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Interstitial Nephritis 

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  1. Open Access 01-12-2024 | Checkpoint Inhibitors | OriginalPaper

    Immune checkpoint inhibitors induce acute interstitial nephritis in mice with increased urinary MCP1 and PD-1 glomerular expression

    Immune checkpoint inhibitors (ICI) have improved the prognosis of a number of malignancies. ICI inhibit the programmed cell death protein 1 (PD-1)/ programmed cell death ligand 1 (PD-L1)/ programmed cell death ligand 2 (PD-L2) immunoregulatory …

  2. 17-04-2024 | Amyloidosis | Online First

    ALECT2 amyloidosis with concurrent IgG4-related interstitial nephritis, membranous nephropathy and diabetic kidney disease: a case report and literature review

    Leukocyte chemotactic factor-2 amyloidosis (ALECT2) is a recently described subtype of amyloidosis. IgG4-related disease is a rare fibroinflammatory condition characterized by dense interstitial lymphoplasmacytic infiltrates and fibrosis.

  3. Open Access 01-02-2024 | Interstitial Nephritis | Online First

    A case of acute interstitial nephritis superimposed on rhabdomyolysis in a refugee patient

    A 46-year-old male patient of Syrian origin, who has temporary protection status in Turkey, was brought to our Emergency Department with superficial wounds all over his body. He had nausea, malaise, swollen extremities and muscle weakness. He was …

  4. 06-11-2023 | Interstitial Nephritis | ReviewPaper

    Acute interstitial nephritis caused by ANCA-associated vasculitis: a case based review

    Antineutrophil cytoplasmic antibodies (ANCA)–associated vasculitis (AAV) typically manifests as rapidly progressive glomerulonephritis with crescent formation. In this report, we present a local case of myeloperoxidase (MPO)-AAV–associated acute …

  5. Open Access 01-12-2023 | Doxycycline | OriginalPaper

    Randomized control trial of prednisolone and doxycycline in patients with acute interstitial nephritis of unknown aetiology

    Endemic chronic kidney disease of unknown aetiology (CKDu) which is prevalent in Sri Lanka and many other tropical countries rank amongst diabetes mellitus and essential hypertension in causing chronic kidney disease (CKD) [ 1 – 5 ]. This condition …

  6. 14-08-2023 | Melanoma | ContinuingEducation

    Granulomatous interstitial nephritis following BRAF/MEK inhibitor treatment for metastatic melanoma

  7. Open Access 01-12-2023 | Sarcoidosis | OriginalPaper

    Systemic sarcoidosis presenting as a rare combination of interstitial nephritis with necrotizing vasculitis and urinary retention due to prostate involvement: a case report

    Sarcoidosis is a systemic inflammatory disease with various clinical presentations that commonly involves the lungs, skin, lymph nodes, eyes, and other organs, including the kidneys [ 1 , 2 ]. Granulomatous inflammation is the hallmark pathological …

  8. Open Access 01-12-2023 | Interstitial Nephritis | OriginalPaper

    Renal tubular acidosis without interstitial nephritis in Sjögren’s syndrome: a case report and review of the literature

    Primary Sjögren’s syndrome (pSS) is a chronic systemic autoimmune disease characterized by lymphoplasmacytic infiltration of the lacrimal and salivary glands [ 1 ]. Renal dysfunction is often observed in pSS [ 2 ]. Peritubular and interstitial

  9. Open Access 01-12-2022 | Tuberculosis | OriginalPaper

    Urinary tract tuberculosis misdiagnosed and treated as renal carcinoma in the presence of diffuse interstitial nephritis: a case report

    The bacillus Mycobacterium tuberculosis causes tuberculosis (TB). About one quarter of the world's population is infected with this bacillus, and it is the leading cause of death due to a single infectious agent and among the top ten causes of …

  10. 19-11-2022 | Lung Cancer | OriginalPaper

    Anti-glomerular basement membrane glomerulonephritis concurrent with membranous nephropathy and acute tubular interstitial nephritis in a lung cancer patient treated with pembrolizumab

    Immune checkpoint inhibitors (ICIs) have become the standard treatment for many types of cancer and have improved patient prognosis. However, ICIs upregulate the immune system against tumors, leading to immune-related adverse events (irAEs).

