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Falciparum Malaria 

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  1. Open Access 01-12-2024 | Malaria | OriginalPaper

    Molecular markers of artemisinin resistance during falciparum malaria elimination in Eastern Myanmar

    Artemisinin combination therapies (ACTs) are the first-line treatment for P. falciparum malaria globally. In the Greater Mekong Subregion (GMS) artemisinin resistance has emerged over the past two decades. This is characterized by slow parasite …

  2. Open Access 01-12-2024 | Malaria | OriginalPaper

    Genetic polymorphism and evidence of signatures of selection in the Plasmodium falciparum circumsporozoite protein gene in Tanzanian regions with different malaria endemicity

    Malaria remains a major public health problem worldwide, with nearly half of the world’s population at risk and lives in areas where malaria transmission occurs, but with the majority of cases and deaths from sub-Saharan (SSA) [ 1 ]. In 2022, over …

  3. Open Access 01-12-2024 | Malaria | OriginalPaper

    Ageing of Plasmodium falciparum malaria sporozoites alters their motility, infectivity and reduces immune activation in vitro

    Novel vaccines and drugs are urgently needed to alleviate the burden of disease by malaria and reverse the recent resurgence of cases [ 1 – 3 ]. Plasmodium falciparum sporozoites (SPZ), the infective form of malaria, are considered a key target for …

  4. Open Access 01-12-2024 | Malaria | OriginalPaper

    Efficacy of artesunate-amodiaquine for treatment of uncomplicated Plasmodium falciparum malaria in mainland Tanzania

    Artemisinin-based combination therapy (ACT) remains a treatment of choice for uncomplicated Plasmodium falciparum malaria globally [ 1 , 2 ]. Six artemisinin-based combinations have been pre-qualified by the World Health Organization (WHO) for …

  5. Open Access 01-12-2024 | Malaria | OriginalPaper

    Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in mainland Tanzania, 2019

    Artemisinin-based combination therapy (ACT) has been a major contributor to the substantial reductions in global malaria morbidity and mortality over the last decade [ 1 ]. The most commonly used artemisinin-based combinations in Africa are …

  6. 08-04-2024 | Plasmodium Malariae | Online First

    Co-Infectious Mystery: Why Artemether-Lumefantrine Cleared P. falciparum but Left P. malariae behind

  7. Open Access 01-12-2024 | Malaria | OriginalPaper

    Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in mainland Tanzania, 2018

    Plasmodium falciparum malaria is a major public health threat especially to children under-five years of age and pregnant women in sub-Saharan Africa (SSA). Early diagnosis and prompt treatment with effective drugs remains the mainstay of malaria

  8. Open Access 01-12-2024 | Malaria | OriginalPaper

    Evaluating the performance of Plasmodium falciparum genetic metrics for inferring National Malaria Control Programme reported incidence in Senegal

    Pathogen genomics is revolutionizing public health by providing a rich data source for informing real-time, actionable recommendations for public health programmes [ 1 ]. Each pathogen genome is a unique record of its previous transmission history …

  9. Open Access 01-12-2024 | Epigenetics | ReviewPaper

    Epigenetic regulation as a therapeutic target in the malaria parasite Plasmodium falciparum

    Over the past thirty years, epigenetic regulation of gene expression has gained increasing interest as it was shown to be implicated in illnesses ranging from cancers to parasitic diseases. In the malaria parasite, epigenetics was shown to be …

  10. Open Access 01-12-2024 | Malaria | OriginalPaper

    Dynamics of malaria vector composition and Plasmodium falciparum infection in mainland Tanzania: 2017–2021 data from the national malaria vector entomological surveillance

    Malaria is still a major cause of illness in about 85 countries worldwide, with an estimated 249 million cases in 2022 [ 1 ]. Globally, malaria cases have increased by 7.39% from the baseline year of the Global Technical Strategy for malaria

  11. Open Access 01-12-2024 | Malaria | OriginalPaper

    Immune responses to P falciparum antibodies in symptomatic malaria patients with variant hemoglobin genotypes in Ghana

