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Direct Oral Anticoagulant 

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  1. 27-04-2024 | Online First

    Direct Oral Anticoagulants: An Update on Monitoring and Antidotes for the Perioperative Physician

    Historically, vitamin K antagonists (VKAs) such as warfarin were the predominant option, and in fact the only oral agents, for patients requiring prolonged anticoagulation. Over the past decade, however, direct oral anticoagulants (DOACs) …

  2. 30-03-2024 | Direct Oral Anticoagulant | OriginalPaper

    Management of direct oral anticoagulant drug interactions in hospitalized patients

    Moderate-strong CYP3A4 or Pgp inhibitors and inducers alter direct oral anticoagulant (DOAC) pharmacokinetics. Whether the presence of a DOAC drug-drug interaction (DDI) prompts in- hospital changes in management remains unknown. We identified all …

  3. 23-02-2024 | Direct Oral Anticoagulant | OriginalPaper

    A ten-year comparison of treatment and outcomes of cancer-associated thrombosis to non-cancer venous thromboembolism: from traditional anticoagulants to direct oral anticoagulants

    DOACs have emerged as first-line treatment in most cancer-associated thrombosis (CAT), representing a paradigm shift in its management. However, CAT management remains challenging and requires careful risk–benefit considerations. A retrospective …

  4. Open Access 01-12-2024 | ReviewPaper

    Efficacy and safety of direct oral anticoagulants in patients with atrial fibrillation combined with chronic kidney disease: a systematic review and meta-analysis

    Published studies have yielded inconsistent findings regarding the effectiveness and safety of DOACs in patients with AF and CKD. Patients with atrial fibrillation (AF) are susceptible to stroke or thromboembolic events due to increased heart …

  5. 16-03-2024 | Direct Oral Anticoagulant | OriginalPaper

    Outcomes of venous thromboembolism in patients with inherited thrombophilia treated with direct oral anticoagulants: insights from the RIETE registry

    While direct oral anticoagulants (DOACs) are frequently used to treat venous thromboembolism (VTE), the outcomes of patients with inherited thrombophilia (IT) receiving DOACs for VTE remain understudied. We used data from the international RIETE …

  6. 26-02-2024 | Direct Oral Anticoagulant | OriginalPaper

    Retrospective, multicenter analysis of the safety and effectiveness of direct oral anticoagulants for the treatment of venous thromboembolism in obesity

    The prevalence of obesity has increased in the United States from 30.5% of the population in 1999–2000 to 42.4% in 2017–2018 [ 1 ]. Obesity more than doubles the risk of developing venous thromboembolism (VTE) [ 2 – 5 ]. In 2018, it was estimated …

  7. 01-03-2024 | Direct Oral Anticoagulant | OriginalPaper

    The incidence of major bleeding in adult patients with urogenital and gynecological cancer being treated with direct oral anticoagulants (DOACs): a systematic review

    Cancer-associated venous thromboembolism (VTE) is a common complication and a leading cause of morbidity and mortality in cancer patients [ 1 ]. Patients with cancer have more than a 4-to-6-fold risk of VTE compared to the general population [ 2 ] …

  8. Open Access 01-12-2024 | Direct Oral Anticoagulant | OriginalPaper

    European expert consensus recommendations on the primary care use of direct oral anticoagulants in patients with venous thromboembolism

    Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), refers to the formation of a clot which fully or partially obstructs blood flow [ 1 ]. VTE is the third most common cause of vascular mortality …

  9. 10-02-2024 | Direct Oral Anticoagulant | OriginalPaper

    The Management of Direct Oral Anticoagulants for Colorectal Endoscopic Submucosal Dissection: A Multicenter Observational Study

    The global incidence of colorectal cancer (CRC) continues to increase [ 1 , 2 ]. As a result, endoscopic submucosal dissection (ESD) has gained popularity as an effective treatment for early-stage CRC. ESD is particularly advantageous for …

  10. 09-02-2024 | Edoxaban | OriginalPaper

    Age-related variation in coagulation factors in non-valvular atrial fibrillation patients receiving direct oral anticoagulants

    Age is a significant risk factor for ischemic stroke. However, the influence of aging on coagulation parameters in non-valvular atrial fibrillation (NVAF) patients treated with direct oral anticoagulants (DOACs) remains unclear. A total of 775 …

  11. Open Access 01-12-2024 | Direct Oral Anticoagulant | OriginalPaper

    Effect of direct oral anticoagulants on bleeding during and after cataract surgery

