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Primary Sclerosing Cholangitis 

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  1. Open Access 01-12-2024 | Primary Sclerosing Cholangitis | OriginalPaper

    Genetically predicted gut microbiota mediate the association between plasma lipidomics and primary sclerosing cholangitis

    Primary sclerosing cholangitis (PSC) is a rare and chronic cholestatic liver disease characterized by intrahepatic or extrahepatic stricturing, or both, accompanied by bile duct fibrosis [ 1 ]. Its prevalence is highest in northern Europe and lower …

  2. 07-05-2024 | Primary Sclerosing Cholangitis | Online First

    What is the appropriate method of pathological specimen collection for cholangiocarcinoma detection in primary sclerosing cholangitis?

    Primary sclerosing cholangitis (PSC) is characterized pathologically by chronic inflammation and fibrosis and clinically by chronic biliary stasis [ 1 ]. As the disease progresses, diffuse stricture and wall thickening appear in the bile ducts …

  3. Open Access 01-12-2024 | Sarcopenia | OriginalPaper

    Imaging-based diagnosis of sarcopenia for transplant-free survival in primary sclerosing cholangitis

    Determining the prognosis of patients with primary sclerosing cholangitis (PSC) is challenging. The natural history of patients with PSC is variable but frequently culminates in end-stage liver disease. The clinical course of PSC is complicated by …

  4. 12-02-2024 | Primary Sclerosing Cholangitis | EditorialNotes

    Risk Stratification in Primary Sclerosing Cholangitis: Does Size Matter?

  5. 03-01-2024 | Primary Sclerosing Cholangitis | OriginalPaper

    An atypical case of isolated immunoglobulin G4-related sclerosing cholangitis with a cholangiogram resembling primary sclerosing cholangitis

    An asymptomatic 77-year-old man with intrahepatic bile duct dilation was referred to our hospital. Cholangiography revealed alternations between strictures and dilated segments from the right and left hepatic ducts to the lower bile ducts, with …

  6. 12-02-2024 | Primary Sclerosing Cholangitis | OriginalPaper

    Primary Sclerosing Cholangitis Limited to Intrahepatic Bile Ducts Has Distinctly Better Prognosis

    Primary sclerosing cholangitis (PSC) is a chronic liver disease where inflammation and fibrosis lead to multifocal biliary strictures and cirrhosis [ 1 – 5 ]. Based on the bile duct involvement, PSC is usually classified into the “classic” …

  7. 22-03-2024 | Primary Sclerosing Cholangitis | Online First

    Primary Sclerosing Cholangitis: Gender Effects in Valencia’s Low-Prevalence Region

    Primary sclerosing cholangitis (PSC) is a chronic disease characterized by inflammation and fibrotic obliteration of the intra- and extrahepatic bile ducts, which causes long-term cholestasis and liver fibrosis. It is more commonly observed in the …

  8. 21-03-2024 | Primary Sclerosing Cholangitis | Online First

    Spontaneous perforation of the common bile duct: an uncommon complication of primary sclerosing cholangitis

    Primary sclerosing cholangitis (PSC) is a rare chronic cholestatic disorder of poorly understood etiology, characterized by inflammatory and fibrosing lesions of the intra- and/or extra-hepatic bile ducts [ 1 – 5 ].

  9. 11-11-2023 | Primary Sclerosing Cholangitis | OriginalPaper

    Proteome-wide Mendelian randomization highlights AIF1 and HLA-DQA2 as targets for primary sclerosing cholangitis

    Primary sclerosing cholangitis (PSC) is a kind of rare cholestatic liver disease characterized by intrahepatic or extrahepatic (or both) bile duct structuring which is caused by the inflammation and fibrosis of the bile duct, accompanied by …

  10. Open Access 01-12-2024 | Primary Sclerosing Cholangitis | OriginalPaper

    Investigating the shared genetic architecture between primary sclerosing cholangitis and inflammatory bowel diseases: a Mendelian randomization study

    Inflammatory bowel disease (IBD) is a chronic intestinal disorder with unknown etiology. Many studies point to the presence of genetic predisposition, intestinal mucosal immune system dysfunction, and microbiota imbalance [ 1 ] in the occurrence …

