 1%–3% of children worldwide, resulting in an average lifetime cost of $1 million to support …

  4. 14-02-2024 | ReviewPaper

    Neurodevelopmental outcomes of preterm and growth-restricted neonate with congenital heart defect: a systematic review and meta-analysis

    The purpose of the study is to assess the risks of neurodevelopmental morbidity among preterm and growth restricted youth with congenital heart defects (CHD). This systematic review and meta-analysis included observational studies assessing …

  5. 20-03-2024 | Disorders of Intellectual Development | Online First

    A systematic review of the psychometric properties of tools for measuring depression in youths with intellectual disability

    While youths with intellectual disability (ID) have increased vulnerability for depressive disorders, cognitive problems and combined functional barriers make them less prone to receive adequate treatments. A systematic review of the literature …

  6. Open Access 01-12-2024 | Hydrocephalus | ReviewPaper

    The genetic basis of hydrocephalus: genes, pathways, mechanisms, and global impact

    Hydrocephalus (HC) is a heterogenous disease characterized by alterations in cerebrospinal fluid (CSF) dynamics that may cause increased intracranial pressure. HC is a component of a wide array of genetic syndromes as well as a secondary …

  7. 17-05-2024 | Tremor | Online First

    Managing tremor in fragile X-associated tremor/ataxia syndrome with botulinum neurotoxin: report of a success

    FXTAS is an X-linked neurodegenerative disease due to the “premutation” in the Fragile-X mental retardation 1 (FMR1) gene [ 1 ], defined as the expansion of the 5’-untranslated-region (5’-UTR) CGG trinucleotide in the range between 55 and 200 …

  8. 04-05-2024 | Online First

    Effects of Various Interval Hypoxic Training Regimens in Experimental Models of Anxious-Depressive States in Rats

    The development of non-drug-based methods for correcting stress-induced disorders and improving adaptation to stress remains an urgent task in physiology and has great translational potential. We have previously proposed methods for hypoxic …

  9. 16-01-2024 | Trisomy 21 | ReviewPaper

    Symptoms and age of prodromal Alzheimer’s disease in Down syndrome: a systematic review and meta-analysis

    The diagnostic criteria for adult-onset Alzheimer’s disease (AD) in patients with Down syndrome (DS) have not been standardised. This study investigated the specific symptoms of AD in the prodromal stage of DS, the mean age at diagnosis at each …

  10. Open Access 06-05-2024 | Online First

    The Within-Subject Association of Physical Behavior and Affective Well-Being in Everyday Life: A Systematic Literature Review

    Physical activity is indispensable for human health, but worldwide and across ages physical activity is declining [ 1 , 2 ]. Therefore, to foster prevention and treatment of physical and mental disorders, the World Health Organization addresses the …

  11. Open Access 01-12-2024 | Mood Disorders | OriginalPaper

    Cortical activation for adolescent-onset minor depression and major depressive disorder: an fNIRS study

    Depression is characterized by depressed mood, lack of interest and low energy, with additional clinical symptoms including poor concentration, feelings of guilt or worthlessness, appetite changes, sleep disturbances, psychomotor retardation or …

  12. Open Access 16-02-2024 | Meningococcus | OriginalPaper

    Cost of Illness Analysis of Invasive Meningococcal Disease Caused by Neisseria Meningitidis Serogroup B in the Netherlands—a Holistic Approach

    This article is published with digital features, including a graphical plain language summary, to facilitate understanding of the article. To view digital features for this article, go to https://doi.org/ …

  13. 01-04-2024 | Events

    SPR 2024

  14. 08-04-2024 | Cataract | Online First

    Atypical phenotypes and novel OCRL variations in southern Chinese patients with Lowe syndrome

    The oculocerebrorenal syndrome of Lowe (Lowe syndrome, OMIM #309000) is an X-linked recessive disorder that impacts multiple systems and is estimated to affect approximately 1 in 500,000 individuals [ 1 ]. The characteristic features of Lowe …

  15. 01-05-2024 | Schizophrenia | ReviewPaper

    Oral health of people with emotional disorders: A systematic review and meta-analysis

    Mental disorders are among the main contributors to the global burden of diseases in the world, with substantial individual and societal costs [ 1 , 2 ]. In 2019, one in eight people (970 million) worldwide were affected by a mental health disorder …

  16. Open Access 01-12-2024 | OriginalPaper

    Relationship between the number of lost teeth and the occurrence of depressive symptoms in middle-aged adults: a cross-sectional study

    Depression is one of the most common mental health disorders worldwide and can originate from genetic, biological, and environmental factors [ 1 , 2 ]. Depressive symptoms, such as lowered mood (sadness, despondency, reliving of negative events …

  17. Open Access 01-12-2024 | SARS-CoV-2 | OriginalPaper

    The long-term neurodevelopmental outcomes of toddlers with SARS-CoV-2 infection in the neonatal period: a prospective observational study

    Respiratory viruses are opportunistic pathogens that infect the upper respiratory tract in humans and cause serious illness in particularly vulnerable populations. Some viruses can invade the central nervous system (CNS) and activate the immune …

  18. Open Access 08-04-2024 | Polyneuropathy | Online First

    Genetic aspects of ataxias in a cohort of Turkish patients

    Ataxia originated from the Greek word, meaning “disorderly’ or “lack of order.” It is a general term formerly used for heartbeat, gait, and movement disorders. The definition of ataxia is loss of function such as gait abnormality, speech changes …

  19. Open Access 01-12-2024 | Mood Disorders | OriginalPaper

    Schema therapy versus treatment as usual for outpatients with difficult-to-treat depression: study protocol for a parallel group randomized clinical trial (DEPRE-ST)

  20. 27-03-2024 | OriginalPaper

    Genetic Aspects of Speech Disorders in Children

    Speech disorders remain one of the main challenges in pediatric neurology. The development of genetic diagnostics is producing ever more data on the role of chromosomal and gene disorders in the genesis of speech disorders. This report provides …

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