    Malaria continues to be a significant public health problem in Ghana, as it is in the rest of Sub-Saharan Africa. Ghana is one of ten African countries with the highest malaria burden with 5.9 million, 5.7 million, and 5.3 million malaria cases …

  12. Open Access 01-12-2024 | Malaria | OriginalPaper

    Geospatial analysis of Plasmodium falciparum serological indicators: school versus community sampling in a low-transmission malaria setting

    Malaria is a disease caused by infection with Plasmodium parasites, and global cases and deaths have declined substantially since 2000 [ 1 ], with 25 countries achieving zero locally acquired cases and many more approaching this significant …

  13. Open Access 27-10-2023 | Malaria | OriginalPaper

    Coinfections and antimicrobial treatment in a cohort of falciparum malaria in a non-endemic country: a 10-year experience

    Falciparum malaria (malaria) remains one of the deadliest infectious diseases worldwide and is caused by Plasmodium falciparum [ 1 ]. The disease was eradicated from Europe by the mid-twentieth century and at present occurs nearly exclusively as …

  14. Open Access 01-12-2024 | Malaria | OriginalPaper

    Anopheles arabiensis continues to be the primary vector of Plasmodium falciparum after decades of malaria control in southwestern Ethiopia

    Female Anopheles mosquitoes can carry Plasmodium protozoan parasites, some of which transmit to humans. The majority of malaria caused by Plasmodium falciparum and Plasmodium vivax occurs in Africa. Between 2010 and 2017, there was a noticeable …

  15. Open Access 01-12-2024 | Malaria | OriginalPaper

    Asymptomatic Plasmodium falciparum carriage at the end of the dry season is associated with subsequent infection and clinical malaria in Eastern Gambia

    Malaria continues to be a significant public health challenge in several parts of the world, where it is responsible for a high burden of morbidity and mortality [ 1 , 2 ]. Despite the impact of standard control interventions, asymptomatic …

  16. Open Access 01-12-2024 | Malaria | OriginalPaper

    Limited threat of Plasmodium falciparum pfhrp2 and pfhrp3 gene deletion to the utility of HRP2-based malaria RDTs in Northern Uganda

    Malaria remains a public health problem in Uganda [ 1 ]. Transmission occurs throughout the year with peak transmission occurring between in May–June and November–December. Although the entire population remains at risk of malaria infections …

  17. 06-02-2024 | Malaria | Online First

    Protective efficacy and safety of radiation-attenuated and chemo-attenuated Plasmodium Falciparum sporozoite vaccines against controlled and natural malaria infection: a systematic review and meta-analysis of randomized controlled trials

    Malaria caused by Plasmodium falciparum (Pf falciparum) is a life-threatening disease particularly in tropical regions of the world. The vast majority of Pf infections are acquired through the bites of infected Anopheles mosquitoes [ 1 ]. According …

  18. Open Access 01-12-2023 | Plasmodium Vivax | OriginalPaper

    Imported and indigenous Plasmodium Vivax and Plasmodium Falciparum malaria in the Hubei Province of China, 2005–2019

    Malaria is one of the most serious public health problems worldwide. In 2021, 84 malaria-endemic countries reported 247 million malaria cases and 619,000 malaria-attributed deaths. Most malaria cases (95%) occurred in the African region, followed …

  19. Open Access 01-12-2023 | Malaria | OriginalPaper

    Estimation of parasitaemia in imported falciparum malaria using the results of a combined rapid diagnostic test. No big help from haematological parameters

    Malaria is the most important parasitic disease in the world. Nearly half of the world's population lives in areas at risk for infection. In 2021, there were an estimated 247 million malaria new cases and about 619,000 related deaths [ 1 ].

  20. Open Access 01-12-2023 | Plasmodium Falciparum | OriginalPaper

    Factors affecting haemoglobin dynamics in African children with acute uncomplicated Plasmodium falciparum malaria treated with single low-dose primaquine or placebo

    Since the 2012 WHO recommendation to use single low-dose primaquine (SLDPQ) as an elimination tool for multidrug, especially artemisinin, resistant Plasmodium falciparum (ARPf) [ 1 ], several studies have shown its transmission blocking efficacy …

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