  11. Open Access 01-12-2023 | Kidney Transplantation | OriginalPaper

    Karyomegalic interstitial nephritis as a rare cause of kidney graft dysfunction: case report and review of literature

    Karyomegalic interstitial nephritis (KIN) is a rare cause of chronic interstitial nephritis characterized by enlarged renal tubular epithelial nuclei. The first case of KIN reported in a kidney graft was in 2019. Here, we report the first case of …

  12. Open Access 01-12-2023 | Acute Kidney Injury | OriginalPaper

    A low BUN/creatinine ratio predicts histologically confirmed acute interstitial nephritis

    Acute interstitial nephritis (AIN) accounts for 13–27% of acute kidney injury (AKI) cases in hospitalized patients and is diagnosed in 13% of kidney biopsies performed for AKI [ 1 – 3 ]. AIN histopathology is characterized by interstitial

  13. Open Access 01-12-2023 | Autoimmune Pancreatitis | OriginalPaper

    A case of IgG4-related interstitial nephritis with ureteral obstruction: case report and literature review

    IgG4-RD is a newly discovered systemic disease in the past 20 years, which can affect any organ or tissue in the body [ 1 ]. IgG4-RKD is relatively rare but an essential component of IgG4-RD. The most common renal manifestations of IgG4-RKD are …

  14. Open Access 01-12-2021 | Interstitial Nephritis | OriginalPaper

    Prednisolone treatment in acute interstitial nephritis (PRAISE) – protocol for the randomized controlled trial

    Acute renal failure is associated with greatly increased mortality and morbidity irrespective of its cause [ 1 , 2 ]. Acute interstitial nephritis (AIN) is an important and common cause of acute renal failure and occurs in 13–27% of renal biopsies …

  15. 30-10-2021 | Interstitial Nephritis | ContinuingEducation

    Lessons for the clinical nephrologist: a rare pediatric case of interstitial nephritis with karyomegaly

    A 2-year-old male with a history of refractory acute myeloid leukemia (AML) received a matched unrelated donor stem cell transplant with a preparative regimen of busulfan, fludarabine, and single fraction total body irradiation (2 Gy). He was …

  16. 01-05-2021 | Kidney Cancer

    Minimal change disease concurrent with acute interstitial nephritis after long-term use of sorafenib in a patient with renal cell carcinoma

    Sorafenib is one of the multi-targeted tyrosine kinase inhibitors (TKI), mainly used for treating advanced renal cell carcinoma. Accumulated evidence indicates a minority of patients develop nephrotic syndrome (NS) as a high-grade nephrotoxic …

  17. 01-05-2020 | Kidney Injury | OriginalPaper

    Carboplatin-related acute interstitial nephritis in a patient with pancreatic neuroendocrine tumor

    Carboplatin is characterized by low nephrotoxicity, including acute tubular necrosis (ATN), compared to a conventional platinum complex due to its low accumulative property in the renal tubules. Therefore, there are extremely few reports of …

  18. Open Access 01-12-2022 | Levofloxacin | OriginalPaper

    Granulomatous interstitial nephritis with CTLA-4 haploinsufficiency: a case report

    Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential inhibitory regulator of immune activation, i.e., a “checkpoint” molecule in immune tolerance [ 1 , 2 ]. Homozygous deficiency of CTLA4 in mice causes fatal multiorgan lymphocytic …

  19. 26-09-2022 | Lymphoma | OriginalPaper

    Renal infiltration of peripheral T-cell lymphoma, not otherwise specified, mimicking drug-induced acute interstitial nephritis

    Renal invasion of T-cell lymphoma does not usually occur. The renal infiltration of peripheral T-cell lymphoma, not otherwise specified (PTCL–NOS), is rare. Therefore, the detailed pathology, clinical features, and effective therapy of this type …

  20. 01-07-2020 | Acute Kidney Injury | OriginalPaper

    Reintroduction of nivolumab in a patient with gastric cancer after improvement of nivolumab-induced acute interstitial nephritis: a case report

    Nivolumab, an anti-programmed cell death-1 (PD-1) antibody, has attracted increasing attention as a new treatment modality for gastric cancer. Herein, a case of acute kidney injury in a 66-year-old man with gastric cancer treated with nivolumab is …

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