  11. Open Access 01-12-2023 | Magnetic Resonance Cholangio Pancreatography | OriginalPaper

    Overlap syndrome of primary biliary cholangitis and primary sclerosing cholangitis: two case reports

    Overlap syndrome is a condition characterized by the coexistence of features belonging to different disorders within the spectrum of autoimmune liver diseases: autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing

  12. 13-10-2023 | Primary Sclerosing Cholangitis | OriginalPaper

    Interobserver agreement and prognostic value of image-based scoring systems in patients with primary sclerosing cholangitis

    Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease strongly associated with inflammatory bowel disease for which liver transplant remains the only effective treatment [ 1 ]. The natural history of PSC is complex with liver …

  13. 01-12-2023 | Primary Sclerosing Cholangitis | OriginalPaper

    Incidence and adverse clinical events of primary sclerosing cholangitis with ulcerative colitis

    Primary sclerosing cholangitis (PSC) is a chronic, immune-mediated, cholestatic liver disease characterized by progressive inflammation and fibrosis of bile ducts, causing bile duct obstruction and dilatation. The dominant clinical presentation of …

  14. Open Access 13-06-2023 | Primary Sclerosing Cholangitis | OriginalPaper

    Anti-integrin αvβ6 autoantibodies in patients with primary sclerosing cholangitis

    Primary sclerosing cholangitis (PSC) is an idiopathic and lethal cholestatic liver disease characterized by persistent and progressive biliary inflammation and fibrosis [ 1 – 4 ]. Although the cause and pathogenesis of PSC are unclear, it is …

  15. Open Access 20-07-2023 | Primary Sclerosing Cholangitis | OriginalPaper

    Diagnosis of functional strictures in patients with primary sclerosing cholangitis using hepatobiliary contrast-enhanced MRI: a proof-of-concept study

    Primary sclerosing cholangitis (PSC) is a chronic, idiopathic, fibroinflammatory cholestatic liver disease that causes strictures of the intra- and/or extrahepatic biliary tree leading to progressive biliary and hepatic damage that results in …

  16. Open Access 01-12-2022 | Primary Sclerosing Cholangitis | OriginalPaper

    Algebraic topology-based machine learning using MRI predicts outcomes in primary sclerosing cholangitis

    Algebraic topology-based machine learning can extract informative features. This approach can indicate visual patterns of the liver associated with hepatic decompensation in patients affected with primary sclerosing cholangitis (PSC). The novel …

  17. Open Access 26-07-2023 | Primary Sclerosing Cholangitis | OriginalPaper

    Oxidative stress-related markers as prognostic factors for patients with primary sclerosing cholangitis in Japan

    Primary sclerosing cholangitis (PSC) is a chronic liver disease with inflammation and fibrosis of the bile ducts. Although PSC has been suggested to be an immune-related disease, the precise mechanisms have not been clearly demonstrated [ 1 ]. PSC …

  18. 26-06-2023 | Primary Sclerosing Cholangitis | ReviewPaper

    The Many Faces of Primary Sclerosing Cholangitis: Controversy Abounds

    Primary sclerosing cholangitis (PSC) is notoriously challenging to manage given its heterogeneity with regard to diagnosis, management, and progression. The lack of disease-modifying therapy and variable rate of onset of cirrhosis, portal …

  19. 14-07-2023 | Primary Sclerosing Cholangitis | OriginalPaper

    Impact of Inflammatory Bowel Disease Subtypes on the Post-liver Transplant Outcomes of Patients with Primary Sclerosing Cholangitis

    Patients with primary sclerosing cholangitis (PSC) suffer from autoimmune destruction of the hepatobiliary tracts, which culminates in ductal damage, ductopenia, lymphocytic infiltration of hepatobiliary tracts, parenchymal inflammation, and …

  20. 28-03-2022 | Liver Transplantation | OriginalPaper

    Patient-Predicted Outcomes Are Associated with Quality of Life in Patients with Primary Sclerosing Cholangitis

    PSC is a rare, chronic, cholestatic liver disease characterized by progressive biliary inflammation and fibrosis and is closely associated with inflammatory bowel disease (IBD), particularly ulcerative colitis. There is currently no available …

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