    Direct oral anticoagulants (DOACs) were developed as alternatives to warfarin. The most common available DOACs are the direct factor IIa inhibitor dabigatran (Pradaxa), and the direct factor Xa inhibitors rivaroxaban (Xarelto) and apixaban …

  12. Open Access 02-04-2024 | Direct Oral Anticoagulant | Online First

    A real-world exploration into clinical outcomes of direct oral anticoagulant therapy in people with chronic kidney disease: a large hospital-based study

    Direct Oral Anticoagulants (DOACs) are the first-line anticoagulation therapy prescribed for venous thromboembolism and atrial fibrillation patients with normal kidney function or moderately severe chronic kidney disease (CKD) [ 1 ]. The volume of …

  13. Open Access 20-03-2024 | Direct Oral Anticoagulant | Online First

    Predictors of Plasma Levels of Direct Oral Anticoagulants Among Patients with Atrial Fibrillation in Need of Elective Cardiac Procedures

    Direct oral anticoagulants (DOACs) are the first-line anticoagulant therapy for the treatment of atrial fibrillation (AF) in patients with increased thromboembolic risk [ 1 ]. The timing of DOACs discontinuation before elective invasive surgery is …

  14. 22-01-2024 | Direct Oral Anticoagulant | OriginalPaper

    Potential of Direct Oral Anticoagulant in Bleeding After Gastric Endoscopic Submucosal Dissection: A Systematic Review and Meta-Analysis

    Gastric cancer is one of the most common gastrointestinal cancers and the third leading cause of cancer-related deaths worldwide [ 1 ]. Endoscopic submucosal dissection (ESD) has been established as a standard minimally invasive treatment for early …

  15. 09-02-2024 | Apixaban | Online First

    Variability of the anticoagulant effect according to body weight in patients treated with direct oral anticoagulants

    To evaluate the variability of anticoagulant activity according to BW, we performed a prospective, observational, pilot study on 100 consecutive patients with AF treated with rivaroxaban 20 mg once daily or apixaban 5 mg twice daily (with a …

  16. Open Access 16-12-2023 | Oral Anticoagulant | OriginalPaper

    Adherence to direct or vitamin K antagonist oral anticoagulants in patients with atrial fibrillation: a long-term observational study

    Our objectives were to measure long-term adherence to oral anticoagulants (OACs) in patients with atrial fibrillation (AF) and to identify patient factors associated with adherence. Using linked, population-based administrative data from British …

  17. Open Access 22-02-2024 | Direct Oral Anticoagulant | ReviewPaper

    Comparative Effectiveness and Safety of Direct Oral Anticoagulants Compared with Warfarin in Patients with Low Bodyweight who have Atrial Fibrillation: A Systematic Review and Meta-analysis

    Atrial fibrillation (AF) is the most common type of cardiac arrhythmia [ 1 ]. AF could present as persistent, permanent, or paroxysmal AF [ 1 ]. Ischemic stroke represents the most morbidity-prone consequence in patients with AF. Strokes related to …

  18. Open Access 01-12-2024 | Direct Oral Anticoagulant | ReviewPaper

    Efficacy and safety of direct oral anticoagulants versus low-molecular-weight heparin for thromboprophylaxis after cancer surgery: a systematic review and meta-analysis

    Venous thromboembolic events (VTEs), including deep vein thrombosis (DVT) and pulmonary embolism (PE), remain major causes of morbidity and mortality in patients with cancer [ 1 ]. Patients with cancer increased sevenfold risk of venous thrombosis …

  19. Open Access 21-02-2024 | Direct Oral Anticoagulant | OriginalPaper

    The effect of off-label use of reduced-dose direct oral anticoagulants therapy in the treatment of pulmonary embolism comparable to standard-dose therapy

    Direct oral anticoagulants (DOACs) have been shown to be effective and safe in preventing pulmonary embolism recurrence. In this single-center retrospective observational study, we aimed to evaluate the efficacy and safety of reduced-dose DOACs in …

  20. 28-01-2024 | Direct Oral Anticoagulant | OriginalPaper

    Direct oral anticoagulants versus vitamin K antagonists in patients with atrial fibrillation and stage 5 chronic kidney disease under dialysis: A systematic review and meta-analysis of randomized controlled trials

    Atrial fibrillation (AF) is the most frequent sustained arrhythmia, with its prevalence in the general population estimated between 0.5% and 1% [ 1 , 2 ]. Chronic kidney disease (CKD) is one independent risk factor for presenting AF and for …

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